tag:blogger.com,1999:blog-26507505947873979712024-03-05T05:38:27.561-08:00NeuroNerd"Il CERVELLO - è più vasto del cielo." E. DickinsonGiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.comBlogger19125tag:blogger.com,1999:blog-2650750594787397971.post-79747067231878899282014-02-21T08:34:00.002-08:002014-02-21T08:34:55.761-08:00Cosa c'è nella testa dei pazienti in stato vegetativo?<div class="separator" style="clear: both; text-align: center;">
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<span style="font-family: inherit;"><span style="color: #333333;">Lo stato vegetativo, quello che un tempo veniva definito “coma
vigile”, rappresenta una delle possibili evoluzioni del coma propriamente
detto. D</span><span style="color: #333333;">opo alcune </span><span style="color: #333333;">settimane </span><span style="color: #333333;">di coma, infatti, pazienti che hanno perso coscienza,
comunicazione e riflessi riacquistano alcune funzioni, come quelle vegetative e il ritmo sonno-veglia. Possono aprire e chiudere gli occhi o muoverli in maniera
disordinata, respirare senza ventilatore, sbadigliare, deglutire, afferrare un
oggetto quando viene posto sul palmo della mano o anche ridere e piangere. Tutto,
però, avviene in modo automatico. Questi pazienti non hanno coscienza di sé e
dell’ambiente circostante, né sono in grado di evocare risposte riproducibili e
volontarie, finalizzate a comunicare qualcosa, comprendere comandi verbali o
visivi o allontanare una mano da uno stimolo doloroso. L’evoluzione è, oggi,
imprevedibile: parlare di “stato vegetativo permanente”o "irreversibile” non ha fondamenti scientifici
anche se, per convenzione, si ritiene tale quando sono trascorsi 12 mesi (se è
stato causato da un trauma cranico) o 3 mesi (per tutte le altre cause:
metaboliche, neurodegenerative, vascolari, infettive…). <br />
Esistono, però, condizioni intermedie tra la coscienza normale e lo stato
vegetativo. Nel 2002 è stato coniato il termine di “Stato di minima coscienza”
(MCS: minimally conscious state) per descrivere questo tipo di pazienti. Questi
presentano alcuni comportamenti sicuramente definibili volontari, ma che non
sono costanti nel tempo. E’ tipico l’inseguimento con lo sguardo di un oggetto
in movimento. Sono possibili anche altre manifestazioni come l’apertura a
comando degli occhi, risposte semplici “sì-no”, scrittura, verbalizzazione
elementare o con strumenti elettronici facilitanti. Si tratta di pazienti che
possono ulteriormente migliorare le proprie condizioni, anche se in maniera
variabile. Pertanto è fondamentale poter distinguere questa condizione dallo
stato vegetativo, per tutte le difficili decisioni terapeutiche, legali e
bioetiche.<o:p></o:p></span></span></div>
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<span style="color: #333333; font-family: inherit;">Il clinico, quindi, avrà due obiettivi: primo, determinare la
capacità di risposta a uno stimolo (generalmente è più facile per il dolore); il
<span style="font-family: inherit;">secondo, invece, è stabilire la presenza di qualsiasi forma di comunicazione
riproducibile, anche rudimentale. Se presenti, questi rilievi ci permettono di
distinguere lo stato vegetativo dall’MCS. <o:p></o:p></span></span></div>
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<span style="color: #333333; font-family: inherit;"><span style="font-family: inherit;">Questo può essere molto difficile: si stima che ci sia un tasso di errore di circa il 40% con i mezzi attualmente a
nostra disposizione. Si è pensato, quindi, di sfruttare gli immensi passi
avanti compiuti in neuroradiologia per “visualizzare”
le immagini mentali, e addirittura valutare le eventuali risposte che i
pazienti elaborano a semplici richieste.</span><span style="font-size: xx-small;"><o:p></o:p></span></span></div>
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<b><span style="color: #333333; font-family: "Arial","sans-serif"; font-size: 9.0pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: IT; text-transform: uppercase;">LO STUDIO<o:p></o:p></span></b></div>
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<span style="color: #333333; font-family: inherit;">In uno studio che ha coinvolto Cambridge
(Regno Unito) e Liegi (Belgio), 54 pazienti con disordini della coscienza sono stati
sottoposti a metodiche innovative, come la risonanza magnetica funzionale
(fMRI), una tecnica in grado di “colorare” le aree che, durante determinati
processi mentali, consumano più ossigeno e quindi sono attive.<o:p></o:p></span></div>
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<span style="color: #333333; font-family: inherit;">Sono stati messi a punto due procedimenti: uno motorio (immaginare
di essere su un campo di tennis e di agitare il braccio per colpire la pallina) che “attiva” l’area motoria supplementare, evidenziata in giallo/rosso nelle
immagini, e uno immaginativo-spaziale (immaginare di camminare tra una stanza e
l’altra della propria casa) associato al giro paraippocampale, in blu nelle
immagini. <o:p></o:p></span></div>
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<span style="color: #333333;"><span style="font-family: inherit;"><span style="font-family: inherit;">Una volta localiz</span>zate le aree, è stato chiesto loro di rispondere
a semplici domande, modulando la loro attività cerebrale durante le scansioni
in risonanza magnetica. Ad esempio: “Hai fratelli?”, rispondendo di sì, immaginando
di giocare a tennis, e di no, immaginando di girare per casa. </span><span style="font-family: Arial, sans-serif; font-size: 8pt;"><o:p></o:p></span></span></div>
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<b><span style="color: #333333; font-family: "Arial","sans-serif"; font-size: 9.0pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: IT; text-transform: uppercase;">RISULTATI<o:p></o:p></span></b></div>
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<span style="color: windowtext; font-family: inherit;">Dei</span><span style="color: #333333;"><span style="font-family: inherit;"> 54 pazienti
reclutati nello studio, 5 sono risultati essere capaci di modulare
volontariamente la loro attività cerebrale(tutti con patologia traumatica).In 3
di questi, test aggiuntivi hanno rilevato qualche segno di consapevolezza ma,
negli altri 2, niente di tutto ciò. Un solo paziente è stato capace di usare questa tecnica per rispondere a domande tipo “si-no”
durante la risonanza magnetica funzionale.</span><span style="font-family: Arial, sans-serif; font-size: 8pt;"><o:p></o:p></span></span></div>
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<b><span style="color: #333333; font-family: "Arial","sans-serif"; font-size: 9.0pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: IT; text-transform: uppercase;">CONCLUSIONI<o:p></o:p></span></b></div>
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<span style="font-family: inherit;"><span style="color: #333333;">Una piccola percentuale di pazienti in
stato vegetativo o in stato di minima coscienza ha un’attivazione cerebrale che
riflette qualche tipo di cognizione e consapevolezza. </span><span style="color: #333333; line-height: 16.8pt;">Si spera che in futuro questo approccio possa essere utilizzato
per determinati quesiti clinici. Chiedere al paziente se sente dolore, e
scegliere quanto o quale analgesico somministrare. Chiedergli cosa pensa,
controllare il suo ambiente, comunicare le sue scelte a medici e familiari. In
una parola, conoscere la qualità della vita di questi pazienti, entrando in un
cervello murato vivo. Uno dei grandi misteri della medicina.</span></span></div>
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<span style="color: #333333; font-family: inherit; line-height: 16.8pt;">Roberto Infante</span></div>
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<span lang="EN-US">References:<o:p></o:p></span></div>
<h1 style="background: white; margin-top: 0cm; mso-line-height-alt: 12.6pt; vertical-align: baseline;">
<span lang="EN-US" style="font-size: small; font-weight: normal;">Willful Modulation of Brain
Activity in Disorders of Consciousness </span></h1>
<h1 style="background: white; margin-top: 0cm; mso-line-height-alt: 12.6pt; vertical-align: baseline;">
<span style="color: #666666; font-family: Arial, sans-serif; font-size: 8.5pt; line-height: 18pt;">Martin M. Monti, Ph.D., Audrey Vanhaudenhuyse, M.Sc.,
Martin R. Coleman, Ph.D., Melanie Boly, M.D., John D. Pickard, F.R.C.S.,
F.Med.Sci., Luaba Tshibanda, M.D., Adrian M. Owen, Ph.D., and Steven Laureys,
M.D., Ph.D. </span><span style="font-style: inherit; font-weight: inherit; line-height: 18pt; outline: 0px;"><span class="citation"><span lang="EN-US" style="border: none windowtext 1.0pt; color: #666666; font-family: "Arial","sans-serif"; font-size: 7.0pt; mso-ansi-language: EN-US; mso-border-alt: none windowtext 0cm; padding: 0cm;">N Engl J Med 2010; 362:579-589</span></span></span><span style="color: #666666; font-family: Arial, sans-serif; font-size: 8.5pt; line-height: 18pt;"><a href="http://www.nejm.org/toc/nejm/362/7/" style="font-style: inherit; font-weight: inherit; outline: 0px;"><span lang="EN-US" style="border: none windowtext 1.0pt; color: #006892; font-size: 7.0pt; mso-ansi-language: EN-US; mso-border-alt: none windowtext 0cm; padding: 0cm;">February 18, 2010</span></a></span><span style="font-style: inherit; font-weight: inherit; line-height: 18pt; outline: 0px;"><span class="doi"><span lang="EN-US" style="border: none windowtext 1.0pt; color: #666666; font-family: "Arial","sans-serif"; font-size: 7.0pt; mso-ansi-language: EN-US; mso-border-alt: none windowtext 0cm; padding: 0cm;">DOI: 10.1056/NEJMoa0905370</span></span></span></h1>
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Vobbertohttp://www.blogger.com/profile/00580279520012953526noreply@blogger.com1tag:blogger.com,1999:blog-2650750594787397971.post-37504324361161855562012-08-13T11:43:00.004-07:002012-08-13T11:45:51.828-07:00Neurobiologia della saggezza (1)<blockquote class="tr_bq">
<div style="color: black;">
<span style="font-size: small;"> </span><span style="font-size: small;">"Più lontani si va e meno si apprende e ci si avvicina alla verità. Per
questo l'uomo saggio non cammina e arriva." Lao Tzu</span></div>
</blockquote>
Ho trovato tempo fa una review particolarmente interessante che mira ad analizzare da un punto di vista neurobiologico l'attributo umano della saggezza. L'ho trovato innanzitutto particolarmente ambizioso, la saggezza è un attributo unico della specie umana e particolarmente riconosciuto dall'uomo stesso fin dagli albori della civiltà, quindi ricco di storia, tuttavia mai è stato sviscerato da un punto di vista prettamente scientifico.<br />
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Per secoli la saggezza è stata dispensatrice di religione e filosofia e le prime definizioni della stessa sono rintracciabili in questi due campi: in campo religioso la saggezza è quasi universalmente riconosciuta come virtù, mentre in campo filosofico è definita quale giudiziosa applicazione della conoscenza.<br />
Alla fine arriva la scienza, e questa review in particolare, che prendendo in analisi la saggezza compie un azione non nuova, ma che personalmente ho trovato molto utile. La saggezza è un costrutto e come tale va considerata. Ho detto che è cosa non nuova in quanto già le civiltà antiche la ritenevano un costrutto di diverse sottocomponenti. Certo è che questo complesso di componenti che la forma varia sensibilmente in base al periodo storico che si considera e tra le diverse culture, ognuna pone un'enfasi particolare su una di queste: nella grecia classica la razionalità, nelle culture dell'estremo oriente l'equilibrio emotivo, etc. eppure tutte queste concettualizzazioni della saggezza condividono numerose caratteristiche come la capacità di ponderato processo decisionale, la compassione, l'altruismo e la capacità di intuizione. <br />
Nel XIX secolo Gall, teorico della frenologia, incluse tre le 27 funzioni mentali la "sagacità comparativa" e la assegnò alla regione prefrontale. Solo pochi decenni fa, discipline di maggior credito scientifico hanno cominciato a considerare la saggezza come elemento degno di discussione. Erikson suppose che l'ultimo stadio della sua teoria dello sviluppo psicosociale, che andrebbe dai 65 anni alla morte, centrato sulla risoluzione con esito favorevole del conflitto tra l'integrità dell'io e la disperazione fosse la saggezza. Negli anni '70 Baltes et Al., Clayton e altri ancora hanno cominciato una ricerca di tipo empirico in questo settore e nonostante le prime teorie della cultura occidentale ponessero l'accento sulle facoltà cognitive, Ardelt et Al. posero l'attenzione sull'importanza del autocontrollo emotivo. In pratica l'evoluzione della moderna concettualizzazione della saggezza ha portato a condividere notevoli somiglianze con alcuni dei più antichi concetti di saggezza postulati nel Bhagavad Gita, un antico testo indiano di contenuto religioso. <br />
Recentemente la sorti della comprensione dell'attributo umano della saggezza sono legate alle attenzioni della psichiatria che, come le altre discipline mediche, ha cominciato a porre l'attenzione non esclusivamente sulla patologia, ma sullo stato di salute, la prevenzione e quindi i fattori protettivi nei confronti della patologia stessa. Comprendere la neurobiologia della saggezza può avere un notevole impatto clinico, come lo sviluppo della prevenzione, del trattamento e della riabilitazione per persone con importanti disturbi neuropsichiatrici (es. demenza frontotemporale). Tuttavia i ricercatori si sono tenuti alla larga dall'indagare sulla saggezza soprattutto a causa della difficoltà nel definirne il fenotipo. Si può considerare certamente la saggezza come un attributo distribuito nella popolazione generale lungo un continuum più che come un attributo raro limitato a persone-simbolo, però, sebbene sia piuttosto piuttosto stabile come tratto all'interno di uno stesso individuo, si esprime negli altri con sfumature diverse e inoltre è anche frutto, in misura significativa, dell'esperienza e dell'apprendimento. <br />
Dunque anche se non esiste una definizione consensuale di saggezza si può asserire che essa sia un unico costrutto psicologico e non solo l'insieme di caratteristiche desiderabili riunite sotto un'unica etichetta unificante. Le componenti della saggezza sono:<br />
<ul>
<li>atteggiamenti/comportamento prosociale</li>
<li>conoscenza pragmatica della vita</li>
<li>omeostasi emotiva</li>
<li>riflessione/comprensione del sé</li>
<li>valore del relativismo/tolleranza</li>
<li>riconoscimento e trattamento efficace dell'incertezza</li>
</ul>
I substrati neurobiologi di queste componenti sembrano includere diverse regioni in comune come la corteccia prefrontale (PFC), in particolare la PFC dorsolaterale (DLPFC), la corteccia orbitofrontale (OFC), la PFC mediale (mPFC) e il cingolo anteriore, più alcune aree sottocorticali come l'amigdala e lo striato e sono fortemente influenzati da pathways monoaminergici.<br />
Si può quindi procedere ad esaminare la neurobiologia di queste 6 componenti concentrandosi sulla loro presunta localizzazione neuroanatomica, determinata in primo luogo da neuroimaging funzionale e in secondo luogo sulla funzione dei neurotrasmettitori ivi prodotti. <br />
<br />
ATTITUDINE E COMPORTAMENTO PROSOCIALE<br />
<blockquote class="tr_bq" style="color: black;">
<span style="color: black; font-size: small;">"Di tutte le cose che la saggezza procura per ottenere un'esistenza felice,
la più grande è l'amicizia." Epicuro </span></blockquote>
Una delle più consistenti componenti della saggezza, sia nella letteratura antica che in quella moderna, è la promozione del bene comune a prescindere dai propri interessi, mostrando comportamenti e attitudini prosociali quali empatia, cooperazione e altruismo. Così i sociopatici che possono presentare una squisita cognizione sociale e un controllo emotivo al fine di facilitare le loro motivazione egoistiche, non possono essere considerati saggi.<br />
EMPATIA. L'empatia facilita i comportamenti prosociali, incluso l'altruismo. I neuroni specchio, originariamente scoperti nei primati e successivamente riscontrati nel giro frontale inferiore dell'uomo con tecniche neurofisiologiche e di neuroimaging, potrebbero essere il substrato neurobiologico primitivo dell'empatia. Nella corteccia prefrontale i neuroni specchio si attivano con lo stesso pattern sia in individui che compiono una determinata azione che in individui che guardano semplicemente qualcun altro compiere la medesima azione, cosa che suggerisce il loro ruolo nell'apprezzare la comunicazione non verbale. Persone con una maggiore mimica somatica incoscia hanno una maggiore disposizione all'altruismo. Quando i bambini osservano e imitano le espressioni facciali, i neuroni specchio si attivano e questa attività appare correlata con il livello di empatia. Naturalmente l'empatia è più complessa della semplice mimica somatica, richiede di prendere consapevolmente la prospettiva di un'altra persona e ciò si ricollega alla "teoria della mente" sviluppata da Perner e Lang e consiste in un modello che spiega come una persona capisce stati mentali altrui e le emozioni. Le ricerche di neuroimaging nell'ambito della "teoria della mente" hanno costantemente mostrato l'attivazione della corteccia prefrontale mediale e del solco temporale posterosuperiore. La corteccia prefrontale mediale sembra coinvolta nel "mentalizing" ovvero concepire il mondo interiore degli altri mentre l'attivazione del solco temporale posterosuperiore si verifica in risposta a stimoli visivi rilevanti per la percezione degli stati mentali (es. mimica somatica, espressioni facciali). Studi con risonanza magnatica funzionale mostrano il coinvolgimento della corteccia prefrontale mediale nella percezione di stati emotivi condivisi. Lesioni alla corteccia prefrontale ventromediale sono predittive per deficit empatici. Fondamentale per l'empatia è la capacità di distinguere il sé dagli altri al fine di evitare un mero contagio emotivo, ancora la risonanza magnetica funzionale ha indicato che il giro temporale superiore e il lobo parietale inferiore potrebbero essere responsabili della differenzazione delle proprie emozioni da quelle altrui.<br />
COOPERAZIONE. Al contrario della concorrenza, la cooperazione è legata al comportamento prosociale ed è stata studiata con tecniche di neuroimaging usando un insieme di attività (es.giochi di fiducia/reciprocità incluso "il dilemma del prigioniero). Studi di risonanza magnetica funzionale dimostrano che la cooperazione attiva la corteccia prefrontale mediale e il nucleo accumbens/striato ventrale, coinvolte queste ultime anche nel circuito centrale della ricompensa. Allo stesso modo la "punizione altruistica" (punizione dei trasgressori delle norme sociali al costo di se stessi) attiva la microcircuiteria della ricompensa. Al contrario la competizione diminuisce l'attivazione delle aree attivate dalla cooperazione o attiva altre regioni come la corteccia prefrontale dorsolaterale. In uno studio con risonanza magnetica nucleare alcuni individui sociopatici hanno mostrato (rispetto a soggetti di controllo) una ridotta risposta dell'amigdala mentre si mostravano non cooperativi durante un compito di cooperazione sociale e una ridotta attività della corteccia orbitofrontale quando cooperavano, suggerendo una mancanza di emozioni spiacevoli mentre infrangevano norme sociali e una mancanza di emozioni positive mentre invece adottavano comportamenti cooperativi.<br />
ALTRUISMO. L'altruismo si sovrappone alla cooperazione anche se è da notare come in quest'ultimo sia presente un danno potenziale a cui il soggetto altruista si espone per aiutare l'altro. Harbaugh et Al. hanno dimostrato come l'idea di donare volontariamente del denaro comparata a quella di pagare le tasse (percepita come necessaria per il bene sociale) causi un'aumentata attivazione della microcircuiteria della ricompensa (caudato e nucleo accumbens).<span class="" id="result_box" lang="it"><span class="hps">Questo</span> <span class="hps">paradossalmente</span> <span class="hps">suggerisce che il sub</span><span class="hps">strato</span> neurale dell'<span class="hps">altruismo</span> <span class="hps">può essere equiparato</span> <span class="hps">a quello del</span> <span class="hps">più</span> <span class="hps">istintuale</span><span class="hps atn"> auto-</span><span class="">piacere</span><span class="">.</span></span><br />
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<span class="" id="result_box" lang="it"><span class=""></span></span><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiuyRn9dSniOiQwIIYOZ5zDtsRu9OKRkMBwmyWGZA2Eth7lmUGrOUE3IUb5FebZH1s9OXPOqpyelPMAzIc8kbFUT6V2sJboE8yVDbFHwT5SpzgcIYoXr_jd4dI-srGBFOE-4YqS9_t7vA/s1600/yoa80110t1.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="335" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiuyRn9dSniOiQwIIYOZ5zDtsRu9OKRkMBwmyWGZA2Eth7lmUGrOUE3IUb5FebZH1s9OXPOqpyelPMAzIc8kbFUT6V2sJboE8yVDbFHwT5SpzgcIYoXr_jd4dI-srGBFOE-4YqS9_t7vA/s400/yoa80110t1.png" width="400" /></a></div>
<span class="" id="result_box" lang="it"><span class=""></span></span><span class="" id="result_box" lang="it"><span class="hps">Diversi</span> <span class="hps">studi genetici</span> <span class="hps">hanno riportato che</span> <span class="hps">l'ereditarietà</span> <span class="hps">dei comportamenti</span> <span class="hps">prosociali</span>,<span class="hps"> compreso l'</span><span class="hps">altruismo</span><span class=""> va dal </span><span class="hps"></span> <span class="hps">50</span><span class="">%</span> <span class="hps">al 60</span><span class="">%</span></span>.<span class="" id="result_box" lang="it"> <span class="hps">Inoltre</span><span class="">,</span> <span class="hps">diversi studi</span><span class="hps"> indicano</span> <span class="hps">il coinvolgimento</span> <span class="hps">delle</span> <span class="hps">monoammine</span> <span class="hps">e</span> di <span class="hps">alcuni</span><span class="hps"> neuropeptidi</span><span class=""> </span></span><span class="" id="result_box" lang="it"><span class="hps">con i risultati</span> <span class="hps">più importanti</span> <span class="hps">per i ruoli di</span> <span class="hps">dopamina</span>, <span class="hps">serotonina</span><span class="hps"> e i</span> <span class="hps">neuropeptidi</span> <span class="hps">ipotalamici</span> <span class="hps">vasopressina</span><span class="hps"> e ossitocina</span> <span class="hps">negli atteggiamenti</span>/<span class="hps"></span><span class="hps">comportamenti</span> <span class="hps">prosociali</span><span class="">.</span></span><br />
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G.C.</div>
GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com2tag:blogger.com,1999:blog-2650750594787397971.post-58578634371401096712012-06-06T05:01:00.001-07:002012-06-06T05:01:20.345-07:00RIP Andrew Huxley (1917-2012)<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgPCu-I2D2NE27_guEMMUALs2-da6nEqUhaa4SWMxFSgTPrOUzwgB5tr8un-pI85omoBRN_dBKqyA97l4ZdwKwQylrKSQRjifdKeWvbNp7j_TZTf3z7MiTRIeSW62QSzDwzgi9ig8NrJw/s1600/huxley_lab_photo.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgPCu-I2D2NE27_guEMMUALs2-da6nEqUhaa4SWMxFSgTPrOUzwgB5tr8un-pI85omoBRN_dBKqyA97l4ZdwKwQylrKSQRjifdKeWvbNp7j_TZTf3z7MiTRIeSW62QSzDwzgi9ig8NrJw/s400/huxley_lab_photo.jpg" width="298" /></a></div>
Ricordiamo con questo post Sir Andrew Huxley, fisiologo inglese<span> vincitore del Nobel per la Medicina <a href="http://cdn.blogosfere.it/scienzaesalute/images/Premio-Nobel-11.jpg"></a> nel 1963 per le sue ricerche sulle basi della conduzione del potenziale d'azione, venuto a mancare nella giornata di ieri.<br />Possa il mondo averlo in gloria.<br /><br /> </span>GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com0tag:blogger.com,1999:blog-2650750594787397971.post-9572596287774116692012-03-29T11:07:00.003-07:002012-03-29T11:12:31.459-07:00buon compleanno neuronerd!<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgGBNgRNCIBiTrvS9UPtApqiPFMECJgx_r25f6O4ogo943qBMx8NnL_s4k4UnMcFJMC17ojA36d-gKhTbTciNTqGtgLhpAThvjthHGLP2sWTXMMMLB_5PlNFQ5cAHSbOaW2l67XCAsQdejt/s1600/2924265735_f8b5983cfb.jpg"><img style="display:block; margin:0px auto 10px; text-align:center;cursor:pointer; cursor:hand;width: 200px; height: 150px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgGBNgRNCIBiTrvS9UPtApqiPFMECJgx_r25f6O4ogo943qBMx8NnL_s4k4UnMcFJMC17ojA36d-gKhTbTciNTqGtgLhpAThvjthHGLP2sWTXMMMLB_5PlNFQ5cAHSbOaW2l67XCAsQdejt/s200/2924265735_f8b5983cfb.jpg" alt="" id="BLOGGER_PHOTO_ID_5725383163499907762" border="0" /></a><br />il blog neuronerd compie un anno.<br /><br />Si festeggia nel migliore dei modi: tra pochi giorni partirà la nostra sperimentazione con il professore Viggiano, docente di fisiologia della Seconda Università degli Studi di Napoli. Stay tuned<br /><br />grazie a tutti voiVobbertohttp://www.blogger.com/profile/00580279520012953526noreply@blogger.com0tag:blogger.com,1999:blog-2650750594787397971.post-41244841039531345872012-03-02T04:34:00.008-08:002012-03-02T05:47:52.818-08:00Apologia dell'errore<div style="font-style: italic; text-align: center;">Un uomo di genio non commette errori. I suoi sbagli sono intenzionali e sono portali di scoperta<span class="st">(J.Joyce)</span></div><div align="center" class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm; margin-left: 36.0pt; margin-right: 0cm; margin-top: 0cm; text-align: center;"><span class="st"> </span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><span class="st" style="font-size: small;">La biologi</span><span style="font-size: small;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiiI1gxuw-Q9s0OFSsr2aiNY0HFTP6IXV-iorYTDu5s-O8m-ToeK4mBVBRzABbZzP6fHtOUOAktzl7k7sLHjSogqlt3sBu444d67RXdExTZf3MYHdbuKpEJ8IWqOzGPzk-WovqaltPt0g12/s1600/big-mistake.jpg"><img alt="" border="0" id="BLOGGER_PHOTO_ID_5715281316425619186" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiiI1gxuw-Q9s0OFSsr2aiNY0HFTP6IXV-iorYTDu5s-O8m-ToeK4mBVBRzABbZzP6fHtOUOAktzl7k7sLHjSogqlt3sBu444d67RXdExTZf3MYHdbuKpEJ8IWqOzGPzk-WovqaltPt0g12/s200/big-mistake.jpg" style="cursor: pointer; float: left; height: 134px; margin: 0pt 10px 10px 0pt; width: 200px;" /></a></span><span class="st" style="font-size: small;">a è il regno degli errori (e degli orrori). Darwin ha fatto risalire le “prodezze” umane a innumerevoli sbagli di un organismo microscopico, incapace di replicarsi con fedeltà. Dal batterio a bipedi forniti di grosso sedere, abili mani, cranio crivellato e rapidi </span><span class="st" style="font-size: small;">a </span><span class="st" style="font-size: small;">ciarlare. Non dobbiamo necessariamente scomodare l’evoluzionismo, né i filosofi, per celebrare l’errore: la DNA polimerasi, l’enzima che duplica il genoma per destinarlo alla cellula figlia, commette un errore ogni 10<sup>9</sup></span><span class="st" style="font-size: small;"> </span><span class="st" style="font-size: small;">nucleotidi (e non è l’unica a sbagliare). Sembrerà poco, ma non lo è considerando l’innumerevole quantità di specie viventi e l’enorme tempo</span><span class="st" style="font-size: small;"> a disposizione concesso dalla Terra: siamo predestinati a inciampare lungo il cammino. </span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span class="st" style="font-size: small;">Il tanto osannato sistema nervoso nasce con i riflessi: risposte rapide, involontarie, a stimoli ambientali. Famosa l’illustrazione contenu</span><span class="st" style="font-size: small;">ta nel “De Homine” cartesiano, nella quale un bambino ritira il piede perché si scotta: a nulla valgono i consigli materni, senza sbagliare non potrebbe capirlo. Ancora oggi non possiamo minimamente fare a meno del dolore, nemmeno dopo l’infanzia. La scuola di guerra tedesca ci ha donato forse il più famoso aforisma: “ciò che non mi uccide mi rende più forte”. Il dolore metabolizza gli errori restituendo crescita e robustezza e nemmeno il più illuminato dei cervelli potrebbe mai farne a meno. I genetisti ci assillano con “le mutazioni sono il motore dell’evoluzione”: così l’alterazione genica che fa impazzire la cellula, il tumore, è assai vantaggioso per gli organismi unicellulari, mentre diventa letale per quelli grandi e grossi. Un errore ci uccide, un altro ci regala le mani di Paganini. Troppi errori cominciarono a diventare insostenibili quando si volle camminare: è solo per questa ragione che la selezione naturale risparmiò la comparsa del cervello vero e proprio. In primis cervelletto e gangli della base, veri e propri dittatori degli arti, in grado di porre il veto a più del 90% dei suggerimenti inviati dalla periferia. In secundis la corteccia cerebrale, supremo tiranno di idee, emozioni e istinti. Come discriminino giusto e sbagliato resta un mistero: secondo le teorie odierne solo quando, dopo tanti sbagli, il risultato</span><span class="st" style="font-size: small;"> corrisponde all’obiettivo. “Sbagliando </span><span class="st" style="font-size: small;">si impara”. Le stesse sinapsi crescono a caso, e quelle non stimolate vengono recise.<br />
</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><span style="font-size: small;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgR6GGHsqazXqEhhjdHHgZ-nrrSwOLzJMB3e4Lj46_D3At8UBJzii5mzOuZQsCZT2M8b25fMtaEMG40wssznnCplAhk8Qp9QOm5PqqE80NZ2cdDG3YQSIUEXwde9epmPc5x-QupAyt6w9ul/s1600/Clarac1Fig2.jpg"><img alt="" border="0" id="BLOGGER_PHOTO_ID_5715282283827334322" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgR6GGHsqazXqEhhjdHHgZ-nrrSwOLzJMB3e4Lj46_D3At8UBJzii5mzOuZQsCZT2M8b25fMtaEMG40wssznnCplAhk8Qp9QOm5PqqE80NZ2cdDG3YQSIUEXwde9epmPc5x-QupAyt6w9ul/s200/Clarac1Fig2.jpg" style="cursor: pointer; float: right; height: 200px; margin: 0pt 0pt 10px 10px; width: 170px;" /></a></span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><span class="st" style="font-size: small;">Il primo dei sensi a comparire nella filogenesi è stato l’olfatto, poi gli altri. I motiv</span><span class="st" style="font-size: small;">i, sempre gli stessi: un’esperienza negativa con un alimento, un odore, un suono o un colore bast</span><span class="st" style="font-size: small;">erà per evitare il contatto futuro con quella sostanza. Medesimo discorso per la comparsa del centro del vomito, l’area postrema troncoencefalica: sopperire alla poco consona ingordigia dei nostri antenati. Per nulla infallibili, anzi preda di condizioni e suggestioni. L’occhio e l’orecchio di Alex deLarge ripudiano i film di violenza mostrati mentre i medici gli iniettano una sostanza </span><span class="st" style="font-size: small;">emetica (che provoca il vomito): l’errore viene qui asservito dalla società per abolire istinti moral</span><span class="st" style="font-size: small;">mente sconvenienti. In un recente studio di Kim BR è stato dimostrato, con semplici compiti valutativi, che la devianza da norme sociali viene trattata dal cervello come un proprio errore di valutazione. Una suggestiva guerra civile tra neuroni: liberali e neuroni specchio. Questi ultimi, scoperti da Giacomo Rizzolatti vicino all’area di Broca, un centro del linguaggio, ci invitano a scimmiottare chi è davanti a noi, e gradualmente a conformarci agli altri individui della nostra specie. </span></div><div class="MsoNormal"><span class="st" style="font-size: small;">Tutto ciò è ben orchestrato: in un recente </span><span style="font-size: small;">esperimento di Hester viene analizzata l’attività della corteccia frontale posteromediale (pMFC) prima e dopo la realizzazione di un errore; </span><span style="font-size: small;"> dopo l’errore i comportamenti vengono significativamente rallentati e meglio ponderati. Ma ancora una volta la società continua a baloccarsi con le nostre menti, infiltrata nel Super-Io (di cui probabilmente i neuroni specchio sono un aspetto fondamentale). Un rallentamento post-errore è stato osservato anche in un lavoro di De Bruijn,</span><span style="font-size: small;"> persino dopo errori altrui, in una situazione cooperativa; al contrario, in un contesto competitivo, vi è una tendenza ad accelerare i compiti. Questo indica che il sistema neuronale in grado di processare gli errori ha un’alta flessibilità, determinata dal contesto. Infatti in un altro articolo dello stesso autore gli errori in un contesto competitivo sono stati considerati dai soggetti come perdita di gratificazione sia se commessi da loro sia dagli altri partecipanti. Tanti gli studi a riguardo dei centri di controllo degli errori, ad esempio, Longe mostra come l’attività della parte dorsolaterale della corteccia prefrontale sia correlata ad alti livelli di autocritica, associata a un grande processamento degli errori e inibizione di comportamenti, maggiore in alcuni individui. La porzionale ventrolaterale della stessa corteccia prefrontale è invece associata a incoraggiamento individuale. Tutti questi studi aiutano la ricerca sulle malattie mentali come il disturbo bipolare e la depressione, ma non solo.</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><span style="font-size: small;">E’ proprio l’a<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgsYl0Tv6FPwLmwiSMNIvq4ILtIZnYE5Ayyor17hWwcTuddUFfvlgF_Y_wm_Yz7Lo5RclN8VRhrXHGkkazKn2w7EdyNLA2-ezh3YICoiCYz5MUWljNElRV4m1Xu3qUXwstgyI6yZeD_jUlT/s1600/mistakes%252Cadvice%252Cshort%252Cthatswhatshesaid%252Clollused%252Cmistake-67eadafe7964874ce4f27d34ef375a4c_h.jpg"><img alt="" border="0" id="BLOGGER_PHOTO_ID_5715283393704204898" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgsYl0Tv6FPwLmwiSMNIvq4ILtIZnYE5Ayyor17hWwcTuddUFfvlgF_Y_wm_Yz7Lo5RclN8VRhrXHGkkazKn2w7EdyNLA2-ezh3YICoiCYz5MUWljNElRV4m1Xu3qUXwstgyI6yZeD_jUlT/s200/mistakes%252Cadvice%252Cshort%252Cthatswhatshesaid%252Clollused%252Cmistake-67eadafe7964874ce4f27d34ef375a4c_h.jpg" style="cursor: pointer; float: left; height: 200px; margin: 0pt 10px 10px 0pt; width: 141px;" /></a>uto-incoraggiamento, la self-confidence, la grande forza che spinge avanti, cioè verso nuovi errori, la produzione umana. </span><span style="font-size: small;">Non possiamo innalzarci restando a guardare i volti altrui: “I pedagoghi e gli educatori della prima infanzia riconoscono nell’errore del bambino che sta imparando a parlare un indizio del suo lavoro linguistico, che non è solo di semplice mimesi, ma anche, e soprattutto, di costruzione creativa e personale. Il bambino, in altre parole, non si limita ad imitare le frasi sentite da altri, ma utilizza il materiale linguistico di cui dispone per creare nuove frasi e nuove strutture sintattiche mai sentite prima. Questo lo vediamo quando il bambino dice “io ando” invece di “io vado”: capiamo soltanto così che egli ha utilizzato il verbo “andare” – che ha sentito da qualcuno – per formare la terza persona singolare per assimilazione.” Magari tutta l’arte fiorisce in questo modo. Non si può certo creare a mente vuota: spesso le grandi opere nascono da errori da parte di un riproduttore, come una canzone nasce da variazioni di un brano noto, inebriata da mille influenze. Homo sapiens e i suoi prodotti (alti e bassi) sono semplicemente figli della serendipità: non potremo mai toccare il cielo, ma non abbiamo alcun limite nell’esplorare la Terra con le nostre braccia e le nostre menti</span></div><div class="MsoNormal"><span class="st"> </span></div><div align="center" class="MsoNormal" style="text-align: center;"><span style="font-style: italic;">Il progresso non è altro che brancolare da un errore all'altro. </span><span lang="EN-US"><span style="font-style: italic;">(Henrik Ibsen)</span></span></div><div align="right" class="MsoNormal" style="text-align: right;">Roberto Infante</div><div class="MsoNormal">Approfondimento filosofico: http://www.libreriauniversitaria.it/apologia-inciampo-dona-massimo-bompiani/libro/9788845270659</div><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;"><span class="st"> </span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm; margin-left: 36.0pt; margin-right: 0cm; margin-top: 0cm;"><span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 12pt;"> </span></div><div class="MsoNormal"><span lang="EN-US" style="color: navy; line-height: 115%;">References:</span></div><div class="MsoNormal"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kim%20BR%22%5BAuthor%5D"><span lang="EN-US">Kim BR</span></a><span lang="EN-US">, </span><span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">PMID:22038705</span></div><div class="MsoNormal"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Longe%20O%22%5BAuthor%5D"><span lang="EN-US">Longe O</span></a> <span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">PMID:19770047</span></div><div class="MsoNormal"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Hester%20R%22%5BAuthor%5D"><span lang="EN-US">Hester R</span></a> <span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">PMID:18189005</span></div><div class="MsoNormal"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22De%20Bruijn%20ER%22%5BAuthor%5D"><span lang="EN-US">De Bruijn ER</span></a> <span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">PMID:21347989</span></div><div class="MsoNormal"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22de%20Bruijn%20ER%22%5BAuthor%5D"><span lang="EN-US">de Bruijn ER</span></a> <span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">PMID:</span><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">22347154</span><span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;"></span></div><div class="MsoNormal"><a href="http://marcofantesca.wordpress.com/"><span lang="EN-US">http://marcofantesca.wordpress.com</span></a><span lang="EN-US"></span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm; margin-left: 36.0pt; margin-right: 0cm; margin-top: 0cm;"><span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 12pt;"> </span></div>Vobbertohttp://www.blogger.com/profile/00580279520012953526noreply@blogger.com0tag:blogger.com,1999:blog-2650750594787397971.post-16328119759215252542012-02-04T17:40:00.000-08:002012-02-05T06:27:39.566-08:00Spinoza ha anticipato Gazzaniga di 300 anni.<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh3NB1bFcU19Q6aDFs2pTe6Ds03UAq5-PONxufbrtIjdjuAXn7a71EH53HZfkKdjvDB5TDuAq3HAglqSqG4Y9Hxqcn0BntWWwg-cT0rBtYKSnatBx17F9ZjJBZqotWGO3qNBJVHmLbrhA/s1600/spinoza.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh3NB1bFcU19Q6aDFs2pTe6Ds03UAq5-PONxufbrtIjdjuAXn7a71EH53HZfkKdjvDB5TDuAq3HAglqSqG4Y9Hxqcn0BntWWwg-cT0rBtYKSnatBx17F9ZjJBZqotWGO3qNBJVHmLbrhA/s320/spinoza.jpg" width="255" /></a></div><br />
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">Spinoza ha anticipato Gazzaniga di 300 anni eppure pare che Homo Sapiens non si sbatta né il primo né il secondo. “Gli uomini si credono liberi soltanto perché sono consapevoli delle proprie azioni e inconsapevoli delle cause che le determinano” un periodo assertivo, quasi da Bacio perugina, quale occorre. Tratto da “L’ethica”, monumentale opera scritta dall’ottico olandese, esempio di libero pensiero che ha addirittura lasciato dire a Hegel “Philosophieren ist Spinozieren”, rivela la subordinazione intrinseca della coscienza nella fisiologia del sistema nervoso. Lasceremo spiegare il tutto a Gazzaniga e al suo straordinario lavoro “Un cervello, due menti” (1972). Gli esperimenti che alimentano quest’articolo scientifico sono stati condotti su pazienti “scissi”, pazienti cioè la cui epilessia aveva acquisito una dimensione tanto grave da dover ricorrere a un intervento chirurgico consistente nel tagliare le connessioni nervose tra i due emisferi cerebrali, il corpo calloso. Gazzaniga dimostrò che i due emisferi in questi soggetti non comunicano più e siccome l’area del linguaggio risiede solitamente nell’emisfero di sinistra, il paziente saprà esprimere solo ciò di cui quest’emisfero è a conoscenza. Se si benda il paziente e gli si chiede di toccare un oggetto con la mano sinistra, egli non saprà descrivere tale informazione tattile poiché le fibre nervose sensitive afferenti al sistema nervoso centrale dalla metà sinistra del corpo decussano la linea mediana e giungono all’emisfero destro isolato dal sinistro e quindi dall’area del linguaggio. Quest’esperimento molto semplice è servito da guida per altri, uno dei quali di importanza fondamentale. Se si induce segretamente l’emisfero destro ad avere una reazione, l’emisfero sinistro sarà capace di percepirla, ma rimarrà all’oscuro della sua motivazione. In che modo dunque la coscienza tratta il materiale inconscio? Ebbene, se si chiede a questi pazienti il perché della loro reazione, essi verbalizzano ciò che l’emisfero sinistro riesce a dedurre dalla situazione, inventando delle spiegazioni come se sapessero realmente cosa sia accaduto. LeDoux, un neurobiologo che ha collaborato con Gazzaniga in questi esperimenti, riporta nel suo libro “Il cervello emotivo” il comportamento dei pazienti: “se ordinavamo all’emisfero destro di salutare con la mano, il paziente salutava. Quando gli chiedevamo il perché, diceva che aveva creduto di vedere un conoscente. Se ordinavamo all’emisfero destro di ridere, il paziente ci diceva che eravamo buffi”. Le spiegazioni dei pazienti scissi non sono prodotte dalla conoscenza del perché delle azioni, ma solo in base alla percezione delle azioni stesse. Da tali esperimenti fu quindi dedotto che “molte delle nostre azioni hanno motivi di cui non siamo consapevoli (perché il comportamento è prodotto da sistemi cerebrali che operano inconsciamente) e che uno dei principali compiti della coscienza è quello di ricucire la nostra vita in una storia coerente, in un concetto del sé. Lo fa generando delle spiegazioni del comportamento sulla base dell’immagine di sé, dei ricordi del passato, delle aspettative del futuro, della situazione sociale presente e dell’ambiente fisico in cui quel comportamento è prodotto” (LeDoux, Il cervello emotivo).</div><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">Anche se irrelata dagli esperimenti di Gazzaniga, quanto detto da Spinoza appare ora più chiaro. L’importanza del periodo Spinoziano rimane tuttavia sottostimata. Homo Sapiens continua a ignorare che la sua coscienza è in realtà un accessorio comparso nella filogenesi. </div><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">Tutto il comportamento umano è determinato per riflesso, dunque è scatenato da processi inconsci. La cosa è anche più intuitiva di quanto si possa credere. Il riflesso è, per quanto semplice, una conquista complessa nella filogenesi e oltre che complessa è estremamente efficace: dunque perché non sfruttarla? Nello sviluppo successivo del sistema nervoso, gli errori accumulatisi hanno portato a un intreccio sempre più intricato di questi circuiti fino ad arrivare a reti neurali capaci di elaborare quanto l’autore sta scrivendo in questo momento. </div><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg35xU62M_cNemQOP8mILCvTNrdcJObUtfJlGZIKDJl0xIlO_mycFw30m8Cb5MAmnDclBd-1CFuobko7gW5d8DtAP-ikBZ_Xt2vOhaV6mTTgxEY9Ko4Z98BM1IV5W0KwmdIXOADtKjT0A/s1600/ritratto+stein.jpg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg35xU62M_cNemQOP8mILCvTNrdcJObUtfJlGZIKDJl0xIlO_mycFw30m8Cb5MAmnDclBd-1CFuobko7gW5d8DtAP-ikBZ_Xt2vOhaV6mTTgxEY9Ko4Z98BM1IV5W0KwmdIXOADtKjT0A/s320/ritratto+stein.jpg" width="260" /></a>Il linguaggio, strumento di elezione della coscienza, è anch’esso prodotto di processi inconsci. Non si pianifica consciamente la grammatica su cui un discorso s’intesse, non vi è abbastanza tempo e la coscienza è tra tutti i processi neurali “l’ultimo a sapere delle cose”. Un esempio pratico di quanto si sta dicendo è la situazione di un individuo che provi a parlare una lingua straniera, quando insomma è un competente consapevole: l’elaborazione di un periodo di senso compiuto sarà il risultato di un pensiero cosciente che richiederà concentrazione per la ricerca di ciò che si è appreso in precedenza. Lo stesso ovviamente non avviene se si elabora un periodo nella propria lingua madre in cui si ha raggiunto un livello di competenza inconsapevole. Detto questo sembra che Skinner avesse ragione quando disse che la Stein esprimeva nella sua prosa le automatiche risposte verbali che abbiamo davanti a specifici stimoli, la sua arte dunque non era che un riflesso involontario. Gertrude Stein obbiettò la frase di Skinner affermando di arrivare a frasi come “una rosa tagliata rosa, un crollo ed un buco venduto, un po’ meno caldo” grazie a un eccesso di coscienza, l’extra-coscienza. Eppure se Dostoevskij afferma che “è proprio […] nella perfetta consapevolezza di ogni cosa che sta l’ebbrezza”, Gertrude Stein ha dovuto infine ritenersi sconfitta. Vittoriosa ne uscì la linguistica di Chomsky. Il concetto è semplice: la struttura del linguaggio fa parte della struttura del cervello. Le parole vengono disposte su binari che il nostro cervello traccia inconsciamente. </div><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">A derubare la coscienza della sua importanza sono intervenuti anche Nisbett e Wilson che con esperimenti molto banali ne hanno mostrato la fragilità. Mostrando ad alcune donne delle paia di calze, hanno chiesto di scegliere un paio e di motivare la loro scelta. Le donne hanno eseguito motivando riguardo colore, elasticità, trasparenza senza sapere che le calze erano tutte uguali. Credevano insomma di aver deciso sulla base di giudizi interiori di qualità, sbagliando sulle cause interne delle loro azioni. <br />
I meccanismi interni di importanti aspetti mentali, inclusa la comprensione del perché facciamo quel che facciamo non sono necessariamente conoscibili dall’io cosciente. In conclusione, ricordando Gertrude Stein in “How to write”: “Come può essere la coscienza? Ciò nonostante”.<br />
Giammarco Cascino </div>GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com1tag:blogger.com,1999:blog-2650750594787397971.post-52218557550400163472011-12-22T06:01:00.000-08:002011-12-22T06:01:23.628-08:00AUGURI<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgHMudE0dZH5l9BxP_jPQ5vG4gInCT_tHOsaf4Hc9c5Jp0mu6ZcJKloJYfGVa0Z6kdhVQMhaS6zFlktbMVpJ9kCN4wiiQ8YHGlFmHfamKNBl7vtavm-WFsOJ6r29cyOLw8EdpFKQMR7IA/s1600/santa_brain_christmas_ornament_by_neverlandjewelry-d4e0dc0.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgHMudE0dZH5l9BxP_jPQ5vG4gInCT_tHOsaf4Hc9c5Jp0mu6ZcJKloJYfGVa0Z6kdhVQMhaS6zFlktbMVpJ9kCN4wiiQ8YHGlFmHfamKNBl7vtavm-WFsOJ6r29cyOLw8EdpFKQMR7IA/s400/santa_brain_christmas_ornament_by_neverlandjewelry-d4e0dc0.jpg" width="282" /></a></div><span style="font-size: large;"><b>Tanti auguri di Buon Natale dalla redazione di NeuroNerd.</b></span>GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com4tag:blogger.com,1999:blog-2650750594787397971.post-36269204636719647152011-10-13T06:23:00.000-07:002011-10-13T07:16:33.310-07:00Stress: il picco del cortisolo al momento del risveglio (CAR)<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="http://www.psicoterapeuta-roma.com/immagini/immagini-santandrea/stress%20relazioni%20sociali/stress_notte_e_giorno.jpg"><img style="display:block; margin:0px auto 10px; text-align:center;cursor:pointer; cursor:hand;width: 425px; height: 378px;" src="http://www.psicoterapeuta-roma.com/immagini/immagini-santandrea/stress%20relazioni%20sociali/stress_notte_e_giorno.jpg" alt="" border="0" /></a><br /><!--[if gte mso 9]><xml> <w:worddocument> <w:view>Normal</w:View> <w:zoom>0</w:Zoom> <w:trackmoves/> <w:trackformatting/> <w:hyphenationzone>14</w:HyphenationZone> 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mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} </style> <![endif]-->Il cortisolo, principale prodotto endocrino di condizioni stressanti, viene secreto con un preciso andamento circadiano, regolato dal sistema nervoso centrale. La sua produzione durante al momento del risveglio e’ relativamente distinta dalla secrezione del resto del giorno: essa è sotto il controllo del nucleo soprachiasmatico dell’ipotalamo(SCN) e regolata finemente da una via neurale diretta alla corteccia surrenale tramite il simpatico. Esso è coinvolto in una serie di processi cruciali come il ripristino dello stato di coscienza, il conseguimento parziale o totale dell’allerta, le modificazioni degli altri ormoni, l’equilibrio immunitario e l’attivazione del sistema motorio. <p class="MsoNormal">Il CAR(cortisol awakening response) dura generalmente 30-45 min dopo il risveglio e può essere considerato un marcatore biologico dello stato psicosociale e di salute: molte malattie sono spesso associate ad una scarsa coordinazione circadiana, potenzialmente<span style="mso-spacerun:yes"> </span>rilevabile da un esame del CAR. Invecchiamento e stress cronico sono associati a cambiamenti dell’asse ipotalamo-ipofisi-surrene(HPA) e di altre regioni del SNC sensibili a glucocorticoidi(ad esempio ippocampo)che comportano variazioni del pattern basale circadiano di secrezione di cortisolo, largamente controllato dall’SCN, che influenza l’attività del corticosurrene tramite input ai nuclei paraventricolari: la concentrazione di cortisolo salivare ha un incremento del <span style="mso-spacerun:yes"> </span>50-100% rispetto alla media durante i 30 min che seguono il risveglio per 5 giorni consecutivi in soggetti <span style="mso-spacerun:yes"> </span>sani. Effettuando il medesimo esperimento con lo stesso gruppo di persone, 2 anni dopo, <span style="mso-spacerun:yes"> </span>il picco in tutti i gruppi è a rimasto a 30 min dopo il risveglio, con buona stabilità intra-individuale. E’ bene precisare che il CAR non è associato a cambiamenti posturali, durata del sonno o modalità del risveglio, bensì maggiormente associato a variabili genetiche relative alla secrezione nittimerale di cortisolo.<br /></p><p class="MsoNormal"><img 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D4O1MCD63kQPQ9i5MCMHJiRAzFyIGYexCaAOkTwATHCLqoZEkOGJdBhEWREVDspq5rvqfb21Yb7QOE+UNQAShpBS2bIihm8agWtWkFbA+itAfS2HbVlh+/YEbsO+N4A4mAQuWtD7Drg+4PIoxFMZhybncBlJzCZSUzJSSjMoEsz6FezmONZ/LGz+Wjm8dpg/URfk4iHe/gSX/+y5SGl9RH5SROltYnT2Uhve8x88Zzd+YLV+Zz2spXa/pT+opXZ8YTe8pj6rIXc2Up9+ZzZ2s583EZte0J80UF5SWYQybTnFMYzFqeDzSWx2FQen8XlU3gCqkhEk0gYUjFNIqJ2yZjqHq6tTzlmMyxOjocW5mMed8LnWQ571uO+rWRgZyl4uBHI7wSPD6JvjhJv00vvMitnhaX3mcS7o9hpOnqRS5TzyXI2dp6OXGSi5WysnI1dZKLn6ch5OlLOxi5z8YtcopxbusyvlnMrZ+nU+3T0LBM+zwU+NQ+wB/KD40DlGXH3UMhV8Mdu8vHbXPwH+K+Lsct8rJyLAt8AjBUuctHzbOSiECsX4+V8/DwbrXT4bw8Cp0eh9+nw6VHoU/+VR8Dxfqi0FyzuBgrbwfxWIL8VKmyHC9vh7GYouxnKbQMJZLf8mU1fesOdWfcfrXoPlt2V7C8t7qVcu6lZQP52fHYrNrMZnQWyEZtdDU+lfOMR93DINRxwDQVcQ0HXaHBx0L/g8Dodnjm7e9bmnnEsTtsXJq0/wD82ZBoZNI4MGkcGzUMOo8Oqt5r6LEadyaAx9mmMfZo+rV6nVWs1PVqtQqdTajU9qt7uHmWvStXT06NUKBRSqVQslUikcrFEJhJL+WIJRyBmcgUMDp/JETI5QhpTQKZxmXQWi8VhsTgMBotGoVNIZBqJyCB3Uig0CoVGJlOJRHJHB7Gjg0giUahUOrmTTSUxqWQGsaPzs89//A/wqp9gqv43suanUEg1FltLeQYRvayitd2nPL1PfVJFf1LLelLDefqA33pP/Py+oAMhfgmRd4J7SCAVBdJNBcvJUAkF3t0JV3ZClJ0gJam2m1LTTavpplV106rU9CotrUpHrdJTq/po1VpmjYYNVnEhWgZEQwdr6GAtE6RjgfUcsIELMXAhNi7EygEDsXHBdiFsQIwYkqIGhTXDIsiYBDYhhk2KwXOyGndvbVAHiuiqI7rqmK4q3le9bACtmkCrJtCaEbRlw27ZsFsWzJYFs2VB7VjRuzbUnh19YIcf2OEHg8ijYVRmHJudwKQn0EfjqMJUY3Gq7s1c3elC/Wtn4/Hc46OJ1iVr00hfE4eJxrTAoS04bGs9/gkW8xSPedFc245BdtQRSE0NnQ/x7U3oZw2o542Yjof4diShDU9oba5ra2xsxza+QDY9JzS2NTc9bWxpb3z0vO5xO/45qamD/LiD9JRM6+jofEghPWLSW7nsdh77GZ/zXCEhanuYFp182Kxxjg0GnLNRtysZcK9E3OsJ71bSv7fqT28Hi3vhk8PIm6PEu8zKaWb9NLt0mk6+O4qdpuPn2fhFLnGRiZ8dhf8W/0UmepmLn2eSF9nly/xqObd2nlkCyn65EABO+J+yB54C/x3+u14gFy3note5yE0hfFMI3+bDn+K/KcUB/BfZyN0AohC9zEcu8uGLfPg8Hz7Ph9+nQ+/TobNMGMjpUfDdYeDtgb+C/wf1v7AbKOwG8jvB3HbgI/VQbiuc3gqlt0Lp7eDRVuBw03uw4dlfd++tLaTXPIcri/tLC3up+f2lBeDDbtJZkb8Znd6IzGxEZtbD0+vhmbXI9FJ4Mu4bi7iHg4vDAddQYHE4sDgacg8FXAMAfs+cHcDvmrqr/EDbX8E/PNA/PGAatPfbLX0Wo87crzX2aQxalV7Tq9X2qdVqlVqp1ii1uh6Ntqe3t1ep7FF0dym6lXK5XCKRiMVSiUQmlSgk4i6+WMLmixgcPo3FpbP4dBafxhRQGXw2ncFmchh0LoXKotLYNAqdTiRyKCQahUmjMCkkOrGD0vGCROygUEh0OpVFJzGYFAadTCK9fP7Z5z/+EbLqZ7jqz1G198GgB2h0NbkdKqeC6M+qqU+qaI9rWE9A3FYQ/8kDUet9Wft9CREqfVkr76hSk8FaKrSHAu8iwqVEdA8R0UOCdZMh3WSQklrdTavqZVT1sB5o6ff66A8MtAf91AcGWrWOXq1mgXrZIAMTZmDC9EywngnWM2v72WATF2rhQx0csIMDtnPBDh7EwYcOCuHDYuSIBDUuhU/K0HMK3LwCu6hE+1SIsB4RN8KTBnBCD0rqalN9oBU9ZK0ftmqAruohG2bYpgW+ZUXs2hB7duSBHX7oQBw6EGkHMu1ApgeR6RF0dgKTncJmJjEHE4jCVH1pBvdugXC2iHs7jz92Nh9NPFmxNw3qmqlUGKyhFlSPwDRjsQ1wdAMM8wgHeQqDPYWjniCxLWjcIyy2BY9swcEf4dAPqzEP4ZhmLK4ZjXsIwrfU1LfAG1vq0U0owhM04QmqsRXx+CXu6cuGx8/rW1+2PG/FdLQTGOQmLuMxn/FYyHqqFHf2q5jWPtmwWTM7YvPOTEUWF5IB10rEvZ5wby959td82d3g8UH41RFQ+ZdPM+tv08n3mdT7TOosm7zIpgD852mgvQfm/7GzTOQsEznPRi9ysbN06jyzdJFdLefWLrKpcj5+WQxfHQcr+IHclJJAlb7JRwG3n+YmH70sADcLoXIueJ0P3BaDt8XgbcEH4L/Mh66LkdvjxE0pfpmPnWfCV7ngVS5YzgUv86FyIVQuhM7ygfc5//uj4Fk6dJ4JA5cUZ+nQ6WHg3YG/wr4iHzj553eCHxPObYeyW8HsZiizEQTwH276DzZ8++vu/XX33tri3tpCen3hcNW5vzy7tzQDzPn2lmZ2U9MfC/70enh6LTS1GpxcDU6tBqdSoYlEYCzmBbQP+V1DftdQYHE06BnyLw545wc8TofH6XDPDSzOOlwzdteUY2HSDgz8JkfN48NmAP+gvd9h7QfKvtmgM+m1/TqtXqNWq7UqlapXpVCpFRptt1rT3dPT09WllMplckWXVC4TiSRCoVgikkvFXWKhjCcSs/kiOptHZXIodA6VwaUxBXSWkMvgcFh8KpXbQeaRaXwqhUXrJHFIRAaZSScxaEQ6pYNKfkmhdFBpRDqDzGRRaDwGg8ug0Entn/3j//oRqvoeAXwPA66qqb0PR94nvYAqWDDmczD9KYjxFMRtgwnbYKKn1bK2KuXLKhm5RtrxoKvjvppcq6MieklIeQdK2oFVUdEqGlJFg/fQID302m5mlYpTreHV6hn3+ukPTIwqE73ayKjtY9QA+M0cpIWLMHPgJjbMyAKb2BCbADYgRjpY1QPsmgEuaJAHHhLCh0QIIJMy9GwX1qmoc3XXeXvxQQ02ZsAkTegNC3LNBF/ph64aoOtG+EY/ct2AWNPD10zVm1bQrh18OATPjsCzI/DMMCwzBM4PorNDqNwwOj+KzU1ic9O47BT6cBJ5PEc4caLfuZDvFiAns5DSHDYz82hr+KFVXU8kQmpxD2qwEEwdCocDYXBgTD0C0wJFNtUiCTVYPKiuAVHfhMHWo5EEBLLhZ+h6EKYOha6DYuruYRt+WtcIbmzCwuohmBYE/gm8vg3x+CXuUTuuqRX3qK3+ZRua3I5nkZt49BY+/aGI9bhX9NLUS7fp5cMW9cyw1TMzHnE7U8HF1Zh7PeHeWfYerPtze6GP+FNv08vv0hsA/vPc8kV+qZxbusimytnERebufF7B/z4dBvyfpVNn6eXzzMpFdrWcW7osJK5KkeuTUKXtr7AH2vUK/qtsuHKDcJOPlguRi3z4POO/yPluCoHbkv+25L0tLl4WAuW8/+/iv8wGLrKBy3zoshgG8L/LeC+ykfNM+CwdOkuH3h8FgWfBWTpU6fYr8k92PMfb7tx2ILcd+Ct+QP56IL0VOtoMfop/f929v+5KrzuB67395emDlRngw97S1Ef5k6vByZXAxLL/LonAWMw3EnEPBxcHK/j9rpGQdzjgHvQtDH70P+ieGwDwu6YcwFXf1JhlYsQyOmQaGTTabUarxWAy6kxGncnYZ+zXGfS6Pp1G1avr6enp7lb0qrrUGqVK1dPd3S2XdYulEqlcJpHKhUKxkC8SC2VSgUzMk/AFIi5PxGTxqDQWUOTpdD6LJRKw+TyumEITtZN4HVQhicQivSAyXnYA8qmdNEoHFQi1k0Yj0pnEDh6NzKN3MEmtn/30x/8ArfpHDPhn6Af30Z9XPawFMx4i5SQE7zmI8bSG9qSW2QbhPqsVPqvuar+v7nig7YSY6GgjDaEnQw1USD8NaqBCTAyYkYYw0ZFmBspERxppCCMNYWagrCyMgVJjZoDsHJidA7OyQGZGjZVd6+BBHNzqAV7NEB8yLICOCBFAhgWIcQFiQoicFCEmhNBxIWhCBJqSQGbl0AUF3K1EBrsxsR5Mqhe3qa1Lm1qKtrZXA/hXA/gTB6FkJRzbGl4PPDy2NeaN9XkzvGRDvRrAvh7EvRnCvx0mnI7Wn403no80Xk62XEw+Ppt8ejHT/m6y7Xj06ZvJF2fOundO7Hs35p0H/cqNOXE3Z2db1hx1w9r6jjZIDbS2CglFYZB4NIaAxxKaUU2NIBymGoUCYTEIHA6HwWDQaDQGh8Zi0RgMCotBYDFwAhZGwELq8OAGPKQRfb8FD31Sj31EwDXX4R4/JDx5invcinr5qJ7W/pDZ2cwmNwkYj8WsNoWA2KfgWrXSYZNqdsjqm5mIueeXg+6NuHc75dtN+Q5XA/md4MlB+PVR+DQdf59JnWVW3x0l3mcS55nkeSZ5no5dZOJX2dhNPnGTj9/k7wCfZyPn2ch5PnqejwJz9fNs/Dwbv8wlr/KpD4XlnxdXPhyvfzhe/3C8+uF4+fY49XFWFyp/LNeVXBXCV4XwTSF8nQ9d50O3xciHUvTnx7EPpehtMXKTi5SPAuWjwG0++qEQAxYNbnLA8D8M/PGPF4Ghci54lg5U8v7IX8npUfDtQeWSL/h6L3Cy4ytt+oCjfm7Tn9vy5ra8uS13ZsN1tDafXl/MbLiBpNcXD1cXDlbmD1bmd5IzO8mZ3dTs3VQ/ObMVn9qMTa5HZ9Yi06vhqeXA5JJ/IuWbBBLxjkS8IyH3UHBxMOAa8C84gNxd7zsHfPMDXqfD63S45+zuOfvCxOD8+MDcuGN2zD45aq1U/iGH2WbW9xs0+j5Vn16tN2h0Oo1aq1L1Knp7unq65b09XcDnbqVM0SXpknVLxV1CvkTAl4iEMpFYLhTJ+AIJlyPhcqUcjoTOEpKY/A4Gt5PJI3IENJqIRhPQaDwanUOlscgUGpFM6iB20ih0ColK6iSTOslkIoVKptEodBqF3kklkqkUKplBI9I/u/ePP4JV/wTAj/1ZTQsYynyE6iIjuc9qma219Kcg1jMo7zmogr+fAhngYgd5WDsb5eAiHVyknYMY4CGsbKSNg7Jz0TYOyspGWtlIOxc9wMc6uPBBPnJYiBwWIgd4MAcP4uBBBvjQYSF4RAQZk8DGJcgJKWpCigEyI8XOyjDOLoyzC+NUoOaVqMVetEeN9WswIS0upscvG+o3jQ1Htpbjkfb3U8RL57PrhfYb14sb14sP7o5f+sm/8JE+uDv+ydf+z8GOX0dI/xolV/JvMcpvopTfJRi/iTH+Ncb+TUr0q7jwFyHhL2OSK3fz+wX8ezfm1IN97cYfLzZlZh6tOeqGVQRSKwQCA4MQMAQChobCsUgEvg5WX1ddhwfh8XAsBoVAIKBQKAIBw2LRaDQSg0Zi0HAsBo7HQAlYSAMe0oCHNGOrWupgj+tQD/GY5jpsSzP2yVPc01b0s0Yc8Wk95Xkd7SWBS30oYrYqBERdF8emk/0A/3rMs5X07i35gfWeV4eRN+lIBf9pOn6HPxu/yMQvMtGrbAyYwF1lo8CZ/AJIIXZRiFXwX+QSl7nkdWEJuIH/KH/1trR0U0peF2OA1b8r/6oQvs6HgE7+phAG/N8WIzeF8EMREgsAACAASURBVG0hVk4Hzw/9l5lQpWu4yUc/Pk0il/nIVSEKfC7nwueZ4N/iPz30vT3wv9n3faz5vpMd3/G2t7Tl+QH+7OYicIGfXl+sBFjaAfwDg73KeG8rPrURnViPjK+GJ1ZCk8vBiZR/LOkFMpH0TkS8I2HPMHDCB9j75u2+eTtww+eb++vMzzVjXZi2zI8POMccc+OOmVHbxIhlbMg0PNA/5DA4rHqbWW/s1xr0ar1B06dXazQqlaqnAh6IUiHtkotlUiGAXySQ/gA/myVis8UslojGFJAZvA4aB/BPpwtpNAGVyqVQWSQynUSmEkmUThKRQqJTSHQykUYh0alkBjACoFGYVDqNxWKxaSzqS+pn1T/7CbzmcwA/7l7tEziC/RhTwc9oBbOfwwQvIOL2WsWLB+qOBwMs8JQEOysnTEuxs3L8jBwzKUFOSVHDIsSIGAlkWIQYFiFGJagxKXpcih2XYSbk2Ak5dlyGGpMix6TwMSl8Ug6flMOnuhAzSsyMEjOrxAOZV2AXlLjFXpxbhfdqCH4dIWgghI31kX5MwoRfttZv2hr2Bx8Wxp++d3Zeu2m/iDB+neR+sSr4/Ybgy23ht/uSPx5JvjsUf5eWfp+V/zmv+I+C8s95xZ/zij/luv6U6/rPvPwvBeWf0orvjlR/yhq/z1i+ObR8vW/9RaT9wt34fhF36sO98RAKCw37Uw2rdsJoL4HahkDAoVAkCg2HYWrhOCgMh4MQcLUNddAGAhqDRsKhMBgMhkIhsDgkCglHIeFoFAyHhuEx0DospAEPaSRAH+JBLXWwFgLyIQHVXId+3IxtfYJre4ptbyYQn9aT2vDUF3gAfxe/Uytn2/vkoxbN3LDNPzv5Kf795UB6PVTYDb0+Arb6EmfZpfPs2lk2+T6TOEsnzrPxcjYBzN6vsjHgnq+Cv5yPlYvxy1ICwA/cC1zlU9eFpdv80m1+6W79ppi6Kaaui4lK2f9U/qf4AflXuWCl+N8WI9f50M9Liats+PzQf3EUAI4JN/noTT56XUwAbUg5F63MDsu56HkmWPFfkX966Huz73uz73u95z3Z8ZS2Foub7tKW53jbC8gHtvcq+A9XnZ+a/zR7S3NAzd9OTFfkr4XHloNjS4HRpG804R2Ju0fi7pGEZzTpnQDkA7N9gL3XafM6bZ4Zm2fG5p21A/gXZ6zzU2bnpMk55pgbtc+M2qZHrOPD5tFB45DDMGjX28w6q0lrMWqA4q/V9arUyl6VQtWr6OmWKxVSRZekSy6Wy0QyqVAi5gP4xUKZUCAVi+QisVwglPIFEgZDwGQK6SwhgJ9I47yksjtoHDqdT6PxKBQOicwgkmhEEo1IopDIVFInlUykfcqeTmXRqSwGjSlg8wV0DvVZ52c1938KA/0UCfoc8eAe9j7oKQLJfIKRkRGcthpmay2zDcJphwtfQiUvQAD+MW7tQhfGpyJ4e/E+Fd7Tg3UpUIvdyKkuxA8yrUDOKFFTcsyUHDPVhZpWoGe70XM9mLkezGw3aqYbPtMNn+1GzfWgnb1YZy92XoWbVxFcPVhXD9atwnnUWJ8OG9BjQ/34sBEXMyITZvSyFbfhwO8ONeQmW94uvCh7ybdR9q9WRb/bkX95KP8mI/++KP/PV4q/vFH8+ZX6P15r/vON9tP85a3uv07V//lW/f2x6ruC7s/H1v84Gf5jYfjr9OC/pmiXvsennrr3/rrXvrr8fP3uRN2KAzelbmC2ItFwBAqFqUNj66GYOhiKgIYSMLX1WDgBg8QgkGgkCo/F4fFYDBaBRMCQCBgaDsGioHgUBMDfjIc+xEMeEaCP6uCP6uCPG5BPm9BtjzDPWrDk1of0F49oLxroHXV8eouE/UwhIGrl7AGDYsyqdY7Y/bOTcc8CgH8z4TlYCWY2wqX9yJt07FP857nUWTZ+lomdZ+OXufhVPgHU/B9UfgB/uRg/y0XP8zFgInBdSF4Xkjf5xE0+cV1Yui4sXReSn8oHTu9/R/7Hnv86H7ophD+UopXKX8FfKf539b9wt4AAXENc5uJ3NxGZYMV/Rf7poe/NgefNgef1nvdkx13cdBU2FkpbnpMdHyA/s+7NbLizmx6g5z9Ymau0+vvLTqDhBwLU/B/IXwuPLQVGU/6RhHco7hmOuYfi7pGkdyzlG/+04QfYA3FPWz0ztkrlX5yxOidNs+P9syO22RHb9Ih1atgyNmQadhgG7XqHVWc36WxGrcWoMRk0fbpejVr5KX5Fl0QuEwGRSYVSiUAuVQL4RUKZSCgTimQCoZTHF9PpfBpTAITK4JNpXBKV00ll0+gcIBQqC/BPItPJFMbf1nw6lcWgsZkUloDFE9JYrJedn9Xc/ym09vNP8TMeoyVEGKethvG0htkG4b5AiDpgkhcg5csqTWfVGO/+YjcyoMUHtNigDudTI909MK8KMdcLn+2BVTLXC3eqEE4VYrYbPaNETSsQM0qkU4WaV6Pn1WinCvHJdyKdKtS8Crugxi2ocW4Vzq3CeNRYrxbj78ME9OiAARUwoOImRMKMBDZ2NwfwB2MNRefTU8/LsxDtwxLv19uS3+yJvzgUfZmTfnss/e5E9u2J6pvjXiDfnqj++Frz/Rvtn97q/vRe890b9dcn6q8Kfd8UTd+fDH1bGP79of3fltlX/tZTd8Opv+GVl5BfIOxO4FcGsJO9DbTHCDgYgoBjGrD4JkRdPRyNR0Ew8Fo8CoZHIjEIJBaBwWNxOCwSiQCjYFAUDIqGQ7AICB4FacBAmnCQZjy0CQ9uJkAe1UOeNsLbmpFtzcjWJlRrE4rS9ojxsoX+spHRWS9gPJZx27tF5D4FF8A/P+oIzE3FPQsrIc9G3LuV9B6thbObEQD/u2zsLJsE8ANbsefZ+EUudpmLXxXuGv7bQgI481/mY5+2/ReFOLAIfFVMXheSV4D8XPwqn7rKJ67yiatC/A5/3v8p/v9DfjFy1+QXIx9K0X86if/TSRw49t+U4pf5CID5IhsCOvxyLlyZIFYqf/nuNYTQ3+J/d+B9e+h9e+h9c+B5tespbbmKm67jbferXe+d/HXvx+P93TA/vb54sDIP1Pn9ZSeQvaW57cQ0IH8zNrkRnQD8r0fGl4MjS4HhpG8Y8J/wjiR9oynfeHBxsFL2vU6bZ84KxDtr9805Kmd+oPLPTRhnhq0zw9apYcvEoGlkoH8IkG/ROixam0ltMaj7+3r6NAqNWqlWKTRq5V8P+XJxJXKZSCZRSMVdEpEcwA/I5/JEAHs6S0hnCRkMQaXgU2ksGp3NYHLpDC6VxiZTmGQKk0JlUUlMKolJITIoRAaVxKSRWQwqh0njMslcHp0nZnAkDMZnD+5/Dqn9HAX+KaLqPrYK/ASJpD1GCYlQAD+jFVyp/N0d1Vpi9Qj/Zws9cJ8O69WifDq0RwN3q2FeLWJRg3Cp4Qsq2IIK5lLDFzUIIG4N1qVCz/cg53vgC7133zPfC51Tged6oXO9UKcKNq9GLmhQLi12UYfz9wHBBPTokBETMmKC/ciAAZG0YFJW9JINs2LHrg3gdsYas84nr70vTsO0qxTnFxvif94S/2pX/Nsj2b/nuv5Q6PqqpPuyqP1DQfNlUfvNif671/1/fGP8/q3pj+/6v33T//VJ/1dFwzdF059eD/35eOgPh8ZfJVhl//NTb9M7X/2xF59dIOxOEVYGsCPdhI6HkJqq2looAo/C1cPxeBgahQJhILVYBBSHQGFgKAQYjoBA4TAQHF4N4MfAITgktO4j/oc4aAMe0oQHP6oHtT2EPm+BP2uGtzYg2+qQLx7WkVobgDM/n94i5TzvEVMM3fxP8Se8rpWQZzPh2075jtbCua3o8UH0B/jLhdRFIQ5c7N1t5uYi17nIbSFxW7gb2gP4z/NRYK/mspSo7OcBD4tr4MHxUf5VIXxZCFwWAuW872/ZAwFKPTDq+8WrxC9eJQD/wGJPORcGOvlyLlw56n98zydSeSKcZ4IX2RDgv4L/3YH33YH33ZHnDv/e4vE2EPfJjgfAn17zfDze3+3qA/iBOg/4rxR8IJuxScD/p/hT/qGkD3gEjAD57/AD8v8W//SQZXrIMjlk/gH+QbPWZlKb9N0GjbJPo+jTdGs13VpN96c9v6JLUmn+peKuCn6hQMoXSLg8EYcrpHNEQM/PZAqZTCGLKWTQ+Qwqj0Kl0+hMBpPLYHKpNDaZzCaT2RQKh0HlUElMcied1EGjEBk0MotOYdMpbAZVwGMKZFyeUsD77MH9z6Ggn6Jg99C11fga6A/w05+CgDM/gF9HqhkR3FvoRXh1WI8O5e1De3Qojw4R6Mf4dGiPBulWI9xqBPBc8OnQXi3K14fzaDFuLXJRg3Br4W4t3K2FubWwBS10QQsD4tIiF3Uojx7nNeCDBlxAjwXkR8yYiBkTMiKCRmjKil+y4Zbt+GU7fnUAvzPenJlvPfZ1lKOMD0u8f9mQ/GpT+m87Xb8/7P0yo/kqq/2yoP+yoP+qaPjm2PjH15bv31j/+Nry3Svz16+t37yyfPva+s2x+Zui6S9vBv7y2vHlke42TLvwtr/3PnrrbSgu4nOuuv2Z+uVBtEOBf/kIUguC1MKQCAQKBUahYSg0BkZAwHBQGBqKREPQKAgCAQEjYbUYJAgNh2FgMCwCikNC69HQBgykGQt5iIM2EuANePDDutq2h5D2Flh7E/xZPfIZAd1aj+l8Ukd+RqC9JPBojyTsZ90isqGb79B3AfiDzumE17Ua9m4l/TtL/h/gB9r+s8zqRSFeLiYqr/Rc5u8GbJ9W/jKQYrxcjF8dJ6+Ok1fFxOXH7Z2/4gdW9wrRq0L4qhi8LPgvC/5P5X+K//ZjgMoP4P9Qil4fx6+P4+VC5N2R7+2h9ywbvCxGr0ox4GlyWQhcl0I3x+HrUqic959nveVc+G/xv933vD10v953vdpbPNl1ney6jrcXS1uu4uYCIP9o1X205qrg31uaOVpzfYofqPnrkXFA/qfFfy08thoaXQoOLgWGK/4T3qGYeyjmHvr0wP8pfkC+3zngdTrcszbXtOXv4h+09TmsOptZM2BS2Qzdxj5lv07Rr+026Lr1WqVOrQSGfAB7QD7Q9ktEciAioUzAl3B5IjZHwGLz6RwRjS2kMvh0Op/JELDoAhZdwKLwyFQKlcagM1hUGotEZhCJTBKJQ6HwmDQ+lcQmdTBIHQwqiU2ncIFfksl8DlsoEfAlfOZnD+5/DofcwyKrcBAQoRb2FIWiP0GLSHdtP+1JLesZlN8OFrfXdndU95FrR8TV82q0R49b1GHcfehFHcqjxwQt+IAe79NhvVqMV4vx9+ECenxAj/f34bx9aG8f2qNDeHQIbx/Sb0AF+tFBI8atR7j1iMU+uFuPdOuRXgPW14/zG/EBPdbfh/L3oYL96LAJHTGjQiZY0AhNmgkpK37JRliyEVYH6rbGH6bn20q+zusk8xerwl9tSn+9Jf/NTs+/H/Z9nTV/nTX/IW/8smD6umT57pX9+zcD378Z+O6V/euS5Q8l+1cl+7fHjm9L1m/zxr+8tv7XK8tXhz1lL/nc8/y99/Erb33Bhcu56g5m65YH0TYlvqMVBUEga9FYGBwJByGRcBSmDvUIT8BC4PAqMBKExCOxBAyagEUQsDAsHI6Fw7EIKAEBrUdDG9F3+JvrkQ14cHNdVevD2vYWyPNGyPN65PM6zLNGHKm1gfaigUls4NNbgKs+vZLn0HeNWjQA/qRvcS3i204FdpcDf4sfmPYD+K+Kycu7vvpuxnZH+iP+y0L8spS4Ok5en6Qq+IHfBRZv///gr8ivtP3Agf/nx7G/tv0nidtXycti9O2h9/W++30mcFWK3ZwkynnPZcF7VfTdHAduT4LXJX857znLuP47/K/3Xa/2Fo53nMc7CwD+4uZCft35Kf6jNdff4q+U/c3Y5GpodDsxDdz2AaP+9cj4amh0OTCcCgykAgMp/xCAP+4ZjC46wguOypn/7+L3zTncs7bFGevClNk5afoU//iAEcBvt2htZo3D2GvVK806pbFPadarTAaVQdetVck/xQ/UfImYLxJyxUKZWCir4OdwhRX8VJaAQufRaDwGnc+iC9hUPovCI1HIFBqVSmOQKYxOIq2jg04ksqlUYQU/uZNJp3DpFC6FyOpop77o4LDYAgGfzWF2flZdW1MDvo9AVcPh1fDq+614mLgDrSRXM578hP70c9azB9wXNfz2GlFbteIZSPMSPs6FuHsQHl2Npw/s6yfMa/CzapTfio/0Y0J6VLAPGdKjokZczIQP63EBLTpkxAT70QEDyq9H+vXIgAEVMmLCJmygH+PToxb7EIt9iEU90m1AefrRbiM60o8JG9BhAzrYjwwZESEzMmxBRKzIoLU+aK6LWAgJe/3KQMP2SHN+ru2tj3Qd4/5yRfLLVemvNpS/PdD+9qDvi0P9l3nLF1nd7/P6PxT7vyyavypZvj62f1WyfVm0fvfW8N1b43dvLN+/HfyyaP321eB/no3/Nm24CZHfzD9862547cYfu3H7k7D0TN3aAEYvxjx7CALVwqBgXB0S3oiqrcMgcNiGejwKg4AiILUYBBSPRhDQiDokvA4Ow8FrCUgwAQnGwWvxCFADBtaEQzThEE3YmkZMdSOmuqUO0taMbG/BPH+EbmtGdj5FE1sxlOd1zM5mDrlFQHum4JN1XRybQTpqUzvHbL658bhvfj3u21kJ7K75i1u+0rb/1V7o3RFQ9pPAnP88s3WRWysXUuVi9DwfPs/HLvJL5fz6xxu7yFUxCLxmd1NK3paWLotrl8WV6+LqdWn5upCsHBMuc/G/7u3fXcWFLvOhct53XQreHIevisGrQvj2OHZTil7mQ8AXb08iN6XoVSF8VYheFxO3x6nb48TPX6U+nCQv85GLbOgyH7kpxW9K8U/v+YEPF9nAWdr3PhM4ywaBvM8E3h56X+0tHu8svDn0vj7wvNp3H++6i9uu/OZCdt2ZWZur3O0Bsz1gY/dg2XW4ugCY312a31te2FlZ2Fpa2EzNb6ZmtpZmgWymZtbikyvR8aXw6Ep0fDkythQeTYVGUqGRZHAYSMQ9HF4cCsw7fHM276zVO2v1zdn8Trt33nwXp9UzZ3FNm+bG9dMj2pkx48yYcWrEMDFkGHXohq3aIYtm0KweMqnt+l6rrtuiVdr6VLY+lVnd29+j1PQoehUypUyslEl7FV09XQq5WCLi8aUSkVQskYolYrFYKBRzeQIWm89k8bgcIZsjoLF5nQz2CyrjJZlJJrNpVC6TLOx8yX5B5LRTOc/IrE4Kl07j0TpZLFIn5eVLGolIo1CJJBqRwiTR2e1kJpnGpTF5NBabTKd9VlVVVV3zMyj8Pgx8H/rgZ0+wEOELpKzzPrv1PuvpvQp+8bMa5XOwrgMxJYD7NSi/AezpA3sNeJeuzqlG+yy4SD/qB/gjBnxQhwHGdZUE+9FAAPzePqRbj/QYUF4jBkjUiI30YyL9qJARBeAH/AcsdX4jPmTCxW11y476ndGHxfnnZyHadYz9i1XRP69Lfr2p+OJQ87sj7Rfpvi8Lpq9PzF8dm/5Q7P9DwfTveePvc/1/KFi+Ktn++K7/+1Pz9++sf34/+PWx9bvXjv94P/KbI91NuOPNfNOpt/G1B1taxB5OozIzjWsDuE/x4xCIBmQNAQ3HYurRKBgMWgutrUJBQQQEjICAYeAQDByChdX8XfzNuNombE0zrralDtLahHj+CP3sIaq1CUF+hiO1Yant9QB+If15t5CqV/L+e/yB453Q6/3ou6PEaTr5PpM6yy6d55bPsxsf8cfP89EK/pti6m/x3xRTV6X1y+LKVWHlqrhUwX+VDQMHfmDPDzi33ykt+G+OQzfH4crS7k0pelWI3hyHb47DN6Uo8OruVSF6XYzdlJI3pfiHk+RNKV7OhYED/6f4KwHwn2f8Ffln2eBp2g/0Cye7LkD+yd5iaWexsLWQ25gH8FfezL9b41l2AamM+veWFwD828uuraWF7eW5ivz1xNRafHI1NrESHQd+Xo6MAfITgaFEYCjuHwwvDoVcg8GFgcC8w++0+532wLwjMO8ILNr8Lisg3z1rcU2bnBOGmVH9zJhxerQfwD820Ddiu/M/bNY4DCqLVmnWKKy6Xquu16zuNfZ2a3uVvQqZQipSSCXdclm3vEsulkgEQolIDOCXSCQi0d1iH5sj4HFFHK6QxuZ3MtjtZOYLEoNIZFJIXDpZSOzgvCRxK/hpVC6FyGIRKbROEp1Eo1GYnURaB4lJpPJeUDgUCofO4DJZHCab9Vn1g6rqqp9CofegoHuw+z97ioMC+Hlt1ezWB8y2+5z2akF7jfh5VXc7SE9EzEnQEQM+bIZ7+2p9eoxbV+fS4XwmbNiADPbBg33wkB4VNWJjJnykHxvSoysF/6/sgQdBP9pvQPn0SG8/ym/C+C1YvwXrM2PiZmzMhAmb0GETOmhCBU2IoAnhNyP8ZoKvHxc0YmNWwrKjfnfs0cniy3KUeZ1k/mKN/6st8a93u7446v19VvvvOd1XRcOXr4y/Kxi+yOv/vWT8w7HldwXjF3nT74uWb94avzs1f3dq/uN725evjN+8tfzpbOi3ub4P0ZdvFure+xpeuTFFFyYzW5ebe7xqJ+gkmNZmMKgWDoHgcAhEPbIGj4KjUPUgOBgEqoHV1OBAkDoolACDouEQJAqKgVYTkOB6NJSABOMRoHo0tBELb8TCm3G1D/GgRwTw43ro00Z4axMCmPlTnuPJz3AAfi7lsYjR3ium9/cIrHrJmF0zP273Oyc+xV/Y9J/sht8cxAD8p+nkWXbpIr9ykVsv59fLheVyMQFM8i/yS+XC6nVh6Y5xKXRdCl0XY9fFxHVh6fp447K4cplfviou3T0gcpHLTAi45APWeytcgWcH4LycC55n/OVc+KYUvz1OAC3A3fv8xRjwR4A3eW5KcWCeB5T92+ME8EVgz+cHGz7A9uFZJvw+HQK2+oDrfUD+D8p+esWZXl/4mMX0+iLwfv7hyt0l/8HK/P6Ka3/Ftbvq2llZ3F527aw4Af8byem1+CSAH0il+CeDw3H/YMw3EPMNhN2DQEKLA58m7B0IuBxep9U9a16cMS9MGecnTXPj/YD8yWH9xJBhfFA/ar/zP2zVOoxqS1+3SaswabvNuh6Tprdf1a1TdQP4uyRihVSilMnlYolUKBILRRKRWCISSyQysVgKXPLz+GI+T8zhigD8LyisFyRGZyeL1MmmkgVEIvclifuCwmknszspXAqFQyIy6Z0MGpHBJHPpFG5nJ6uDxCaS+Z0UPoPOZ9C5TCabzWZ/BqsBgWvuIaD34aD7yOoHz+oQYhJWRq7itdUyn9xjPrnHe14tfFEreVbV215jIMEXZOhYPyFqgnl0NR4dytNX7+nHe03okB4BJGxAR43YmAkXNeLCBkwF/98Uf2TAgAgYkUETKmjBhG24kBUbsGLiNmzMiola0CEzMmhC+U0onxHpMyJ9JryvHwdU/tXBxr3xFgD/7RLznzf4/7Ij+vWu7DdHyt/nVF8W+746Nvyu1P+bvOGLovGrN/av3wz+rmj5bd78RcHy1WvTd6fWb9+Zvnlr/MNJ39dvTP9RHvrqleWfEi9fz+PPgwB+XH6+MT/XumJr0Iowrc3gmloYGIzHIRB1iFocEoZE1tUgEWAoBA2CNkDgzTAkAQZFI8AINAQLqwHA16EgeASoDgWpR0Pr0dAmLOghHtJSB3vSgHjSgGhtQj17iHn+CAtUfqDt51GfiJkvekQ0QzcfwL8w4QjMTyb8C+tx3+5qcG89kN3wFXdCb44S7zKpd5nU23TyNLt0ll+5yK2VC6vlwnK5kAL+P5xyIVUupD5e2sduStGbUvS6GLsuJCv4y7mly0IKwH+Tj5bTwat84pP1/vh1MQbU6rv5XDFSzgXP0r7zTPC6GPv5q8rLP7Hb48SHk+TPX6VujxOfvMMfucxHgN8FNvx/gP+v0/5cFMBfeZ8PyMme53jXXdpZLGy5chvz2bWF9IozveI8WptPry9kNlzZTU9205NZ9975/7jSt7/iqlT+7WXX3rJzd2luJzW7nZzZjE9txCbXoxPr0YmV6Pin+BOBIQB/1DtcScQzVHkKhD1DwcUB37zNM2d1z1pc05ZP8U8M9U0MGSaGDOMDhjGHftTeN2TRDJg0Vn2Ppa/brOsxabuN6h5Dr1LVq+hWyuQykUwqlsskcqlMKpaIBEKxUCQWisRCiUgkAab9PL6EyxNzOSI2R0hl8Trp3BcU1ksSm0hkkzrZFIqATOZ3knidZA4QEolFJDIpLzm0Th6dLKSSBaROLrGTR6IIKTQxmyWi0zh0OpPFYn2GrAHDqu4hIPdgtfeQ1Q/aG1ASMk5OqeY/BTFb7jOfPOC314jbqyXP7ve2V5kocJccE9FjIkaoR1fj0cD9+jpfP8FnRIf74SEDLGxARvpRUSMa6N7DBvSnB/5KCxAyYkJGBJCwBRW1YSIObMSBDdsxCQcmbkdHbZiwBRUwo/0mjM+I9prQfjMhYCJELITUQOP6cPP+xOPSQvtZiPZhjfPLLcGvdsX/siv99b78d3nVV8eGr44NXxzbfluy/lvB/C9p4822+ny1+2Zb+y9p81evHH86G/nje9u3p/1/eKX9+k3/f12N/+ls5JdJ0skc7szf+NqDLbowRVdz3vlkxYZXCVGPm0DV1fBaMB6DQOIRNRgEHIGoB6EwUBjq/6PsvbrbTpM0z7yfs7vdPV0mJYoG3lt6kRI9vPeWDvQkLAl67wA6EB4gAXovEoZWjp7yysyq6qrMMl1+Znp2LvYz7MVLojhZnd2758QFpSMeXf3+EfFExPPiYeh0OCYLiSEh4FgUFIWFkDGwdDzyPvzghww8JIsIuw9/YQ6hJI9clo8ry8cxCsh8WraEna/kl1TKWPVaoalR2dNaZ+u3zo4P+GfGE/A/W5iOrbpOdoIv90IvduefhW8PLgAAIABJREFUP5t7sTv/cg9gH7qLOUD+Wcx3GZ2/S+YAfrDSM/9D8CcEP1Av3A78IrN3v+5KTO/OI56bg+Bl1H8VC1zHg2+P5t+fzL87nrs5AMWCJ0H+zYH/5sB/B//tvRD4L4Dd0OtnztM9z+tdNzjgB2d84J4PkB9bsUWXx/cWxnfDY89CozvzYJN3bHfJBtZ7gf63NW9LbPWsz42tBUdX5kYB/KuBobXg8H3+F9y9IWd30Nl1PwD/3mmrb6bTN9Ppne7wTLW7Jtqc9lbHuHlmzDRrv68CWmyDptFe43C3/q7hb+htb+rraO61Nve0NXVZGlqNNRZDralFZ2yu1jdUN9dVNugq6qq0YNSn1Sg0aqVWo1IrVQqZXCqWKGRKhUwplyqkEiXI9gKhjC+QCgUyHk/G5EnKOKJStriMKWIwJAyamMaQ0JlSJlPKYIjodCGNJiihcUvpvLIiAbNMwmLIWAwZky5l0MRMppTLVfI5Ug5TwOPwRQLhF7hUGPLRQ1Tal8jUB+iUR0XpWDmdoGKmSPLhvNwU/uNkWRFUWZymfvqorjS1lY+bLCc4G3DuFsRMA2SyDj3dSJluIU21YFwt6Ntoxrrv6Xb/ruDnMhA9BrTHgHYaUC4j2m3Geiw4jwXntGB9Vry3Dec2Y2fNuBkDbspwqwVMG8gOA8Vjps61Zy12Zm/0Po6NFr6YYb4JSz4sKz6tqz+uaT6saX6+W/vdfvMvYg3fRK2fn7VdLTdFpmULvfRQd9m2TXLiq/68bfnNSdfvX7f/7pXx2+Om7070f7ns+/P50Oc5QbSP/HIq63iSGLcRYjbq7lDmvAVbJUHnpKc9SkWmQQH8UDwahcRQEWgSAo5FQ9AkKIaCQBHhMDQiBYlKTaR60Pknfs7AQbMI8Fwy6jEFnUfFPM3EF+WQSvOopXnY0jwsgF/GfaoSlFbKWHUagbFB0dNaZx9od9oG/TPji77ptZBjY9GxszgdXXMd7QReREIvIqHne/MgzmPBs+jcaWT+LLJwHl08j82fxXynUc9ldP5vlX+i5r+D/+/L/h8S/O5qeycQ8F7tzJ7tua/i/ovI3GU0eLMfensYenc89/bIf3PgBf0FaARAOQDgv973AfgTAeA/3b016ny540zc8N7BP7G/NhFftceWJyKLtr0F+27Ythu23aV9297y5P3Mvzk/CpL/xvx4Av7VeVti8pdY8gXTPsD8nKsbRKLzD8x2+x1d3ukO96TVNdE2a7MA+O/N/1rBPf9Yn2mkxzDUo78Pf197C4DfYtBZDLWAf0Ojrqm2or66vKZCXV6h0pYrNVqFRqNSq5UqlUomk0kkEkC+TKKU3GV7vkDK58sFfDmAn8aVlnEkdLaMyZQy6ZISloTBkbNYMiZdxKSLysr4hWXsQjq3rFjMpEuZdCmTLmExpCyGmMUQ87hSLl3IZwklfLFCIv2CmApHPXqITv0SlfIAm5pckolXMklqVqr8KVr0GCrMh8iKoMqiVE1hUjMT3q9In9VR3Y04jx7uakHMNGGnGykzzcSpFoxbj3LrUW49xq3HuJqxziaMswkz24gF8CcCSP1OPcFvxnmNGI8B7TKi3SYMgN9jwfmsWG8bzmPBzZpxDiN+2kCc0pOm9KQZIwXAH7RmAvjjY0UvHaybkOzdkuqrjcrP61Uf1ip+9qzuX2L6z9t1H7Y7rlZM+67KxX6+v50+18le7BMs9QvjU+Xv14y/Omj9zXPTt8ct3x4Z/3g68KfT0a/nlc86Kc/tOSeTlH07PmYj7QzhQ1Z4hQidTU1NSkGkQUlYNI6MgeGwaCSGikOnI2F4JASNhaPJKDQJBcejIHh0akLtA8ofUPuoOAQY+H0P/pLHFNoTfCLzy7hP1cKyagWnoVwE4J8Y7HDZhwIOWwL+yIortuY52PQf78w93w292AuDOI/7z6Jzp3vhs8jieXTpIh46j/tPo66rWOgqNgd2dYEUfxWbu4qF/v8KfkDeA5kcHOcCU5CzZ3MXkbmr2Nx1HNh+eIA0AH73et/37nju7VEQpP2bA3/CI+C+TfDprguQf9+3A8TB+uTB+uT+2kR8ZTK6ZI8sTuwt2PcW7ID83SXb7tLEs0V7wpZvKzQGJv9bYfvG/Pjq/NhayL4enrhP/t9O+lw9c65uUPl/r/P3O7p8M50g7QPyb8NmnR7732x8gJPHcK9hoKsZ9Pz9nS39HfqetqZOc73FVANmfsYWXUtjdUNteW21tqZKA+BXa+QqlUKlUigUCplMJpVK5VKVTKKUSZQSsVIsUghFcqFQKRQqRUIlny9n8eR0nozGlTM4ciZTyqRLi9kSJlfBZspYdBGbIaaV8gtKWQUMLp0mYTHlDIaEQROyWSI2g8+kc7hsgYAhlnClCpFMJZF9QYWg8CnJWMhDTFoSAZpGyyFpOFQ1B6IqwEry4aInUHkxDMBv5KLGK/M89VmeJrzPiPSZMLMt+OkG4nQTYaYFAzK5x4D1GLAAfiABJJhPYA9+DlhwPhPGY0A5DUi3Ce22YDytWE8r1mfFetswrlbsrBk3Y8JPG4jTBvKkngJGfW4TJVH2H9hKTl3cyznZ20X115u6rzZrP6xWff2s6ecR/fv1mndbXacLxr2ZivUx5d5M1ZG3eWei0mfl+IyMw9mKj1tNvzzQ//Kg+ZcHxt+/HPjDy7GfhSq2reknttznUxkHE4SoDbs9iA5Z0zQCZCYp9WEyMhVGwqJxRAwMh8GiMJlkbA4WTkZBMTgklozHUQmYdDwyHQsjoiBEFAQHT8HBUyhYeDYZm0PBZRLROSRkLhl1H/7CbGJRDolRQKQ9wSfg14hoNSpeU6XE2KDobav/e/hja574und/w3e4FTjemXuxF34ZWXgVXbzY959FA6d74bPI8nl06SK+cB73ncZmr2OLVzEwzHNfRN2XUf9VbO46tvhDo74fEvzAui6A/zLmO929NQU63Zk/352/iMxdRHznEc95ZPYyPnt9cAv/zYEf9AIA/jeHget4EBj4JQKs+t937LoP/+HG1MH65P7qVHxlMrY8FV2ajCxORBan7si/hT9hyAlOeneXJnYWJ7fC9rXQ+Hp4YnNx6nYEEBxe9Q8mVn2WPLeyX0L8D8x2grYfFP/uyVan3TxrMznGjbM2k9NudtisU6NtYL1nvN9sG7DYBtpsA20jfcbB7pa+jsa+jub78LdZ6sC2j6G5uqm+sr5GW1utra3WVlSqAfxKpVyhkMnlcrlcLpPJAPlSsUIiVkrESrFYLRarJRKNRKwWCFRsvoLOk9F5CgZHzmTI6GXiIpaYxVNyWHIOTcSli2ml/KclzAIGl86UcjgKJlPMoPM5bCGbyaOXMTh0toynVIpUKolCLhR/kZb8IzjkEQKSgoGnEeBJ9BxENZ9SwYRLnqTwHyeLnsJET2GKImh5KczIxziaS8KdNF9rxqwR7jAgZvWEWT3ZaSC5zVi/ieQ3kXxGotdAAmqfq5ngaiZ4DQR3Cw4UAu4WnEeP9+jx7hac20jwmkk+C9ljITmNeIcR724l+9rTvRaqx0zxWEiuVoLTgnVY0A4L2tGK9JopPgvV30oJtVOXezJ3RvIPpkteuJmX88I3C4qvNmu/2W56t9L0Yc34eaP9w1r7xz3T+VL5cyf7zMV6Oc1+PimOjikdDSVWJTXQx/r6oPlPr+t/H1X+t6OWP7wa/Pnp5PsVVbQffzqZfjSZFbenn4xT4sMZwY6MGgEpA/cwDQKDIkkYOJaMgJFRKVQijAhPIsCTMQgoCoXCYHAYDA6PxuAQCCIKQkKnkTEQChaajodmEGBgq5+MSsnEQfOJiEISqjQdQ88lluWRivNwxbkZZfmZzKIsblmOiPVEKaTpVOLGSrW5UdPT2mDr73DbhuYc9mXP5Ob89O7S7MGG93DTd7TlBVLfy0jgVTT4Kho8j82fRedOI8HXewEQp5HgWXTudM8D4jwauIzPXcXDV/HwZSx0HvdfHQYvYr6zyK0sf747cxV13j+2u2/XdRX3vt5xvd7x3EQX3saXbiLBN9HAp+P5N4dLN4fzN0eet8/dn175vzoNfXyx+PZw4f3R5IcTx8fnro/PPe9OvG+OPFcHnst999sD95t9z3XUcxXxXu55L3f9l7vBq72504jz1a4DSP0vd2YTpr3Az/NwYwrwH1+Z3l+dOVhz3Fb7d6f7idgKTW2Hp3cWZrYXpjZDExvz45sh21bYvhoYArHiH172DS15hxc9Q4ueoRV3z4q7Z9nVvejuXnB1Lbi6Qq7OkOu2+HdPtoJu3zFuBoKfb7LdbWt1jJgnh0wTg4nk3zrabxnuNQ106fs7W/o6mvs6mnusjd1tDR2WllZDg6FR11Kva6nXNdfp6qsrdOVqXbm6SqOsUCq1SoVGoVTI5HKpTCqWSaQqoPCJJUqpTC2Ta6QytUSq4ouUfJGSK5AzOeJSuqCULqAzpRyeis0RMJg8Gk1Ao4nodDGTKWay+EwWj8cQcelCNkPIZAgYDAGNLSxjCUpYAg5bzOeJ+Xwhh8P6IvXRT+FpySgYFIeEkVFpzFxMNS9dS0NKn6YK8lLEBXBxAVxeCNGWQA089ExT8VofJ9SR6zGjnAb4bAve0UR0NONm9UivEQemdB493qMnulsI7haiu4UIUHc1Y++EwLswEjwmos9CdpuJTiN+1kRwt5L9HRm+NpKvjeRtJbrbiK5WwqwF77BgHBaMvzXd35rub6XMWylL3RnbI/mHM7RXXvZVWPpmSflpXfdpve79Yt3nFePPN9u/WbVeL9W/XdS9Canfzileu0XxCdFin6CvIrdVmeXsZn4+bP23t+1/OdL9eb/xdy96/uV08sOqOjZAOJvKOJrMitmox2Pk+HDGXGdmvZiagXuYlJqWCiNi4FgKCkFBp5LxEBIiCY9IwiAhaBQCg8HgMFg8GoVHwUHmB/BTcRAqDpKOh6YTIOlYSA4R8YSIKiAiiymYsmx86WNiUS6+KIdSlp/OKs7k0bPFnHyVqEynEjZWKi1N2p7WBvtAp8c+DODfCs3sLs3ur3sONrxHW14g+L/Y87+MBF5GAoD8BPyA/LPoHPDwOot4L2LBq/15QP5FdP5iP3B9NHcZ9wP4zyOus2fTl5HZxMnNXdt/u/x7c+C9iLrP97xvYvPv9sNvY8F3+/6PR4H3Bwsfj8Ofns99eu7//CLw1cvQ1y+Xv36x9uHI8/7I++HY9+n53KeXC59eLr1/vvj2OHy7AhjzXkd9VxHf1V7gai8A4H+9Nwuc/F7uzILm/2Rz5vnO7Mm242hz+nB95mBt+mDNASK2NhNdnQafAHDGexfT2+Hp7YUpAP9myAZiNTiwPj+0Pj+04h9ccPeGnL0L7v5l39Cat2/V07vi7gHwh1yd886OeWdHQvl32ltnbZZZmwXA77a1OsfMjhHz1LB5arh1YqgNwD/SZx7qMQ506QH5twO/1vp2S6NFX29o1LXUV7XU65pqq+qrK2oqNDUVmmqtqlKlKlcptUqVSqFUyOQyiVQm1wD+JVKVRKoC5IvECr5IzhMqOHwZiythcqRMjpTJljNYMmDsw2SKmUwpiyVjMsUMJo/O4PCZYg5T9Df4mQIaW0hjCzlsMY8r4vOFXC77C2hKEgKShoLBsXAkCQlh5OB0/OwKBkZSkCZ4kiopRIgL4NJCiLYEauRjppuLN/vZCx05PjPKbYC7W3DuZrJHT/SbcaDbv2ObcBdEVwvarceAduD23wBdwIB1G3FeM8FtxrtMOKcF77GS/J3UQAc+0IH3txM8VoK7jehsJc1ayLMWcsCa6bdS/a2UQBt5sStze+TJoYNx6udfr6jerGg/rlW/Xai88mpvvJXvvbVvnFUnk8r3c7WfFmou/arYFH9lmDPbweyoytHLsoYMpee7rf/rq/H/eWb+fbz+14fWX70euw9/dJxyOEKMD2eEe3Ka5Fnp+IdfPkp+lIZDwXFUNJKChhCxqUTkAwIqCYNMRaOgWAyCgEUQ0FASMvUOfhgFC6VgoRRsGgWbRsakZhMRj8moJ0TUUwKikIQqycSW5BKKcvFFucSyJ2R2KZXPyJRwH6slxTo1r7FK1tpc3tvWODHY5bEPz89OrHintkIze8vO+Jp7f91zuOlJwA/4/3vyz2Pz57H5hOX29+C/PAgC+M+jwF3TdfZs+mLPAcby4Ormrud3n0dcF7GZsz3H+bPZyz3v21jw/UHg41Hgq2Pfz06Wf/5i+RenS99ern17ufaLs9WvX658Pln7dBT+dLLw+fnS5+dL74+X3h8vvTteeXe8khD/ruKJyj94GQ0COzAw53/1zPk9+I+3Zo43Z482HIfrs+CJDgB/ZGXqtue/c+8AOX8rPLkVntwK27fC9s3Q2Mb86Opc70Z4YHNhcCXQG3K1Bx3WBU/3anBg3de/5u1b9vYueXrC7q55Z8fcbHvA2Z6o/4HUD+B32q2zoybHiNExYp4esUyPtE0OW20Dllv3vh4jSPtg2tfd1tDVWm81N1gMtcamGn1D9R385TUVmtpKra5cXalRVqhVWo1Ko1Ir5QqZTJZw70gEOOzhi+RcgZTNE3P4Mp5QwROqWFwZjSlisnhsjpDLlXO5SlDng8NesNLLYgoZCfiZgjv4xXy+kMfjfYGEQlAwOCINjkiFYNNSyjLROl6ujk0SP00VPEkVFSGEhXBpIURTCjUIsLOGsq0+9mJ7jt+E8hmRPgPBb6DMmdPD7SSAt8eAvSvsb/l3NqPceozXiPMacW797VDArcc47/h3mXD34Q92YYKduEAH3ttO9LRRXK3pTkuG05Llt1JBBK2UxZ7sndHCo1n2aUB8uVL+ZrX6/XrN21DFpUt541TfTCleDQq2W+nXs5Uf5huOZmRL/QxPF81mKemqy2sRZxjVOeuz1X+8sv2vm94/HjX95rj129fDn9a1CfgjY+T9IXx8OGOpP69Jnp1BSPryUWpSKhYJw1JQSDIGQsRBSaiHBFQSBpmMRqdhMXAiBkZBp1JQySQUnISGktDQBP8g+WeT0Y8p2HwSKg+PeEJCFmfiix+TivIIRbl4WgGJU0YVsjNlgscaabFOw2mskrS1VPRZmyYGu7wTIwn472f+kx3//cz/vWr/lvx46DIeuIj5L2L+y/jc9+C/PAhcxv0Xt3f7rltbjrvdm/v8X8Y8N/szN/HZN/ued/v+j0dzP3se+sWr+Z+/DPz69cbPTxa+OQr96nT9d2/2fv8u9uvr2C/Pd395vvbNq6VPJ6GPx+H3J+EPzxfenYTfHM2/OZx7czgHTIHBruFt5x9z3z0i5LwPP/Dwvw8/eKUjsjIVWZkCmT8Re8uTz5ZuC35A/vaCbTM0tj43sh7q3Qj3bYT7VoI9YU/7vNMadncs+bpX/f0rvr5lb++ityfs7gq5OoOujqCrA8DvnbYCtd9pb71d+xkzz46aAPwg84/3m0d6TMO9psFuQ4J8kPY7LXVtpnqLoRbM+Vrqq+7gV9dUaarKlRVqhUYt12pUarVSqVQC+MFiTyLEEkUCfg5fwhXIQQvA5snpLDGLzefyxHy+ks9X34efyRCwmEIWS8RiiZh3nwAGQ8Dnyfg8CZfL53A4XyChqSgYFJ4Kg6ekYVKTSzNQ1bysKhZO8CSZn58iLIQLC+GSIkg5DW4WEzwW5u4wb7Xn8XwbJmBG+o14v4ESNJNDVqLfjPObcT4T3me63dIDJcB/AD/g32nEOo1YAL+vg/L38LtaM52WLHcb0WMl+a3Uuc7M5b687bGSIwf3tU9ysVJ1vlRxGS6/mtPc+FRv3crXo5wNQ9a6sexspuJ9qCk6IQ12lLpai2zN+f26rB5llkFIsZtYb7esfz3t+fML0x9fd/zucuTzRjmA/3gqOzpOAfAvD+Q3KLIziCkPU6FJEAIMiiUgYCR0GpkAJ2GS8ehkLCoNjYLiMVAyBpKOSc1EPSKjESQUHHwCyBhYOh6eSURmk9FZJFQOCZ1HROfhEU+IqOJMfGk+peQJpfgxAcAv4mTJBI+1spIaLbepWvr38N/v+Y+3fd/r+b9X7QP4z2PzPwT/edx/FvPenfS6L6J39lv7HrDJc7bnACI/iOv49Psjzzcvw784XfnufP3XF2vfni/+6nT+3a7z1eL4fmDwOGy/3Al8Ol7/xXnk2zcHv3+//cvL5a9ezn31cu6b8/DPLhY+vg7eHLvfHIVuDudvDuevD4LXB8Gr/bsPUNxzFnV9D/7jjemjzemjzenDjSlQ9u+vzsRXpuMr0/8Z/LatsH0rPL69YNsMj6zPD20u9K+Hetfme1aCPcuB7iVf94KnM+RqX/b2AvIXvT0Lnu55T9e8p2vO3ZkY+Cfg/17ZD3r+8X7zaK9xuNuYqPl7rI2g2+9qre8w11oMOrO+2tSiMzRV6Ruqm2or6qs1tZUaXaW6UqtQq6RqlUytkavVSoVCJpGJQdoXSxSAfPAhEInlPJGUJ5ICx36uQArOe9k8KYsn5PAlXIGSzVUyWDIaU1TG4NJYXBqNx2AIOBwJuPxnMAQMOp9O44kEaj5PxmbxmUz2F9DUhwhICgoGxcAhBHgyLQtZyaFoaUh+/iNOXrKgCC4ogkuLoVoa3CIj+ayczSHOQneOrw3lsSA8JrzHSPFZyAErLthKCFjwAQveZ8J7jX8T9lwtSLceBWYBd+NAlFuPchpuYxaEGeNqxbnb8P52nL8dB8p+j5XktlJcbVRXG9XVSnC3Eb3t5PmurKW+JzvjtAOH4KVPfr6oezWvPZ3X3ixUfLVe98uthmuvbLvz8dG49Npf/3ahZXtY6G7J8+sLgi0F/vq8QF3esCprVFe879T99rDtLy/Nf73q/dP7ia82K2IDhNPJ9OOp7JiNejBMuIVfnptJSk1Kgz+CEmFQLAGOIKChJBKKiIUQ0FAsCopGwQhoOBUDz0Sn5qCSyWjkLfwoOAULzyCgskioHAqGgkdmEzG5RHQ+AV1AxhTnkErzqEVPKCV5ZHoBlUvLELFz5IInWllprVbQrFPchz8h+D1bdPyQ4Pe9nJ+IHyr7z+P+06jnPOoF8F/GPDdx91XUCVZ0APyXMdf1vgcs8L47cH08Cnw+CX0+CN88875esR/NDxzMdS8M17g7tVMWzaS1Zqa72TPStuga3Fmc/nwS+vnpync3G9/dbPzsYvHjy8C7F763z703h+Gbw3CC/6sD3+W+9yLuuQ8/EPxONmeO1qcON6a+J/jfxg+V/YuT2wsg7Y9vhce3FkY3wyMboeGtxaH1UP/qXO9qsG9trn81OLDo7Qm5Ope9vUu+W/hD3u6Qt3ve2z3n6Uos+d+H3zHe6rG3ucYtAH77gAkM+Qc79aDmB9U+IL/TUtduqjHrq836alNLlbG5Glz111draitVVVVKrUauUkqUKolaI1drFQqVXCITS2UKiVQulsgkUrlEKk/88RZ+kZTDl7B5YhZXAoLNF7F5YhZXxmTL6UxpAv5iOpfGFLC4Ei5XymaLmQwBk8Zn0vgCnpLLkbCYPBaL8wU07UdI2CMMEkJAQymYFEYuvIpH1NBSuU8ecfNThMUIYTFCUgQB8PvbuUsDtEBnprMV5jBDHCasw0icNeNcbWi/Ges343wmrM+E9RpxifofMO9qQYKvwH34Z/XIWT1ypgXh0CMdJvSsGeO0YL2tRBDuNqK7jehqI7qseJcV727D3yb/jozF3vytMdrhrPiVX/U6WHm5oPu41fSziOG7Q/MfX3f8+tjwbkV9Gao7D9W+DuiWu5nOmsw1fcFhG+PETI+b8zfN9JCJd+yo/e1+259emv542f2H91Nfb1VG+/GvJ6gn0zn7Exmg51/qz2tW5WeSIF+mwZJgZASCQMJgiBgYHg8nYVF4NAqLRGGRKAIKlY5GZqMhj1FpRCSchEKQ0QgKBknFIcC2XwYBQcYhMonoxyRcPglTQMUX55CK8ygFeeSy/ExGQRa3LEfIeizjF2iljDqtpEWnScAPBL8l98TG3NTOwsz9nv9kx/981wfa/r8n/z8V/E6jnouY7zLuBxX+Tdx9GZm9PnBdxmfPozMXMcf1gevm0H194LqIOd7GPWfbMwfhsY3pTldnzVCdsE/HGm7gDjUxuqrKzBq6XsNpUnFrley6Cq6hXhIcbIsEJt7FV//lbO+rV5tvDsI3h/PvThauDxevD8PXh+Hro/mrw+Dlge9833W+7zqPuc+it+S/3Pnb+3wg7YM5f2x5ApAfX5n+QcFvYWJ7YWJ7wQZy/v3YCA2vzQ3+75r/4LK/b9nft+TrDft6Qt7uOU/XnKcr6O70TlvBnv+9JZ/WmTGLa9wCyv6pYfPkkGW83zzcrR/oaBnsNvR3tiRyPkj77aYaU0ulqaXK1FJlbK7UN1Y21WnrqzV1VerqalV5uUyllKjUUm25QlOuVKplUrlIrlDJ5EpAPgiRWCoUSfhiCVcoYvNFgHY2T8xgC2hMAZMnZHCFdLaExpLSWNIypqiUyS1hsEsYPBpbCO7/WUwhIJ9LF7KZMiZdxGYJeFzRF0j4TzGoJCwqBY9OJWMeMB/DdAJSBTONX5DCe5IqKkEKixGiYoimDGaWEn1WzvIIM9CbOdsOn7KkTRgR483osSbYeEuqx4DyGFD3p/2Af68R49ajnM0IZzPifgkA4He0IAD8M0aUw4R2mNAeMyUx6nO34V1WnMuKc3dg3e0EwL/XSg13P94cLTucFb8OaF8Fqj5tGX9z3PMvh60fduo+Rmo+x2rf7Ghehar33cp9t2apm+avyzpopb/vFnyycs6sj69G5Ucj1Tdz5j897/7TS9NvT9t/fTP+zXZVtB//yk45mc45mMw8GiXFhzMW+x63aJ+mkyE/SYE8hJLQaCoVjydh4VgsFBh44ZBYLAJDQGHSUahcFCwPCcHDoUQknIxGUrGodByaikOA9V4SFp5JROeR8U8puMJ0QnEOqegx+UkukfYkh1mYyy17LGTmy3hFWimrvlyur6m4D39wxrY0GwA6AAAgAElEQVTknlgPTu4szIAX6fbXXbf8P/M+3/U93/Ulqv2LeCgB/2kk+EOjvsuD4GnUcxn3X+0HgMh3E3df7Dku47Pg/u/6wPX22Pv22Hu17zyLTO/6exZsppm2yj6dRC8sqWVlm6SFQ7XcYQPbWllSLy2okZRViOlyfrGUXyCXFtayOX21tSsTtoutta9fHnzzav/DybM3B5tXB3f834P/LO4APX/isAfAf7g2ebw1c7Q5fbA+mYAfTPt+cNQXtm8vTOws2gH8G6HhzfDI1sLwZmgMKH9rwVEw6lvxj67P2VaDAyuB/sVA34K/F8AfdHcGXB0/BP/MsGFm2JDo+W0DlgT8oOYH5Hda6gD8xuaKBP+38OtUdVVqnU5dUSFXqcVqjUxbqSyvVKs0colSrFRp5AoVSPgg5wtFEr5AJJTKOAIhg8NncgVcgZQrkNJZ/KJSJoMroLH5ZUwRgJ/GEpcwOEU0ZglLQOeIGFwxiyVi0PmMMh6HJuAzxWUlAnqZgMMWikXyLyAp/4BFPsQjkpGpD9CpPynJQ2sl2UImQlyYJi2ESAthyiKEthRRzUB0aTN93dyNQYnPkuNpRc+Y0myNkLEG5EgddKwxbbz5ka0ledKY5jBDHGbItD55xvDIaU71NBLcjThnA9bZgAU7v7ON2Ml61HQtcbqebG8gjNSiRuuQk81YRzNuthE9rsdOWUjTrWS7mWAz4W2tRHsbadxCcLYSnGbybAvVZ8pf6qatDLJ2ZnjPlzXnm+WXG9WfI/qfRUyf1ut+sdP8r/GWX23p3oZrzvzqw1npZj83UF8QbWWfdhV/HHlyNlT2zil4t6j4xX7dr87MP39h+O1511/fjH6IlC+3p72aSj+2Zx6MUQ9GcPu29PkBaqO8KJeMgkCRUCgWDUdQ0UgyHkMgkqkYLAmFwCKgGCQEi4USSHACBUagwIgILBlJoiAoVDQmk5D2mJqaTYBREAgqOjWHiCigYguomKJ0bGkWjpZDoGfhaU/TmUUZXFqGgJUh4eWopQU1WnZzjaS1ubKvrXlquCcwbV9wT6/5Z7bD03srM/GV6YM1x/Gm62TLDR7nAlf9L/bcr6L+0/j85f7i5X748iB4ue++iM+eRzxAYwNP913F5m72Q1exucu44zw6c7rrer3jOX3mP98LXkQC53ve092Zt8fem/js+0Pn52Pnh+jMxero1oTebq1prxU3a+iVohxJGbKSh+7UZQ015Tjas8Za0i1qTL0IVSUminhoGhtWJkDS2RlKFUtfVzna3r7j87+L7Xx9sv7xMPTp9frlUfg0Pn9+ED4/mD+Peq+izuuI4zrqudh13z7X8cz16pnrZMt5uD4DzAuONpyx5anI4i38seWpyMpEZGVib9l+b9vHtrtk216Y2AzZwEnfXedvB9O+9bmx1cDIsm8IxIp/eDUwsugZWA2MrAVHl7yDIWfv/GxPcKbLN3nP22PS6p7scE7cGvtMj1imhs133b55uMsEHHt7LXXdltpuS22Xua7dVGM11FgMOotBZ23RmRsqjHVac0OVuaGqRadprFQ3VqorKuQVFXJtuUJbrtSU377SI1OpJRKJVCqVyRRSmUIqU4lkSqFUIRArxDItVyBn86Q8oYIvUnL4MiZHzGCLOGwxnycTcBUcpoRZJubSZFyajFMmZbFEHI6ExRLRyri0Mi6bIWQzhPRSLq1MzOFIhGKBUML+Avro/0Kl/QQHTSbCUqmIR7RctFpAlTJu4ZcUQL8H/9awzN+W7WlFO8wQWyNkuBY2UJ02Upc2UgcdroWM1EHHG6DjDVBbXepkI3TWgJpowgDHHlsTeqIFa9djx5vRY02ooQroYDV8QAftqUnrr4eMNSFsTXB7PXSsBTuux402YwYbkQMNiKEWzKgRP2rEjxvQU0aiw5DuNz8OdxQu9xdFHOyrDc3NhuZiRflmrfJqoeKVV/YmXP5dRP+7qP7jRv3b1eqXAcXGIMdVk7dpZh53Ft8MF370yH+5VvXLSN1vXuh/d9727WvzH877/u3N2NudiiUr5NVU+pEt43A8/XAUv29L93eT6yRPs4mI1DQoBIpCwxHpGBQZjyGQiCQkioRCEDFIIg6Jx8PxRBieCMGRIAQ4goQgkBEEMhKeQUjKpTzKJcGycJgMLCSbAM8lIR8T4PkkZEkmlplHZuVTyvIzGYWZXFqWkJUt5eVppCW15bxmnaytparf2jI13ANsfNb8MzsLM5FVB4DheNP1fNuTgP/1XgDA/zo2dxFfuNwPX+wHEvCDJ/eATy6A/zIavIjNnEdnzvbc53v+i8gcgP8y6v9w6P18EngTc76Jz549m9wNds+NNY2ZZU01PJXkqYiXyWPiWcUpWh6ipz7Tbs5zmin2JmKXEt3Mg+vYKAkNxixJZTJhBQUIBj1dzC9tKNfYujo33NNnm8Gfnax+/WLt/fHSm4Pbzv9633cdc11FAfx3L/bsOF/uOE+2HUcbjv3VmaMN59GGM74yHV2a/E/hB+SDY37Af+JbAE59VgMjK/7hRCx5B1cDI+ArEHL2hpy9c45u/1RHwtUzAT9w8p0aNv8d/MaBTlNfa31Pax2Av8Nc226sbTXWWAy6tuZqAD/w82iuVgP4q6tVlZWKinKltlyp1apVGrVCpZTJlRKJRCqV34dfIFbwRXKRVMMVyFlcCYcvA18BBlvEYIsA5ByOjEkXMWhiFk3CokkYpWLg5MdkCpkMAYPOZ9EFTBqfUcajlYrYLBGfzxUImV8gU/4ZmfwjbGpSBhKWi05jZCPKuRQNBy0uTJMUpAH4NSXwKjq8U5MR6OXvjMr9bdneNoyrDW5rhPRXpnWpkwZ1qcM67GA1crAaOVyNGqqCD5ZDhirSRqthvbq026iF9NfDe+vhvfXwnjpYr/ZRb0VSd/Wj7pqkvvpHQ00pIw1JQzVfDtUih2qR/VWIrgpodyWstwbZX4ftq8V01UHH9ASPNXex++laX8Hm0JNjF/3DlurbeOXXW5pPa+XX85qjaf6JQ/wmXPF5rfZqteLddvXFsnZ7jOusy18xsyNdzNcjjLdzql/tNn633/Tdif67F8bfPLf85bz//74evVovX2iFvJykHtmoRzbqiY0QH6e6rLhqweMMPCQlFQKBojAIZDoGRcKh8UQCCYkiotFkHJqERxFxcDweSiDACCQoCQ0lo9BkJIqETKXgfpxF+nEOKSWHgMrCw3KIiBwiIgE/4zGJlU8pzctiFORwyx6L2HlyQaFWRqvVipqrlVZ9db+1ZXKoGxj4Afija7P7qzP/LvwvIx4A/3ksfBEPXewHLuKu85jjbM99+8Z2xHe+572Oz1/H5y8igdu5fcRzu+ofCVxEfNf7gW8OfV8d+t7sOV9uT6/7e0a6yht1TIUkj06jFBZgiwtRZUVwesFDNTetu5Y8ac4JdlBdRvJIBa5NiGpgoVUlMEERVFCGKM5LKSlAlhVTRLySugrlgKlxdXro7c7Cp9ji1wdLX+2HP8SDb+O+m5j31ggs4r7cAx6+ztueHxT8a44E/ID8O7V/Ym/ZDuB/tjieCMB5AvXEJwB8DkAkPgGJEmDZN7Tg7g+7+sKuvpCzNzjTNefoBJbe7kmra6I9ccwHjH0mBs3jA0ag8w92GQc6Df1tDb1tgP/6Tktdh6muzVTbaqxpbak2NpTr6zT6uvKWWm1jtaqhSt1Qpdbp1NXVqkpw3qNRKdUqmUIukcolEtkd/CqJVCmU3MIvlKhBtmdxJQn3bgZbRGdL6GwJnXV70gtu+0pLeXQ6n07nA7cfYO/BKOMxaXx2mZjPFIt4fBGP/QUW8iUm7QE+JZkKS8uGJ7My4ToepYqLFhemiZ+mJuCvpME6NRlz/cLtUYnXkultw3ja0RPNiB5tapvsy25tUn8lvK8CNlCFGNEhh6sRA9qUXlVSn/pRT/nD3oqk3qqUvqq0vhpoXw28T4fsrUHaKlNHq5JHdSnDdcljjan2hmRb3QNb1U8GqmADVYi+SnhfJbK/CtNThe4qR7Wr4a06xLCeGOjJ3xotjYyXxGwFL1ylbxa5v41WfLMqfx+WX/gV+zZuZJRz7JC+8qheLSne71Zdb2o3x9mTtblzBvZGJ+/YJj6bV/wi3vztkf7bw+ZvD5t/e2T666vefzsdvlitDJthL+zpRzbqkZ3y3E6Mj1MdFkwlL4uKTU1JhUBhaCwSkYFDkvAoHAFPwRFIGAweeWfRj0dQSch0MiodD03HI6loJAWTQsH9czr+HzPxSVk4BLjqyadinqRjCtOxxVnYkmxcWTa+LO8xszCPT3siZj9VCEq0UlaNWtRYqWw36Aba9ZND3cC3e9U3vbMwE1t3AvgTNf+LHe+rXf/34D+PzZ/H/ecxJ4D/Ku6/ObjdqL+Oz1/F5s73/Ff7wEvLe7Mfuo7PX0R8lzHP2yP/p13Hu13H2cbUpn9grLumSkNjsKhPizElGRBmPkZMJwnKMLzCpApuakc5elCHc3VnTJpJvVVYkxhVw0IpSuD8QgirIJX1JJnxFFZajKMzckSC0koZt69JtzTa9zo0/XE78PN46OuI/0PE/W7PdR1xXsW9l5HZq8jtef/tE10gNpxHG87D9dnEkO8+/AnyE94ewK4fnPSDS57N+dHt8N++CN/L/6ARWPQMhF19C+7+BXc/SP7zs12g/ndNtDntVoft1sB/asQ0OWycGDQC+Ed6TEPdpsEu44C1sb+9sc/a0NPaAGy8EvCbGiv0dZrmGk2TTg3gr69U1Vara6pUlRWqcq1So1GpVCq5XC6WyAD8UgkY8qsEd7t990t9JkcMgsEWlXEkpWxxCUtUxhTR2EI6S1jG4JfQuAyGgEbj0el8DlvMZokYZTxg5idkysRsmZQvlvKFX2CgD4mINBIcSoakZEAecrLhdXxyJQOagF9VjNSWIirKoF3azNCgeGNI6DZRvG0oXyd2shndo4WYRQ/aFQ+7NA871Q96yh8O69JGa6Ej1cnDVY9GqpNtlam2qjR7NWxCh7DXoO01WFsN3laDd1TCpythkzrodD3M0QibbYQ6a9OcNcm2BvR4HWa0DjtWRxitJw3pCP2V+B4tprMWO9RM8nVkb44URWyFMVvBwdTTY0fRtZ/9YrosPlqyN8zY6mdsD3Jik9Jjp/rVkuJTvPbtTsX6KH2knOJoKJm3sncn5ZdrVb9+Yf3967Y/vLD8/tj0h6O2v77o/euL/ovl+pAR+dxGPbJTjifIJzZcfJw6a8FX8bPTcSmpkDQYHI1DITNwSDIBjSNgqUQSHo3BwGBYBJSMQ2WQMBkkDJWIoOJTKFhoOhaRjktJJ/w4Hf+PGbiHmVg4uOrJo2IKMnFF2YTSHHxpDr4sl0B/ks8ufiKgP5VwCgD8OpWwoULRYawB8HvsowD+Z4uO/wD+V1EvgP/2nj/mA/CfRzzAVA9c3V/H5y+jwbNd3/U+uNX3gr8HB/9vjtxvn01fbk5FAoMTnXU1SjqbRn1ahHxSDK/Ix5j4+e2q0joORVWcVsuBtSmQbbK0tmakvhpeK4VoOWkyGpRfnEZ7+jA/55/pWQ/p+WnFTxFPCjDFJRQuPVfDKzOohKF+0/Pg+De7vm/3A98eBr6Oed5GXG/iAWABCm4HXz6bOdmcPtqcOtqcOtlyH204wWLP/upMYtR3H37g5wUCXPX9zc9nbmQrNAaO/BJtfwJ78BVY8g4C7EHyB50/yPzeCSsY8s2M39r4Tg4bJ4eN9gEDsPEY6TEM9RgHuw2D7U0DHU191obetsYE/G2mWlNLlaGporle01iraahRN9SowahPV6msrlBUahXlWqVWo1KpVMC0TyJWSCVKqUQJlnz5IiVPqOAK/rbbCxI+KAGYHDGNKy/jyErZYiDvMdgCGpNXxuQwmcJE5mcxhfRSLpPG57ElIpZUxBZLuBKZQPJFWtqXeAycgkFRYNAMWJIgD1krJCuKH0iKIKDsV5egAPzd5VmLI7KNIb7HTPW2obwdmGk9frAKbZWltise9VYkdWm+7FT/tFf7sL/y4VBl0kh10nhtyrg2yVb+yF4BsVVAx7WIsXLUmBYzXo4bk8NGFLARDWy0Ej5eDZ/QwR21KE892mUiOFrwk824ySaCvZE8Xk8er6eMN2QMNpFHGokOI2mhM2OtN3t78PHWYN5qX+7OaOF6f8FqT/FKV9lKF2Oth7U9yN0dEUTdwnfb1R+2KvfsrAldxmR9kdNctm6XXaxWfnvS+odX7X9+2faXl21/ft7x384G/nw6fLNuCBmwJ+PUIzvpaIJwNI6Oj1N9ndRayeNsEhQKhyGQWDwakYlHkAlIPBFHwuFxKDQGASegUJkEXDYJn4lHUdAwIvohAZlCRkHTcWmZpAdZxJ9m4dOy8dgcCiqLhMghIfMzMEXZhJJcAi2fzC5IZxbmcUryhcynEu4ThbBIK6PVaIRNVYq/z/wJ+I82nCdbbkA+UPtOI8HXMd/rWODv4U/c5/49/Jcxz0XUexkFb3L7rvZnL2JT57tTe6EB95C+ScXiFpLo+UhmIYTPRPRL8qZ0zPEaZguPqi2B1vOQJim6mZ+qlKfIBI9k7BQJDSIogXBL0koLHuRm/kMx+cuyrNQn2alZWSlP8lG0EjKPnill5rVViQJDLaeLo98eeP9ytvDb56GPUc/bWOAm7nyz7wErRq/3Zp9vTwH4n297QNpPwB9dmowuTSbgT5C/FRrZCo08C42CAIY/O/Mjz0Kju+ExcOG7FhwFRX4CftD2L7j7Fz0DC+5+IPjNObqDMx23Nzzj5pkxy/TY3Ytdw/qJIYN9UD8+oB/rNwD4h3qMQx3NAx1N/e2N9+FvNdbc6fzlTXXaxlpNU522QaetrVTpyhXVWnmFRl6hVoD1XpVCKZcr7+BXSaQqkUgFjnk4fAVXIOcK5CD5J4p/JkfM4CjobBmDDd7zEbM5AiaLw2RxwG4fiyVi36n9bIaQz5HymAIeUyBgi8Q86RfJaQ8wWAQRiyLAIFT4A+4TZI2IKC99IC2GSgrSpIUwbRmmvAxZSYP1VGQvjym2R0X+tgyfFe22omYMhPF6cl85uleL7NXCOxSpbbKH7bKkTkVSj/JRnzplsDy1W/FPvcof96ke9igfdskeWSUpVkmqVQLR81Kb+cmNokfNslS9ItWoTO0shw3VYKeboBMNkIkG2FQjxt6AG68jjNeTJ5oy7I3U8TrcTBM2aCaG2iiLndmhjjy3MdPV9tjXWRjoKPVaSr3G4qClbKmDtt7L3LGLblaqP65XHkxyZ+uzJuryp01Fa9Oy86WKX8ZN/3pk/suJ5b+/6PjTi44/nw/98XL0/VZnyIA7HqMc2UlHE7j9EcS+LT08kNekLMjLgCNQcBQaS8AgswhIChGFJ2LwWAIBgyVgsEQ0mopFp2NQ6Wg4FQUjYZLwiGQiHJqOhWSRHmWTHmUT4Dl4YhYJkY6HZhLh+RmYwhxCSS6hLI9Ef0JhFOSwS3L4jBwxJ1chfFouL6uvFOhrFe0GHej5v1f2gx747+E/jftP48HT+Px5LAzgv4i7LuKzCduc+/Cf7/kvou5bJ8+I73o/8ObQdxmffr49tL7YOzlYa9IJFIxc4VOCshRTwYQ3S9BDdXkDdU9NqkwVAy4rTavkoGp5iEp6ioABETHgajZWwyDIiuDiwjTukwfFGf9nMQVSmgl9Qn2UQ334JD+trARLp5NYLKqM/6SjQRwebbhZHfrT67k/vAp/FfV+iATfHrjfHXpuDrxXcfdZ1PXy2czx1uThxiSAH4z39ldn7k56J74HPyAfwL8zP7I9Nwwi8Qn4IcEP1PyLngHwCQjOdPmnOoIzXf4pq3fC6hwzT48ap0fNU6PmW/eeoZaJoZb78A/3Gv5d+FuNNa3GGqO+ymSoNrRUNjdUNNWXNzdUNNSW11Tdwl+plgMDX7DbL5cqJGKFRKyUSlRiiVIkUvGECg5fwebJ71b6FaDhB0/3sLgSFlPOZErZbCmfJ+NxxWwmh8VgclhsJlPI4Uh4PBmHLWYyBMC6n8sSs1kCFpPPYYsFPOUXj2CPEFg4Go1EQVMIsJ+y8uA1ErKGmSIrgSXgr6ChAPyrNtWuTTzXke2zol1tyBkDYaola0RHHqrGtYrhRn6akZ/SJoJ2yGDdMni3DN6rgLcq/8Gi+q+t6h9blD81yB42ix40ih41iVNVzCQ580sZ54GM/0DK+6mC/5MqaVKLFj5Y/qPB8h+NVCfZ6+Hj9ajhatRQJXakhjBZT5moxXmaCfOt1FBb+pw112PJtzdkduqIQ005o/V5A5UZg9p0R0PeajczPi556dN93mr+uFq1N0yzaQmjFemThqdbbuWHzfrfHVn/eNz635+3/Y+XnX943vmvZwO/vRj+/KwvbCQej1GOJ8iHdkx8GLpvS18ZLdRrip9mo1AYJBqDI2JRCfiJeBKJQCbjCQQUCg+H4qFpFCQ8G4NMJ0CIKAgRDqNioFmk5CzCo0wsPAtDTsdDqThIFglRkI0vySMX5+ALs7CFWVjaU3DSlynmZitE+ZWq0sZqganx+4IfgD+6NvtD8J/tB8725wD8oOcH8F/F/beeWVF/Av6LSOB0dxZ4eF9EfDcHwffP/Rexqf3VrsmpxqY6toyXJy5KL6dntggzLCJcnxZvaaTWlmNF7GRa0U85pckKFkJJh0kLHgqK4MoyfB03u46Vqc5HyXIeCXJ+xCD/lyIKvDAdlk96lEf5suBxcsHTtKdF8CIGhsZIL1cUDrRwojNNvzlw/P5F8OuI91N07v2R992h582R53rfcx5zvtp1HG9NHm7Yn297DtYcseWpBPx7C/YE/Pc8fEc254c354cB+ZuBwc3AIIB/e254Kzi0FhxNRELtW/IOLnkHAfnLvqGwqw+M9wLTnb7JNretdXbUNDVimBox/RD8o3364V7DUI/+34XfYtAZ9VVmo85kqG5prGxuqGhprGysq6ipUtVUKKu18iqNokKtKFcpgY2XTCIHZ/xSiUosVotEKp5QBeBn86RgpR8s9oJCgMWVAJcuLksq4Mp4HCGHzmbTGXw2i8EQ8HgygUDB5UhYTCGbIQTvdrA5AhZbwOVKRSLNFwhEMgTyAIFIwqGSKOifMnIgWhpKW5gmZxL5RSmcJz+SlaZoaajyMmRnJXV5UrA7xfO0Zbhbyd528qwZ5zQTp1rwIzqkRQOt5f+4nP5PNbxHzVJkkxjVKMbq5cQ2eVK7Am4Uww2itGrmP5aX/R8N3BQdE1nB+a+V3B9X8L4s5z5Qsx+qmMkadpqGC62VIxsUiAYFvEGe2ixLNqlSOqphA/UYRy3M24wLmslz5vT51pxQW57PlDvblN5fTbVVZjo1mQE5ZaMq47Sn6Fdh0V/2tW+3hO+2pDerFSt93EFlzogmL9RBP/ZI3qwrvzs0/v6k8y+vOv78yvzdUdNvX3X/4WLqZ2u9IUvGyUzmySTqeBy7P0zdH3u8N5zTUsXPyiF8iYI/xCCRBEQGBU0lYQkEAgn703RCcjoBQkJDSUhUOoaSgc2kojKzSKlUXBIZnUTBpGTiYdlEVCYelY5F5JIQuSREHgVVkIkpfUykPSHSnhDL8gm0QiqXliVl5chZ2WpeXrW8rK6C31At6WzWDVhbpoZ7PNOjAef4gndsa94WW56Irc3sb4Aner1gve/eSX/wIj53sR8Aq/LAXfv2Kc544Go/eHU4d3kQPNsPnMb9F3HXWcR7HQ+/Owq/O/RdRz1HS9NL4wPNDcoqTUG1jGjUUDrLczvlWVYxuVNKKK9IEnN+zCtMoudBnuakFeckS5+m1hSmDLByevmPreLHOjZJWAjnPoGxcyGlpIf0DEQh4VEJNaUkM6kk51Fx/sOC3B+XFj4UMdPkLFSdNDc43Pw8PPHzo8VfvQy/25t6G/G9i/rfRP0Xu+7Xz5zAyXN/zQ6O+eOr9tiKLb5qj6/ao8vjkaWxyOLU3sLks5B9N2yLLE5El+yRRdvewngC/tu3+ubHwahvc86+EbStB8bXguNrwfHl4NiifyTsHVpw9dw+3efuDTm7gY2Pe7LVY7c4x8wzw4bJYf3UCPDqNtmHjJMjjRMjzRMj+vEB/XBvy2C3YaDHNNhrHuxoGGwH8Nd3mGutRl27sbbDVNem17Xpay2GWrO+BrzYUV9ToavWlleoQKg1coVSIpUJpTKhTC5SShRqmUohU0rECrFEIZarhDIVRyjliZVgwgde7ALGXnyeTMCXi4RKsUglFCh4XCmQ99gsEYcj43LlHI6EwxYzGTwmjcticDksPpuuYJSKOUyJWKD8Agl7hICCDb9H6dgHnHxEFQtXUQYXl2F5hcm8gp8oaGkJ+Ffs/G0722WhOs1Ej5XkaiW4W8lTLfjRGlRXOUovSq5h/qiW/WUjP6Wen1rPhzQKEXpJkl4MbeZB9UJIA++fm7j/ZJUjLCJMjwreq0Z0qxEdcnirGG4SwowCuEmAapEhGsWQOn5SA/+BXvywVZnSUw7tr4bNNiACZvJCR9ZCR858e064M3+xp2ipt3h5mLbcVbykf7ylzzsbZH67qP2fL5r+nxv9p131h23tzUrVci9nQJlhr85bG2S9DEo/7pT/+sj0r8cdf3ph/eML47eHjb952fWvZxOfl9sXzNTnUxnPp9DP7fiDEcrBaO7uQEZLJSsnC/sQDnuIQCHRiHQiOp2IJhGxmSRIBhFKwaYRkGl4OJSExFDRZCqakkVKTcelULHJVGxqBg6aRUBm4lEZOGQuCfGYjMynogsyMSW5hLL826AXpfPo2VJWjoyZpeI+rpaX1VcKGnXSjqbqAWvL9Eivd2Ys6LIt+sa3Q/YE/Mc7nv+P8F/GfBcx39V+4PogCF7pOd33vY57L/Yd5zH3dXz+Oh682HW+WJ9anem1GxsqJfnV0vR6BcFUTu6syuksz7MoMvUSvFCQxitKYWUkF+GS87APWTnQRjapX5o5Lc+xKXN6FVmNHKz0aYowP1X0GEly1zIAACAASURBVMqmptCpqaXUFHYujJmbRst+SMt9wMh7IKbBKhip5TSojoWfMav3pjs+b7l+fRD8Nup6+2zmY9T1ad/zJuY+3Z19vuM43J6Ob07drvet2qPL4yCAdT+Afzc8sRu27S3YI4s2AH+i7Acif0Ln+w/gB/yHXT3zs11+R4dnqs092eq2mcEmL8j8AP6JYdPUSAuA3zYI3uoxDPQYB3pMA9bGAeut2g9GfR2munZLfQJ+U4uupbG6sa6iTlf+/xJ2n9Ft3ne+4H1279x7psRxbMuS2NHL86A39k4CRO8dJNg7OsAKEqwASBBEYSfFIrF3qlCiSIqiLFl27NiOE6e4yLHj5MbJTGZmZ8/evXv27O6Lh4S1uZO55/xfPOT7D/719/1VVhj+Ar9KLVOpZWqNXKvQqJUapVwllSilMpVUqRErNAKpUqzQCWUaaLUvFqvFYrVEoon5l0o0ErH6ZfwSiU4s1gqFSj5Pxi0R8TiXjXq5Gh5HJuDKZBLlK6iUOCwikYiHkXCJNPx1UQ62WkgyFqOk+VhxfrKsMN5Qgizj4AyFqJYyyqJXuObjhG2UkA2MOglRJ2HMRR4xEbx12P4KaocGZxUlN/HjzaIEqywZGo3K5HoZslGEsauwbVpYtzFluI7or6SGynHhCny4AgxXEINGYtBIChgpI+X0Tj3gVMDNwniz8HqrIrGnFDlYgfVWYoLN2EkX7UZn2qSTMdpMCDYRJp3MBXfu7jB711u878m/18N+GpZ+ulrxxWHjlyeN54u60znN/THthC2/UwWMWXIPxxTvrht+dqfuiyPnF4etXz1wfnVk+dVh02fHHZ+f+p/PmhYdtAcB2sMA/mSYdDhIvzPA2uwmm0tzMxioRDgqHg6ikTgGgGMRMQwKlkrAkPBIAhYaKAIWRcLhKABAB5PpIIwOwugAnElAsoiYVBI2jQxA+LPp+FwmPj8VLEgHijIJxVlEbiFTxElVcFPVvNQY/qYadUtDBYR/YtQ7Oza0NOXfvDF0cHN4fzl4Zy18uDkGvep92f+/ix8K5Hr79tST21NPbk+dHUw82h8/3Rt7fHv4/Hb47dtTj3cnHiwH1iLuYWetWSWo4mKaFIBVB5q1gElHadYxquRkNQeZn4VhM9EiIkYAwEVUZL2AMVxbNGvmTlbSx6sZoRpmlx5s5MErihDGfKw6DSVIRfBTU6TZKEkmTJyRJMtOVuSlGEtwThHeLgKsYoqvXjDdoj8MOj+c977YjHyw2f/Rnv+j26H3bkfOdkP3NgP7GyO3tyMv499d/L5px/aNoZ354Z35YSjSb/vG4M68F8J/ceA374sl+S1PD6zP+lanB5cnLzb8i1N9C5O98xM9EP75SOdcuGNmNFbDb4/6bFGfI+K1BwetgX7rUJ8FatE9MmAZHjBfhPZ7LP1dlh631dNpgeb8TkftxcN+R32LvS6G32aqtjRVQo16qysMFeV6Y7k+FuOn0SrUGrlGq9DqlCqFWqlUy2QKsUQhlijEcpVYpuZLFBKlXiTXQu06hRK1RKKBhkioFItU4svWnRB+AV8ulepFIg2fL+dxpTyuWMCVCPkSkUAqFqihb5lE+goq6RoOnkDGwQiYeCr6LWE2ppxP0BfCZQU4WQFMXZxUxkOXsrGlBahWA3lhULDqZYdtlKAFH7YDEQcYdZJGTAR/A36kiumroHm0uHYFrEMN9xhQHiPGbYA3qRE1IkSdEOfSEPoq8cFG3JSVPNlMG6tAjVdiJ6vxU7WEmXrKTCNttok518zyG8E+LdotT3HLk/o18GEjbrQaCNWAgWY8lPM1aiEM1CAGqmDBJnDKxdzozdn25Gx2Zm935N7u5zyMKE7nDac3yx6MqfcD0s0BSaCG1a3BLnuKP9is/PWD+i9OrF8/an/xoP3rhy1fH9u+eGh5cdb9+an/nanalVbG0TDtZBg8HaIcDTLuDjB2e4h2AzOHDofD0ClwCg5BYuCAVCKKQUGBaDQOgcCj4GQASyXgSHgkCY+kgGgyJomKS6EDcAaIYBLQqSRsBhXIohOgNX8OA8hl4vNYQH4avjADjOFX8tI0/DSDOCuG31Vf7nE1Bwe6JkO+ufHhm9NDW/PDt28F7iyP3FsdfbARebg1Bo3j7fGTnYn/YOaH/J8fTELFs5eNOofP74Se3Z0635s8mPNGuxpd5eIaUY5DnNKiQts12CopXCuAqYQYMQfJyU3IZeJLKBg1GVuXjncr0xY6pQ9ChqMh5R13zn5XzqY7c9pC7dNhXBKMmUuozQP1hXhZBkyaniRLS9LnIatKgIoiTEURxiFAtynJTg21syq3ozIvbJbt9zd+suj/xV7/L2/7fnow9N7B8JO94OHWyP5W8M7e2EWG1/LQ/k3fy/g3bwxtzQ9vLwQuC3suY/wvsr37oQs/aNqP4b81cfGwZ2GyN4b/RrjjRhi62L9Y80eG7BGvNepzRH2OkM8+MmCD8AcG7MFBe6xjh7fHOuix9HSZuzubPa2N0G6/zV7bbq9vddS7bPVOa53TVOVoroZKeqEufdUVhnKjDurV931/To1Cp1XqtMrYe36JVCmSKcVylUiqEogVQoVOKNPwJSqeWAn5h+Z/Pl8O1e1CpbsvDSWXKy8pkXBLJAK+VCyQS0RyiUguFsiFfIlYKJLLJK/gkuJARBIVBydhEmiYq8JsjJEHavKSpXkYaX6KqiixrARpZOOMRZj2MuqSV7g8UBixk0fMmKAFE7LhIg4w0IwPNIOROmakjhmspvjK8b5y7HAtMFwLDFYgm9WwSkFSHR/jUhL6y3GhRsx4M2aiARdtwEYbsONN+HETYdJCmrgcw6WYIQPap0P6dHC/HjFixIRqwGg9KWAGQnbSmIscdZLCFmDMSphrY6z1Zh/6BPu97NXWrCVHxq32wm2vdH9UvxcuuxfSbA1Klzq4/kqqrxK8FxH/+n7zN+e2r84cvzlt+/J+G4T/xYntN+c9n5343p2u3POkPxymnQwBJ37yiY/xwEe/O0h2Gii59CQUAotEMEAkjQUQmAQknQIHMFgsEoVDIUkAlkLEkUAUEYCTCDAKFkHDIxggChpMAjqNjMuk4SH80Myfy8RD+NnZJE4+XVDMVPLS9KJMoyy3Ul1cUyZqrFa56su7nU0j/e7/KX7I/1+d+XejT3YvMjmeHIxDzXPPb48/vj3y+CD07O7Uk/2ZjbG+niZNkzq3WZ3Vr0O4NSizAlkqgImK47n5iZycpOKsJC4LLaUk1abBvCrKvk/+izv23560/Gq7+pcr+o8XZM/GOLseRrQG1atEdYiJ9hJKLZ+kyYbJ0+IVqXHlhehGIbmKjSnLhxsLrteIEEYpqlyJ04uxTZrU4WbZg7Gu39wffnE/8MmB7/mO7+294NFWcG89cLAVjmX4QZP/zsIA5H9jzr81P7yzOBLDf5Hkf2Nwa25gY6ZvdaYf2vND+NdmvCtTAy/jn5/ouTHugfDPhdqhXt1/gX/M7wz5LsBD+Ef67cP9Nn+vxd9rucTf3NXRABXzdzgvJnyoRTfUpdfRXA3V8zbUGv9d/JB/6CdAolJJFEqJQilVamQqrUShFkqUQpGcL9NwJSqOSFEilHNF0MWeki9SQtQvbvVewg899eNwxDyuVMCXivgykUAq4ImFfIlIIJaIhQq5+BUyPJmCSKHjEDRcciqYIMnDlwuJ2gKYKBspyU6U513XF8PKirFVbFxHKfVGH3exJzdkJcbwh+1AoBkfspLHmigTJtpYE2W0jjBSA0Aduwcr0C2GlAZhkkWM79RQBisJoUZMpAkVbcJEzEDEDESs4JidCNXqRp2EsB0IVWKjNcBYLRiuBYI1uNFafKSJOGGhRuzkqIMy3Uq70c5c6mSudKfuDuYeBjlPo7rziPbhiHR/kLvdx9sZkOz6NDs+3bZXfKuLO20v9FeRpxzMZ7f0L05s3zx2fXFi/eLI+dld12+OXF8f2746tX/9pPfXx96fzFUc+fNOh6mnPvCRj/rYzzodZj4cJrlKyQWMeDQShUDR8Wg6AyTQSGgSGU4jEYl4HB6NADBIAh5FBJBEAEkCEQwAxwTxLCKOScDSASQduEjsz6BgMqnYLBouh4HLYwEF6UBxFhHCzy9iKLipBnFWuTyvUl1cXSpsqFLG8E+Memei/sVJH7Tnv7saOFwPHm2FH25HYuN4J/pXZ/6dyMv+Y/ihhtlPDiaP1qJzXpfTyKtXMlurM4INxK5SoF6KVnMR/IKEooyr7NTrvPQUNTOxOj3OrwQOfYIvj63/+y+9//ZJz++Ozd/crvl8U/fTJcGjYOaKEwhXYvvUxDYhsZkPVObDDDmJqvQ4bW5yBRdrKEJoC2BadqJOkCIpiRNy4wWcJJ2E2KzPn+xt/uxO4MWD6M9vjzzf9D3dGTneDNxe9h+sDkExPtDkH1v57y4ObswPbS4Mby0GthaHNhf8UN3+2o1+qKXP+vRlSv/lk95YdO/ShGdpwgM17Zobc1+s+UPQe96Wy0o+x8szf3DQHhiwQcv+QJ9jqM8+1Gf391q8veYBT7PH3dDVUedpN0FZ/dCc77DW2S31NnOdo7nS3lRlbqxorjfW15TVVhlqKksrKwyVFxlemjKdulSrMmiUOpVcq5SJ1CqhSilRqWRqnUKjlyjUYolSKJJzZeoSsZItlBcLZJD/WEk/9NQv9vgH+pPHU/B4Cuien8+TQNHdnGIetOaXiiUKufQVOjyFDEuioVPo+JQMUrIkHygXEjVFcEkuWpKdKMu9pi1MLivElBeiHSog4syabGWNmHEjZsyoDR1x4iIOcMSMizpo4xYQyvAJNRNG6oHhWsBXDQxW4jzlSXZpYqeS1F/K8teQQ81AyISJWvGhZiBsAqMW4riDNNVCnWmjTrZRxltIkyYi1Ip7wkKJmElhMzlip427mFMt9KkW+lwbY9mdutadttOTft+X/zhc8nxS8/684cNbpc8XVI+npCdRycMR+X2/YmeQt9bNu+EsnDClHwzzf3Wn6ZtT1zenbZ8fWz67b//8Xsu3p+2/O3P99rzl98+9Xzwa+nih6km46DzIeOwnPvbR3g6kPw4wz4KUlnJqHiMegYAlI4gYNJFCAIlENEBEMKgEChEH4pB4DBzEIckgjgziiHgMA8AzADwDwDFADB1AXqz/iYhMKhYa2XRsfipYlElgZ5M4OWROPp1XSJeXsKCZv1xZWGUQNFQpWxoqup1Nw70dL5/27y36760E7q8FH26GodI36ONk+6/if7oXebp30UU71l378UHk0c70+cHMyebYxsRAwFXXrMmrVxM6GqgjFqarjKDjo7i5iUUZ1zipVyWsBE0qypSD8MqIR4OS3z9q/T8+H/rXz33/9T3Pb45cP183fHJL9tEC952xrP1u8lwT6DUALWKcjYtpLERUF6SoMt6SZ15TFyZL85Okhcm6EoRBiFJwEmSceBkbpioBVRxaZ4P+/Ib7k73wz25Hn28G3tkZfbwVfLDifbDsj4V5HNzyQ/Jfxr+5MLy1OLS1OLSxMAgl9kDT/vp0L/S27/s6n1hi/4RnacIzP9ENZXUvRN3Q5P8y/rGAEzrwi3jtUDHvyODFhD/kieG3DfaY+roau911XZ21bldTR0tTu6ux1dHotNXbLfVWa73N1mBvqrA1VpoaypvqyhpqjXXVpbVVZVWVpRWlOgg/5N+gUWqVMpVMLNKo+UqFQKmQqXVytU4qU4nECrFIwZNrSqQqtlDOhuSLlTzxxYU/9OyPw5O+jP/l034eV8xlC0vY/BI2X8BVCHlSiUguFUteoaYkAQnXibB4BjY5g5QszsOX8UFNEVxdCMjzUiD8pQVoQy68QQDrryWFbZShJnTQgg07sGMtQNRJCFrw4y7GuBUzbsFFrfiImRBsIgzXEYdqSb5aSn/Z9Rbx9S4VcaCU5asijzQCgUZ0yAZONJPGm0kTZuK0jTLXQrvRSp1uIU86CZM24oSVELWAYQshaCaOWIhBGyXopE276DMtjKV21lp3+lZX+kFv5kmg8N0Jwftzyh/Py96/Kf1gVfLJpuLnG7qPl3TvTipOJtT3Q5rtfslGL+/dm+W/P2//9qztq6N2aOb/6qjjuyfdf3za8Yd3Ov/0QeDrt0d/tlT1fIL7doh1PkQ699OfBTLOg4zzEKWtgpnLjE+BJ8bBMEgUnkjAgQQUmoAiEpFEIhoEkXgckgBiqRQChUwEARwVi6NiMVQshobDMEAUk4BMJaHTKOhMKjaDgsmgYCD8xVlETg65JJdSUsDgFdJlHKZOmFEmzTEqCqoMgsZqVQx/ZLhvYnTgxtjA2ox3d8H37+I/3or8NfzP9qPP9i8iul5uj3u6deN8f/5wOTTra/M06BuUGQ1aXFsDztNArlfheNkJ6ZQ3Myk/EqReL8tBN+SRRuRpW1b+V5uO//fLif/z6/CLn3T/8qTty8PuT9aNP1mQ/Him6EmItdeJm2nEDBowLhHSxcM2F8Fr8pOU6VckGW9KChJ4+fEleXHS7HgDG25gp5RyYJoipCIPy0vFNWnFG17T0+Xhj/Ym3t0MvbsTeWc7fLY2fLY2fHt5CGrasX/TBy34IfxQYg9Uur+1OLS56F270b880wMd9UN7/s357yt8Ifm3JntuTvbcnOxZmPTMjblnIh3/Mf7wINSrwzEyaB/qs/p6zP5uu7/HAbXrGewx9brru9113e66NmdDu6sRwn8x7dsaHI4mW2P5y/jra8rqqo011caX8Rv1GoNGqZZLFBKhUKvmKxU8hVyk0kiVGolUKRIrJGLlBX6xgiNSlIiVfIkK2v9Dt/1/Db9QqITwx077BSUqEV8hFsjFQskrYPJ1AjyFhEKS0cgMIlqSTyrjE3WFcHUWVpWNlWdjFHlobTGqlJ3ULIH3VJJ8jaQhEyloo4Qd5LCDGLbjQ3ZM2IEdtwNjNvyEAxyzASETJmzCjzZhByuT+8sxPaXIbkNKT1mKrwYdbMZHrMSIFRy3g1ErPmLBjVvwU3bCrIMEjSnXxZhwEscdhIgDDNnwQQt2womdbgXmOoi3umkbA2kHw7lHUc6jKcGzBfl7t9QfrOo+XC/76VbFz3erP9mu/nC9/JNd7cfb6mc3xe+tKj69U//VSfvvnwy+OO776szx5ePOz0/df3jS848n7b+73/bbs+FPjkIfrFlOJ9X7/sw7XvLJMPj2KP6Dccov5tLaG3PzWShEEjIxhZSIZCKwmRgsiAPeYlDTKEQGiCfgsTg8DgXgUQCAAAAYi4anElEUfAqdgGASL0Y6GZlBxmfR8Hl0MJ9BKGQS2GlkbiZFlE0vyWEKClgyboZanKWX55WrS2oNkqYKjaO5srvVNNLvnhgZnA5558cHV274tpaHbt8K3VsNXz7sjx5tRqEtwNH27Nn+jSd3Z57cnXx8EHm0F7roz3PZY+9y2z950S3v/sTJ3vzqWGTIaeuokVQJUU0qeEsF4K4ANMVJmYRr2UCimJRUTrvuKkQEVIxNb9HHm/W/f9zz3z6c+L8+Xvz8wH8+4TiOuI7DqvOw6Fm46LGfedhHnWnGt8iSbQqChXOlsSTeyE6W5SbzMhN5mfGSnOvK3KviYgQ/P5mfByvJTuHmILg5CF4OSi9mTnZUn94aerYdfL4fOtsaOtsOHK0HHm6Mfn/at+DbmfdCZ/u7C0Nbi4HtpZHtpYswn+/P+Wa869OD69ODGzMDW3PerTkvtAtYnuhcmXSvTLqhxE6oV9+NSOdsqHMu7Ibq+WLF/GN+57jfOu63jvlsEa8VuvCD3vb4+iy+vovdfn+XqbfTBDXndrfUd7U2dLU2dLoaWm01LnO1y1zdYqmxNtWZGyua60sba3WNtfqGGkNdpbG2vBxK74TW/GW6i/R+nUotkcolUrlUppAqNVKlRqxQC6RKnlgu56ukIrVYrBaIVVyhiitQCgQasVAnkIiFUgVfBB3vKYR8lUioFAqg1b4MOvkX8lUCnpLLUXCKZexiHo8rEgllUonyFRI8gYiAEZEIIhKeBiIh/PoihCYHq8nDKXOxqgKsjo0uZSc1ilK6y0m+JsKQiTRiJYfspJCdELLhQzZcyI6B8I/bgTEbEDZjoxYwYgaG65ADFdg+I7qnDN5fgRiux4XMYNRGiNouG3Ja8RNWYNpBnHWR55zkOSf5L/CH7UDIhg/Z8BD+xU7ySg9jezDjdiDvQYT9aJL/9g3puzdVP1nTf7Rh/GS78hf79b88aPj5bu0X92s+u1f1ya7xF7drPntg+eLI+fWjri+PO3931vq7t/u/OvZ+tuv+cKr+2Wjl0wnnvXDH1oD6Zjt72kqbtWIWXcidbvx5OPOTm4JeM5ufDoIwDBJOgKPoaFwqBgBBUhyZQCeCFBBPAHB4AI8GATQIIkEQTidjyCAihp9BgDMI8FQiEurVk0UHoMIedgaJm03l59K5uSxhYSqEXyfLNao4MfxdLc2Bvs7xwMB0yLsw4V254du85Y+98HuwEXmwEYHkH+9EH+7Mne3PQvjPb0fP9sPQA97H+6OPv1/wj13+Iky+dzL3YGNixtvTXWd0GTn1cpzTCLRXEho0MHF+Yh4FxqXjDOkYayEqbGTteeSf3q397rn7u6dd3zzsfHHP/ZMVx8Fw6Vhz4Zg5Y6El/b4v9yyQtd9NDVfB7MI4uxTn4MZZeMlVHIQsJ4mXniDMTlTlJWgL4iSFcE7G9ULW1Xz6VU56Mi8LwctCaLi0gEV7d6bn8Zr/2W7wbGvo8c7Iw40RCP/FVd/FMx7/7sLQ3uJwDD+U5/N9994ZLzQ2Zwe3b/hiRwB/DX9MfqyYF3rkN+azjPlsL+Mf7rMM9Zr/An+f2wzh72ptgFp0x/A7TVVOU1UMf3O9oakOettfXlteXmnUlZdqynTqMp0awq9Xq3Sqi9AuiVQulqvEcpVIrhJIlXyJQilSycQasVjNl6h4IjVfpBYKtWKhji8WCSRyCD+XqxTwlCKhUsCX8nmSfxc/jysS8CVikVwmVb1CRiUTkXACAg7CU5ggQpxHNApIOjZSl4fVFeDUBVhNMVbPwUD43WUEXxMwZCKM2EijNmLQCoxacaNW7KgV+zL+iAU3biNO2EmhZtxgJW6gEj1QifbVYIJNYNRGGrMTx+xEyPa4HZxwEGacpFkXGfI/5SJNt5CnW8gTTiLUuvMi2NOFm2sFb3ZR1/pYO97MOyP5RxH2yTj3fFb8fEn54XrZx5vlP9up+dXtxs/vmb64Z3lx1PjiQfNn90y/OXa+OG754sj57bn798+6vjt2/+aw/4ObnYd9Nas13KXSwvlKyahBGijP8RpY/TqCRw/v1icMVibPtdNuh0oGG4qUmYR0NIaIwGCQABpLRwEAjpoM4IgAjgjiCSAeAAEcCGAIIIZIRFMISBIAp+DhNBDOJCAh/CwCgkXDsmjYdBouiwXkp5OKssicXBo3l87PTxUVpcl56SpRplaaU6YsqjVImirUTlOV29Xk97RFh/pmwr7FSd/KDd/6kvcv8D/YDL2M//zO9PndsccHIQj/+f7E4/3RR7sjl502xx7thM/3x965N/vjh9M7s96RliaHQWDVpps12M5qilOHFXDfyE9/K5+KkDGJdTlAv4q81y/6xa719+87/uWjrt+eOT9cqX53vurT3ZaPt1xrgxK3kTlQRVlx59zz56+3UUIVyDZxgo2XYiuKt3JhVcVIaUYCLzVOkQszcpCV7BRhXnIh62ou7Y0s0usFjDh2WnJJOkJdQh2ol+2Nd54uD76zN/pkd+Tt/dDxZvBoPRjL8NtfGtpb9ENVPXuLw5D8rcWLAM+XnvT//+Rf4J/xQPJXJt0XQd1jXRD+v6jnmxntmBppmwy0QvKjXiv01Gdk4KKY92X8A93mGP7utkYIf4ezvtUGHfJXOporrU11lqZKc6PR1FBqaihrqiuD8FeV6yvKtOWlmsv5X6NXq7RKhVKplsmVEqk8dtUnlKkEUqVKqpFL1BKpSiBVC6RqgUQrFmvFQk0MP4+n4HKVQr5KKFDweZLYEPDlQoFCwFPySuQlbKlQIBUJZRKx4nv8IBIOIFKYIEKYRywVkHRspDYXpSvAaAoxWjbOUIIu4yQ3CuHuUpLfBAyZwYCVOGIBRyz4ETMOit+bcIAQ/qgVHzZjx23ESQc5YgYGqzCDVRhfDSbQgIem/TE7MWoDxh2EMTs47iBMOAiTTuKMkwQNCP9MK2XSRYLwR52EiVbyXCu40EG61U3b6Evd8WbeHck/irBPJ3hn0+LnS+oP18s+3qz8ZLv6lwcNXx5av3pg/+rI9uWh9fND2zcnHS+O27586PrTe73//NHgPx8HPl7s3OysmijjjklYc1LGtJzl55NbeXgXD+sQwC3CpHrelWrBj6z6xJ5mYruWok1HcEBYBiaJiICh4EAyEg8noHAYPIADIfkAHgvg0QQQSyLiKCCaDKCgjj0MEMEkIFkkZBoJxaRjGTQ0k45JZ+JzMgnFuVR2HoWTTxUUpImL0+W8dKUwQyPJLlMW1ejFEP5OZ6O3qyXi750J+5am/Cs3fGuLgwc3R+4sj9xfD0ML/qOt8MPt8MPt8NH29Onu9NnBxNntyKO94OnuyNlu6PFe9Pwg9Gh35GwvCPXYfbQTfvv2xPsP58+3R5eGXd7mUruuwKqlWDSYFiOxkpeYmftqFusqm4LUMkBbMTBjyf5wvfZfP/L+8y/6/7dPvL973Pn+fPWhT/7ekumLB/1nS41+q8ilIw9Wk2btjMlG/EgZ0iNNcbAT7QWJdg6quhAlYSXwWQmafEQFB1VZlMzLTipOu17EisujXcujXStgxHPS4HoB09ekPJjsOlv1vXsQfro/+vQgfLwZfLA2Esvw+4v03hj+i+jey2Ke9en+9en+zdnBWG3f+oxndaoLkr880fky/vmo+y8qeaeD7RD+qNca9Vqjg/bwoC00YL/A32v9a/ihNb+7pR7CD838MfyWpnJLk9HcaGyuNzZU6SVABAAAIABJREFUV9SWl9dU6iH/UGFfmU6tV6t0KqVarVUq1QqFSiZXy+RqKMNLLFNr5Dq5TCOSqoQyDV+mEcm1IqlOLNYKJGKRTCmUqAUCFZ+vFgnUIqGSz5NcTv4X+IUCBZ+r4JVAl/wyqVghl6peIaKSiEg4AYUgoOBMAlKYRzTwiZoiuDYPri1AqguQWjamlIsxlqQ0iRDdRorfhBsy44ctQMAMBMy4ETNu1AqEbOCkkzBuByD8IRNmzEqYsJPCJryvBuevxQ7X44NNYNhCiNoIESs+Yr14IxTzP+EgTNkJ0w7ipJMYww/t+cdbSFPt1IUO0s1Oyko3fb2XtTOYcSeQdxxmn43zHk2Jni+pP1wv/2ij4uPNyk936z+/a35x3/btafvXD1u+fOD4+qT1xXHL14/a//y+908/HvjVUu9GW0WfssBdQhnho+fk8Fl5UlBw1Zx/rSHnzdq8N6uL3iorel1b9Kqe/6Mq5fU6zlUN8y0VLVFIistEx4PJWFgyAYYlAjg8gMND8nFYNB6HAQEckYCjEbFUAoYGoil4OA2PYBKQaWRMJhXHpGMu8LOwOZmE4lzyJX6WmJ0q56cphWkaSWaZqrDGIGyqUDqaKzscDYNuV9jX8zL+3QXf7VuB++uxq77w0VboaCv0YGvqeHv8ZDd6sjdyshM42Qmcbgcf7YTfvhN+vB+EMjmhZtvP7k58eLp0/6Z3ttfU36hyGLJNGrBOnmzRAtr8hMysNwpSE6QMTHUG0K+mHUVU373n+X++Hv+3z6b+/HHkD2fenyyYVlzcJRd/L1h5c0DnM0uqOAirBD7aSBmtxnnVKV3CpFZ2gqMAbuVgq/IxIlYyl5moyEXoC1O02Vf5WUmctDhOWkIB7XoBLa6AlsBmwnVcZsCivT3V/WjF+2w3eL4TeLI3+nBjJIb/7mrgzvLI7VsXST4x/JsLw5vzvvW5QeiEf326d3Wyd22qb326F/rP2nT3y/KXJzqh5jyX8t2xBf/L8ieGWyIDNmiEBx0h6Hq/9wK/t9f88p4fmvbdLfWdrroOZ+1Feqe1tsVS4zJX25rrrc1VEH4owLehuqKuogIK86goU5eXaqD1P3Tbp9PoNRqdWq1VKXUqtV6p0kkVWrFMrVJo5TK1SKriy1UChVog14qkGrFYLZJJJQq1WKYViTRCoVYs1IhFKqFAJuBLBHwIv1QokImESqFAwefJ+FyRkC+5wA8iEggoOAGLImCRTAKSn0fQ8kB1MVybn6ItgKkLEZpilKEEbSxJaRaju41UvwkzZMYOmbHDJvywCT9iAkJWYsROnnIRJxzgX+APNeOG6/GBBiDYBIbMUHMefMSKD1u/D+ofdxCg9T+0BYjhn2ohT7pI4y2kiVbyVDv1ZidluYu26mFs9LK2B9LvDuU+DBVf4td+uF7+8WblxxtVn+7Wf3bH8sU922+P3d8ct784sn994vz6rPWPzwf+/OPgrw+7Vh06tyyrKhfbkJPoKX5zTPyjMdGrIdEP27lxTVk/NDL+zpD6qj7zDWX2a4q8V1XFr6kz/0FJ/5GRdd1Af1NMuJ6BwmJTSCgMDQRwkHw8DoPDonFYNIDHgniATgLoJBydgKHgkRQsjEm4CPBh0TAsOiqdjs5i4fIzgKJsIiePxM0j8/OZomKWnJ+mEqVrpVllqsLaUtFfw7++5N1d8B3c8l9e9YcfboePtoJHW8EH2xPH2+PHO6Hj3cDxztDxztDJ1sjpdvD8YPTJ7RAU1wnN/88Pp95/OHd7zjvmbnTXSk1aVrUCbhBcr1HgNcXYgrS3+PSEslRMK484Z8v9ZK/xv/069H9/Nf27D6e+eRr8+kH/JzetK062z0Drr8puK8ts4oFlWdd8NakHAdVyW75XjWxnX2svim/OhdXlIbWZcB4jiZcGUxSi9cUwVe5VYQ68mBVXQLueS36rgBZXxEgqZsAUheRhs2Z/wn202Pt4w3+64YP2/EeX7XpivfqgPJ/9pcDOzSCEf+OGd212AJK/NtWzOtm7NtUDfV+C71iZ7IS+b413LI51LkQ7Yvih3L7LAI8OKLprfMh1id8RGrCP9tmHe61DPRa/x+rtNXt7zZfTfnNPR/PlVr+u3VHTZq9us9e22WvbbHUQfrupIYbf3Gg0NZQ31lTWVVTUVumqK3SVRg3k32hQQ/71WoNOo9eqdRq1QaOGWnfpZHKNUq6RydVCmZIvV/EUKr5MI5RphBK1RCGXKjUSuQ7CLxFpIfxCgVTAl/B5YgFfKhLKRUIl5F/EFUv4UoVYqZKqX8Ej4oloBAmPIWCRDBDBzQG0PFDDRugLk3RFKepCmLoIqeegSotTGoXIrjKaz4SE/A+bsMMmfNAMRuzUcRdjuoU04YDmfzBqxU/YSZMOctiEH20mhkykiIUctZGiNkLUBkRsuLAVC63nx1zE8RYStAWYuNwCXGz7WynTrZTJNspkGyWGf83D2OxL3RvIuDuUezRadBrmPJqSQPh/uln9yVbNL/aaPrtj+fyu9cVh29cPW746Nn/9qPl3T1v++YPA18dDd4JV3crU8nyUKjPJkPmGLfcHQ7wrY8LESSnOr8TZ8+OMpFc1hNc1lKtK2lUp/XUp/TUR4zUJ6Y1S6pVy+g8MlDf5BCwdBYIYAh6HuhwYAI+FFgJ4LI5GxNNJAIOIpeCRFCyCAaLSyLh0Ei6disqgobMY2FwWNj8Nz84AuNlEfi6Zm0cVFtFlPKZanKaTZRrVBbWlgqZKub2posPR8PKyf3Xev3HTt7fkvb08dG9t5P5G8MHm6NFW8OH26PFO6OHu1PFOFMJ/sjt8sjt8uhM43Q6e7vgh/492A2d7wad3o8/uTrx9e2xzbNDnrDHpi8tEgEZwXVz4ml6MV5dQpcwkNTXZnguMV2UeReVfv93+37+Y+LdPJ1/8ePL374V//6jn1xuNB56iQQPOKkWX89BGxus9KtKT6cZPt1s3u7leFbqTndhekNCQhzBmwcTMZDYjmZeFkLMxKg5MkX9NlA1nM+MKqNdyiW8VUOKLaMkcJlxTzBix6g4mu44We8/WfSfr3pfxXzTt+Sv4ocQeSDs0LpYAU10x+atT7v8Y/8un/dCBHyQ/3G8f7bcFe21DPRZft8XbZR7sMQ32mAa6zf1dpt7Opti0726p73DWxvC3Wmuhlb/d1GAzVVuays2NZaaGsuZ6Y2NNZX1lZU2ltrpCA+GvKNNC6/9SrcqgK9Vp9BqVVqXUqZQ6peqyaa9UIZUpRHIVV64okSm4UoVAqozhF8u0sWX/BX6hWCAQ8XliAV8iEsrFIgX0EyAXKZQSlVqm0ci1F/jJAJaARdJAeEk2XssDtRxkaXGKgQ1XF8LUxXBtMcJQlNwgQLhLqT4T0m9G+U2YoWbMsAk/aiFFHbSJFuZ0C2nSSZhyESedxHE7OOWkzLTQohYwYqFErZRxO23cQYF2+1E7PmLDhZ3gmIs40UqeaCVDh3+TTiI0Yvhn2qjTHbSpdupkG2Wpg7zSRVvvYW71p+0PZt4dyj0aKTweLT6blj5f0n64VvHJVs3Pd+p+dWD6/K7187vWF4cd3562f3Nm+uas8du3HX967v9wrXOkhl1TmCRhvc5jvS6g/hcj/b/0FMSNlpAmRXmjGlprAaKccFWDva4DklVAkgx/TYy/wqfH8YC31PjXyoh/U0n7oYqGysCgiWgkFgPHYhA4LBLAYwkgngCAAA7EYfBkAEMnAQwCnoJHkjFwOoBkEtAsEJ1BQWXRMHkMXD4TW8jEsdPx3CyCKIdckksRFNIg/Hp5Vrmm8GX8vu7Wl/Fv3vIf3PLfXh66uxq4txY4XB95sDlyvBM63Ysc702f7o2f7IZP9kZO9wKP9kfO9oJnu6GjjYHH+4EY/mf3xp7ejZ5uB+eHujsb9EZRhowNk3LeKMr+OykXLS9h1WQBdSz0oJBx0CX6ZKf2zz/r/+8vpv/lo+mvPhj786fjf3635/Md46Evy1+OaBIn6dkJ5pzr227Zn85Cv9hqHW9gdQmTPDxYR0GSnU+qKMCI0mBFzGRONkJUiBTnxwuzXhdkppSkJnBYifnka3mk6wWURF4qpkKUHXEZ7832ntwaON8cerTpf7I3Gjvw+5/iX53pj8m/iPGY7YnhX51yr890x/AvRDsWoh03Ip0x/LH0vhuRLii6d2K4JTLguMDfZx/psfo9Vm+XedBtGvA0D3ia+7tMfe5mCD+01Ycm/5fxO01V9qYKh7nRZqqOHfhB+BuqqmoqtVXl6kqjqqJMXWnUQId/ZXqVUVem0+hVCrVCppbL1Aq5Rq7QyhVaqVQew8+RytkSGV+iEEqUEoVcolALJWrowE/AUwoFCgFfKhJJ/gI/5F8j12oVOp1Sr1PqXwFQGDw6EY9NANAIJgEtKgDKhGR9MUnNBjRFeGUeXFsAK2fDq9jJZhHaU84INZFHm8DRZnTIDA9bYGN2+KQLM9WCn+ogTbaDU22YmXbMjXbsQjt+vgWcd4DjreB4KzjRRphpJ812kGfbSJNOIGrFTNlRU3bUjAOYayHPuqjjNvK4jTrtZM06MDdcwEIr4WYL9VYrfaWVtd6eudGRtdVO2O2i7vVlHgzm3fUWPvQXnwc4z0ZLnozL35vTfbxc+YvN+l/sNP5yv/mzO5YvD52/PXO+eOT89Ynr69PuP54FPtvpW+vRO9S0ioIf1JD+cxPxb4zUVyqpf9vOuNZfdN1b8eatpgSvNMFIvCpDp6hAlBwbr8HH6fDxGvxrQuRbPHSihnKthvmqlvpqJg6BQmQg4SgkCofFEUh4IgtPoRFIaApwnYEBSWiAAAcAGAmA00A4i4BMAxFpADydhc2goXOpmBIWQZBB4WZSSvLoXHZq7HmvXpxeJssyKvKqS3lNtXKnqdTtrPP3uMaGembD3qXxgZWZwfX5gfVF/87NwMFq6O5m+HAzcrgZgm77znbGz3Yjj3ZHHu8OPd4dOt8ZOt8eOd8efb7V93zH93Qr8P6d6cfbY4/3p398vLy74JsYaHRW5Gl5yJKC5Iz0pAxmiiQXXcsFzUxSSwFxprn43aWGb867/umT4X/9dfTPvxz78wejf/7p5G/fGfpwq/5wIH+sFO4qimvMRy6Xx3+7VvPHOx33BtVuCWjKT+5T0Pok5BoOUZ4JL2LE57Li8lKvC7ITVTnxqrQ3uFnxnPTEIkZCLiGBQ0XxaBghC1fDz5noMN6ebD9a7Hm0NvB0fwS657+/MvJgY+zlGL/YgR9Uwxe7yVud9EDNtldnu9fmPGtzntUZz+qMZ2W6+9Zk963J7pvRruVxz/K4Z2msZyECBfV6FsZ658Z6ZqOemUj3TKR7Otw1OdoZHW4N+11QRPdwr93f4/B2Owbdjn63s9/t7Otq7HU39HQ0dnc2dnU0dLQ1tLpqXY7qztamdldDi73WYamGmvPZTNU2U7XdXGVpKm+qMzTW6pvqDE11hoYaXW2luqqytKqytLLCUFFugGL8DHqtQa/V6QwajU6l0kC9umQqtVSpEssVQrlUIFVA93xcoYYrVHFFCq5IJpYoRGI5XyDhlAhKuEKBUCoSywVCKZThUcIR83gykUgViwCUSFVymVqjUOoUilcABAxAXcej4wgoOIuAlBTgyvigvhBUFuG0bJymEKUvQpQVpZQXJTYKkZ5yxqwtfdbOnLGTZxyEORcw30q42Ulb7mLd9KQtdtGX3JSbbsKym7jaSV1tp620MubbqAvttJudjFtu5nIn82Y7faGFMm8nzrcBc63gjTbSQjttro0x08KYbmHNtqUttBGXOsg3O2m3Omi3OhirHaz1zowNd+Z2F22nJ3VnIHfPV3RniHsU4J2HhM+iwuez+p8sVXy60fCrPfOv9y2fHVg/v2v/4p7jN/fbfvOw87eP/H84C3+5N3w/0NRdmqXMTtBk/Jd66t+3MF+1pv2djfVDDzO+r/Cat/LKijUxoE6qpLwlR8XLcSkS9BUV/qoeiKsmviZHv8VBxInxV/WUV7XUHxYDKRQUDY1GI7E4NB4g4ckMLImOI2AIuHgKikBEgwQUCMLJIIJOQLAIyDQQmQYi6GQkk4jIIqELaQCbSWSnkYuzaZzC1JIC1kVhjzi9VJpZJs+t1Jc0VEvtTfpORy2EfyY0uDg2uDw9sDY3uLlwgf/ORujeRjiG/2Rr9GRr5GR76NH24NmO93zHd74TON8eeb7je3c/8HRn5Nl+9OHG6OnO2PMHSxs3Bsa6q9prikrFOG4hPDMdls1EyLLQ9UVAZx4ppM7a75Z/sFz/1aO2f/zI/+dPI9/9NPxP7we/+yDy1ZPBj9ZrDzpTg/Ir/cLkSFXuB0O5/3Jg+tVS3ZI1z1kCr8uKc3Iw1kKELhclTk0qZsQXMuOLU+NFOUnaApgmJ46Tcb2IFVdAS8glJJTQ0EImXp5FMiuK5/vq7s66Hyx4jpd7z3cCj7aGH26MHK2NvowfmvMvrvq+f9XTB+FfnfSsTHSvzl6OC/w9y1Oe5SnPrbHu5XHPykTPzfFeCP98tGdhrHdhsn9urAdiPxHsmAh2jI+0jwXa/B6z32Me6rH5exw+j9Pb5ex32/s6Hf3uC/w9HY1dHQ2dl/jbnPWtjroW+0V0n81UbW2ugn4CzI0VTXVljbWl0Kiv1tdWai/l68uN+rJSrUGv1es0ep1GqylVq/SX6b1aqLZHJFMKZBK+RM4VKbhCFVeo4YnUPLGSL1EIhUqRSCUQKLhcKY8nEwqVQqGSx5NBtb28y39C+T88oUIkVshlar1aY9RqXwFhiQTkFQL6LQI8IR2ESfNQ5VysIR+jKkRr2Tg9B2MoRuoLk/QF8fUCVEcpfdqaNWVNn7TSJq3kKTtp1kWdb2UttmfcaE+fbWXOusizLtKcizTvosw7GfNO1pyTvNBCXWqj32xn3GqlL7moi3bygo0010GcbiFMuYjTrZTpVtpEC32ihTnZypprJ9/ooCx0UObbqPMt1PkW6mIb82Yba6mNvtSZutSVfdOTt9pbuOPlHA7xHo5wT0blT8a179woe2+x4r3FiufzxnduGN65YfhguuqDuaZfbva9OBh7Pt0brpNqc+C5hH8Qkf+XBvprA5nXB7Ne92W95U9P6Cm84qt9a7MtMWxMqmO9pcRclaDfEiB+IMe8pgWvNFN+oMe9yYFfL4a/JQZe01DfkBASi9BIAI9GAxgUAOBxRCqGRMMAeBwGBsBJJAyRiCaBKDKIoBNQTAKSRUCyCEgqgGCAqAwiNo9KKKCTClmU4iwmtyCDW5gqLE6DqvpKpZmlspxyLaeuQmqp03XY6/yelrGhnunRgYXowK2pwbW5wa3FoYuZfz10dz10f2P0AeR/0/9wc/B0q+/RTu/Zdu/Zdv/Zlu98c+jpzvDT/ZGz7eHT7eD99eFH+xNv319Yme4Lu3TtlXkaHjovMyGdAcslw5QMpDkfmNamHXbKP5iu+mS19ssHtu8+GPzjT0e//SDwjz8e+e7H4d++7fvZWt2ukxwU/P2MAXPmN/xhVftPB/WPh/ijRrBVAG8qTGkogJenx0szEnjM61xmIo+VxGElCjKTFPkweX5Ccdr1fPr1PEpcPimJz8RJ0kF9EcNdKd8YdR0t9B8udB/e7D7Z8J1sDB9vhh6uh+6vRw/XIrHo7hj+70M7pnrWpnpWJz3Qx8pMFyR/bbZnbbZvdaZ3ZbpnZboPkg/hX4x65qPd/yP+l/37uk0Q/qG+i8m/323v67T1uxv7Oht6Oho97Q0Q/jZXrctR7bRWu2w1LfbaFnud03qR3mFurDA3VTY3lDfWlTXUltbXGOqq9bVVutoqXUy+sUwHTft6nUan0WrUBgi/XKGRKzRSpUYsV0H4eWIZRyDj8BVcoYYv1gikar5EwecrhUK1UKjm85UCgUok0ggEqpKS71/4XZT9XVYBicQKmVSlVarKNJpXyIh4CuoKEf0GEXYtE0yU58HKSxDlhWhNMVpbhNax0YZipL4wRV+UUM1HWlREdznJXUFwV2K7qjDdNWhPLaanFuytI/XUgp4aXFc1oqsa7qmG99ag+mrw/bWEwVqkvwEzYgJCZnDUBAQbcdAYteICJvRQE9rfhB424YdN4JAZ9JuAoAUbtGBDZmywGTvShAk2YkLNuIgZCDYCw03gcDNl2EQPWVMnXGmL7RkrXVnL7bnrXYU7fey9gZLdAfa2J2+zK2e9M+OgPW+/nXfqr3p3wr3b0+SQsjiUH2YQ/1MJ+J/q6W/6MuOmMq/cyEkMZSV62K8PNVzd7kqYrE02ZV3R4K7IkK8LUv5WjP6BHP+jRsJ/NuLeFCISClLi2Og3ZMQ31cS3lJirVACBB1BwAIvBEkgoIh0FktEoLAZOIeIoRAyZgKaAaDoBxSSgmQQki4higJhUEj6LSsxlUPKY1IJUOjs7jV+QzStKE7HTVbwMvSjTIM4ySHONGnaNUWyu1XbY64Z6WseHe6dHBxeiA8vT3o153wX+ldE7a6P3VkcP14MP1kcfboZPtwYu5fecbfc83uw52+g/W/edbQcf74wcr/uONnwPtwLvHM69fffGYrjL3yC06dKkhcn5aQn5DGQJEWFkIHt4lNMe0S/na19smn6+VvWrO83fPuv97ieB338w+o/v+f/0fui/Ph36+WrdYQv9pu76bQvzZxO1f9iu/GajYq8zY0CZ0ilBOoSYejZSmxYnTIvjMa+LU5OEqSkltHguM56flcDLiru44ScnFJBhojRAlUutEeUMW423p7pPbnoPFzz3ljwP1wYfrPkfboaONiKHa5GX1/yxAM+LO/zp3osJf9ID+V+Z7l6ZhvD3QeOitneyd3WyF8K/NNazMOaZj/bMR79f80NjKuQeC7RFhlqgiO7hXutQn93nscfw93U29HbU97Q3eNobPO2X+O1VDksV5N9lq43htzRdRPc11pW9LL+2SldZUVpRbjCW6cpK9bH0Xo1KrVbpVUodhF8mV0PyX8ZfIlDyxTqBRMuXqLgiGZ+nEQp0QoGOz9MI+FqRUC/ga0s4you3fQIF1LQrlvYtEiskYoVSKlNLpa9QUYkM/DUi+g0C7EommCDPg1VwkZXFaD0Hoy5EqApStIXJuqIUfXGykYuoEqIMkuRSaZJRkViuSqhQx1eoE8uVKUZ5Srk8uVyeaJRfMyquGpXXKtTx1Vp4jQ5Vr71u0ifYjCmOCrizHO4wwlzl8JYKRHcl3F2e0lGW1FGW1F4O66xEtFfA28ph7vIUd3lKVwWsy5jiNiZ1lSd7ylN6K+HdZUh3KaqtDN1mxHZVAQN1YLCJEDaB4QbShIk2a2cuuFJvuliLDtqCjTRvJaxasKtm0p0O7v2+0rFGniEnPgP7Sjr4Cg/8QQX5Si/zrfnU11ez4yM5iV3cH400x233xU03Jtlzr5TiryiQbwhhfydE/r0Q/Q861P+qx76hxMBKECmFyKsC3Btq/OtlmNcycMkEXAoci4ZjCACKREOTaBgMCQunEnCXA+rSi2IQ0UwSJo2Iz6QRc5iUnFRqTio1P43Ozk7j5WbyCtOFxRlKbrpelK0XZeolOWXq4hqj1FJn6LDVX7ToDnkXot6VGd/mwvDO0vDuzcDByujdleDdleDh6siD9dGjjdDJZu/JlufRlufRdtf5ds/5Vv/5pu/JxvDj7bGzrdDDNe/Jhu/J7fBPThYfbU+M91q7jYWNUpqsAMbLgAlZGDUN0c4hrJjYL9br/njf9e1d26ebNZ/uN/zmrPN3z73f/ST4T+/0/eHp4Bf3On88ZXjcnfN2Z+aPfcKfhMt+tlj64Q3dsoPZIbzq4MbZ+Ki6IpQ+PUmcdl3IuiZOTRIxU9iUuALqtaLUa/mpVwqZ8fn0uHxKYhEVIcsilXFSLRr2hLv27lz/8S3/3QXPvZs9R6uD91eHjjZC99dCUMcOaM0PyY9F92zNDcTwL493rUx0r0x0X+LvvRz90Fib6vsf8d+IeKbDXdPhrqmQG/qYHO0cC7SF/S6oIXegz+bvvWzO47b2ua39HQ197fU97Q097Q3dbfVdrQ0dzlqXvcpprYYGlNsZW/Y31pU31pVDJT21VYbYqKwoLTfqY/Jj6b0qpV6l1F+k91507FCJpCqhXMqXyHliJV+sEUoNQqmOK1Kw+WK+UMcX6ngCbQlPzeVroD85XBWEXyRUvoyfL1KKJUoIv0oieYWCTqEDcUTMFQB2NYOYJCuAG7moCjaujIPW5KeocpNUBUmqgiRtMUxfAtMUJ4l4CWJ+gkQYLxNfl4njpaIEiSBJzE+W8RLl/ESFME4uuiYVXZNLEhQyuEqB0kqu6WVxZcrEClVylQZWrYbVaOC1WoRNlWJXw6zqFIsqyaxJtupgVgPcrEsxa1JsGphDB3fo4A5tslOX0qpLbtOndOgRrTqEQwN36BAtpajuCnR/NdJXCx+sQA5XYyIN4JSZMG8nLjmJtxzgLSd+0RK/6cTd7czZdBV3qwki2j9koF7JJfyNmHhFDb7RQf7RTeZrm5lXR3KudQh+FLLEbw3ETTYl2nOvlGHf1KKuSOCvClD/wIH/PSf5b2WIK1osTIpK4SDi2MgfSVGvlmFeY2MSWOgkBAqeggIwKDIVTaZjsTQ8gg7i6SAOGhQQTQHRVCKKRkKnEzAZVCCLSUxnEjJYxNw0SlEmoySTWZKfyi9MU5Rk6IRZelG2XpJj1JTUlsus9aUdtnpfd2vUB8383tWZoa3FAIT/9q3gneWRu8sjF0V+66Hjdc/xuudko/vRRtfjzb63t/zPtoPvbEef7sw+3ow+2gg82Rp+/+7Yxw/m788PBWzVrYb8aiFJkp0oYMSrqCnWbNxSU/6nC5V/etv9p2dd3562/uqO+ecH5s8ftH7z2PPHd/3/dN765aHz3YXaE7/0WT/305Dqw5DhsEex0sVedbMjtdR2fpyl8KqlOKUuL8WQnqBIvSZmXBOxEnms5AJKfD71eiEzPp9+tZCZUMhIKqTBimlIVR5l5+HfAAAgAElEQVStXprfUS2eHzTdnes/WvLeXeg9vNV3f23w7orvwfoo1KITWvNDjTov5fv+YuZfHu+Cxsp098p0T0z+ynTfytTA8uQFfujAD8J/I+KZC3fPRj1TITe0z4+N6HBrZMgZ8jkD/Vavx9Tvbu7rMEH5/BD+3raGnvYGT1u9u6W+3VHTaqtqsde6bDUOS5XNVGltroDkW5urGhoq6uqMtbVlNTWlNTWl1dUGaFRWGMuNpZD8Ur3BoCvVqnUx/CrlxfU+JF8sU4sUMqFMCT3sFUoNAomWJ1ZyBBKBWCMQa3hCFYcnL+Er+CI1X6TmCpQv4+fzL6L+BWKVWKKElv0GleoVEJVMBRMA7FUcPC6djJQUoLUcpKEIZ2DD1fmJmoIkVUGSPDdeUZCoLk6R5yfIOXA5J0VekiAviZeXJMg5KXI2Us5GqYvhGjZMXZKk4iYqeYlyfpJcgFAKMVphklaYZBCllEngFRJEpRRZKUVWShB14pRGGaJZgWqQwxvk8CY1olmDbFTBGxXoZhXarMFatViLBmXTIGwamE0Da9PCXBqYTZVi06S49LCOsqRuY2Jfedz/R9lbhsd5Zum62Xume7oDRlExM4OqxFBiKmZQibFYUqGguAQlZpYskyyTbBmSOHacOGAHOwyOY4oTJ5mGmd4ze599zuzz43M0ngyc61zX8+Or+n+/613rXetZoRpkpA4Zb8ZMtuMWbPiVDtyhTvxGJ3bVCd30ELY6WZM1FHMBqIrxQhFpfyUNJKaBhbi9Xcy9RzMOnshOimbvc4v2znTCtqKQmXaYPSuhGpdgwKUo8AlC3P4i5At8VFIpCqzGwDRYaCUqpRB5oBKzX0s4IMdBcrEwAgYNw1LxeDaDyOSSSRwqmksmpVLIXCqJQyEyKTgmBcek4dkMfAYNm8EmpKeSeHxSWjolL4tZnMMpzWSX5KWVC/iyknRtVbZelGOQ5Ndqy1vq5PbWao+tOdLdNRr2zwxFVsb7j8wPbK7Ez6wNASb25zfiO4eHdw4PXToy/OKx0Vc2w1eOh14+7r9ytO+VY8FXjw28dnz8xubMjePLrx2beX1z5K1T8ffOT7x3ZvrMqH+wtabLUFRTQZdnw/UZKFch61Bz2R/ma/74iuXRu8FH74S/ezt851rvZzudn53v+PZF9/0rvseX2z/bbLoxX/fKgOpaQHg9KNr2Vc2ZirxGrk/L6FaSXBVwuyDFKoCY8hFN2QhjFlzJh4j4sBI+PJcDyeNCi1KhAlaygAMtTEUWp2KKOVhdEd+hK4vaNEeGu84tBHdWw+dXApcOhy8eiZ3biF48PrJzZOzfh/2Ty/0nl/uf6urxAzH/F/gDvyh0ZD50eDa8MRPamAkdmwsdmQlsTPWtTwXWJv2rU/6l8b7Fsd65sZ6ZEd/kkHti0PW0RqL24YhtMGiN9plD3aaAB+jeN0e9v8DvbvV7Wnud/zH8NlO9tb3O2l7X1trQ0lzX1FjT2GBsbqptbqptaqxpqK9uqK/9Ffw6jV6t1KiU1WqVUa0yKhQGwLcf2NUlVspFchUAf5VEXyXRVknVVdIns73lIkVJpbS0SgbM+ZdWyXav/UAJsFL0xPxLIlUp5BqdSl2tVj9DQMPpFCiZCCJiYBlsgrCAoCzGqguI2kKEWgDTFSHVhQhJLkiaB5YXIiX5MG0xTlOEVhXAlQUQpQCmKkCrC/CaQpIxH1ddgDOWYAwlSE0xXFWEUBZjVSV4YyW2phxTU46pq8Q1VhGahMTGCnxDOa6hAt0iIbTLia1SfIsM26bAt6nxLUpsq4xsUlEtGqpNS7FqiBYVzqLCmJVolwreqYBbFVCrAupQQ9w6ULcuqVefEGlAxRqQ8WbkeDtyzopctiFWbfBVO3SjF7/ppa4043vKEw2cF0S0BBENI6GQxWRYKfqFDvaBrXzQZk6CP+sFl/iF+S7EiX7YdBvUkr7fgE4wYEFqQoqYkFiI2sPEYvMRMAUcpEOmiJBJhcgDpZiDCkKyDgcpwsJIGAwMS0Xj2VQSm0UlsWi78JM5FCKDjGeQsQwqjkUnZNLQmSxcOo+QmkZIz6IU5LHK87gV2eyiHF5ZHl9anAbAXy0V1OkqWutVtuZql6U56OkcDvZODYSWx2KH5/qPLw89Df/5jfiFjSfwXz81eG2r/+rx0MtH/C8fCr283v/KoeFrhyaurc9fOzTx1uboO6dH3j8zduv46KkB30hrrUNfWFPFMBYT3aL0oyb1l/Ndf33Z/ZfXmr55J3D3/ejjj0Ye3Rr47JLrs7P2r3c6vj5ne3DW+OnRuvfX296eabzgq1hvTh8z8oL6NJs+s6mSYCpD2Yog7VkHzNnJNgHKXkhoy8fpM+DCdHhhGjybB83jwQq5EAE9MZcJKuKhilNxxRysoSTdUyeOO42b464z88Hzy5HtFf/FjdDORmR7PXbx2Niv4N8lf2spBiT5T+uXa/9T5M8FN2ZCwD1/F/61ST9Q8Fsa71sY7QHi/OSQezfmj/V3DUccg0HzQMAU6zOFe9qDvna/pxV4z4962yKefwO/r6PJZa8H4O+yN3ZYGwD4LW215taa9rbGlua6xgYjAD9wEPwr/HqDQaev1hur9UadRq9W6nbhVyqrAfjFMq1ErtuFv0KkrhBpqyRasUInVekqxLIKsaxcJC2tEpcJJcDP0ipxVaV8F36RSAWQL5JqZHKNXKZWyxUameyZFHwylAjGkCBEEiSVCasqIOuEdEUJWiFAKwswygKMQoCW5SGluQh5PkohQOuLUWoBTJ4DkueAVPlQTQFUUwBVCyC6PJw+H28Q4KoL8MZCfE0RwViINxZhlZVERQVBVU7QVZCMVaT6SnJDJbGhnFBbBW4Qw5uluBYZvkmCbZQgGsSQBgnILEO3S5DtEqRZgrLKMHYFrkOO65DjHHJ0hwzpkME6ZTC3AtKthgb18HA1IlqDjjfgxxowM82oVStuzY5atkFWnfBNL/KqA7vVgDeVw4TMPa2kPW5qYiMlOZdy0EBOjjETj2QnreclhTP39Qmfn3QkXhpOnmmCt6QmaQkHtMT9GlyKGomSJsMKkPAc8J4ixPMSfKIcB5FiQGLMvnL4fxPDEyuRiFwUiYSiQ7EsBJlJodD4JCKXSkpn0TPZlDQ6LpUE45Og2TR4LgORwWZkcpgZHBqfSUxnE3PTaYU57MIcZkker6okXVyRJi7nSit5Ollenaa0XlthadI4LfUBt3U42D07HF6fHji+PHRyffjsxuSZjYHTR4NnjkbOHR27fGT26uHpq4fiVw+Hrh8O3tjwv7HR+9a69+0V5+tzlqvjzVfi7tfHem4Mu28MOm6NOG4MtO94VJt24WpN7rKGd6w69SVb7qeTmm+Pt/x8o+/Ba77bt/wP3+n/4Xr0u4vBb7c8Hx+2/GHT9NEZ8zenlZ8fVb05LbsQEh/vrJqqy43IOWE5s1GV0iKDNgigjXyYI4fkLmR0Cgh2AdaRTWvLJuvS0OWpKQJOQh7nYD43QcBJyGYjczkQASepgo+oLkl31cpG/fVrU23bC+5zKz07q/6d9dD2WnR7vX/nyMjlzant9Ymza2OnV0ZOrQxsLUVOLAU3F/2bi/7dIv+vIv8v5f3A4Tk/ML0LTPKsTXlXJz0rE+6VCe/aVPfqZM/yuG9x1AN4dY0PPNHoQMdIv2M4Zh8IdcX6HKFuU8jbHvK2RrwtEXdz2NUELOTsc7X53U/G+ICCH9DM+6Srz1TnaK91tNfa22qsLTWtddrGGm1LvaGtua6lsaa5vqaxoWa3t7faoNbrlFqdUqNVaLQKpUqjUmvVGqC3TyOVqaQytVyhFco0Qplm97leKFSKxWqZTCcWq4GnPsDJD/DzFAqVwD4vIOBXiTVCiVYo1oskBqlSJVeoVAq1VqF5BkmEoIlQLB6ERyexiMllGRhVMVGWh5AKiIDEeXhRLk6Yg63KxlRlY4BTQFmAkQmwkjy0OBclEeBkhQRZHlIhQKsKMeoirLoIqy5GA9JUEbSVBG05vroSX19FbKwiNFUSWioJjSJ4kxjVLMa2SAgtEkKrDNsmR7cp4O0KTJsc3SpDmRQYiwpnVePtKrxNibOpUFYl0qaAdyihLg2s2wDrq0GE69DRamS8HjPWgJlrxaxacas29IoVttGF3PYSd0zoWQ28QZCoZOzpoiX0scBNzCQhJ6WVBR7lJh/JPLiUuT/Aez4o2rPgTj4fT56ohzVyk9TEA2rifjkmUY6CSyHIIgS8AHGwGLO3DLu/DJUoxIDFuIRK5G9EiINCDKwQR2bhWCgiG0lhkch0JoHMpBBTmbR0Fj2ViuOQkHwyKpOByWFiUmnkNCYtnU1NZ5OzUimCLGZRLqcwh1mUwy0rSBWW8SQVqXJhml6eX68tazIIn4Z/Jh5am+o/tjS4tRY/vTJ6ci168rD/9JHw+cOjlw5Pv7IxcW1j6OYxz4en/Z+dDXy65fnoWOdHG+YPl5tuzdZcGaq/PtZybbDuSkT/+qDxzSHjKyHFTnfVpWDetUjR+6OVXy6oHm213t+2/vRG+OGb0S9f7f3qZd/tHdftLfvHq01vTelem9beWDJ+uVP/+bm6KzOiOTszXk8Za+JFdcyOEmSnCG0RQKwZYFcmpjebFMgjBwsp4VJqqCzVXcxoysFJ+dBiTmI+OzGPnZzPSclkwnPYKQJWYikXqi/idzepp6OtG7Pm07OuM4ve8yt959eC22vRs2uxcxvxC0fHt9fHz66NnV6NPwV/4L+A/8mr/mwfwDwwxrM21b066Vkedy2Pu5bHPSsTXoD8+WEX4NX1i12XYzhmj0dtQxHrQKAz5reFe8whb3vQ0xJ2t4Q9zWFPM7CZ44k87T2uVndX038Bv621tr1B31Sra22ofhp+YLCnvkZXY9RWG9R6g1qnV+n0KgB+lVq7C79MrpHJNSK5FmjmB17sgW08UqlW+EtW/6/L+Z687ckA/qvEKpFUJ5bpJTKjVF4jUajlCo1aqdMp9c9QSDAyHkLGgCjwRA4mqYyP0RSSVAKMLJ8kzSNK84iSXIIklyDOwQuzsFWZGEkWQpaLlefhJHl4YQ6uMhtfmUcWFdCkAriiCKUqwahKUcoSpKIYpiyBq8uQhgqMoRxdXYoyliLqylBN5eiWCkxLBaZNhGypQjZXYJorMK1VuHYxxixDW+SoVjmiRQZvkyHa5UizEm1TYqwKtEWOsihgFgXMpoR1qiBuLbSnGhaqQ0QaUKP12Mkm3EwrfslMWLeT1m3Ywzbslpv0sjP1UC3KW7bXkPZ8I3NfNBUcyYA18w/W8CHedNhSJngz58B82p4+7rNRyd6NHvD5MehwPaSenaAmHlAS91Uh9lbBQGUQSCEYUoRKLMTty8W8kI08UIoBS4kpMsIeEXKfEAMuwWFTsWQijooh0vEkJplAp5HIbDotlUlj00gsMpZLw6UzCZlsUnYqO4vLSmdTeQwCn4nPSaMW5rCL89jFuamlAq6wJFVWxVeJMrTS3Fp1SatB9DT800PBlYkoUO0/sTB4ciV88lDf6Y3I+cOjlw9NXd0YuXFs4JtLnsevh//0ZvTHV7of7NgebJvubTV+fcR4c1b9wZLh1qz69WHJ68OSWxOq92d0H89Vv7Mm+GJL+GhH98OFup9ett59sfPxO8OP3pu6czH4yVbHJ0fbPjvc+P6i/o1xxavDyldHdNdWm66t1m0OloXqENaKF5xCiFtINAvQnnRYJycxlIOYrqTOVlJnKqjzYuachLOozRkScTqLSMYsZBUnpYCRnM8C57NhmUxoQSqkkJNcwgLrCnmBdsPSkP3wjHVrqvPUvHt7qef8anh7LXp2bQBY0bW9Pn52feT0ahy47QOtu5uLgf8M/qdCfTfQybsy4V2Z8C6Pu5bGnIujXYujrsVR18KIey7unB3qmow+gR9YyxcPWwdC5oGQeTDgAFp6I93tIW9r0NMS9LREPK1Pww8kAu6upi5H/X8Gv6O93tJsbG2obms0tjXXtTbVAvADZn6Ak6+xWmuo1hgMOr1e+yv4ZXI1AD/g2w9s6Xrat/9px+5d/isqZFViRZVYIZQon5QMZHqJ3CCRG6okcolUqZRrtArdM0w8lImBMFFgFjIlDQ8WZZCMZWxjOUNXQNDk41S5GFUuRpOP0wrwWgFek48zCLDaXJQyG6HMQqlycap8kqqArCqg6Avh1cXImlJ0dQlcXwTVF0GMpfC6ClRTObqhDF5XAq0vhjaXQlvL4e3lMFMF3CpEmStR7eWo9jKMuRJjFWJsYpRNDLOLIXYxxCGBdklgTincJYW7pHCnBOaSw90yqFcJ7VVBQzrYQA1ytB493oReaicttZOWzKRVC+mQjXTERj7VSbvg5V61ZI/JYPWZf6dj/9bJTRjPQPRnw1r4e9o5B2KZkKMF4DOFSYuZB/tS9/TL9h/vTTk7Co0YkrWUvUr8PjX5QCVqXwkiuQgOKkxKKoDty8U8l455no88kItKFhJSNNREIWqPEHOwDAPOgkOZMAQFTSAT6GQSi4wnMKk0DoPOolGZVBKHTuaxaHw2PZfPzeKy0liUVDqez8Rn8ymFOexSAbc8P61ckCosSVVUpalEGRphllFW0KStNDeqAfjjAd/kgH9pLLwxF91cGTwxHzu1HDq11ntmPXz+0Mjl9fHrR4bfOzP0+J3IXz8e+R8fx39+s+eHq50/XrF/d6H16xOGz9bU32zWfLPV8OlG9c0Z+dsT0k+WDQ83zV+eU917yfjDteb7LzY/vGa/86r38R8mH/5h9tvN0PsL7R8s13162Pjphv7jZcPNMd1rEc2a2zhtLh9uTus3kpwVSS3pexvZyc1stJX47GAhcsec+8Gg7NMxxUfD8ptR6TVf5VZz4aySFyinmPJwSi6kmAYSMOACNjqHDS1Og5XyQWUcqK6QFzbVrA53HZqynpjs2JpxnV3s3V4Onl15Av/2odHdt/2Ty/0nFqObC5FfRnf/NdXfLfVvTPVsTPs2pn2Hprzrk561CffahHt13LU67loac+7CvzDiBMifHujYtesZj9pGw5Z42DwYbB8ItMX9trjfNuC3RntMIW97wN0a9LQFfe3AWp4ncrf1uFo9zmZXZ+N/Bn+HqcHeVmdqrm1vqgHgb2mobWyoaW4wNtVXN9YZnnT4GXR6vRaAH5BCqX0afqnKIFbodtd1S6VaiUTzK9/+p937ZXKNVKaWyp4cE2KxWizWikSaCrFMJFMq5BqNSv8MCwNmokEcNISLgWaSEJWZFG05R1fO1OdjtLkodTZCk4PU52OMhfjaYmJdCam1BNtSjGktwbaV4kzlBEslyVJJMlcQ7WU4RwXWXo6xlCDbCyGmIqi9HOEUYbtk+A4J1i5CdQhRnWKkU4p2yTAuGcopRXeJMV1irEtK9CpI3SpytxrvU6NDMnRUjokpsDEFtl+O7ZdjB+W4QTkursEOa3FjOtykEbfQQFxtJh9ppx4z0zZttMNWyrqVvG6jHOmgb7tTr3Rnvd6Xt1PL7y5OUXH+WxPnd1F+ykQWKpgJMaXucTL3jGUknywCny1JnslK7uEfHJQnnAikbA2BA8oDCvTfKVF79dREMe5AKTZFgEopAyULwHuykL/LxO1JQx1MAx8ohO9XkJOluANyQoIMlyRCJpXAwbkoFB9LpOPIFByBSSZz6XQ2ncaiUTkMeiqLzmXSOBQil0pKY1GyUml56YyCbFZxHrcknwPALypOlVfy1VXp6qrMaqmgSV1halB1mesCbuuQ3zvR37cwEjw0Gzm+PHBqMXZ2NXR61X96JXx+bfSltdE3N4c+e3H0p88m//j51PfvD9257rvzivPBta6vdlrfOaz5cFr22ar+4bb1h8vOL7ba3p5RvT2h/Hiu+qvT1vsXu3541ffwFffD6z333wj96fPZBx9MfDTecdWventK++WJujtnG29vNt8cUl/sKBtWCkJCxrCaetiecbwje1xN8eTAHVxErApxJVL58yX7/37H8y8fuP75hv3Oieo3x8pPthfMariRKqqrmGjkwytpoGIGopCNzWaBivngqgyomI+qLkgLtRvX466NSfvWVNfWjOv0fPfZpdCZ5cjZ1aHtQ6PnNsYA965fwn7k+Hz42BxQuv/XaL8x1bMx1XNosvvQZPehKS9APgD/6rhrZcy5MuZcHO0C4F8Ycc4Pd80Odc0Mdk4PdAB6mv+hkGkw2D7st44EbPGANdZrDvtMAW9bwGPye019Xa3AZp6erhZgmM/ravE4m/8L+B3t9ZbW+l/BD5Bfb3zS26vTaXQ6nVarVao0wN4OoMNPrtD8Cn4gku/CDxTzgaoeIOCnVKaSylQSqUosUYolyt3/hTKVRK5Rqww6tfEZJjaFjkphYiB0LISJh2Zx0CW5xKJcnCgLLsyEVWVAqzKg4myELA+tLMCpiwhGAbqljNwpY3pUbJ+C3iOj9MlJQRU1pqTHlPSwjBIQE/qEuIAYF1WQBzX0qJ4a1pJDGlJIQwhriRE9MWogRfREvwoTUOHCWnJMzxisYcbrmMMN9OFG8pSeMm2gThuo0zoKoHk9bcFAX6inLdVTV5vph1sZJyzsMw7Oha7USy7+RRd328k+6eKc8HC3e7Nu9Je/PyB+N1C+KiZZMvdpWb9x8faMZkBiGUgvH+xm7Q9xDixkpZwuStksSoinJ7t4KVF58gk/+NQQLKxK0mNf0KP2GykHJdi9hcgDGbC9IgSsBLZXgPh9HnZvDjKJl7gvM+mFCtwBFTnZQAM10UBmKthMgtYT0VU4TCYKySLgUylkHp3KpZLZNDKXQeUyaVwmLZVGTqWR01iUbB49P4MpyGIC1/7SnNSyXE5VIUdWylWU87RVWbXywmZNZWutvKO9xu+yDPZ5xmO988MBAP6zS+Fz65Gzq4Ezy5ELa6MvrcbfPtH/7fXRP32z+vjTmdtvRT97xXf7mu/+9e7PdsxvrGlej1XcnFR8c9b6l1sDP78R/nzL9Mak8mp/5c2ptj+s2O/v+B9eCTy4Fvj+7f5//nrp/ttDN7y1J1oLXh9XPnjR/t1V+9cnmq8GKrYaMvrLYIebOFdDJR/Oyj9fM3w4r3klWnXOW3JjqfqPN4P/5178n7/0/OVD6w83mt4/LL4QSz9kyhtRMaNial8loyULI2NCK5iwEjYqh5kk4CRUZYBlGVh9Pq+nTrMUcxye6jgx2Xli2n1ytvv0QuDMcuzs6tDZ9ZHt9XHArntrKbK5EDk2Fzo6Gz46Gz4yHfkV8+sTvieadK9PutcmXGsTrtVx58pY1/Jo5/Jo5/xwx8JI58JI58KIcy7euUv+bL99th/w6rRN9FvHoubRiCkeaR8PWscClmG/dbDXEuk2B71mv9fS4zHvwt/d2dztbPn/hN/eVrcLf0tjDQB/Q72xoeaJdT/Q2KvVajUajUbzhHyZXPk0/FKZWqLUS5R6iVwH7OoFyN8FflfAGh+xWC0WyQFJxEqJWAns85NKNOVShVCilMrUCqnmGToeRMGkkDEgAiYFi04kU0BMLoTOTuZyEKlcJCDgm5eK4vPQRekYcT65ppLVLuU4pFSXlNinJEc05AE9O6ajRzTUkIocVBLCalJMRx4wUONa0oCG2K8m9GtwAzrCgB4X0+OiOmxMi+jXYYcMpGEjbaSGOlpHGW8kTjQRxo3kiRrKuJE8ZiCO6gljBuKUkTJTS5tuIM82URZaKKsm2hEr40QH87Sbfc7DfdHJvOTmnOvmnelJuxwU3IpL3o+IX7Xl9ucm1LJ/V8f63WBG4kQWxM2HdHDAMRZ4lJe0ngs+WZy0LkgI80FWDqRHnLjmTTwVgw6qIc2khEZMYi1hvwjxXAF8TwZsrwQFq0QeLIE/WwR/oQgOykpKzEzaU4w+oCKBamkpDmZShAUaYSGiHJyJhpURUZlUQiaNnEElcUk4NhGfSiPzWHQei56dys5gMzI4tKxUWg6flpNGzc9kFOWySrK55XncqkKOqJApKWZrKjNr5YVN6opmo9TRZuxzmgf7PGPRnrm4/9BsZHNl8OxC6MKhMAD/xdXRy8v9b22GHtwY+evtpccfjn1z3f/1Fd/D6z2PX+v5+rz51pr69X7xmxPKL86Yf7oV+tMf+h+/1XP7XMt7y4obMe21mPKDpcZPN01fbnf8cCP6f3+5eufl0KU28bSc/tKA6PvXfPevd76zot125pxq5h1tQ38yL3twov7TdfWd0w1/vuH5663ev9zq+dNHY//r2+l/ujv8+BPf/ZvWb6+0vbeufilWNNOaG1HQwlJGRM61F5A0HKiYBS1nQQRcUD57vzADpMjGqTKZFlnluLdlfcxxbLTj2ETX1ozv1HzgzHLszMrg6dX46ZWRkyuhreXQiaUnLj1HZkKHp8KHp8JP4vwv2K+Ne9fGvatjnrUx59qYc3W0a3W0a2Wkc3m4YynuWIo7ZgZts0P2ubhjLt45M+gAbvvTAx0zMRugyZh1ImoB4B8Jt08GLeNB87DfPNhrifRagt2WXq/F5zEHXO29zif8+7qafV3N7q6m/+Lab22psbfVWVrrWxuqmxuMLY01APz1Rn1dta7WoDfotTqNVqPRqNVqtVq9C79MrpYrgMu/VipTixU6iVIvVeglct0TD59/G+p34z+ww1MslkokMolYIZUopRKVTKqWSdUyqbZMrKwQK4VCpUiofIZKSiHhkwk4EAqTBEXuRxIP4hhJaMZBGA2DYOCQTDyCgYNS0SASIoUITyHCGSwsj4vLS8cL8/CGYnxbFc4pwfkUeJ8C75Xj3FKUW4pyyxBuGcIjR3oVyKgUGZEgIlJYRAYPK2BhBSyogAbkkH4tdECHHNRhBnW4fg2qX4sY0EMGDeCwAR02oMN6VFCL8KthQTU8qkcPGHHRGtRALSbeiB1rwcy04xetxDU76VAn6byZuG0nn3KxNl3sbV/m9VD5VUfeERnWnfo7DfW/t7Kfm8kBT2RBTJwUKws6wUZPppoK+okAACAASURBVIE28qEnS0CrhcnBNFgrG+asSJh27Nnw7huQJbeTU5oxSfW4fVLE82XYhAJ8kggBEaESymHPloKfK4OCCsGQfGhCEfagHJ9cQ0rsoBwYZhxc4UKX0vEhPqmFgxOwyPlMUiaVwMEjmTgUl0xMY9Iy2Iw0Jo3PoGZwaHnpLEEmKy+DnpdBL8hmlOXyhIVp4kJulYAuEjDUFRlGqaBBXtJULbG3Vvd2mQZ63aOR7l34T8/5d9ZD51YD51ail9bGLi9F3z4eeHBj6B8/mfzhrfA3Lzm/vdzx+Krn51e67pxueH9JdnNEfmtO8/HpltvXO7971/uXTwN//bD78bX2T6ZUV4OF1+Plb0zL3t2o/f5a8F8+X/v8TPcZY2EkH7rVXXj3mvvLFy0XR0qPtrN2LJlfrYv/+KL5s8OGiwPF7x2t/8c/DPzvu6P/1/34//pm5e8/mXj88eBPnw58/07gzqXOdxeMF7qLRlqz+xS0oJw5qEl3llCqeVApG1TJTCnNQBRyD4oywcocvJRHqSvJi1qNy4Omw3HbkbGOzSnPL/DHTy7FtxaHTq6EtpaDQIXvyEwAIH9jMrwb6nexf6LRrpWRzl3sF4fsi0P2hUHbZMw8PWCdGbTNDDqm+m2ARd9Uv2M6agUEwD8eeQL/VNg8ETDH+0yDvZZonzXUY+/1Wr1uU8hj9rvbe52tAPzeziZnR8N/UfCzNBttrbXmlrrWhuqm+upd+BtqDP8R/FqF8omB76/gF8m1u/ALJf8m5u8W/IFHPgB+uVwplyvlMrVM+oR8qUQllahESr1YoZNKtTKp9hkKGkTFQIkoEAqaBIckIeBgJBIOR8LQGAgWB8Ph4Tg8HIOFojEQFBqMxkDQWBQCj8DSMYw0TG4eUluBdkhRXlFKpxRnkZDMEnKnFNctgXZXJTorwVYhqk110KxIdEgTXeJkjxjslcKdUrhNAvHLk3uVEJ8a7tagPVpMjxYZ0MBDKnCvJKlHAe5RYzxqTKcC4ZRBepSQgBrcrUIGNagBPWqiBrXUiD7WjjljxV3oIOw4sOe6sCftqBd97Df9hW+5BJebmXPlzxuYICX92YHUg0f5UBdrb3PqvlgmaJyfMM0/uJSbsFaQPJWb0puaYOLtay7e36o84FcldxTvbeb+vpay10BOluJBRZjkXFRSFmJ/HvxACSJZhExRoBI0qH1a7LM67G/lhANKLKieTm5NI7fxU1y8fROpSYcY4AAVV8/AZtExeAqWQiHx6Yw0FoXFwGTRiFkMUjaTnMWh5vAZ2enM7AxWdgarIi+jUpBWVcgRFjNEpXRZBU8tyjPIyuqMwvYWjbezJdbbNR7rWRgJrk9Hjs5HT6wObK9Fd5aC55Zi22tjF9dH3jzW/8252B8/HPvp5uCdy55vL7ofXfbe3en6atv6yVbrB8frPzxe/9lW8+1t870XO7971fv4ndBfPo3/eKPj02Oa1+KCmyPl700o7512/fnNmTc2uhZFlGAJ7EJc/eBK4OOjja8N5t2Ip39zrOqfX+n9aKXuQqzyyrT+9pXQ//xy7f/5duOfvlj40+fjf/x47Kd3h358K/bDdf/ts9bXpiWn+/jjLeyAkhKUM0fUvCEJ1ZoLKWXsT+fAKtMQoixIZUaCPB+lLqAbStI9DaKpQP16f+ehuGtzsvvMYujUYmhz3n98wb+1HNpa6D0x37M513t8tufYdM/Rqe6jU91Hp3qPTocOT/YdmvCtj7vWJ7rWJ+xrE9bVcdPKWBeg5dHOpZGOhbh9fsg2N2id7u8CNDPgnB10zQ66pmKd42H7SNQ+GnOMxhxjEfto2DYatI4ELCMBy2DA1t9nifVaQ92moK9991W/z2PudZt6XO3dzjZfVyuwk9fT0dxhbeiwN3bYGx3WJoulwWSqa2uvb22ra2+ubmsytDRWA1v6gAH+ulpDbU11jdFgNFQbdPonvl0qrUalVyjVu498coVWpTaoVEa5XK9QamVytUSqEklVQOZfKdaUC1VisVYs1j6J/yK5WKKUKzRKlU4oklcJZSKxAigZADu/RGKFSC6WSOUqhbZaXfcMFQOmYWFkDASLAKERYDQKhkTC4XAoCgVCo8G7wmAgWCwUh4PhsGgUBo4iwcl0WFYaRFuKdMlQfVKIXYRqFWKaxQS7FO+RwDzCZEcVqK0KZZFDbBJwlxjqE8H7JMhuMcIjgTslMF9lklcE9ipQ3Wp8txrvU6J7ZfCAFNojhXXLkV4FyqlAd8pRLiWqR4sNGvBRA2GgmjBaR5htJqyaiSc6yRe6GS8HOa/2pL/Sy7/oS30tKLgVKL9uzd3U4Aezf1PPSjHxDsxlgg7xQC7WXltq4mAmbJiftJRx8HBR8npx8mhWgptzoJF7UJ+9R1Xye0vl3vqcZ/XM3xsoB/QUsJIAq8CAChFJxag9ZYi9IsR+LTallYK00eF2WoqFsr+FndJEgbVQsW1MdDN9v4P++wHmgVk6aDyD6c1gqjnkDCqGQUSzyFg2BcWmIrPplFwWPZfLzOEwMtm0TC49O42dn8UrzkwtzeFWCFhVRUxRCVNeyddKBEZFWZ2x0tys8Xa2RHs6x6Ld88OB9anQkbnI5nLk7GpkZym4vRg9uzq6sxq/cST61dnoz++P/Hxr6O5LvnuXvT9c6Xlwyf3NjuOzM6aPt5o+2Wz8bLPpm1Ptd8/b7r/U9d3r3T/dCv3xVu9P17tun6j9dEnzh1n1nRP2b7d7TgRFE2XQ5XrWxycc318PfXG86etDurvHlI/O6d+dUb7UX/biqOzz855//GTxf369/g+fzv/5o6l//GL6zx+PP7418PB6390X3Z9tNV8dr9r0ciea2QElKaxkj2r4I3JGZyGyip2Yy0VW8OHCTHBlRoIsD6kS0DQFqV01FRN9tev9jvWhzqNjnpNz/pMLwc15/7H5vs3FwIn5PoD8o1PdRyZ9RyZ7AB2eDBwa71kb86yOOlfHOlbH7CujluVR09JI59JI5+Jwx+Jwx0LcMTdomx2wzvRbpmKdU7HOXf6n+7smox3jYftwxAZoNGwbCVlHApZhv3nYb96FP9xjDvraf2nvbe/zmP9D/rvsTV32pn8Df1tda9uTSf6nt/QB8NcYDcBUj16r02m0APxqpUap0gC+nTK5Wq7QKlV6pbJaLtcDlX/pkzkfjVCirhRrKkRqkUgjEgHFfLVIrBBLlFKZSiZXC0XyyiqpUCSXSFVSmRoo+0llaolSKpMr1UpdtbruGToBRsNDKVgoHgXBY+B4NAKNgsFhEAwcjIaBUNAUNAyERUDwKBgRgyBiECQsCo2CoTEwAhGczk7RFcDcYkRAmGwRQuorYNUVqCYRxiaG2SuT28pB9RUIixBnKkPZypAeIdYnxrmrkE4hzClGOIWwTiGiU4rzqGluFbVLhvfIsH0qvE9B9MoJLimuQ4LplGK75ASXmuzV0YJaQlhPjBqJQ/X4iXbyUif9aB/3VDT9nDf/lDf/uDf3xWDlW32ii41pMyVQD/tvW5kHolmgw9ngOd5BD2d/Typ0LAMzmAk9lL1/swy0VHggyH/Byk40cpKEqc+Xpv2tMvc5Ke/vJLTnVOSDOgpMQ0LI0JAqeJIM+Rs1+lkj9kAbMaWLhuhhIoMMWIgO9qYmdNGSO0hwBw1mYxzsYu0JcZOGOIipbHI8k+zmEjRkZBYexMSDORRkBg2bzaDnsVl5qZxsNpNPo6TRqTk8TlF2RkE6sySbVSFgVRWxRSVsWUWaWpRjkBfVV1eYmpReR3O02zEe9s0P9R6aCB6dDW8uhLaXgxcWg+cXomeXR84ux68finxxOvrjO0N//0783svd9y57f7za992V7rsvOr+6YL99xvTViZYvjjXe3my5c6r9zrbl7uWOh9c8j97o/Yd3Iz++3PXtiaYv1mvunjB9ftR0oqfwbDvzrXHZj68Hv3+15/629S+XO3442/jJunjLl77TX/LhCdNf/jDzL/eO/cMXiz98MPrj+8P/8PHE378/9N1r/tuXOj4/0/bhkZqXR0uPudnjTayQmhLRcEd1vFE1y1eGV/IhRTxUWSpUmAmuSD8oy0Mq86nKPLZdXzLeW7M+YF8dsG8MOzene7bmA8d/ecM/OtN9ZNp3eMq3Mek9NOE7NOE7NN5zaLxnbbx7ZdS7NOxcHO5YHHYsDtsWhs3zcdPcgGNXs/32mZhtOmqdiljGwx0Tkc6pmHMq5pyMdgEWXePhjqGQLR62x8P2kZB9OGgb9lvjfZZ4n2XAb/3/Bf8vk7wNdkuj1VRvMtW1t9e3tdWZW2tMLcbWJmNLY/XT8Bur9U8P8z4Nv1pjUGsMQKlPodQBTf6Akzcw6iOUqCtFygqRukKkBmb4gYYfsUQpEitEYrlYogDgr6ySAieCSKyQSFVyhVYsl0llCqVMq1fWPMMkw2l4KAmdgkeDCGgoAQ3HIWEoKAgHA2MgKRhIChYKIiCgJBScjEaQUHAKGoZDQnFoGBkPyWSADHlwdyXEX7bPLALpykCSIpiyFFVXCasvSTYUgTRFyNpSsj4foxegGsuwLZXY+lJYfSmoUQitF6JqKpDVFZh6EblOSKquwDSKcVYtrVNOd8rpXWJ8pwjTIcabxcTGKlKdkNZQjmuqwjWL8S0yrEmNs9cQPe10v4Pjb+C667nOBt6MvfCCs/yEgRPJTm5nPGehPzeRlngobf8w93k/P2koHTORgY/noo7l7D9SdHAs99ku7rPN3GQlG1zC3Cfg/K4s7YVS9gul5D1icrKGAjdSkEY8zIBJMWN+20ne66Ene6hgDxkUoED7GbBRNjLM+n0veU8PGdzLQvSmwXsyQYFMVCAD35+WPJkGm0pFdTMQKhIokwjiE1HZFFI6jZbFZGazWJkMRhqVmk6j5XA5BelpRem0smyWUMAVF3LFRRxpSaqqIlMnyq3VlrbVy9yWupjXPh7yLg71HpoIHpsJbs737Sz5Ly76dxZjZ5ZGziwNXV0Lf3Iq+uit2B9vxe9f6fn2ovuHa33fv9p3/5rvmyuuezu2b063fX286ZvjTd+eaPnmZOu3Z013L9i+vuL77jX/g8udd8+03d1qvrvVemer7b3F6jur6ofn2v/4Zu93r7gfXej46Zz1oyXlS4M552KC947W/3Rz4K9fzP/p07kfPpz4/v2RH94devxm9NHrgW9f6vz0TMtHJ+reP6y/MlZ23MOZbGJEtLSYjjus441p2H4hSZ8BL+UgyzgQcRZEmJEoz0Wq8qnKXJZdVzztr98Ysq8O2NeHOo5N+jZn+44DGf60/9CE59CEZ33cuzbmWR3x/iKAfPfCkHN+sGN+yD4/ZJ8btM4OWHYLeIAA8ifD5tGgfSzkAJz5xkKO0aAd+Acw5B4K2ocD9uGAfdhvi/dZ431WAP5oj2UXfsCrE8AeIB+48Hs6mt2OJrf9iYGXzVRvNdVbTfUmU4PJ1AB0+AMrOp/s5/1lkv/pYf7d+K9Sa7U6o1ZnVCi1UplaJtfI5XqZTAfEc2DI94ktj0hdKdYIhWqxWCuT6QD4hSK5UCQTieViibJKKAOCPyCxRClXaCskokqxRCpRqRXVzzAoCDIejEMl4RHJBCSYiITh4RAcDIKHQ3EwCA4GISBgJBSCjEaSUAgCAkZBggkIKB4FJ6GhmRSIMR/RI4JHqg6Y5VB5MSg/O6UwDyYWwGR5KeIcsDAfJRRQi7Mwgkx4qQBdXogszgcV5ydXFYMFhdCcnJTcXFiRAFOYj87NhRUWwqtEhPpyqklEswvxXUJMp4TQUE4Q5WGKsvGCLHxhDr5YQCgqxAmKMYUV6DIpQagiVwrxWRXY7DJcs5a53Ja9oiA7eQdrGQlO5p4p9t5J5m/DnN8OZICm0rGjfNRoHup4ftJi7p5A2m/aU39v4KZU0UEFlP3F7L0C9v58+j4BcX8FPkFDgjTTUHYGqpOBHGAkDKWCY6mwXia4hwoKMiHDqYhJPnKM8+wAfb+fBunjonozka4MiI0PNfNQvrTnJjKSjmQhltLRTjZMTAJnYhB8DI5HJvPI5DQqNY1KzaDTsxmMPDY7n8MR8IilWXShgCsu5IkLeZKiVGVFuk6cZVQVthiFblNN1G2eCLiWBrs3Jvybs6GTcz07iz2XF3ovLETOLo+eWRp+ZTXyh83Id6+H//zuyIOXe77ZcX53tef76/6Hr/fefa37u8ud985ZvjnR8u2JlnsnWu9utd451XZ32/zVZc+3V7zfXLDdOdd+b7v121Mt98+YH513/OlC+48vWb6/5nr4Yte909bPl6tvjFZdm6z84Fjto+u+f/h44qcPxh7cjD96b/jxe/GHb0Xuv9Rz90X3V+dMn5yq+WRL/8GG+spY2aaXN9PMGjAyYobUQS17RMOISKh1GchyBrSEBZLnISTZKQD8qjx2Z3XZfLj56Ihjbci2HrcfGfccn/EfnQ5sTAUOTfpXRt3LI66lYfdi3LUY9zzRkG95xLMYd80NdM4NdD4d5CfD1qmIbSpim47agY/JsHUybB3220YC9tGgYzTo2CV8JGAfDDgGA46hYMdwoGM40DHc54j32uO99v4+S6zXHOk2Azn/buTvdrbtBnwAe5e90WlrcNmauiwNjvZam6nebm6wmRts5iarqRGI/E/v562vqwaG+X/Rvyb/eq1OrdEB8CtVOiBdfxp+uUL7a/glQPeeTiTVVIrkFUJZlUQukillco1IrKgSygDygfxfKlOXiUQVIqlUolErap6hkWBEbAoWmYhHJBLgyQQ4iAiDkOBQHBKGQ8LwKDgBjSBikEQMEo+C45AwMjKZgARjEVAcDMwnpBjzUCEFZlgFapfDhYIUDjeRzYXmpMEL0qAFfFhBJj43m5jGR3P4cE4Wgp0NY2aksNOTeVlgckYSiZ/ESIOlZmBSMzDMdDg9C8IpQIhzcbWlJEsFpkuEdMoJtWW4vDQUOxXL5BE56RRuNpWdQ2RmYRnZGFY+NrWIyC/C4nKxqExkZSluWM+arkS10Z9XMiG9nIQxzv4o+2/8vN+MZ4Kn0hCDfNBEFuhIAXQk47nO1P9ey3tOwk4qJCUIiPtLaXvzyAfyiQfysQfKsAc0RJCFhejlY6Jp6BE+dCAV5qUn2Un7XdTESCp0NA02zoMcygFPpMF8TJiZAW5lJ9TQX1CSnpeRDjbzXgikH1zPgZ/Mw85nYO0MRCUBkYZDsUlYDhnHoxDSaKRsBjWXSctj0XOZtDwOpjiNUpXLFQvSJQVpsqI0TWWmUZZtlAta9JWuVn3MaZrwO5cGfBtjfSem/afmfBfnfZfmui/Mh88uj55eHH5xOfLu0eD9VwN/eW/0u1f6vj7f9eha7w9vhL57K3D/Lf/DK513L1runmm7d6bt/qnWOyeb75xqubvd/vVOx/2X3fde7Lh3yfzgkuXBjuW7HfuPlz1/vmz5/rLt7mXHnXP2O8dNH89V35pVf3Cs7v5Ljsc3en+8GX34ZvS7m4OP3xn+7s3onSvd93Y8d87Zvzrb9OXZmi/PGD44rHxppOiYl7fQyorXsWM1qREtM66hx2TUxixkJQ1Szgbri3BqAUyeDVdmk7R5HLexYjnSemzMvh63rg3ZNkadhye6D433rI72rY72LQw5F4ac84OuuQHn3IBzrt891++eH/AALXrARq2pfsdktGMi4hgP28eD1vGgdSJkmwzbAU2EbBMh21CvBQA+3mcd6rUM9piHei1DvZb+XsdAX8dAX8dQX8dQX0e8tyPe2zHU44j2mKI9prDPFPS1B7xPxnj6PO2+rtZ/T77T1uC2NnWa64GdvIB1p9XUaGlv+FXO31Bf3VBvbKg31tXq62r1wEFQV2t8UgLQGwD4NdpqhVL79LX/l2d/rVimBsZ7KsWaSrFGJNVJ5AapQi+SaiqEsvIqqVCqkCjUQJEPuPP/ciOQiyXKcplUKFXIZDqtqu4ZMhGExybjUIlEVDIJCSLCQBQYlIaAo1EwNAqGQcOfFhaDICIT8SgIBo3EwCEcXIo+F+FXoIfUyS1SZGFWMp6SgKPDWGx0OhuRzkZm8MjZPGxaKprFQ9LTkNQ0JCUVRmJBKXQIjgMicSB0NorNwbE5OAYHTeMjKOmIonSErgRvqkC6RHCPAqcvxaTxECQunsbDsdKI3EwSJxPP4CMZfAQ7A83LxWZnECjpVCyXVJ6FHhQRxgsS6wm/kbPgfg5oKC3Jn/NsKPvZ+bTkiXTIQGbiUsbB+SxwgPtse+pvNbzniyj7BISEMtKBcsLvBZj9RdiDJZiDlZj9WkKCjQEKpEIG+aBeHryLndJE3FuLedZE2RvigcfTwFOcg4dykSMZaBMNoiEdlJGfF+L/phT7t+XEvRJGUhMzYZAPOp6F2MpCxbnwagYkhwFmk5CpVEw6A5/FIGTTCbl0Qj6TVMAk57JRxemkqlyuOD9DLEiXFaVpqzJq5Fm18vw2Q6WnVR/tah/v61iIeTZGfMcne8/MuC/MeC5Ouc/NBM4sjZxaiF9cCL611nf3Su//+GD88fXQnYvuH14L/Hgz+uhm6N7NwP2rnXdfst+7YHlwznzvTNvtrabbp5q/2W67fab9wSXbD1c7H11zfP9q1/fXPI9e8nz/ou/nS10PLnZ8fc5x+3THt0etX6+1fHG09Ytty4+vuh9f9z16PfD9G9FHbw48uhG790rfnYvuu9uer0+bvzpdf2en5s5O9R+OKV4eLT7Rk7HUzhlt5PTX8sIaRlxDH1IxTTlYCRVawYHUV1INJWhpJlSWgQfgXwq3HBuzrcfNq4Pm9eHOtRH3cty7OORbHOqe7e+a7e+aiXXORJ0zUedM1DUTdc3G3DODnVP9jomobTxsHw/bx8Mdo0H7SMA23GMe6bWM9lnH/LanNdRjG+y2DvgsgHa/Iz5rtNsW67EP9NgHeuyD3fbBbvuAzxbpbg/72kLedsC0A+jkB/Zw/vvI77I3emzNLktjh6muw/TEt9fSWt/WXNPWZGht1APuPU/DX1ujq6vV72YBtTXVQAqg0eq1OqNaYwAe+YCCn0ym+6XbVyOWqcUyrUiqqZJoK8WaKolWLDcAnf8VYnm5SCaUKaUq7W5vH9AjJBIrgIOgSqESylQymUGlqHuGiE/GYRLw6CQKFkxBQ0hwMAUGZiKRSCQchUIAQiLhSCQcg0HhcBgC6iABCyHgsXg0io0Hq7LgHjE0LNnbIITlpSUg8AkwEozKwHIYGC4Tx+fSctnobC6Gz8OyeTgaD0dlYykUBBEHJTIhFBqCRoIz8CgmAc2komgMFJkNK8hC68uIliqkWwz1KDDaUjSXh8RySQw2jMND8dMxqXwElwtN5YDT06B5WahiBoHPYTNYdBEXFS9BTmbtrcf+jYKL6WWCY9ngvtID4fwXFvmJE1mgwfyko1kJcU6ik/7bxtTfyHjP5xKeExAOiGgJlZjfFCMPlmGSKrCJQswBHWG/hXqgm7kvxHjBloZo48Fr6Ik64gut1L0hXspsBmSZm7DAg4fYiFpSSiV+fyXl+XLy35YRf1/FSCykoqUUcBcjcSU1ZTsVMsdJbmDvz+bsZVPhaUxMNoeQyyFk0TFZFFQ+A1fMJQtS0aWZFGEeX5yfIcpLlxTw1BVp1dKMOoWgvbrK22aIdbWP9zgWws71uOfomO/UlPPcZOfOeNfZqb6zC8Mn54fOzwauL/vuvNT9Tx9O/Hwjeu9F389vRv7+3YFH74Tv3grcfbXr7hXH3cu2hxesd8+03d5q+vpk0+2zrQ+2TQ8vmH+82vHzG+6f3/T9+Hrvw1e6v3u57+G249551+1zzm9PO+8ec9w9bLl3xnH3ZddP19x/fNP/p5v9j9+I3b8avPtS993L3ruXXHfPuL460fbVydr7F2oeXKr5eFP1ynjpmWDusok71sTtr+cHNbS4hjqq4dgFRDkNWsmFNouZNeU4cTpYzMeoc1iu6vKFYNPRUevakGllwLQ65Fge6loYcM3G3HP9HqBKPxntmox2TUS6JqPOyahzKuqZjNknorbRkHkkYHmCvd8W77MO+drj3SbgCABOgdE+60ivZajHNuCzxDymmMcEYN/vNcc8ppDHGvbawl5bzGuPee39Xnu/1x7z2MK+trCvLehp83ta+9wtu/D/qtS3m/P7HK1ua5PT3NBpbuyyNNnNDabm2pZ6Q2ujvqVB19xgaKrX78Lf2FBTY9T+wj9QAjAANp4arV6jrVap9XKFRqHUqdQGAH6VGnjt04hlaqDPTyjV7cIPNP9WShQVYjkA/y7tgO0/cBZIpCqhUl0lVYrFWrnU+AwXA+Li4CwMmgjDoKAYOAwDgaISU2BExB4Scj8FlUxFg6hoEBWdRMMepOMPUtFJTDyUTUAx0OAMEkhdiLEp8HY5WFqMzGQkktAHKDgQgwqjkWAMAo5LZFPSwGQ2mEZHptKJPAaJTcfRmAgKB8qgIOhkOJUIpRCgVCKMRkIyKGgmFVOVBjMWIe1SqEeV0qmA6oug2UwEg4BNY+N5T0TgsQk8NonHJqWxSBQqnsBiEln0Mh7BmQd381/QU39bxj5g4qd0ZyLimcgpHngmNXEiIymen9xfnNTNOtDJTanhJpfR9+eQ9+dSDhYQ9heh94ihe5TQfY2YRA8NEWKjQiyon57Sx0jqZif3MRK8tP3ttAQjI8XCTplMPXiRt/cUD+mlgQSEBDp+fy5+n4qwv5EKaWZjK9LIhYRkHSWxl48a4CJ62ZA2DlzGSilHI7MwcAYRTqej+SycgEUo4eKr+KTyLEZ5FqMsk16eTRMJ2KoSfrUwp04qaJQWOIxiv7l60NU06bcuD3o2xnsOT/SeGPWeHO/eGvWeGet+cS5yZT760nToykzoy9PhP78589f3Ju6+4nn0Zs+jt/0/vT/44K3od697vn/N9+CK65sLtjvb5gc7poc7LQ/O1d+95Hpwxff9jeBPNwf+/p2hn94aeHw9/OiK/8GO7eFO58PznrunPbe3Ou6cg3UMDwAAIABJREFUtj28YP/x5Y6Hb0Qe3Qg/eLX7/svOB5c7Hu447p2y3z5i+ni+48Zo4weHrfeudX1/y/TRtvjmasXlWOFRR9pEMzdSzYnqWHENdVhF8ZXha1PBogyYtgShEiQqchJl6XBVPtXdUDnaW7M4aFoasi8NuRYHfLPR7pmIbybim455gSrdVMw5HnWMhMxDIdNw1DQ2YJ2ItY+GLcMB+6DfORRwD4WcA0FbxN82HOgY7LXFfOao1xTzmQd6rAM91v5ui99l87tsfW5bwGvzd9v83ba+bnO3tz3ucQx6HDF3R8TVGfZ0RHps0YClP2Qecntjnc6Yyx11unpt5m5HS8Dd3OepByI/IG9ni9vR5LQ1dFnrnY6mTkejw1Zvt9ZbLHUmU11za3Vjsx6I/E31+uYGQ0tjTVNjTWNDTX1ddWNDXV2tEYj2QOVfp1WrVQqlUqlUKlUqlUaj0+kMOq0RMPPVaPVA8FeqdAqlTiJVSSQauVxfIZJWSeRCqQKQSKaUKNQylVYsUcpkCrVcoVVItQqpWq5QKtVKlV6oVIvlKqVcY1QYnmFjkxmoFDwkGQ0CY+FoHIaIRGFAYCgefpCISCKjoBQ0jIKG/L9kvVV0W3ma7l0X35pzZqoLkhhk8WbeYjIzBQxi2NIWWbJkW7ZlSzIzxLFjSuKAw1CBoi5m5hRDd3VXV1WwqlJJdc/0mTnfXHxrzXehTGbWOWs9F1pL17/94v95abiAQfMUeC4LC9S4TIeDakhcTAg9VXCfFe2zFFjrwBJVPiHbRkIFLCXOwq9GlYhagDACgpCoCDTrbEWzckYlZ0kZhYlJVMIQchWNZu9bKkh0u07irQaSZvmwU5Z2gFwNUKKUK1DMqET0SlinQnQaTKfB9GrCoMT1DMpSKKFgUBovVwKxYlGP/kEb+T+qiAdDqq19urwZvWBNl7ehz10vyl0o2TZe8nCfKi+qzLWxOZXkw0b0wUL0wTL4oSroQTOUb4fygriwVyEd18lnjcCCSbpkkgyr86d1+dO6/D61IKQUdKly17U5z5q2PWIAOth8NfogDW9pQfNSuGiIlvSqZG4d3ohsa0YfDCtyu+itCSqnSyUOa8S8jm5SyEuJHBO2pYzMrVNKtxeSzVWaHYX0jkJ6ZxHTXKawVGlcDSa+qSTYWt5uq+vzt050cbtT4eWR9gPT3Yfnew/P9x6f7T2/PPTk/skXjux+4+Ty8wdnL+7OnJnqff9o/0+vLv+vz/ZffW34+ltDP30wfuezPTffn/vlveGf3hm+8frA1Rf7rjzbnYX/2tPBK8/333h1+Od3Jm9/NHf7w92/vDvz8+uTN14avfZs77Vn+64+nfnhifT3T/T98GTv9ed6f3klefPt6ZtvTV5/bfDKC8krT3dffaL7u0c6vznW9ua8+9GBHc8uOr7+feevH6f+8rL3o1M7X5gvP99XuB7VzXg1My7lPfh5bcF2vchWKXNUCWylgiad2FOlmO12nlrqOr7YdXxP79H5/oMzqQNT/fun+g/OpY8sZPZPpffPZPZN969NJvdOdO+d6F6e7l2b61+f7lmd6F0aSy2NDiyNDe+dGFqa6F+Y6N0z3L8w1Ld7MLkw1LdnuH/PcP/iSGrPcP98uns+3T2bScwP9swPd88Pd88MJaYG43uHYkuD8cXBroWBxPxgYm6oc34kPjvavjvdOdMbn+3rnupLjHTHhnuj4+noSCo42BfNlv3ZyH8P/mQi2NPpT3TyXR18Rwcfj/ujUW9blIuG3JGgKxxwtwU9kZAvHMoW/Hc9/LLwZ5W1780u+We3/Vwuj8vpzZp5O5x373ba7G6b3WOxusxmt9XKZc94t1j/y+e3xepotTmbW2wWsyNbNnhsNpfNbre5bXZPq81pMTtcVnfAwd+nhLZRsm1wwTagIB+WShEIhiBAIhPCwgJEJMbEckImJ2QSEhDScD6L5SohoQaValFIA4pKcSFXDiZboL7mPGcjVK4WELJcHCigCAlDSGkMVqIsRAphTIxhMgZHGByhUJAgZDQLsAREoSCFggoS1atYg1qhpmkaRetUYq4S7jOj4xw26CJ8tVipElGglImG9CykVkIqDarWYjo1YWAxAwmziBwnMQCDNLTYbZK0G/Pt7MM1xDYP9j+7VVvnTcL9RQUbpty9pq2Tpoczhgci2gIXm1tHPFSEPaRDHjSAD5RBDzag23aB+a1wrh3N5cmt3crcSVPBUol4vUQ4qi3YYxDtNYmHtIIwkxNnt67oc54tKzhqFPPMVhK8XwNujeOyAyy0oZZPaQQxNWRFtuyCf2elH3bhDwSIB3tUgpRW3GeiurTyDtW2DuWD7cqtfo3YaiSbSrWtRqqlkDYXs/Zypbta623QB3YWhptL2u1VvfyO4ZhtIuGc7vXM9nnm+rnZPs9iOrA+2n5oquvITPfx2d6N4fhCwjsbdz0x7//T07P/+4vD194c/eGNzE8fTP7ty70/f7j79uXJW++P//zW6E+vD998KXX12a6rT0evP9N29YXUT68P33pv+vZHc7fen7v51uSNV0avvzhy4/nU9WfTV59O//j71JWnUteeSd18of+XV/pvvDlx/dXhH19Ifv9U53ePx7+7EPvyWOijde6Zse2H2gxHuqveOh65/cn0Lx8kv7xgf22l6mKqeF+7fsannnEpsvAP1kM+TV6dSthSLHHWyG1lsh1qUaBOe2gk/PzRwUfX0hdXBs4tpU/O9x2d7j401XF4JrY5Fzs01X9wsu/AeO/aWPfqaGJlrHN1vGttIrE62r081L13qG95OLM6Org6mlkbT61P9C8P9a0M96+OpFZHUivD/ctDfVmtp9vX0+1rmfZ9g+37h2Lrw7HVwehypm192LM+5FsZDO5Nh/ekwvP9obl+/1y/b6bPNdntmOj2jncHh7vCw73R0b7oYDKYzfPvLfbdg7+7g++KeTuinng7F2/nYjG+vd0XjXrDfkfY7wj5Xffgz+b595p82UM9/yWOc7vdDofDbnc6HK7suU6ng7M7XNn5fxb+7Oaf1cqZbW6L3WOxe1rv9gLtzWZHi8WZ9erjnC7e5fI5nR6HMwu/3eZ22zw+hy/sDt7HwNtoMI8EBJhMDMvEkEwMyEUAUADmy+ACACmAECGICKWoWIjLc0loGyMXKECxCpSppMJiJNdVJO7ZKUluf9jTCFZphLQsH5OJSUxO4TIShWiUxAkIwyEChxkCpTAYR+QECtAEqCAxlkBZHFdRlJZlNYyCxUkCQmoVMq4S67cQExwx5Kb5OqJMSShRRSEN6WlQxQAKFaxUIzoVbqBRIwGrITFDoDCBMIS0Xit2GcUWlWg7K3UB/9CnylktB49USNcKcya1D/TpH+g0bXHqRI10TinykBHdakC2FIEP1sFbzKRgB5izC85pQh6yIP8You8f0m1ZKspbL8od1woXDcI1g2BCnRNjtnSx25aNwicrJQdNonZqa4X8oR2AYJiFTxqw4yb5kiEvrhLx5FYfkxPWCENsTpje0qXK7dMKZhTyZY34WKHwTHH+hil/RC0KKBGrRsWVsFwJ6ylTcOWst0rJ16mCjdrQdl2otTjmKO/x1fUFGvtDjclAfQ9fnfBWptt2ZNp2Jf0NXZ7abnd9h7263VLVYa890t/yyfnRf//m+I13p797NX3z/Ym/f7Vy++PF3z6bu/3RzK/vz9x+d/rn14avPtfz49PR689Gb7w88Mubo3c+nPnt4923Ppi5C/9Lwz+9NHT9+cyVZ9JXnklfey5988XMTy+nb76Uuv7K0NUXUt8/1fWnR6Pfnm/7+lT4w/2eV+ctT45WLPvYOU736AJ34735v3068dVjrrcO1j4+WHogrp/xqaed7B4HsWjDB+pArzq3TindaZS461B7JbRDJe7YaTozFXrtaN/ji92XFhMXdnefm+08ORU5Os4fGndsjFo3J4KHx/wHRnz7h737Rrz7Rrxrg97lQW6hj9vTz+/NBPcPRzdGYxuj0Y2xyOHJ2KHR9sNjscNjsYMj0f2D4bV0YC0dWM8Ejw5Y72rIdnTItjnkODxgO5i27BvetZppWko2LyRa5+Lm2Q7rbId5tsM81V0z3lE33L59IGoZiHtHe6IjyVgmcbe9l+ltyyrb7e9PBHvivs52Lh5xxyOeWNQTj/qiUe89+P975L/X4bsHv8ft5DyubP7v9XrvwW+3Ox12T9bJ32pzOJyc0+XNwu9weh0O3mrlsuT/3/A3m102u5tze/2ch/e4PS7O7vBY7F6v3etz+IJOf9gdvI9B82i4gIbEFCTHQBkMiEGZAJTlwUIQEcGICEVEMCySwyIxKivAgXwSEJKAmJXLlFJhCZrnKhJ3Nxb0NtzPNcprNCJGLkQlUhwGcFxOICCBoAxOkzhBkThNYQyJEChAoaCKQBkMY3FcSZJKkmZxksEIGiVplKxTglwllmwlxtzEoJPma6lyFa3ClCYa0tOghgGULKhSQDoW1VOIgYQNhFzPUgxDEQRgoERVrKiOktTTQBjNGdSKlkrlK8WCad2DSc0DEcMWX1H+do2oFN+iB35XCG0pR3JqgYda4C0+Ot+OC5xknoPcypEPxBUPjBty9hbn7SvMHdcKl/WCQ0bBoi5/UCdI64XLxdJHyiWbJZIZpagTFiVQ2bQG3F8K7i8WLuq3RbS5cUVuWiOeNMBDGkmPIr9TlRvT5S4rpUd14kuFggumLftVD2TorWEV7DMZYzWaSLUqXKngK2hvJe2tpnx1DF/P+nZpAy26Nqup3VHc7igMW/SBVpW/RRm26CM2Y6BF592p4XZqXY0aR53G3WjcE61/9Uj/v31z6taHi9+9MnDjvfG/f7Xy18+W//rFnjufLPx2ec+dD3ffemviygvJH56JXX02dvPVzK9vj/720exfP5n/9cPZn96e+On10Z9eHfvltckbL49ceT595fn+6y9lbr4yeP2lzNUXUlef7fvxqcSfH2v/4/nQ16f9nxzxvrHH+vTojrP9mt1uYqCFPZS2fPvCzN8+3f35JfebB2ufGq08nCic82unneyCHd9jxQbq5T5NXqMG2mGUuetxWxXSrJclzYVnxxwvLLtPDLWcGDSfGLQeHbQcHWw9Mrjz8GDDocHqo6P1R4ZrDw3VHRpq2Bhq2D/QsNpfu9hTORWrnO2sXulvPDTasjnesjnStDnSdHy89eS4+eS4+fhoy+bQrkOZ7RuphoPpxkOZ7acGS04NlpwYLD4xUHp8qOLoQNmRVNlGX/FqqmKpp2IuVj4RLBvjKyb9lTOhmvlI7XSnaTxWlAqU9PrrBtqdY73tI8lYJhHtTwRT3aHsJyBLfl9XINnpT3b6e+K+RDsXj3jiEc+9+zxtAWck6PpPu37ff+v2e/+PyO/zengf5/F4XC5XNu13OFzZAx5Wi9Nitd+L/Fab2+H02u0+s9ndavVklR313zP8bLG47Q6Oc3v9nJf3cG6nx+7gLHav3+UPuAN+T4B3++9jUDEOFKBSEQnKaRQlERCRCwFJDi6T4zIQl6KYBEXFMCoBcZmcBGUYLMFAKQnKFaC4jCxwl4q7dwiSO+7n6iX1WrESkGJSCINADAUwFMBQmEEZCsNJAqEZhGEghgRUJKynMAqFGBxRkBiDYRSCUAimICg1zdarAE8F3NOMDDvgASf5n5Gf1TCAjgF1DKinIT0NaSlYS8FaBlGjQg0JKSmcwmAKk6owSSEhq2DQmBrq1QBDWsGI6qEBzUMJQw5vEpqNkgom1wj/zii7vxLasgPJscNbAsjWTio3zOS1sbntzLYuduuAeuu0MW9vYd5aYd6UUXTAJDxTJNoskcyXyMeKgYUiyeFi4dFy6UEjuKJAF1hgQS/eU5K/uyh/RpvXZRJmdMJFHXDAAO3RSAaV+QlNftwo2mOQrRrE6/rcOfUDCeofXMT9No2cK9MlGvQd9epojSJQSXGVmKcSc9Wg7lrMu1Ph3anwtyhDFk3QrPI1MdxOittJ+Laj/ibKt4Nybye9O1XOBoW5mjFXM8Ou0vNzoTufHLv9yeoPrw9ff3fs71/s/ZfPVn77cumvXyz99bPlOx/t+eWtqasvpX94ruvKcx03X83cemvkzkdTv308d+fy7K33pm+9NXHrjfFf35r76bXxqy+lr77Uf/3V1I1XM1deTH3/XP+VJ7t+fDz+5wuhr0/znx51v7tqf25i5/neqsMxfM5NpprYvZ27vnpm9n//ceOrJ4Jvb+58bqr6aG/RQkg37aTnrPBuMzxQLw8Y8nfq4R1GmaMeM1fCZpN00G44k2l4arLyVKb4RKp4M1lyuKdkM1l2NFV2PFNyYrD46KB+c0C3OWDYHCw8MlC4v9+4nNDuiSvHw8q5mHq933B8vOzUROnRQePxgcLTI2WnhotODhWeGDQdyxg2U7rNlO5YxnB8wHhigD2eYY6m2aNp5Wa/8lCfcn+CXe+k5zv101H9WFA7wmlH3LoxzjDtN82FCqfb1eNhfT9n6PZUDcVck/0dI32dqUR7fyKY5T8b8Pu6Ar0dfE/c198Z6O3gu2PergjXEeXiEW807GkLuqIhdzTkzj7syW74/eec35et+e+J93G8j8taejidTqfT7XS6757uMjusNofd4XE4ObvDY3dw96YAWc6z/f//svqwelptPquDc7t8d5sJDs7q4Mx2Pks+5/G73L77GFSOSkWwSIzLQAbGKBBCpSJInIcAAkQuRGQySAJAYggSQ6gcxkEYQmUgJEVBGQ2Ji6kCR7kwsUvQu+N+d7WwXitWQ3JCimIgimIgigEoCisRhkIwHAMJRkqxEoYSq3CZnoAUJMwSCEsgNAbRGMzgiJIk1TRdr5a4yoCunfIhBzjgxPk6vFSJ0BBO0VINAxQycBmNlpCwgYTVFMSyMI3kKhCxCkPVBM0QOEMiWgotZkiHGvGr5R0aQVq3bahI0F8CBkxIiwosprYUwg+UQQ82o3k8JeqgCtJk3iidl1TmJtktGXrruDJ3TpO/R1+waBDuNQkXSoCjpfJLpZITxeI5o3BAL5rQ568Y8teLtu0vlu4zwfv0kv36vHVT3lKheFovGy8E9pigg0b5ZiGwahBP6AsG9bLhImx3ETylk2aU+SHmoSbygRryoR0qsauQ6qxTxusU0VomWEN4azB3HeqqQx31qHcX7dlBcjspvpnmm2nPDty1HXbvQHyNMn673FUns9fInA2YrQZrKkOay9H2BuVyT9MPr6/++sn6lbcnrr09/rdP9/zLZ8t3vlj829erf/ti9faHizfemLz2cubKC70/PN9x/eX+n14f/OW9sdsfTd25PHvnw5k7707ffmvyzruLv7w1ff21wWuvpq691nf1ldT3z6f+9HTfj4/Gfng08ufzwS+Pcx/st7wyv+tSqvpoxLTehuzxq5JNinF/9eXHJ//j6uk/Pd/9/knHi7N1J1Nli22GaSc9YwbnWsDBBiBcKNyhB3YWiu0NaFOZxFwoGnVrzqaLnx3TnR9kTqfpE0nF8V7V8aT2VMpwMqM/Nag7kVGfyKhPZDTH0vrNPv1Gj2YtrlyOKqbD7EKM2UhpTo0bz45pj6XY432KsxnDqYzyZFpxvJ/5P7SZog73UQd7qQM91L4uZrmD3hMh5kP4cEAxHFAN+zQjnHbMq5vwqaf8qtmAcjKkHAtqk059t6tytJObG+ge6+vq64xk4c/qHvmJdi4Z53tjvkQ7l4U/1sZFQ+5wwNke9mTn/PfsOgP+LP/+bNnP+zg/780mAl7O7fF4svy7XB63m7t3t9PhdGfTfpfb53T5bHaP1cpZrVyr1ZtVi4VranXf9eq0cGY7b3X4nA7u7pMBq8ti91ocfq/Tx3n8Lq/f4vHeR8AAKpcjMgiTY5gEgUVSSFSASIRyye/k4i1yUb5cKJYJZIAQhCUIKkOlkFgMiOSAGIOERkpgLRN07MxL7Pifzsq8erVID8OkFMdAFEEBFANQDFRjCgrBMEyGUUKSEVCkgIWFakisU+FqFmEJiMFBlkAUJKogUZZA69UiZ5m0c6d40C4bcKJ8PVrMAoQcQkmRkpaXKNAahqgkUSMBKyiQZEAVXaDCpHocNzIaDaumaZolMS2JV9JSs1oWK5KNVIIztdhwNRMx0WYWLaG3luMPN+C5HkaSUMtH1LJZlXhRmT+mzRlTbplmty1pCtb0klWDZNkkXS0BVqvxU1XQo6Wio9qcMfrBburBAcXWRV3+rOYfZ4tydpdK1wuFJ/U5ZwyCgyZovohaLSQOF2HHS+DNMulamWSuWDJbhC6WKNfKqSkt1EEKrXhuFb6tks5tUop5HdJeTUaryUgNGaolffU414A7GxBHI+LdRbu3E65GlNtJcLswZyPkaABd20G+XsA3ilw1QluVyFkHmavA7cWSxiKpuwQZ4cu/eHb21sdr196duvb2+J3L83//bPnW50v//M3aP3+575cP9lx/feLaK0NXXkp+/2zn1ReT119N3Xx7+NYHE3cuz/720exv703deXvqt/eWbr09c/ON4euv9197re/Ky33fPdv3x98nr1yKXLkU+e5c4PNjzndWW5+dqD+TKDnAq1eC4B6/qrOB6DXrXz+V+o+rZ//8fPL9E+6X5xtOZyr2Rk3TTnq6FZhpkg82yCPF4katZGeh2FYPbS8RtBYKxt2KC2njK1Pq4z0Fx3vEx7vBk73k2ZT6bEZ7NqM9k1GdSWtPp/WnUoYTfYYjPYaNDsN6TL8S0eyOapY71IfTunPjpjMj6uNJ+kQP80i//nRaebKfPdHHHE/Sx5P0sV5qs5s41IkeTCoOdCv2dSlWOti9MeXuNuWMn5n0kkkP2c8xQ7xmLGCcChmnQ7rpIDsToMd51ZhPn3Qak67qyYR/YTg52t+V7Aj9d/iTnf670T7q6Wn3dke5RMTTFeE62zyxNi4SdIX9jiz8bUFPkHf6vU4v5+B97nujviz5wQAfDPC8j+M8Lq/Xm+Xf7eayo75sw9/t8TpdXqfLy3kDHi5gs3ssFo/N5jXbfBY7b7HzrVZvs9nz3+G32L12m9tudVjNNovZYbZxFoff5eDcHt7m5Vs47j4KELCImEWkJCDGZGICkMEysaygAJPlwKIcuSAXKMiHJBJELsm2AwBxASQV4XIpIxea0HybUdxVDyS3C10mvEFNsjAEi4UKUKiGC0hAAENSCgJoGGQQSIEhCgxR4mj2h47G9AyuwGAGAZUUriAxGkdYktipk3jLpd2NknE7NO5muRpKQ2AIojIRpJGh9CpKrcYVCkhJy3WUrJAGNAhYSKGlSqxYCRpYmVYlV2hgSgMjJKohVHx5zaKl5GBr/nrrw+lGaIcCM0CwQiIqpuBKUupSyYaLkAVl3qYmb6WwYK5EMFmav7sof79esKETLBaLJivF65W5x6ukx4plC3phn25rl+b+MdU/HTJsXSvbNqL5XVzxQMIgHS3BVorhsybZUybxhVrZhQrxExXSx8qkZ4okh8vgpQpspAhIm8A2fEuIzGmF/nE7en+rMrcZ2+JhRNYieVs9G6tn2quJrga6vRYNVgLRRjRcjwfqMV8d4qmBHNWAvQaw10GuRtTXSDmrkaw/urlKZq0BrLWyHaX5PiMx0Fr10r6R3y4f+/G1oStvJG9fnvyXz1Z++2Llb1+t3f5y+afL0z++OXDl5b6rzyeu/L79xtOha0+Hb7wY//WdoTuXp3/+aP7ah7tvfrL823t7br87d+vN6RuvjF59IXPlmeQPTyd++H3Xj491/emR6B/ORD7d9L00v/N8quhYXL0RojaC2JKLGtxJd9crHpuP/+2zYz++PfDuxaaXd+96IlWxGTVOexUZMzrRQgxvB4OFD7YotzQXSe31qh2FqNMgXuRVj40aL4zjR7vw493kqSR1pp85l2HODzIXhpiLw+ylNP1IWnEqrTncp19L6PbGVUvtiqV2xd4QeaiHvjiteXxGdyrDnuhjzg4ozwyQjw9rLqSVp3uZk93M0U7mYIzeiLOHO9UHOpl9cWI1Di9EgakQNOpDB910yqlKu4wjnHY6yO4OY7vb0LkgNs3Tk7x6LKQb4nVJp77LYhoMt072RVKJSHdntL8j2BcPJGP+ZEcg2RHo7vB3RLn2sKsz4k60c90xb2e7tz3sagu6wgFnOOAMt/kDQc7LW31+SyBkD7W5A0GO93v8fmsg4AgEXOEA1+b3hn3+sMcfcvNhDxdye4Iuzu/mAh6ed/t4t8/vCbg8bpfH7XS7nC7PvSzA6fI67FaXw+lxuV0Ot93itpk9DivvdgSddpfVare7PU6fz+p2290et5uzWexup9fj8nk9ft4bvI+FRRRYQAJCQi7CZGJYLATEBYBIRAICRJwvy88FBAWIDCBhGIcBFJKCUhEgEcIyMSUXFhIFtiJpe70sVr3NYUCrlRgFyCFRAQ0WaBAhDQkxFGQQiEVhFoWz5CtxVEVgKgLTUqiewdUkpsQRJYUzOILDAIHADUqxp0SeqJeM26EJj8JXTxhYjCAVBgLXU4RWQSiVKMuCSlquJeUGSsYich0JFzKwkZZqKbGGkbAKgFGAcgqiScZTWbERqHqqk360HZpuxlsUKAEDCCjRKDGjEtqulkaNQEqZt2QUrehzFgtzdpfmrZQKDhYJD5iEs4XCTGnBwbLcR8plF4rAw0bZvEk0YcxdMuWeKhWfrhKtGLdOqLeNGkRTJdDuYvl6sfRoqfRUcd7FMtFzNdDz1cijZeCpcmytHB83giEqn8MeCqkLWokHqsF/aKC2NBA5ZlZsKwXbtitj2xVt1XisjmirgX0VskAtEKjH/g/4nXWQqxH11uGOCtBRATiqIUu5pLVc3FIm2lGY18KKYnXa87OdP7935Nq7U9feHfjts7m/f7X+96/3/e2rtdufL938aOraO8NXX+n//un4ny8Ff3jM+/3j/NVnY7feHLjz4cwvl3ffuLzn5ifLt9/fc+vduV/emv7ptfFrLw5k+3w4wS1lAAAgAElEQVTfP9n5p0eiXxznPznifXvV8vhwxbEO1UaIWuexIxFm1asYbmI7a+hjA56b7+775eOpT55yv77X/PtM1WbUOOlh0q3oeDM+sgMOFT3UpN7aWgZYt6t3lWK+cmgtanxsovDSFH0qSZ1M4ieT+JkUdX5QcWlE/eio5tKI+nyKOZtSnujTHOzVrnZqFtsVi1F2OcrsDeFHkuxjs4andpseGVGdyajODihPpYmLGcW5PupUL3m8mz7SRW3Eyf0d9EaXci3GrMSoPVF0rg0aD8DDXjzjYVIu9YBbN+rTTAfZ3WFiPoTOBYlJPzvOq4b96kGfNuUxJZ2lYzH7bCY+0Bvr6WpPxvzJmL+3ne+N+7OOPZ3t3libOx5yxSOebLUfCbnDAXcw6A4G3aGgP+Dn/H5nIOAIhVzhcHaf1+cPePwBT/Z5b4j3BX3eoI8Pee8q4PX5Pbzfw3s9fq/Hz7l5h4ezuz02l9vm4mwuzu7y2Zxem9ObXQfIJgh2m8dq8ditvNMecDk4m9Vlc3F2j8/i9NhcnMvptVtdFrPDbnO7nF6Pm7+PBgtQSR4sysFlQlQqgkQFoFiMAQADy1CxUJaXL88Xw1KQgDAchhBACoASmVQISISEvKCIEllLZeEacbDsAYsOKKcBXCqWiwQUIFAhBQwqJXBYiSMKDL4nJY6oSUxD4UoM1NGYhsJVBKqkcBqDUVCGQWCtQuYphXt2gBN2ZNxD++oQkwKiaVpLIFoK1dCokoEVDKCmADUp0xAyEpMraUjPQjpaoiNEWkaiZUEVA8qVEEHh9qrC44mGjxYq3xzTLFgJCw1LUEiIAISWZrV4oQbYpZF6lYL+YmCffuu6KWetJGejNO9QsXClSDxSJOoyFWwW5z1WKn+6CHrEABwqApaLpWtFkpNl4MVq6YliwYY+d80gWCoUzhaJpsrEU1Wyw4U5Z0oFT1bKni4HHi+Dz1YQ68X4iFJslv7Ojm0JGWVm+qEq+f9Thz1cjW+rZ8RNxdJAI9u2nQ1UoaEaNFgLeyplnmqpvw7116G+OoSrgVxVgKMacNVCnnrEV406S+WuMsBTBTvK5K1FomZTQZNR0KSRBKuVBzL81Xc2f/10+efLk3//Zvlf/3Dgb1+s3vl070+X529+MPnze2M3Xkt///vYt+f5b884vz3H/fhk9OfXB359f+rXywu3Ptn78ycrtz9cvPX+ws9vz2Thv/JM8vsnE989Hv/TucgXx3yXN9yvLey60F90JMIcCtMHQ9SRCLM/qB63qDprqD1tDX94bu7v36x/80L03Q3nMyM1m1H9hJtOtSATTeTYdjhSvLVJl2OuhM07lDvLkFAdth4vPD9iOjtGXxhizmXIMyniXIa5NKx9bNT46Ijp4pDhkTRzpl+xmVTtT6j2xtjFKLs3Qq9EqbV26nha/cR80VO7Cy+MaR4ZUj8ypDwzQJ3tJ070YscS2GY3caiL2Bcn1uLkvk56IaKYD1PTIWI8gI7w+ABHZThlv0cz7NNM+NVzoSz8+EyAnPArx3j1SEAzxOtSHkPSWTrabpnNxAd6o72JaF/M3xfz3/0E3HXp88YjnkjIHQ172tt8bW3ecMgXDHCBIBcIegO8PxjgQ8H/PNEZ8gUDfID3BwIhvz/o9/t5nud5r5/33nX48QUCfNDvC/m8Qc7jd3v8TpfP4fTaPT6rizM73GaHx+ryWl28xekzO7wWh9vm9DrcvN3lt9jvVgE2R8jt8DnsnN3ls3t4q8vrcPNeLuh1B5wun8vNe7gA5w3eR8mFmDQflQgwiQiVimGRGJJIEBlAgRJMIgYLxEC+DBACkAQAJFK5WARAUplcJJeJcKDAQBY0F4n91UJf6f2tGmkxIUKkAkBcQAECFSxiUDmGYSoCVeIIi0IMArIopMDg7KofDUnVBJz9Nws/BslJFGnQoL4qKtmMT7qwURfO1QBGRkSRiIaENCSkpiANDWtoWEODGhJQE3KcAFgW1ikgPSM1UJJCVl6oRE1KjNCiJAGby1UnUrVfHal/Z0E/Y0eaKIkUQ8UogqpZSseo1WiFCtilEAVM0L7C/I2ivINFWzcKt6ybcnYXilImcUQnPFSUe7FM9lQheMEg2yyULRWKZw2C3UbhRpnoUIlg05hzVL9tQ79tjzFvvFQ8VAXurxQcKhdsFuYeM+SdKJFuVuKzRqAD32ITPhSkhBGd1Ine7wD/yY5ta4BzaihxtSbXUYXydQRXCQdqkED93XuHvjooK64GcFfJXNUyTy3grYfCtYSvHPJVwqE6gq9ELSZxi77AYhKbi2RcFT0ZbfrDS/t/++rwb18u/du3+/71DwfvfLJ055Olnz+av/n+xM/vjl57qe+7R9v+eNb71VH7V8dcf77QdvOl1K23J29/uHDn05Vbn6/c/mT11oeLP70zd/3VsR+fy/zlyZ4/PRr/88XYnx+JfnHM99EB1yvzOx5Jmo5EmM2o4lhMdTBE7g+qZ5zankZmzFXy/rmhf//zsR/eyHx8wvf8VMPRuHHSQ2XhH29E24tzm415rVXwznqytkjC10JLEf1mUnUkhT46Rl8aZS6NKC6NqB8dMVwaMl0cLDyfKTyXVpzqVx3uUa13Khaj9J4ItRKl1mP0wYTizLDh8bnix6Z150bYc4OKR4aUZwfYk0l0sxs5lEAOd+P7O/GVdnQpgi6345MBxUSAHuXJQR85wFEZL5P2KTK8ejKgmgmpdrcpF9ro+SA9zdPjvGqE146FtUO8ps+l67IaMsFdE8m2dHdbbyKa6ghk1dfhT8bvdvu6otntXW807M3e5AyF+azaAsFIMBANZ9/ze8IBLsT7wv5AwBcN+Nr8fNjvD/r9Pn+A8wXcvoDT6+V5X8jHhzyc3+ny2Zxei93bavWY3Vyzw7XL5txlc7Y4vK1OX7Od22XlWu2c2eHNqtXOtdp8Foff5gp67F63w+f2+F1cwO0N+vhwyB+NBNp9gYjX38bxYY8vdB8LSVhEzsAyXCpGJCJUIoUkMlmBCJMWYBIRKpEiYgAQAnKhVCYSysUFACiRyUWwXIIDBXo0r8lYEKgsCJY90KwVm3ABIhWAMiEJCBlISMByCEJUJKzAQQaV04iMRmQsBigJSEXCLCLPwq/AYJZAKRTCYYDC0AY97q9j+1vxCScy4oA9lRITLWJIREODGhrUUqCORrLKfgVwAmAYSMuCekZqYmQlKqhYjRepCRWLsIjcVsGeHa37+nTdG8vqEQdQS4swlIIRgqQYhUKhVzEVSryeBcwaeKZQtFIsPFSUf8i0bbkwd6qwoEcnCrCClZLck+WS88WyE0bRWpFkolDYq8/p0uR26x8eNW1dNW07bHj4qG7rAUP+YpFkplS+0iBZqylYKdq6bNiyWiJaqACSeqEbfyAGCHuVYJzJCwH/I0XkJilJiyynBhOXMg81F0ndlbC7HOSroEA94m9AfA2gt/auuBrAUy33VMu91QBfC7XV4YEq2F+JhGrJQDVuN8ladBKrCdhhELSYgE5z8dsX5v/61bF/++PGv36z79ePln9+d/afP13+7dOln9+buPnG4A9Pd/3hLP+Hk+7PD9gu7zN/fZK/9mzfT6+N//LO7J2Pl+98vvrXL/b/+vHKjXfmfnx55Lun+799tPPb87Fvz0X+cCLwyYbz3WXzC5O1pzs0B/34kRB9LKLYCBL7AqoZpzq5g+lv1jy73vmv3xy/9eHilxfDryzsPJYwTfPsQCs2tYueaMA7igVmo7C5Qt5QBVUa8r3VsqWQ/nCP5nAveW4AvzTKPDmpe3LC9OiI4XxGfz5TeGGg6HRKfaJfdbBHudLBLkbpvVFyX5w51Mke7lE8Mlb42EzJxXHtmSHqzAB5Ok2f7KeP9GAHu+D9nci+Lmwlju1ug2eD0GwIGfMrRn3KQS876FUMehVDPsWQXzkSVM5F2IWIYk+bYiHMzgXYSV45xquH/drhgGrQp+5za+7C3xfK9Lb19USHusJDXeFMVyjVEUjG+Z52bxb+WBsXC/tiYV97m6+9zR9p80faApG2QDwcjrcF4218NOQO+x0hnzPk87TxfNATCnGhMB8KBYLBgJf3uzne7vaaXS6X18tzXt7hdFuszlabM7u90+Jy7rLbtputOyy2XTZnk921y+re3uposriy2mW2N1kcrXa31eV1cH63jfM4eQ8XcHuDbm+Q8wZ5LhTytXl9fs7LZ3UfKRMxsIyBAFwqQSVSEgBxEIYkMli0FZMW4HIpLpPDUjkkkUAyMQJKQKkIlIpgmZiUFeiR3GadIFhZEC57sEUvMqA5kCwPkotIQEiDBQQMgBCmJKD/Dj+DyhU4qCQgDYlka34FBjM4QqFQNvLX6gBfPd7bAo/YZEM2kK8CyhRyNU0rWUDLgnoGNjCwgUZ1NKZjcbUCp3BASUM6BtTREhMjM6lBkwbTqVAlBrJyiatGeWGu8ZtLDW/s1494kWqFlEVwFiEVBKOiGCPLlCmpKgVay4JRrXjYJFsrkh0sKthbnD9uKuhS5geQbXsLcw+Xi46Xig4WFSyViYbKRFF9Lqfc0qL4pzb91vHCvFVDzhHttmMGweEiyb4iyWJNwXqteH+lcK20YLlCMlYqbdPl2pVbBggwowTi5IP9yD+t6uQzCrkTyKnGhWX0gzt1BY4SubcM5CtAvgrw1YC+OsBTK+Pq5N5aOVcj46qkXJWUr5YFaoFQDeqvhr0VEF+JcpWY1QQ06aStRmCnKW+XXhxu1L14ZOxvn5/6//5y8q8f7f3umaE/PZv+7cM9//zp3l/enbj52sDVZ7q/Pef/40n3h0stb8w0fHzAdeWJvusvDV9/feLWh4u/fbZ65+sDv3y6euO9+R9fHvvu6dS3jya+PR/79lz718f4D9etbyzsenqk4kS7coPHDgepo23s4TZ61UdP2Oje7WSikTkx6rzx9oG/f7H5p6djb662nEoWzQaUA63Y1E5qqp7sLpXYC8UtpdLGSmmdKS9YI1uLFJ5NF59Ka451Q48MsE9M6J+cMF0a1p9Lax5J6y4OFp7oVx3pVe5PKJfjzGKUXolSG3F6M8Ee6qHPj5U8PltxYUx3dpg+M4gf7UEPxrEDXfhaHF1pR5fb8YU2fDqAjPngcR4Z9SlHvMoRr3rEqx71qcYDyskgMxViFmPUUjuz1K5YDCnn/Opxn3qE1w4G9GmOznBs2qvvcxePxc2zA+2DfdH+3vbBrkBWqQ4+2c51R92JiCsRcXVHvIk2rjPk7ghznW3ejog/e6Wnqy3YFfF3hN2xkKONt4S9ljafM8pzEbc76vG0+7ztfm+bnwv4HB6PxeludtjNnMfhcTutVnNLS4vZarFY7a1ma6vd3Gxt2dXasqu1pdlibbZYm8yWXa3WplZ7U6s9+6qn2WI12212t8vJeTw2B+/hOI672yl0Ot12h8/pzu4R+nlvwO+7j5KLSUBMyCS4VIJJZYQcwkEYB1FMthWV5CBSASIRInIJCkgQUAQDAkQiAoUCRCRkpAUlWIHDJIlWCCMlD7QahDp0GyDJAWVCVJZPyYUkAiIopSJBJQGwmIxBpQwqZTGZApcrCUBHYwaWyMKvILFsw49EkRqD2FMPJZrEg2bhoAXyV8OVKkzPqGlGomIAAwOZaNhIIToSVTOESklpSMRAo0UsUsjKTUrApIE0WlShghkcIWQSe636/MKOLy7UvXnAMOWjaik5BUIqnFCStJKk1TRtVFFFKszAAA0Kabsemi+E1wvFC4X5oyZBL1sQA/PW9TnHSyXHSoT7CnMXSoUDJaKQJtdGbmkgHua1BelC6ZxRuM8gOFYkOlEqOlpcsF6af6hMeKSk4EipeH+lfLRY3KbL5fQFGQropPPamfunDNuOloLzSrED2VpM5VcQDzQqcuxGsb8MCpaDfJmUr5QHagFnrdRTK7sHv69K6q+SBarlfC3E1yLuctBRBrgrcGsJ0qSXNxsAa5mwWS8JVKku7e6+9d6x//jL+VtvzH9yqvPzix2/vjf/vz5f+eXdiV/eHL75Qt+fz/q/PGR5faL+qXTZmwstPz7We/25oSsvDf/0ztzty3t/+fLAz5+t3vxg8dobUz8+P/j9E8m/XOz87pH4H48HPlqzvj634/cDpSeiikN+/FiYPRlVHW6jl9z4cAuW3EF1b2dXurZ/8ujU3z8//ePLPe9sWM5myuaCqkwLPtFIzdTTqQrQWySzlEhbKoGmkoJorfxQrPTxoeoLA0XHEtTZlPrREcNjo8bzA5oz/Yoz/YpzadXhXmajW7HeyS61M3si1EqUPNjBHE8wm33spcnyx6YrHxnRnB7ET2Xgw13Qvgi0FieXIvieMLY7TMwGiTEvPsxhoz5izMeOeVXjPu2kTzcd0M0FVfNhancEX+kkljvolXblYkg1w2vGfdohXjcQMGa81IBXMcAbUlzpeIdlJhPJ9Lb1dodSMW867kvHff3tXE/EnQg7ExFXd9TdH/H0trm6Q47uoCsRdne3cV1hT1fY0xH0dARdHSF7PGRpD7RGeXPUZ2vnnZ0eSxdn7fTaY7w94rX7OYvH2eqyNzstu3wuC+cy28y7WpsarZZmh91ss7ZYbXd5N1uazJYms7nlP2U1m61ms9liabXZW+2OVqfL4nS1cg6rn3NxXqfTbXO6bQ6nxW23BDhXe8ATC3KxIBcPee/TkSgLg6RcSsikiFgCCERyoRSWghScg0gelhc8BAhzIKkAkQtBeY5U/BAqFgH5eUh+vkIsqCLE3mKgo1IcMf6TuVCkQ7fIRFulEgEizSMBIYWhOMGqKSjLvwKX3yNfRYIaEtHRmBJHlDiiZsjsih6NYzVFAk+DrKtZmGkRZFoBfzVapST1tI6kREpGamCgQgo2ErCWQNQMoVLSxSxVrqIrNGSZBinRIiY9otZjpBpiGAoBpOY61cn5+sunK15f08352HpEhgBSBYUrWJqiKJLElSpCq8UVSrmRBd06fMyI7tEJZ/S5wwZBRiHug0VHNHmniyXHi/L3GbctFOYOGgUBcotZfv8uIj+gA/uLkCmTfK9JfKhMfLxCtFmWd8IkPK7P21RtOarPP1wGzhRJO7QFIaOkixL5sN9FNPcv1kmOVYNTilwbsVWnyC1H768jHrJpC4KlULgc8pdKAxXycB2Uhd9TK/NWy3xVUr5SGqyUharkfD3sb0DclZCtTO6qxG3leJMJbDLB5qLcRkWOTQdvJLkfnlv7jz+f++Xl6cub0a8eS/z9473//s3+O+9P/frWyE/PJ7886nx7oea5dMX5uPblye3fX+y5/tzQ989mrr8+devDxZufrf/06dpPHy7dfHv2xitjV59O//hY7/cXOv9wzP/BivnlqfrH+guPhumDPHY0xJyMqjaCxLwNGmyCU810X5N6Nlj10sHkbx+duvFG3wdHHOcGyueCqlQTOt5AzjWyQ1V4oAS0FkusNZClXNRRC2y2lz41WHehv+h0UnMupb8wYLgwqD+XVp1KUsd70OM96EYXva+TXo0zi1F6qY1aiZIH4+SxLvrkgObxmapHpypOZZQn0siJFHg4ARxoR/dGyYUQOhfEZoPUpJ8a8eLDHmLEx4x72QmfaorXz/oNuwOGhbBqKUIsRdDVBL7WQa20s0th9QyvHffph3yGgYBxJKgc9qsHeEPSVTTYtmus15/s9HV18MmwKxlx90U9yYg7EXZ2hRxZ+DNRZ3/YlgzaugPWnqCjJ+zsCTu7g652vy0WsMaCLfFQSzzUEgu2tPstUd7a423q8TYnuJY419rmMQecrV57i9vW7LY08s4m3tlia20w76q3W3Z6nK1uh9lp2+m07XRYd9ktO+2Wpqwclhar2WKzWO02i9NhcTktLler09lkt2/nHK0Bn4Pz2pwes9tr9XBWv9ceC/t6or6usCcecEZ9tvsYVMygYhISZQ38KAggARARS7CCAkoipuRCVJYLSrfJ5XkyuVAiLUBkACAEQQFAyaUVKqGlJIcr3uLRP2TX5pSgebBQJMsHMTFIg3IMk4CkBMFgFIdwAiZwmMIhGrtraM0wAEnKcVxO4BBDkwpGyVBKimArVAK+AetuBtIWaW8rZC4F9AoMxlhCAdE0qKORMoaoYMliEjVSiJHBaBRnCURByVWsRKOUaJQyjQLSKFAjyBIyeVOD4thSzecXyt/Zp57zkg00DIIwRVFKVqGgSBVNGJWMUUXpaAyjaJOCteo1MZO610Ak1dKEIi9OPbzfsO1gYd5GiWBvcf6wLrdNscVMbWkkt9nxnKBGkjDJMkXS2RLJSrHwcLHgbIXkTAV80CifL4XStdLJGsG6KW9cmRsxyXoMRJDYkjFsOVQhOlUk3s0IvLCgCpdUYVsamNxdGoG9WMbXYL4akKuSBuohfw3D1+B8LcTXyfg6mb8ODtZToXqlvxrOpv1cGcRX4oFq0lOKWnRysymvWScwa2UT/M4/PnPw//3m/JXXRr9/tfvzd6du/HH1X37cuPXF7iuvD/7hia73DnLPTm4/E1Cfixnf3uf58eWRP7008MVTie9fSd96Z/z25cO/fXr8zqebv17ed+O18W/OxL7aF792cOTbM/GPDnieGa89GVccCmKHQ+iRMHYwAO71EON2KtlEJRqQ4R3ogkNzccT7lxdOXH9h6utLnU9Ml60GkclWYLqZmGki0pUCazliKUWtZZi3BmtrAA4kTY/NFp3KgGdT+Nl+4myaPp1mT6fUx/uUh7rZ/R30Rge+FkP2RuDFCLQUQddj9JFO1YkuzcVB4+NjRRfH9acHmKNJ7EgCPdKBHooi2YA/xeNjXnzEg41w9KiXGfUpx3jVuF89HVDPh5RLbYrlNnY1wuyL0CsRYi3GLEeZ2SAzzjNjQe1gQN/HaWb8qkm/PuMx9LqL+0KNvfGmeGxXe/vOZKQlGWnpbWvuCTf1hFp6w629YUtv2JLwWnr8lt6AuSfQlOC3d/N1Pf66ZKhuKLIjFW7o9dck+KqEv7onWJsI1SZCtX3e/1KSq+n1VPe4q7pdld2e6h6uptdb28NVd3uqEu7ybk9FD1fZ7arqdlUlnJVdrsqEu6rTXdXlqU5wNQmuocNV2+Pb3uWpT3ANPb7tHa7aBNfQ7duZDDT3h1r7guZef0uPryXpN6dCtlTU1x/x9EXsfRHbfTQiohFRFv7skg8uk8MiMS6VEDIJJhdA4q1y8RZQmgvKhIBECIhE8gI5KABImahMkWctyeeKt7m0D9h0eSV4PiqWAEKQkMI0JMURsRyXIBiMEzBBIiSBUDhEoSCLAQocZEiAwmUEKiMQkMJQCsNJhCBgslot9DdgiSZ5ulWSNMO2CrhQQ+GUmlHAChrS0UixgihhCRONamhYo0CVFKakISWdhV+mVYE6Fa5XMWWkhoHgXfXs0cXaLy9VvrtfM+PBa3C5XA4SBKFkFUqaUjOkUckUqmg9g9MsoyWJWobwaOmQBg5R+VFyS68yb8OUe7A4f39JwW5TXlq9Jcg+ZKa2bqdybNg2Xins0ItTJvFMsXipULBRlHe6SnK2Cj1UCM+WQb0VBaNlOWvG3HFlbtAgjimRMJU7pM9dNW3b0ObsVufzRE4Fuq0MeqCG2NbI5pmNIq4S9lQCrnKJt1rmqyZ81WgWfn+93F8H+2txfy0VqIECNQhfhfgqYX8VFqyhfBWEswhqNuaZjRKHCRn37fjs0uo/f3ry+puTt94f+fnrtdt/WL/91dK1t8e//X33x8eCL821XuytOOpBn0iXfn0u9su7M9+/NvLl073fvZC5/uroT++v3r588PbHB375YOnqi0NfHAt/sMf36Vzk2zPxjw5wT41WH4sp9/uxAwH0QABd90GzNmSoBettppI7idFd6G4re7hzx2uHxm68OPvDs+mXlrfva8MnW8HpZmKuhRqplzaXAbsKZS3FgK8Wi9bL1hO6R8cN5wewRzLkI2nqXIY5k1Fk4T+YYPbFqX3tyGoUXY4iS1F4KYKux8gjnarTPfqLg8ZHR0znhzUnUuSRHuRwF3Iohu4PQ/NhaiZATvqwEQ867EZHOHKcV0wGVFNB9VRQPRNSLYSVS22K5Qi9GqHW26i1dmq1nd4bYWeDzJiPHfIpB7yqfk61m1fPBw1jnHHAUzoQakhHdnaHGjuD9X3+ij5/RX+guj9QnQrUpYP16WB9OtiY9NX18XWpQF0qWJMKVqVC5alQaTpcNtJWNxisTvMVKV95P1+RDlRl1eer7OerUv7qdKAmE6y9p5S/NhOszwTrM8HadKAmHajKBKsHQjUD/rtKB2rSgZpUsCYdqs2E69LB+n5/7WDb9kyoIRNqGGzbngrUDYQb+8NV6UjNQHv9QHt9JtKQiTQMtm8fjjcNxVuGOpoG442DHQ33UbCQgoUEKERlBahUhMkkqEQKi8SwXIYAUlhWIBdvA0XbEKkAFYtgoUgmzAdEMqgAwCUFJUyOtSTfW5LjUD9g1uaX4kJcKoPEECmDGFCKQkIZLEEQCMcgkkBo/C78FCpnMUBBgSwB0RhEoRAJwySMEhBGQFiDURrcjnXtkqVbJf1mxFGFFmto6v9n472e4zyvfU3dzMXZ25aYEDp3f/3l3DlnoLuRM4gMNDrngIwG0MiJAYkBJJgzmMUgiaIoKlISJUq2ZCVSlqxkydaevWtCnTo1V3MB23NO1VQ9/8Kz1np/7/suQiGjIRkFKilIQyNqBpHTEMWAJAMqaUBJi5W0UEkLVYxEw6I6Ga2Xyc0YS0jEpUX40YWiz6+7Hh/RL3SRblIiFIoxBGVpRk5TCprYkl/L4BRFkSCghYFyJV6vklbD29qh5/tk3EO6gkNGzoqhcEqzM8W80In9vg7bXkUW1iM72sj8oIzTr+ZN6bmLmrxVff6pIsGZInTdCM2aobhx15D2+QOa/AlZfqeiMEhLUwrxjJG/X71jVbljr0EQUBTakd9ZJb8vgraVEDvrVLwOm7TDJmmzCDodwk4b1OWAuoulXhfgc+OkPH4AACAASURBVEu9TtDrRLuLUK8T9LmQ7mLIUwR3F6HeYqK7iOy0YXU6YaMebNIh2d2uR2fmf3t07PsHU789mvzPT5Z++2Dh54djX91Ifni089WpiqtJ6zm//lwQfWOx9C9307+9P/3D2+NfvjLw9e2+b+4Mffdg/Jd3Fv/+3r5f35n/4V728zPh9/a1vzPV+vER78M9tZf7TUcC1AEPesiLH/Tha93oRB3QWwFmqqmBGmq8Gl1ooJY8ptPD7V9eGfn+5dG3DzceDBKjFYKxUmi6Eh11C2sdQJmeX2Xk+8rRRIV4NURfGZLfyhKbw+TmEHVxiD4/xJ7tl5/oYQ4nyLUIvuIHl4PQchjeH0K25D+Rkl/s024OaS4Oq88O0CcyyEYSPByH1kLgkheY6iYnuvDRNjjbAo60wuOd+IyPmQ/K54PyxYB8MSjbE2D2+6nlALkSJNaC+FIQ3+fHF3zUnJcZ72KybfRwu2y0W7PPp97j002167IthvFu93igYshX0udxDnRpBro0g136IY8h67VkvZYRn3XEZx/sMg52GYc8hmGfIRswjAT12YBmOKDM+uxD3dYhj2W4y5L1WMc8tnGPPddlG/TZBn224YAjGywaCRWPhp1bjPlduYBrPOgeD7pzweJcsHg8VDQZcU6GHJMhx0TQPh6yj4fs4xHHRLRoIlo0HikeCzmm4u6JqHMi6pxOlIxHiqfi7tGobiymH0+YxxPmiaRlMmWfSjumM0VTCdt00jqdMk2nDM/hUg4GFKISzlbnR8VCRChChCKhkC8S88TiQolgFyTMx4RcnM+HC7gSfj4oFEN8CcLPNxA76o35HaZdu2W/q5bn65FCSMAD+GJMJCQlPATgA6AIBiQYBBAISKIQiYEkIiURCYlI5ASkIFA5jsgwhIZgGoJpCGURvMII+CuwVKVwsI7fXw8226VaBoURUs0gKhpW0bCCgVkWphgQY6QoK1WxAiXD3zJfzUAaFteytI6VGWACEwnddnx9tuhPV0sfH9EveogyRiIWSnAUUzCsimHUNKmlSS2DaykMxxAMlMgRqU1DOXVoEbqjQfLvPWThQW3Bmr5wnyF/TLUjQj3fiv6+Ft1RjRXWIrtaiIIAXdCv5E7p+HOa/H26XUeLhUfs4EETNGeBE/q8Yc3vD+s500peiyzPx/J6tcIFq3hRvWNBtX3KLPIoOA7wBQe4zYns2JK/y76V5Iu6i6WeIrC7GPI6QZ8L+ieIz4X43bDfDftcyFYt6C7CPQ7M4yCabVijAa6RizNVxjePTf7trY1vbuee3e77/s7Qt7f6vrma+ONxz/3pss247lJIfzNZ/Oas9bOTjd/djf/0VvbnR1PfPRj98mbfV9d7v7yT+f7+yC8PJ/76IPfTS8PfbKb+eCTw3r72h4v1L465TsW1B730Sje56qWWveS+TiJXB/dUwL117GAtNVGL7m+mVjy6Q/GKtw5Gv3lx5PGJzo24PFclGXFLJ8vhUbewyQ1XmvkNNn6qnhysB1b9+GYP9VKWuTrKXB6mLw0z5waZM32yY2nqYAxfCaFLXnA5iKxEsP0hZH8YOhDFTvcqrmWNF4fV5wZlZ3qIEynoaAI6FIX3B8H5bulYBzHSho20wiOt8Fg7MtVNLgZl+yLyfzwKDpJL/3wjtBomDobJvV5irgub9ZALftmMV5HrkE10q+fDpr0R/XxQP9quzrYb5qMVe9P1s/Gq8aB7wm8e95lyXmPOa855zblu67jXNuGzj3gNwx7doEcz6NVmA7rhkHYoqOkPqHr9xn6fccBnHPaZRnzmMZ9l3GfJec2jQetYyDYWsuXC9n8xFrLl/PbxgGMiaJ8MOSZC1omQdSpin446ZqPm2ah5JmKaipqmoqapuHk6YZlOWKZj5smIcS5pm4lbZhPW+ZR9OmaeS9pmUoaZlGE2bZxNmefSlvmMdT5jm8/Y5hOmhaRxMa1bTGufw6UcVFKAiAtRCQ+TCHFAjEsAXAIIBAKhkC8UFIq4u0BBAS4SkAIxxhVBkkJUKkaEElRQoMe31xnyOoz5zYoXypgCNZgv5XGEXB7C55IiDg6IIAiCxWJUKt76t0djEIWCFC6lcKkMQ+Q4qiAwOY6yKMzAiAzFFDhRqZf4SpFEOT9bLxhqgJpsgIYCIRDX0aiWQZUswjD/6PkkA+IsqKQLlRRXRQs1NKShMS1NaihSQ5FGFKOkkrJi5vCM64+bJe8e0My0wWWsCAQgCsMVDKtmWQ1DaShCQ6JqAsFQKY3BCgLVqmiDDjeRhbXSFzIEZ0VdsKQrnNXnD6p3BultLegLdfDOGoRThe1qJQuDNLdPwZvS8Wc1+QuGvJUi7n6TaMkgnbdjPSbOqHb7MZNoXitqYvNb6d8n1HnTBu6kYsewYmdCLajGC4yi7cXgThe8sxTPq1Pwu2xQtwPusgE+Jxhwg34X5HdBficScKHBEiRUioZK4WAZHChB/G7Y64Q9RXCnDeqwwp02pMVG7DYiVSw/Wa5++1juf3974+vr2c8uRD8/E/3iTPhPJ7rfX62/O2q9mta8PFz0/uLuZ2ebvrnS+fR24C+v9/7ywcRfHmQ/v5b86krqs6vBr28mvr3V8+21zNOLqc/PxD9c9z7c23ArV3qx13I0pFrppvd1Ugvt5FQzMtYIjdTAPdX4QKNqqI6ebsAOdLFr3ZrlgPVqrukP5zNPTvkvDdkWmqiJCnS2Gh8vE7W6wHozp8XB7W8hci3Qmh+5kMLvDsmujbFXsszFIfpMP3UyQx9NEmsRdDmILPuQ5SC2EiaWwuhSBD6cIM8Pqm7mTBdHVWcH2NNp7EQCPhZHViPQvB+a6AYGm/GhFmKkjch1YJMeYt5P7Q3R+yP0cghfDuErYWI1TKxF8LUIfiBKHIyRe33sXCcx66H2BFV7gprpbuWcX7s/bl9I6WdjhnG/fjZSfDTbdmbKd3ho975kxb5I6Z6Qe87nnPY4JjsdEx32yU7HVFfRlN+R81iG2w0D7fohj2HQbxrwGXu79emArieg7w0a+oPG/qBxKGQaDpqGg6aRoHE0ZBoNmcbC5n8xGjLlAubxoGUybJsM2yZClsmwdSpqmY5Z5+LG2ZhhNmaYjhum44bphHEmaZpJmmYSxqmYfj5tmU2aZpOmhYx1JmGcS5nnU9b5lP2fFM2niuaTzrlE8XzUthA3LybMi0n9cwTIRcT5kDAfEXMJqXgr8MMlACAUAUKBiJvPL9gu5uyEhTxcLMFFUhjIR6UiVCTGRPkGYketfle7Ia9FscNNFyjBAjGvQMgtQPiFlLCAkIgwEMXFEhKQbL3tpzGIwiGaAGkCxGGIQGAShUgUIhCQQEAaR1gSK1FxO4vF8ZKC4TrucCPYYgO0NITApI5GdSymZBGaBikGZBhIzsByGlKQHCUlUFGAhkY0NKahMTUFqylYB4EkIC4tog9NuT+9XPbooHauA65SSjAQpXFCQTEamtHSlI4mNSSqwWCSBFUUoSRIhsZlSkxHCerQggFGvF9VsKgpmNDm9ap2+NntLfjOBji/DuRW4QXtrCDM8vvlvEk1f0ZXMK3fOWfNn9IWzmtFc0X4oFU0odt50iRe0AFNbH697N/Dyh05PS+rzI8pCptZrg3MN0q4xeBOJ7TDje6sYgpbDUC7WdJhEfuK4WApECyBAm444EIDLjRUiobLkEgFFCyD/SVb4wDiKYLbLdI2M9BugRosyG4LUqsWZqqVbx8f+s+3D31zffjLC7Gn53u+Ohv/7LjngwO1b+51vrXP9cnRxqfnPX+56vnzNc/T24Ef3+7/7cPxb1/r/dPV4LMr0c8u+T674P38rO+To75Hy56He9ruTFZdGLCcjhvWA4qlTnpPOznbRk404UP1SH8NOFAB9dTQvQ3q/jpqTyt1LKhY7WSnm+nDYdcre9vfPtR+bcy9v10+WUHMVuO5UmF3EdBmLvQUFQ63IBPtkkNh9EKauDUkv56TXcky5wfIkz34RgI/HENXQvBSAF7xYcsBfDmEr0TxA0niWC9zcVh9M2c8m1Wc7iNPJqETMWgjAi0HoSkfmPWAvbuJwWZipJ2e7Gbm/dTeELkvTCxHiLUQeCAMHYzAhyLY4Sh+OIofiGIHoti+kHLey8x3y5bC+qWoYdGvXfTrliLmhYRuX8KylHAc7a+9MRu4uxi5lG05nqw4HqzY8Jcd6nKuthXtb7Lua7TtbbDua7QtdxQvttpmdpsmm02TreaJDnuu3ZZts/R1awd8+kG/YTBoHAwa+4PGgZBpMGwe9uqyPv1owDgWNOVC5lzIPB62jIctuZBlImKbjNono7aJiHUiYp6MWqZi1pm4aYupuHE6YZpKmqZT5pm0ZS5lnkkYFzLWuZR5LmVeyFin44a5lHk2WbzFTKJ4Ol40FS2eihZPx5zTkeLpqGMmbpuJW56jEQEizpfyd8EiDg6IcECMCEWwQAhxxTBfAPK5Eu4uEXcXIOBKRUKpEJCKt0uFhbCQTwKFJmpnjW5nq25Xq3Kniy5UwhxAxJUIOZiwkBYVkmIxKsUYKcSCoAyBWRSmUJDEQAqXkiQIwyCCQAgCIagU2boOwEGChEtVXE+xOF5SkK3lDjeCzVaJjoEInNEzmE6OK2UoTYMMKVUziIFGjTisooUqClBTsJrENRShoRENA2hYsR6REoDAaSEPTLg+v1r90YZlr5eo00oJGKcwnMVJNUXrGFrPUHoS0+IIQUhVBCaHcQrDaRmupoT1OHdUhexXFcxp8kfUu5LKHV52ewuZtxvhNEC8ciyvUy6KyoW9LGdcyZ3WcXL67VnDC1nVzkmlYM5BDtslk9q84wbxnEZcz+RVsNu8ysJhrTgj53SwhW6qUAPmmWChS7qzBMorgXdWkfnNGmGbXtRhFAeK4ZBbFHIDIRccdhFhFxEpQaNlULQMCJaBPrfU6wK2mn+nHWwzA+0WaYMVarHD9Tpeqop840jqP95Y+vP1/q8uhL+9NPzd1YFnm7HPzrZ+dn73Nzfavrvb+e2djm83vV9ter6+Hfr53cHfPhz78WHP1zf8X1/p+vR89x9Otv/haMfj5Y77403X+qpPJi3LAXKtk9rXis/tRqabsPHdxGAd0lMNZ2rQnnKop5pNVLHpSnTNq7iYMa556LFa6UKr/kxf2d25umtjpfvbleNl2EwVNurmZ0qwhFuaLBXk2uCZTvHRJHG+l7k+LLuek10eps/0YhtJ+HAEPhCGloPQUgBe9ZPLAXIlTB5IUBv98jPDqs0R7bURzelh5kQGOxGTnoyA60Fwj0861gX0d4G9TexACzvWKZv2yRaDzL4wsRzBViLI4RBwKCJdjyJHYuh6HD0cQ9ei8GoE2htQzXfLFrzK/SHdStS8FDbuC+r3B40HQrpjcdvZZOnldN0r2c7XhjrvJGuvB8tudhZdb7dfbbVu7rZcqDeerTGcqdafrtKdqjcdrzUcqdEdrjMeajSt7TYtN5r31humWw3T7cbpLvNEl2ms25T1mrJ+83DQMuI3jgZMY0FzLmQZD1v/xUjYNhqxj0UdY1HbSNgyEjaPRixjUetEzDIRs4xHzWMxcy5uGYtbcglrLmGdTlon4+bZtH0qYZmMm6eT1lzEMBEz5eKW8YR1ImmbSDjGotaxqC0Xs4/HHbm4ayxWNBa3jcUtzzGoEBHnb0V6OCBCxUKQxwc4XDCPj3EFuFCIiLlSYaFIyOXzuRwOT8j7NxFvB8jnUFKOlc2v0e1s0e5sVe50MzwVwoUAHijhE5JCRswhxWJUgikhVIEgchRhUZhEpAQqxXGAIKQQhkIYCuEwhMMQDsIEiJAQQkKVOqHPLU2WcUbqeEN1wG6zyEBD5P8qv4wCtRRipTA7imhpUEtDGhLXEISGxLU0pGNFernARqMsAris1IEJ11c3Gj4+btvjRatUQhIhKASjUVxFUnqWMbC0gcL1JIaiQhYGZQDCIqRMTqkISS3KzWmwJRV3VlUwpNoRVWzrlu1spfKbUO5uSFiG7upQiONKSR/NHZMXTuoKR7Tb+9T/1q/cnlPw5hxk1gFMaHZtaAQzKmEdvcuOb2tjuGm5xIfnV2E7DNh2BnhBh3BKoLwypKAMzasiC5vUgladsNMkCbnQgIsXdIlDLjjsIiNuKlKChkuAcKkwUCr1uoAt+f1udKv5d1jBpmKktQiq1RbESsH7B0N/e33h2eXUZ6d9X50d+OHm6M93B767HfrhVe/f3g3+8rb32b3dTy/6/3S+8/MbgR/e6vvto5Ff3+399q7/q83WT890f7zR8snhtg/3e+6PtG6mq9fDpkUPttJO7WlGZ3bD4w3oUC2SqpDGyoBoGdhbjmZq2FAZFSuRroe0t0ecRwKysVrJfLPhSMx+Y6Li5njVSpdmsoJYqKMmysVT9erxemakDprugue7JRs91LlB2eVh+fWcbHOIOt2DHomDB0PgWgjckn/FRy35iZUweTjNnspqLuZ0m6PqzUHFiUHqWAo5FpGcCAGHfcC8R5ztAHq7oL5m+VCbMtcl/1/lh46EJUej0mNx5GgCWY+jh6LwShhcCgLz3YrZLtmcR74vqF2LW9fi1uWIaSVkPOnTb0aLrkbcN/ylLwWqXvVWvdrlvt/pftike7hb/3C3/vVG3Wv1uns16pcqVXcrlNfK5FfKFJsVysvV2ot1unP1hpM1+o0qzUqDaWW3ZbnFuthqmWkzT3SYcx7LmM82EXZMRoomI0UTYcdE2DEeso8FrGMB61DQNhyyD4eswyHr1rAwGDQOh00jYUs2ZM6GzMNh83DYPBSxDEUsw1HreNw+GrFMJByjEctWmRgKGLIhUzaqGY3rckljLmkciemyUf1o3DiesowkHdmELZs0DSf0z8mhPAYuQKQFIskuQMpDYAARikQ7CzjcXXzOLoBbAPO5CJ8r5RRIeYWgiMdwJUChhMuRgCK+leDuVua3KXbuZreXKvlakMOKJZhAhIj4DAqwMMKCtBCAIATACCGOiEkpLAMJNYpqcYkSk9IgwGAEiVAETJEQSUoQBULUqJ4PuDjpCs5ggyhZC9fbca2CFQM0S8EsBcppSMHAKhpUM5CalqppqYVkDQSppxAdA6sYKUsDMhmiVrFGGYVBQHERe2S+9subDR9tmPf7kTotj0QRJUHqKMpAkUYKN7G4joGVBEDBYgYVyyiQpjAKwawAEIaFe2jBsEw4opL0qMQ+qrCFzKtnC8vpXXb4+RKooIMR9cr5OWbXnHznHgN3XF+YZF9IajlZvTBrALJmYkrGO2sU7NUUNpDbypCCerqgU8HtYHh1iNAuFeoQgYLkGpHflckKq1heOVlQLxM2a6FmE9pmo0MOOFQM+UsAT6m4q0Tc6UQ8xYyvSBUoVoad8oiTjriwoBPqLoY6iuGWYrjVTjeZyGY9nCjF394I/vbGyFebnk9PNX9zM/3tKwN/eXPs+w+mfvpo+pcPpn56OPTdndQ351r+cLr105upbz9Y/OtnK3/9cPq7V2NfXm7++oL/yXr9o1XXe6tF7+y13R/X3+rVXIrIzgSUax3kXDM61oAM1KKDtfRglSzjJPqqpZk6JFgqTpYKzqQsHyy3HvNTM/X8XCux2Ck/kbBe7XGe8KnnqyXjlYKZBnB/i2rdZzzUrTjsozZC2PEofKmfujbCnBmWnxqUH+ul11PEgSi2Gsa2Mrl9AWIpiB+I0ad6FZdH9ddzus0h2dke7EAPuxrH1oLwik+6p0M60QwP7qb7ditGWsjJDnLeS+4P4SsR7FAEW4/iR6LUwTC6EYPPJsGLSfBsHDoawZeDikW/dmXUuhiVb4S1t5JFr4QcL/utt73mzVbVnWbzS03GB63WBy2mO7Wqa3Wyy43ycw307Ur25Vrla/W6B3W612v0D6q0r1dq36jQX3MrL5eoz7lUZ0u1l2rMl6r1lyqV12pV1yrZiyXUhXL52RrDkVrzWpNzf2fFbHvZVKBoNlK8mCjZk3QvxIvnYraZiGk6bByOWgdCpv6geSBk6Q+ae3ymXr85G3YMhq3/YihoGQpahoOW4aBlNFQyErZlw7psyJQNOrOBkpGQYzRqGgybh6PWbMyWjdmGo9bBsHmLoYhtIOgYDJZkI9XPkcI8FubTuAgEuSJxoVTMQ0QCiMfdkl/CyYd4HJjHkXIKAG4BIOBQHB7IBQR8AJYILHheo2pXm3r7btnvy9Q8tTSPFvExgQARc0lIQEkBBiQBMQRDEhzlYxCfACAGxOUIJEeFalLKIgBLoCRC4BBBQBgpgVQYUWfgBEok8XJOTxUvXgk02GCTksExGUNCLAXLaUhOQ0pKqqSkKlKqpqVqGNMgqJ5CDHLMoMJUCkQuR5UK2iSncVjqLJatz9V8caP+yVHzfj9Sr+OjoJRGUTWO60nCRBMWOWmUYxoWVhOImpQqKSlLoQyGORAwTAgXFPwpBX9KIx5RiRIsz0sWNOP51chOp+T5cpjTSYt65fxJWf4eZf5eI29cX5iWb4+r+P1qXkYlTuvhEbbwtFm418jZTW8rx/Jr6MIGRWGdgl9Kiy0EoET5FLyrWJJXifLqMMFuQtilhv1mKuBgAi55xEmGSvBgGewtl3aXAd4SNORmom5luEQeLWGjbjLiwoJOpLsYaXegzUVYkwVr0CPNejhdST86Ef3bg5EvLnZ+eqr5zy/2fn9/+OdHUz8/mfvrx7O/fDD14+uD391JPT3X9tm5rq9e6v/po72/frb61w+nf37Y++NL/i/PdT9er3l3xfnOkuOtRcsbM7Z7o5YXe/SnguxqO7KnGZ5pxscbyZF6drCKSbmwdKm0t0oec1FDlcS1IdfHh1pP+OTzNehoPbrQzh71685GTCf9mpUmYq5GOlMLHfJqTycsJ6LqEzHmTJI6m8avDstujalODbIn+tmNHupQAluLoCshdCWEr4Tw5RCxGqHWk7LTfcpLWe3lrOZcH3MyiawkyKUwut8v3d8tne8AJ5rRoSZqoFkx2kpMdRILfmIpjB+IYodj6JEYcSxGHo1jx+LQ8YT4eExwLCI5EsYOhZRrIcPZQcfJiPZGxPp2ouQdr+Nhm+m1VsPtevXdRv3dOu0rjYaX6jVXK5iL5dSFCuJUOXrBTV4qpTfLZJtlss0S2WaJ7Gq58nql9nqZ9lKJ5phDdsQhP1qiXnfL1l3kyXL6crX6TBl7qlSxUapaKVXvqzbtaXLMNDlmPLZ5X9GesHN/wr0v5d6bdM3H7TMR00DI1Bcw9AVM/7P8AyFbf9gyEPoHW/IPBcxDAXM25B4OWYdC+qGQcShQPBRwD4eKspF/JgtR65b5AyHTFoNh80DINhR2jUQrnsN4hQwsYXAQhYQiUYFEWACJuYiYy+Pn8zm7xIV5ILdwS34JJ1/MK8AKChChRCKRwgDHgG1vVG9r12xrkv++QstRSraRgkJcxEMlBZi0ABPzaCmCiRASlFAwn4QEpBRkYILGIArnqSiAxSQyGiNwFIFgDIJJKagmiRoT4C1DwqW8ZCUnUSFusgF2JSYjKJoAWQpW0KichhQkKCckKlKqoSEVjKkQREPCRgVu0hBaJaaUoXIZaWYpDAKKHMzB6cpPr1Q/PmzY64UaNDwUlFIIosQxPUkYt+RX4Do5aqTQre3gLCmV40gRAUYUojk9f06ZP60qGFNyMnSBH81rgfJqgV2VQF45zOkkeb0sb1pRuKTlLpt4M0bekC4/qZVmVOKAXNCtEqfZXcesvD2mggbm36spbim5y0nvsrOFRpKvhjlqMF+PcdogcUSG9xkVWZt61K0dKlFl3GzKTUfL5JFyNlhB+isQfzkYKoXjpXimjE5UyePlVNSNRlxIyIV6i7E2O7HbhjdasRotsFsrTVUw75xI/vZw8qtN72dnm5/dyPz02tjfHi/8/ZPFXz6a+/Hd3F/u9X9zM/n1uY4vNv3fPhj+9ZN9v/5x/8/vT/71rf6/Pkh8ca7z8XrN20vOhwuWBzOGh7O21ycdd4dMJ6PMgS54tR050MXubWUnGsnBGjxTjmYrqbFqa9KqnqxRPFio+Opk02m/bMZNTtWQ+5plq23sRpfyXNBwpEO5UIVMlyOnE7rrWfvmgPZiH7s5QF8dZG6Nau6O608OMMd66fUUfjCOroaRLfmXg9halD6cYI/1qM4OaM8Nqc70yU4kiSMRcDlC7AtAe7rBxS5wth3KNaPZZjLbqpzsIOe6qf0hfC2GHUpgR+PYsTh2PE6cyiDHk5L1BP9glHMoIjoawU9G1GfC5tsx+y2v8S2/49NA6ZNW2we1xndr9G9Uql+t1d2pVN2pVt+oVl4sJc67sfNu7IwDOlFEHisijxZR60Xkmo1YsuErxfShUsWZEs1xl3rVId9nk+0rki3YiAULvFSErJcqD7oUB5zy5WL5gp2edsqmKlS5CuV8o2m+2bKn074cdK0ly1Yz5XtT7tl40WDQ2O/X9/uMgwFzf9Dc6/+H/31B6xb9QWt/0DoY+AdDAfdgwDoY1A0EDAO+okFfyWDAPhQybs0OW5PCVh3ZYiBs7A8ahyKOkZj7OUwkJgEJDoghMR8Sc2GAA0nyJYIdAmGhgJsnLsyDeBxUwAO5hRJOvoibjxXsRCQSKQSCQL4W+fcG1fNdhhea1b+rMnCVwPOkMI8C+DhYiEh2woJ8GoRkALbV6hlYxMAIi5MMiVAEX44LGFQooxGSQFAEwmGIgqRamqwwQJ5SIlImSlcLemqkbXaJQyZVYghDInIGVTKYgkYVJCgnpCpSqmVgPc2qSUJJgGoGUsthlQxWylCVnDIxJA4BRTZ6Zbz0kwvl7x/U7e+GGjQ8ksBkBKGhSCNNmRjSwOI6FtGwsB4FDTigxUUyVMQiYgclDmqFszZuTvX8iGJbj2x7mNzWBm2rA3ZWgwV1qKgG53lowZCcv6jmruo4y0burJGT1RWktUhCIWmnuQ0yXoDZfqRIsNfG3c38rorkOPE8G1lgZrg6NN8EbK9nREmbbKlSe8FXiqUBEgAAIABJREFUfifTciPecLLbudSkn6hmBkvRcJkiVCEPVTCBSjxUjsTK4XQZ0luOZurZVBUZL4MjbijkQr3FRJuNbDCTjVa0Vg/UaUShYuzhevK/3tn3l9vJLy60Pb2a+uHVkb+/P//rk/kf35/67vXsN3czT6/Fnl70f301/MPD0b9/vO+vTxZ/eDf348O+v9yLfXGh46OjdW8tu16dNb00rn9tyvrauO3FPvXZDHssjJ8I0ieDyuU2aqwGGahGemqxoRLJaKkuqqRmq+l3V5xPz5WeDePzbmpvvWx/Pb3cgJ0O6m71uU94dTMl0LQLvdCre3nGeWtcd2WYupolrw8zt8e0d8eNp/rp4xnqSAI7HEMPhtGDYfxAiDgQIg5H6Y2k/HSf+uyA9nSf8liaOhxBDgTBpSC2xwvNd0nnOuDpNjTXjI60kGPt8lkPuddPrkbIw0l8I42dSCInE9jJBHYmDZxIi4+k+YdSoiNx8HSU2gxqrvtM99r09xrVj1rMf2wv+kOj5XG14f1K3dulqodVmnsVitsVypuViksl1EU3ecXFXLYR54qUpxzKDbv8kJXZYySmdfCEHp00E4sOZqFYPuuQTxcr553qaRs9ZYTnLPCklZ22yebs8nmrbMpC5szosBUdtEIzpdqZcu1cnWlfR9FquOxApmo5U74vXZoLW0eD5qGAecBvGvCbev3mjM+U8Zl6/NYten3/oH+Lble/z9rv1/X7jP3e4v7ukn6vvd+v/5f8W+b3BUx9AVN/0NwfMvQFDP1B43DU/hwuAVCRGBLwQD4HlfBQkAeI8vnc54UijpCXL+Hkw3wuJuRDPA7ALRDzClDOLkQiAUApIN6lRv6tTv18p2lbm+6FaiNPCTxPifIZUEhAnH/JL5fiSlgqR4UsImRRWEZQMhKmCD6N8nGYR1MoSeIYhuEoRqGQlqUrjai3hA6XiHuqBH11UJtdYmPFSgySM7hSRqpllJLBFCSsIEE1BetYTMfKlCQuJ6RyWqpkQSULqeWYVsFYWIpEQKeDXcuVfnKh/KPDhtUA1moUswylYGgNQxlY2iijDCyulSEqGaxGIRMJmkhQiUtksLiIEgW1/Cl7YY/2+ZR6W0S5w8PuaMR2VMB5pRi3ggIaCEFAJhpVi/drBWtazpIuf0ZXMKrL71HBCZmokcwvYzhdzPZ1p2TJIemQ7SqBd5bivBJK5EA4bmiHTylcazDfSzc/WWn99lT8L6dS78+3XE8WnfTpl1tl41VwyEkE3WS4nA5VUpEKIlGJpivh/iq4b7eip45KVqCxUiRSgnqLsVYrUWfEa83SeiNQq+F3moCXV+L//fGRvz8Y/vxiy9Or6R/vjf7tvblfHs//8O7Utw+G/3yn99m15LPNyNPr8R8fjPz20Z6/fTT/83sTP7wx+OeXE19ebH1yvO6d1bLX5hwv5Yz3Jy33xk03+xQXB1RnUrKzSdXJiHpxN9pfJuytkvbvJnLV/NlqZZ8RO+xRfXKy9Oll52YK21uOLVVT+6rQQ23ky+Ol7y21nY9ZplzQjJs8n9a+tlD68ozxeha/nkWvDRM3h+W3svrTA8y/5D8cxddj1OEofShCrUfo40nZ6T71mX7NiYxiPUatBeEVP7gWxPd2w3Md8FQHNt6Gj7XguVZiqkO2x0csh4hDcWIjjR1Pw6dS4OkkfCaFnE3yT6VFJ/ukJ/uwsxn2Slh1q0v7UqvxQYP2fq3qzTrt4ybrk0br4zrTu5X610tUb5Wp7pfIXi6T3SpXXCuRXXfLb7kUNx3MNbv+okV92qLesCiXdcykAh5hgRE51GtA+i1Er4UZsslzReqclZkw4QtWatiqHHOoJh3KKZts3EJlTWifQdprlE7YFeN2xbhLOV1r2NNZtD9SupKqWs5Ubt3MjUccw0FLv8/Y4zNlfKa015j0mlI+c9prTnvNGZ+lx/sPMh5Xptva49P1+Ew93c4eT0mm25bx6vuD1oGQbYu+gGWL/qC1P2ju8el6fLq+oP45WCJAxQJMJEAFPETAgwRcsaCQx88XCAuFvPytwA8V8CAeR8orBAQcjMOBRBK+WCIS5WnRF+rV27pMeW36XdUGvgrYTgk5DCgmIR4K5CNCDi1FCDFMQ2IG4VIgjwalMgSVYyCLcWhEgEMiikQJgsJQCkcJCsG0DNtkIUKldKiYlywpzFQDzRahhRGrSVzBkEoZqWJJBY0rSFhBwlvyMwROYTBDAAoGVMkglQzWKHCdkrUrWBmGlBbLD4yXfXqh4pOj5vUY47HDNE3KKFJNk1vy62W4VoZolZiaJo0yysJiehLT4UgZA4bUvJxxR0yTF9UVBrXcTgW3nuZU4twSjO9EBdVQXoAW5DSiJS3/gCZ/VVewx8ibMvGG1FCPStzEcJxs4W7i+RUrsM8EtKP5NnBXKS5ygUIb54VWYtd6u+Gz/b7/PDfwHw/6/n6v9+l57yvjxScDzNFuZq2TmamVJp1wohSPl1PRSjZaSceqiXQN3lOL9TVqeuvkmWoqWYFHSzGvE22xQnUmqNIgqDNL6nTCZg3/+lzo/3r/+H++Of7FpZZvrqR/eGXk13dmf3k8/9N7Mz+9mfv+lcG/3Mx8fSX59Hryh9eyvz2e+/tHs78+nv75ndE/3+/94lLLk+M17xwof7DofmXSfm/Sdm/c8OKg7EK/+mRacSKlOhBkR+skyRJ+uhoa2E3nagsmKqCkmnMsoPn8QuPTa7WX+2QzLuFKDXW4hbo+YPn0lOeLC6Grg86ZCnTKRZwM619frH6wp+hWjrw5hl0fwq4NUNcHlGf6mRNp6mgcOxLDjsbJjThzNMYeiTIbUepkUna6R3WqV7WRZNci5HIQ2x9ADwTw/R50thOd7CBz7dRYGznZQc552OUQsRYjDiex42n4VAY8kwbOp6Hzaeh0nHsuDVzoxzf7ldcS2lte/ctN+tdq9Y/q9e/Uat+p1b7XYHq/0fyozvxGhfZVl/yBk75XTL/qZl8pVdx2ym8XK19ya24Xq6/aDOcMqhM62VGdfEVDz7FIjgJGKSCmgWI6NKLGohoypad7tdSQHpuxy0bd+gmXIVekzlllYxZ20ET0GdFeKz5oYgZMzKCVGXIqxqp10y22Rb97KVKxmHAtpNyzCXcubN+SP+UzJr2GhMe8Rarbkuq2ZLqtW6Q7XWmPJePVZ7rNGY8r0+VOd9nT3YZ/qm7tC1h6fKats0N/0NofsPf4TBmvtsevfQ6WclGQR0qFlEiI8vlSLk/IFwhEQi4vbyvw+1favxX4YRyuiCsu5InFIq6RzGvUFXSaCtr0eRVagVKykxLyKIkElwowgIsI+KQEg8UADololEvDPBoAFCCiRgA1ypMTEA5LCYyEERKCKAymCJjU0IpOK5Eoo8L2goQzL10FNJhFBkaqYGgFQyoYUkHjMhKVE5Cc2Nr/C+MYgmMQTQByFlTJICULqWSoQcFaWIpBILeDXRlxfXym5JN105Eo0+1ASBInCUxBYFqa1DOElkFVMlitRBlGpmRIHYHrccJGs40qOqYWDst/F2G5UbkwyPJbsMJ6uKAW5VaighKIUwflx5XSOSO0ouGvyHfsV+2c1+fndAVZhaBfyW2WFRSxBbXoC3v1wF411CHh23B+ESR2CoVNqHBfi+GTY8H/4+Hw//lm34/vjn5+J/nWRsulYcvBbmKlnVjppPc0YTMNzHi9bKBOkaxWhCvZYAUZqsQiNVhvg66vTtNXK89UU7Ey1OsEW+ziOrOowsRvsErqDYJqtuBEf9vP91Z/ezj+7MXOry+l/nx76Kc3Jv/6/vwvj+d/fXfmx1dHvruR/upK6uubmR/uD//yzvjP7+R+fif309tj3z4Y/mKz6YONyjeXyx4slrw84bgzarw1or4xQJ1OKw5H6aUgOdGBJquE0XJhugbva2AmmoCpKqTXyDufcn65mXh2I/HKbM2hFtWFoPGVsfJPT3n+8lLij5vey6NF8/XkkB1c7zK8tdj83mr1/XnNK9P0i6PYjQHyep/8dB99PEUeiaHrUfRonDyWYDfisqMx9mScPpWSn8koT6Tk6zFmJYTv86N7fcghP77fg852EBOdzHiXbKKTme+WLQUVB6LUoThxNIUez4Cn0pIzGfGFHvBSD3Q+IbyYga/1yq6nNC/69C8161+vMb1dYfmwQvNhpf6DKv37VfpHVYY3y7UP3OpXixWvFVP3i8g3ShRvlmhfLVbeK1a/4tbfdemvlJhPmlUH1OSKhtynJqfl8BgtzcmgPhWRUZMxBRmU40EV6VfCYSXYayQGHYqRIlXWKh8xy0btyiGbvMfK9NhlSQOdMtJJM5W00hkHM1imHG80zXcUz0eK9iTdi6myyVjxYMC8JX/Mq490mSJdpniXOd5lTnZZUh5rymNNe6zJTmeyy5LqNqS91rTHleoqSXY5kh79lu29fnPGa0x3G9LdhozX2Os39/tdPV5bj8/UFzA8h6BcHOZRAJ8Wi0iBGBaIRQKALwAKCndwC3ZsBX4Qt1BSkCfh5AMCDlIo4BcI8wpFgERgYQW79dwOI6dFU1Cq5CtEu0i+gBBJULEAA/iIQEiIMKkEwDARQwpYVCAHpSoINaCgERdqGIpEMRylQJAEABIBGRyk1aSq24qkS7GYoyDp2pWpltaZJWpaSlGMgiFlFM4SKIPDMgyWE5ACh5QETFMESSAUJWVpQEZJWFKiomG9nDFgCA6IHWZi74D9g+NFj9e0h0KkxwKSJE7gKIMjahLXUpiKhOS0VCGDYILGEJQGABWEFrOqdr06qZIMkv8Wx4QxXNgNcuq5L1Rzt9UDnEZEUAfyu+TSrJ1ZdbEH9KK91O9niP82Qv63NPq/9SAvJMntDeQ2G7WrBnlh2QCvapkQjNpZwCIVVUDwZLXr8dHe/+ePS//9q/FvHnk/ezj56HrmtQ3/9dnajbhxxSNb8yoO+NRHAoYVj26qVdtXpwmWM55S3FMGd5dDPXXG/npDf52qp4aOVyBel7jFzq+zcOscwG4HUKfnl+Lb94dqvrg88+truZ/vh/90Nvr0Wu9390d/fjT7t8cLf3s0+9Mr2W+upL66knl6s/eH+8M/PMx++1rfN/f7v30w/OzVgS82Gx+tlz3Y67o367o1Yr7Wr7rcS2+mkY0Is9+HTnSAvY3iUKUgWg2l66ieWmaoGpiowgfM4hNB9+3ZzpszrSfj7r01sjcnG5+ejf7XG8M/vp5451T9uRHzXCOR1HMPtZre2dP15HDzW0vWh3tUdyeom4PUtV7mVC91LEmsR5H/Wf4jUeZ0kj2Tkp3JKI8nt6oPvteHLHrRQz5sXxc23UmMd8kmuhTT3co9AfmBqOpgbOu0j5xIAafSonNp4cUMsNkLXkpLrvRg19PymyHtzRbNS9W6N8pN75fbn9jknzjVT0q175eo33KpXnfIXncoHhYpXyuhH7rZR+WaD8qMbzo1rzn1r5aaXyo1X2lwHnNq9unxBQ02p8UmFHBOAeXUSE7JjKrlvUp5TMUG1UyHHGplRR61NK4Ce/RYnx4fNDFjRdrhIm3KKk/ZFSE9ETXRMTMdMeFhI5Kw4UPlqslG04zfsifu2pMun4m7hoKWjM+U9Bqi3bpwpzHcaYx1muJd5kTn/+d/osP1P8nv3pI/0fUP29PdhpRHn+zSJbt0KY8+4zX2+Up7vcW9PutAyPIciQGwlA9K+IgUQKUIJIalQgjgw5AwX8zZLuHuAnh5Ek4+JOCiYiEk4OGFhVA+D+ZJMZHApgZK1Hm1qp2Nsl1VDFcpzkOlIhASwwAHlxSiYgEqRRhQrEBBFgFoSMygAAmJcKmAgsUmDFWjCI1jGIHDOIYikAyBDCRWZZX6ysVeY17CxB+ogBpMEEWiYgY10YSKwGgCximYYnCawmgIJkQSWCZGZWKUFjMymEAlqIQng0ElhshFhWqOsEOr2UjbXj9IPjwgPRXFetWYHlOwUpyEUQyFpYAAlQrkiEQJCRkIxCERBHAYHK7UmQMmW7+WmtSKpjXUmIoekFNxEg/CYAJHhpRMTiufNNFLLt1+m2a/WXWqxH7B7Tyq1axQ1JTBPCRnQxKeR7AtRXH7ldzpYrhPvVMtETolvJQDeHHJ/csXY//3L0d+/XDp+5dyn13t+/R87JMNz+PV3a9MuA+H5DMeZk/SetOnuOJjryYUR/zYaKMgUiFpcSENTiZZrYhWstFKNlajCFfLukvwNgfYZpe0mqBWK1Sp5FUpJb0NtvsH0//xRu6HO22fnPR8cTn+zZ2h7+5PfPdw+vuH49/eH/rqbvrrK0NfXuv55m7vd6/2PLsb+/rF6LNrya8vxJ8cqntrqeL2rOPCqOHkkHajT7mekR1OMathbKEbybZAiVogWiXOVItH68XTu8XTpeBkMTxUL26qa1ZVr2nq13dXZyY64HvrDT+8O/Xz+7NfXks/OdB5NWacqxL2Fe8ab2ra2z+4kuu5utD50mzRy3OGG2OyqwPIsT7jakK5llQd7tEcSskPxpnDCfJIAt/fBx0YpNcHlAfTmrWIejWoXPbL93Uze7vZBQ813Q1NeoFZP7AvAB0MEhshZiVBHu7BNjLi4+nC0z28832S00l4I4JcyVZcSxTfbTM+rNI8Kdd9Uqr7wK1608480qEfl5o+qHC8YVe/baXfsRKv25h7xeq33dr3y3QflGoeV2g+3m35qNP9aqPlgks2Va7J2OQjBtURvfaEgpiXCfvUYEJLjiu1WTnZp5BmlEhcxoYoJkgjEbnUx0IeVtKtEvoNQNAEhi1I0ibrK9YNGXU9WmVcq4zqFSEjEzLhCTvSX4JP1OmWw6VLPeUTqaKBpDUTNsc9hmiHIdhVFOh0BDtswQ5bqN0SajdF2k2RdlOs0/L/S7rLmfEUZzzFPd1FPV5bptu81f97ffa0x5Lptvb5Hc+RGICAAlDChwEJDEhBESQVQlIhBAnzJdwdoKBg66vv1p4PRCSACnZBXCEmQjCRwCTjOeXbG1W72pWF1RRHJtgBifkgJEZBHglwULEAhzBaKpIj0n/Jv7XMj8akWgxWoDCDYRRBEgRBogiLQiocLtMLfeXikI3b6wCyNViTFVUwJKqiaRmukFMqllRgKA2DGApDBCKmYAYFcKkA4nFwkYCRSIwkU2MuqjEXVRiddcbKgWbPxfnwexc6H52uuzhQlSspaVTaS3FVMaEsUepKVfpyhaZJZ/E5SjvNrjZ78W6HvdVZlqruXGj0rzc2nW5wX00kX+wbuN6XPZ8aPB3rPxPpORWMn/SFVpsqFiqdE07roeamV0dy787tfTAy/erg5Ku5qcvJ9HJ9XUbD9BvpSbdyvlKdUHErhHAniO6r0n56pvt/fLv4X98dePru7Cc3Mp+/2PfltfSX50OfHm1/Y77iZEw124pOtZPHw5ozUdXtQeuNXuNRv2K6hY1W0h0ldLCc8ZfT3nLKW051l5FeNxF0kzE37XOS/lKq2QLXa6Bkpen23vgvD6a+v+P901nPl5vRpzd7n90Zevby6DevjDy72//lzeSzq71fXkl89WLi6zvxz2+EPr8c+NPZ0McbvveWq16dc17JmjYyyoNxZi1KrUbxtQi+4kcXutBsC5Kpg5LVYKZaOlILTNYDC5XgRLE0XVJYbCkTamck5v2uop6+Jvr+kZaf3pv56wdzX15PfbTWdi1umq+W9DvzxxtL+32+zk5PJto8myrZGHZdyxofjio2B9VnU8zZFH2+hz6TIk4l8ZMp8kgMPRSRHE3ix1Ky9aj8cEi5EVafjOpOx/SHosrlELXghWY80lkfsifELkd0qzHTaog+EMLWY9KTKeBkSnwiAZ5O0Zf6DTfS7mse0+0a5Zulyo9KNB86Ve85FW875U9s7MelpvfKLG8Vqd+1s+872Hdcqoclhver9B9VGf5Qpf+swfKndtd7HSUXq3SLRjhtxoJaOKtlTpjUl3T0mhYe1iAxBZmmyCQDJVlRUgbGWSZGy2IyKqFEwywUYMGgAgpq4ZAOCeqwiJFKWmT9Fn3aqI7qVQG9zG+gAgY0YoaSdmigRDbbaV+IunIx+1DM2he2pL3mTLc13FkU6rQHO2yBdmuwzRxsM4fbjOE2Y+SfVSDSbop2mP9Fot2RaLclO+ypTluqy5LqMqe6jKkuY9pjSXaakp2mTLf1OQIWo1IBLBHAEiEs3trVKQEFoJSfL+HuAgUFqISHigU4ICJBCSLiS/n5kEiEADAkLNTT+aXybW2qXR55fhVZyPC2SYVcCBRjEJ8GebhYiIEoKRWyCMDAEgoWs5iUQgESkbAEpMAhGQKxCCojKJakKAylUJDGpFUGcbhSGneK+lzQYA3aYILkFI4paZxBZXJKr5IblXI5SYIgwJOI8gEhvUugE6GlClN36e6+9uih3NJLJ2/c2rj24rk3Xrr81qNX3n325K2/ffXq3/5w64s7V948fPZ0dnYtmd0bGziSnTs/t3Z2avXyzKFXVs7enD1wcXrPxb0rN9fP31m//srq5qMDJz/bOPrjvbef3X79+9ee/P2Dpz++9fnnd959fP6l1w6dvbdv8fRg/0K3dymW2VxcvXXo3M31Sy+fuvX5zZef3bn35PyFQ/HoXEvDsqd5T2tV0iSPEsZJvXPTU/v95cz/+GLvL5/tf/po4eN7g5/f7vn6VvrZlfBXpz0frtTeGDCudkAzdcKxLnzBQ53PmG70WC5FDEe9+ukmVX+tPFBB+yooTyXlqaR9VWy0QpYolaecrKcI9rmwrmK0xYCEizUXxvx/fnHy2fXos03fN1cjz26kvrrZ9/TFoWe3hv98c+Cb6z1PryY+3wx9fi30+Y3Qp5f9fzjnf3Ks+9FK69vz5XfG7KdT6lU/uceD7O2Gl33IWgBa60b3duC5ZryvnshU431VaLYamqiRLtSIZ93SvhKuU19dQO/Zwawp1EO+Kv2Do12/fLDn1w8XvriW/HCt5VrCsFgrHXAVjNXqmmuqCGuNsqy5rK4h4ak5kih/M1fx+pTltXHt62PK+1nZrX7qSj97uldxMMqcizFnk6rjCe1aWLPk06wF9cfjlvOpouMpzXqUXfFhezzQohdfCCkWo8aFmPVYULYRpE7GiNNJ/EQUOxYizya01wbcL3WbX6yV33USbxczT5yKxw72UTH7XqnyE4f8UZHyTafmTYfybTP1npV616l6s0T3frXm/+XpPb+i2vY03H3v6NN9ztlBRQQqr1BrrVprVQ7EiuRURQWqyDlHFTErooiSlCBmRUXMCEjOOeccFTDs4N775O7T3eN2j3M/2OOM8XyZf8Az3znmnOP3zhicVkyKrVCP5ShtW7Bnsbs4VcSMd4BiZdBpJ/KJStKsFFaruJecBIf4wlgSTRIA6SLWQRH7EF9wWCA5LBIdlnAyBWiaAEsTEhlSXqqEGy/G46WcZEciQylNVcri5dIoJ36UAxnvgie7sFNcwEw1fsbolBerOZ/keiZFdSJReTROdSzONTXKLSXSNTlCkxSuTAxT/JPk0P8jJUyZEqZMDVf9H6Hq1DBlapgyNUyeFq5IC3dJj5CnR7pkRikzIhUZkYqD0aqvODCDAzMwiIlBTARgsJlMmMGAGSyQYsO02Q9RbVEmDWVRcIhOwAyURYEgOxhiQgAI0farhBSDg3WMvXU0b6+OtJUy92MsOgQycIgqwpgkyEIBNo/NEnH+b4DvP+UXcVEhiQgwtgDFxDhXzOULcJzA2QQBmVzAFH8oxZV2yBXIDkAC5WwJiXPFfHuCsOfxZSIhj0cy6QzqPmuCBrny7KPU+pzYw0+K7jbfr2962DTft/i3T//9h91///zpH3/+wz/+8pf//tNf/vzXP/7h7z//8e+7v/5t/cefN7d25hbnB0ZXRme+X9n9ZeunXzY+/3XnrztDC+NN7TNDwx93f9x5+4fZ0a3F4YX3C4u7U8uznSPvl3b/9sN/Lo2vd9X3dL5sa6h6OfLsWdv9qvuXC6+ePleWV3T9yq3bNx49elBb//DZ6sjMp7nVmuLSSykZl+KSckLDjwXo8/QxNenH285lrT49+svw+Y8jl99PlW+OX1puzdxoztyoTV5/HLN8K2Sk0K/+iENVHJYTyskNRkrjBbcSRbfiRPfi7G9GOFwPdTwaKMk0iJICeHEB/CSj5GCgwxGDY5aPJNYDifVAUnx5KZ7idHfHOwfDpx+eXHiW8b4+cacu5W195kb9kc36E9tvTr1vOPG+7vjGy8TlZ3FrtUlr9alLzxJnH8ZO3YoauRrcm+fVcFJ9P1V2NZJXFM65GoVdT8BuJ6N34ojyKOJiCPekiXskgDyqxU/rsNwAtMBAK/JHcnSATm6h8cq/Ie5w+Bct3l6dN2I/T5b/Ont1vf7gZEXQ60yXkkDkpA8tWy/08XY/IPGjyEMxeZDaIzg9JOJedmp/iXHkin7iqv/AJffXp5weZCtKD2nOJSsrkl1LUtxyE90ORimSgh1SQ51ORmsuJvncznS7n6l+kOF8J0l4PZ4oTSCLErmXEnlVSWhVEvthGlaVjt1Pwh4li56lKp4laXqNsh5fQb8rOeHKn3MXzbiLJrxEo77iGXfpoFrY6yEe8pT2uxBDzsSYu3jQx37Qjzetl26EqDcjfEaCPO/6Oh10JgJFzEhHJFIGn3LkPFcKe1yFLd7S265OeVKnGAE7SQpn2IOZEuSgQHCQK8ng8VJJ9kEBmsnDD/L4hwWSDIE4iUfGC7AEKRrtyI125kU48YJkeJgDHutCJCmwJCcoRY4f8ZGcC1XlJbjlJmpOxcqPRSmOxqgzolzTIzWp4aqUMGVCqDI+RPGFhFBlQqgyMUyVGKZKClcnhauTIzTJEZrUMGVKqCI5RJ4U7JIU7JIcIk8JdUkJdUmPUH8hI1LzFQekETCDhAECYnEABsaiIwwqTKNAVDuW7QGIaocwqAjTjgNSSDYdA+wgyAaGmDAEwHQrjYRicrKOsd8fSX6nw22cYDsSBkBcW+pNAAAgAElEQVQGFWXZyjgAHwYhOsDHwC+j+0kU+GI+gQECLiLmYXwc4aKoACeFBJeHcwicTZCwXkqPd6fFyQ9kaJjHTHiYG+kk4AvFAg1f7MIVCNkcyJbG3k9zw6UnzXE1J0sa7r5cHV78886f1ia3Xj5qbG4Y2Nn+8/c//NfOu7+9//int99/WtvdWXv7YXP9+3dL21uzK+933+5sv52dnOrt6BnpH5ufXJ6fWZ+f3lydWBpo7xoY6l/beb/78983PvxtaeP7ueW1jjf13a2t87MLg0PjV0srz+bklZdW3LxW2Vh1v/v5s7Znz17cvfPwxvWqW7ce3L3zoOpe3eumhdmV9YWNisul2XEZGcEx6caIM7EZD8vujDe1j768N/r0+FrD0e223E9DV7ZHL+0MnNjpOfq2+eDG88T1RzHr9yJmygJ6z6ufpshvxApLE/mX4rELUUh5LP9upKgmXFoQ7nQuSHrEwE/1JxL9yTS9ONvifDJUecRin6YljxrFxw3OJ/xVN9KC+28cmn126P2blHd1qeu1aau1h9ZeH9l4mbX5LHPzafrqk+iVp7EbtSmbdRmLT5Nm7keNVwYPFgV0nXetO6a4lyQri+CXRnCvx5IPUvCaTM6TVOHteH5RGO90IC9bRxz3x88EcM7rOflGWpE/fNbH1lfiRWXn/x68BmEXDJ7+DcWRP45X/HmxcvPNwYnywNeZTlct2Bk/IFMvdXPTWBMaW76Oxg+AxSEuHilRkWdvnbI8zA15nh92/4zhUqpbVoxbXKR3YLBXsN7NZPDwCnB38lWLPJylHi5uWne9xf98tLY83fjwqPHxEY8H6ZK7qZxbKfD1FOBBOuN2Mu1uGqv6EP40TVCb7FAf4/zCLBnxEUz6imY9hfNuggV34aKvdMZHPOrJm3GzH3QTDvlJxv0cRhS8ESfuhLtkwt9xxIc3H+i8Huk5Febx3M8px4WIlLINMixEyg4Sgtky9JmCN+wpHNY61Pko7sgV6WIsQwpnyJgZEiRFwEskRTEYGokwk3hQMolmcvnZPEkWT5zO5SULOMlSLFKKRsjwYCnHJMIsUk6UMxHnzIlxAKOdOEka/gmTU368R36Sx5lY1fFo5bFY1aEozcFIdXqEMiVMmRSijAuWxwTJY4LkCSGqLySGqr+QFKZJCtN8OQgkhSgTgxUJQfIvJAYrkkKUyaGqL3z1JdJJNhOH6DhE54A0lEWBaAcQOgO0o7DpVIxFR1kUAqZxERoO2SGs/SjIwBGIA9mopHY6h+/C7fdECL4LIGzlbCqfDYEMKkI/IMVYAjaE0MF/yk8grC/mf5FfysP4OEJiKMHBSZzAOSiBswVcxCShJ3rQE5S2hzygUyH8cE++E4/H55FCjOCz2DwbQAPyD/tHPM+rHHnSPF7b1d/a+9P7z//+p7/3dY+cO1d4qeh6/+jixvtfNzd/WFxan5iZHp2cmJqen5tdnp2YG+0fHBzom52cmhwYbqttfF39/PXjVy9qXlY/fNL+sq3p5ev62mfNzc2TM6ufPv5ta+NTX09/3bMHI4M9fX09peVlyekZh49kXbp0saT4cnVZSfOTh8MtDf1NrxuePHhWdfN1zf3W+mdLyxsTk3P1dc1HDx1Pjk5LCEnIjM64cena1OL6p59+WZjs7H58auRO0sqjrHdvcre6cn6ezvtpLPdT3+l3b7I2n6dsv0h6VxO1dMs4esqz/rBj1SFxYSp+Pg4uicduRhMPw8nyaIeyKIeScPsLFkm2jkjz5qQHCI6EOJ4MVWT441k67km9NM+ieZgdNnDn4GrTye03mRuv05deZSy9ylx8mbHwJHn+YfRCVcTq45il6ui1ZynrL9OXniTNVYVPVOr7L7u2n5PXZjvdTxBXRAquRwkfJAteHua+OUE2ZkmfpokqogW5ZvJYAOe4FsvRoRcMnFwjs1AH5fp+Z5I6s7ETe6ECCD7mr3Z9dDrw41DFf6zd3mnNnqgw1mY4lAZxzung1ABnN5V6P1NsA7jYgWpbIpDmkMTzORFs8Y0M1SXFmKIjdH5aV2cPldDdg6PxJJReqNIbUPrYuvjsc3DfL9MwXDwwVz+9h19ycPCF9MiyI+abWR73sp2qj0prjooenRTdPozXnJS15Lm3H9e0xNq3B4rbfchJd3LRV7zmJ13yECx7Clf9pPO+olFXfFwt7nfl9nnxhz2Fw868EQfeuFo46S9b0DmvhrjNRHnWm5wvqbEkCTNEyg5y5oaIcDMPOSzGn6hEYz6SCa2k3Vv6ylmcZy88IWFniuiJEihaRAYTXBMKG1FGCMmMxMFkknOEJzjKEx4myQw+niEmEqRojAQNFaCBfMQsxEJkWKgMDpEAFhka7ICm+0guxnoWpHrnxGuOx6mPJmiORKuzolSZEarUMGVisCIuSBFtUURbFPGhmn8SF6L+J8mhiqQQeWKwIjFYkRCkiDcrvxBjcoozu8Rb5LGBzl/xYJDHZpEQg8Oi4gCFhGg4YMumWbFpTNCOxqbROQADA6g4ZEew7VDAmmTtxwEaAQEkbKext/N1+DbI4bswyR4Tj+oM2XEhgA0wMKatGKaLYIgLc75c75EogLOZJAckMADHQT4flRGokIMQOIaRBErgGIZwcbaYRIJlrDRvIFlDzfAAjwbiZhUmw3E+gRMsRIbyTEqvyxmnemveLPdP9zR03r927/a16yMDg3OTs3dvVyUmpGUfPdXY2LmwvLW69HZsYKq/Y2Cke2Ckr292fHx5bmlmcqGjqa23pX20rXuoobnpYU11ZeWNqyWlRZerKqpeP66pfXzv6YPbXQ2ta5PLy0MT3S9f9tTXjnR1Pq+uyT19/tSJs0X5heXFVyqLS6qu5L+8W9n+6kln/aumF88aXz4f7OhcnJ4eHh69ef3WyeNnkuLTstKPHU47Xpxf3ts++tNPf/3++z8sTPQOPD4/WBI9XZK4/Ch7sfHoDyM53w/mfBo4v9Nxer3+8Obr1HevE9ZrQuZKPHvOuzTlONdki2+kkjfT+JWJxPV4vDxRci1OcifB6X6iqiLc8Yyed1iLHwoUHDbap3lzDvsgJ/15ZbHezYVJMy+O7wzm7LSdXG/MXqo/styQtfYma+V18vLzqNWnoZs1yQv34+aq4lefpG28SNt8HrdUZRy5Ku/KdW445vAwRXIzRnwvXvTyoKT9jGTgoqjzpKwuS3orgZ8fQpzSoyd17LM6dp4eOW2Cigzsy4avYxVSe/FBOnoaosd7SngV6d7bvaX/vXX/Y9exyWvGV+n2ZcH4BQMnxdfRU+FqQxcfoEgPUB2sUd/9oiCaPIqvcCWdVTylB6nyZDlobKQqK4nrtyKNrb2fjdTfRqo/INbv4/vvIbysCHdbgRck8nZ0DwwICo2MNmUk6M6m+hZmeJekupcc0pQddntxMbj/SmzXEW27RTLiS864YdPu3AUf0YqvZNlbtOQlXPYWLXgKJl2JYbmwV020qsAOF/aQE3fCSTihFk76irYNXgsWzxaTc6E7kuxgGyahhtmzIxyIcAHXRHDSRbzHGscJf8c5vXDcXzjgKniucb3qwDsipsfLwCAZV8vn+hCIjgv54FQ9hx5NAId4yDEelk1gh7j4YSH3kJRI4iNhBGwh2YEC1ChkG0WASczSSlB/ASvWlZcb41GQ5ncuye14giYrUX0sVpMdrTocqUwLVSaFKGMt8miLIsKsjA1WfSEmSBkTpPyyI0SZ5fEWp3iLU7zFJSFIkWBRJVg08WZ1vNk12uAcF6iINytjTfKvhCibjwAESEcZNhjTloQoBGiHMvcDtnTmATuYSvuS/BhggwLWIO1bKUwhGVSUTsVBazdnmr/LnkCnbyySb80CugPrAM5iYBALByhCkCqEQDHO58AMLgYSCIsDMwgMIDkgQUACAWaPsUUYQhAcjEfCXBzlICQHlhBIkISR4smMV9gkKqmpfiydI+CA4zKBQCtwSTVHPqi8NzezuL6129kzeK3y9tlTeXmnTzY8f9r5prG0sDAlLuHs8dOt9a3LM8szYwv9LSN9DUMjTX29DQ39rc2Tw+NjQwtjI5Odze09b1pGWzs6X76suX39VmXxtWuX79142Fhb29n0ovV1TU99/WhTx2hD42j9i9mO3q6XDffL7pRfrrhf8bD6RvXDa/ef335Yd/9abdX1+up7TS+edzS1DA+Mz8+tbax9ePXsaVZmRlJc/IljpwvyS87nXH704OXayocf1j8vjSzPdLYuPC+ZLUmZuRg3dSN1/HnaWvOhjdbsnZ6c7c7c1Yastbr0zbqElWehSw+1k9fcxkvce3OUdVnSx4el1zN5JRlEWbr4ajT3VrToeYr6RYrH9SiX/BD7nHCHwwbHwzr+8QDynEHw4JBx7P7x1dazHyfOfei9+LY9Z73l9EbHmZ3uU7udh9+3p3xqS3z7JGP2dtzkzeil6tTdhqwfWzJ3XgXP39L05cubTzk/TpfeT5BWp8kaTzgO5TvOlDn0n7VvPCq9nyIsCifPGrGTOvisDjqvA08asQIju9DwrwkqQi6OZyIZgI1JTdALYtSbHSX/37tHP/SenLxmfJUhLQ8hLpqIZDeJn9KLASts6c5WtlIrWGXN9WTZe0OOHrZ8uRVPuV/s/p3I/Wuh2+8Frr/lqfcQHntxLxtCSyMMVE6ADexpC7lSEbd9wgCGwkJ6W6T+Oo3ez2T2jTL6RPu7Jejkp6L8q8+ltOWlNcT5tPoKp92JLQ027UnOenIXvfnL3oJFT968OznnRsy5ESMqSZ8b2SRntjgwJxTCJbXTvLtsTivZDfCd0GruupEZMmuzaE+wPTXSEYmRoGE4VwfBCQS3SuU0qXdZD5a9DXXcDnIe0VuqVU6nHaB4Z7bZWeAl5nkKMJ0UU+MUH45tGEFL5zGzuUA2DmeRWBafd0xEpBBwBAoGEexAPmIQwHohaJJCPhLUk8sIVxM5UW6XU33PJrlmxasy4hUnYlRHY9SHI5XpYaqkEGWsRRlpUUWYlTEWdYxFHW1WRQUqI02KCKM8wigPN7hEmmRRgfbRZqdYizwuSBUXpImzuMWa3WPMqvhg1/hg11iL+iuIbYNyqBycxmFTOKAtwaJwaAegA3tg4FuQsY9FtWFRaACNBTFZEMiAICoKUxEQYNMAHouu5tvppPvMoj3hwv3uUoYItYIZ37JBO5wNcAFAwgLlIMqDABJgkhCDRAGSw8IwBodgcYWQAGV9qdxyFPKEJEeA4zALkApFWntOkg8vUWOdqvr9ITdqrISMEmmzPE8XnL3fUj+1tfGXre2/9A8t3r39NPdE3qmM42dPnrpeXnH/9p2CvMsns08UXiyqffZ6qHe4s7m9s7m9o6mtvbG1s7m9u7Wzt727t717oKl/rGN0sKWv81Vj2/NXLU+eNj1+3Pb8Se3r513dbRPjw1OjQ4Od7Z11dd11df2NjS11LfXP65tqm7pburtbujubOjsaO9oa2trq3nQ0NHU1trU1tPW09M9NrKwt7MyMrt4ov5oUExcXEVN8saT5dcvDO1U3yioaX79cmFz4YfPT5+Wt74e7Fp9d7r4UNFZg3rieuFp9aPfN6Y9due86Tm+0H91qz95qylivS1x4GLnyIGTplv9EkXPXGV5DNvfZQfHDDOndg/wbqbzyWKIiknsnXlaTrnic4lQVK7waJn+Q4fv6VEB9rn9vZehq47HdocvvRgrfNp9/13r2XeeJD/3Hfhw/+nn26M9z2T/PZf/clTdXFd9TYpi5G/65OevPndkfamNXq0xjV71azzq/PCh5miZ6ninoOG8/fUO+WOXSVeTSmOvw7LDsdoyw0Ijn+MIn/MDTeuScv+0JA/WckZbvicRL3YVoqB3iBXHZOYHu8/WX/vHxzs+jWQOlnjVJ/AoLuyQICdV6SIRudNDLiuGynya2YyhsWN42mJEqM+7D/fZhOluOyQbxt4ZUexnC31pD/0ajH0DtKRwfa8hnH6DaD7pYQwoK6snimwFBKCgJY8gMkGsA20tLV3oDKsNXuhRZcOb5mMw3IUF9vk6TvoIFvXBOy5vx4i/6S5Z1sgUf0YwHb9aNO+vGnXElpx25zXLuAyX5XC6YUjrseCjeGRWLMZqPiZ4NfrwcR1aSFIwSwJFcMEYIRkuYegIMIaAjQuKBq2Iq0H83UrcR7TYf7bJodmtxF99z5pU5iAqk0rNi+2ShwMRF9ByOP474k2yDAI0Q42lC4hjJOY2gaVw4hYvFEmQYh2cmBQY+14+HuBMMfzbdm2ET7SA6GxuUlRYSHOYZGuKVFms6ESM7Fud0KFoVH6wMD1SFBWrCzW6hJk10sEekxS3S4hYd7BYV5BpmkocYnEONLpEmRWyQJi7YNSpQGWGURwUqo82qSJMixqiIDlRGmJVhZsVXEGCNwLYYbIfBVByi4hCdw6KiDDuI/g1A3wvQbEEaDWKy2AALAukgSEEgCgICCB3kggyNgBIgs/oiv68McECtMeYeFKLgbIAAWEIAdEIwPgqTMICzmQTCwlEGB6ETBCAQwGKcLSEQGY8Q4SgGsXgYxgZAIZcX6iyIVeGBwm+infefDXa5FBdx49iVxmvdE32ba4uftzb+ODG1+ep1R0nxtdPZZ84cPpl3Lrfiaundm7euXa0oyLtccvnKgzsP6182NL9ubqlr6W7pHu4ZHukd6Wvv62zq7GzqHGgbHO8eH+0cHmjtHm7vHunoGGlrHetoHx8eGRkYHOzu7Wnr6HzT3F7f2P2mpa+5fbhneKh7aHxgfHpkemp4amZ0ZmZ0Zqx/bLhzsL+1t7ulu7ulZ6RnfHV+8+3qh8Xp9TvlFRnxSQlhcaX5V/taeh/dfJB36mxlcclA//jHd7/85eNf/+P9hz8u9S+/KR+4caw5P2Xubvr60yObDdkbjYe3Wg997D3xsfvkRkPm+qvkjRcxq49Mc9fdxotd+i+6tJ6Rvz7u8vSY9OEh8a0EbkUk92as8EGqY026U3Wa7OWxgK7LUZPXUxYeZL6tO/V5sPj7kZL1rvPvm89+6sz9qe/8T33nfug782Pf+Y8957bbcj42Fy1VHx+7mTRzN3Wt5uDGk/SVqoS52xHjpb69F91bTqlfZznXZct6L8mnb6hnbjkPlspbzsmeHhTcieaXWIgcLfuEFj5hRHJ1tDMG+kUTpcQPPuysluMWFtuXhfKz/OSTL3L/8fHun6aOj13zfpoivBaElFiwYB9XPupibafYY+dgZSOytnXeT/W0w/QHyMC9sJ8V2/cA4mUFKL6jCr+x4/zWivl7Gs8Oc2cSRju2vy3kagPJDwByCuhB45lYXAtbGMqUGGlyrZ3SZ6/Ek2Zv2K+K9fVPKA2O6LC4jfmTU37orB9v1ksy5yNc9Jcs+kvmvATT7twv8k9riDEnwXMH/LaSW+fpNO+l+OijeG9WrkWrh40ONxXQQRE1RgxF8OAwHAgj6MEE1cCFQ0n4uJh85q6cN2t3w/w3Q1XzwfYrBucOD361intDKS1xtM+xd0iViSwCjgkn9BzUjwNpSSiIi8Tz0MNc7ATBSceBNAJNwPFwDmHCCR2X8OLCapzmikJqCAh0dIgNMhlDDHJ/Vzedd3BoSHa0y+Eol/QIeUKoPCZIHmFWhwdqwoyaqGDPCItbhMUtMsg93KIONsqDDE4hJpcIozLarIk2ayKMynCDIipQHWNxjbG4RhvkYQFOIQbnMLPiKw7LDmPaYgAVh+gcmIWCDDZIR0AmSNsDUvfCdBuYSUMBAAGZbJAOsey+yM9mQjyIqRFRA2RWZsneUNH+ADEgRw6QjL0ckIJADJhJ4zAZEgQhCYSDQRyEyUGYOELHEboQB2V8tr0AFxOYo5AnwjEchkUkD2aAGIiESslsvevpUK/y7Njme2X9dXVTPdM7Cz+vzn7cWP5pdeXjyMjC06d1F88XHD90/MyRE0WXLl8pLKosK79deet6WWVZcfmN8puP7lXXv2yoe1Hf0tA60D043DfS19nf29E32DM0Pjg9PTo/NTozNTw1Pzm7Mj23NDm1ODne29TV9Lzh5cPn9U9et9a3djV3dbf19Hb0DXYNDfeMjA9MjPaNDfeMTA1PL0wuTo/MzAzOj/RMDnWNj/ZOTAxPTY/NDvQNv6lvrrlz9+LJs0eSDxXlFAy29re8bCy9WFB4LvfO7Ue93ZOLkzvbyzu/vn/3h53F1ZGu9ieP+ooTRyoSFh4nb9anbrdm/jR4+tfRyx/78nY6s7fb0rdeR63VGJbv+s5e9x4u9Og6p24861J7zLE6TXwzlns9mns3WfIo0+FxluPL464tubq+wtCJawkbNSd+6b76h5GK970FH1vOf9+W96E5d+PVyYXqY5N3jg2VH+sqPjpy48Rg+eHu4tSOy/Htl6M6L0V2Xg7tuhTaX+jdd9m3K8+36ZRb02llf5H75HWP8UrlaKm8/Zz4+UFuVSLvWgT/ggk7FsDONmB5ejjXyCw22940AOfdHA1CLQf2o7LksUpxb9Xxf3y4+1/zp6du+j9NE5UHYYVmNMhdjTFF330n/GafaN8+ifU++f4DHhREaw0Yv6N572Wo97OcvrXj/s4K/t1e4Ld7WDagDuJGsckYCqS1YcntAAcqS8EAfOy4WiamQ4hAJjfASuz3jdjrW8IbEFj8FDGnfKNrTdpJo3BZDyzpwAU//pKv86K/ZEkrXfATz3jwptzIf8rf7yK9LUJL5dxGg2bd6PlZr/4QKF8KcnnoTp6R0mJ4duFCOILPiSLQcAIMJhhaEgzBWTlSstFLtRbo+9Hi8TZQvmySrvrxu93QGlf8pkZY4CI5ZS9JkgqDhLgZw/Uo5o/C/hjLgINhBJxIIukkkoECmSSSTBLhOMfAQb1wUM2hO6F2IhSSYahG5uDm7s3XeDCclaSbVmOITg93Sw93TYtUpka4JIU6x5hdooyaCINbZJBHuNkt3OwWbnYNMarMAU7mAKcQkyI0wCXcoAg3KEIDXEIDXCJNqhiLa1ywe7RBGeLvZNE5RQRpvhLBAI9FJ1g0AmJhEBNg0ZgsKggxYLo1TLdmM2zZLAoKMlCQxgapEMsOguxgCEBYsIANuIppOvv/k9/IZyohaz59LwbYgQCNTrMF6BQODGAEjHEgDPtSzkPnI0wJB3LgscU8nIvBEj4pJAgZVyDG+UxrOgFw0nXuTwvzRl6/WOzv35xdXJ5ZWZhaW5jZWl1+v7Xxw9vN7yfG5x8+eHL6ZM7RQ9kXc3KLLxeUFBRWlpU/uFP16N7Duzfu3a68c/9W1aN71U8ePq17Ud/d1jPSPzo5MjU/tbC6sLay/HZl+e3iwtri3Orq8sbmysb60trS3Px4+0jP686WZ80d9Z19bYM9nUMd7f1trb3dLT1dzd3dLT2dTV1tDe39HQPTIzOzY3Mr0zsL4xtzY6uz48sTw1PtrV2PH9WUl5ZVXCoovVBYeCb/yrmSsY7Rrdm19leNlQVFJXmXXjyq7Xwz2N7QM9w/8P7d5g+fPi/NveuvONVZkjxxJ367Pu19S+qHzuzPI4W/TF7/MJzzceDk++7M7TfRa8/My/cCJss8By+pu88rWs/Ia7MdHqWK7iTybiXx7qQLqw6JXxxzqD0qrz/u2XwyoK8gZrX61IfWy7utF2eenhu6d7StLKUhP/bZmfCqrJBbacG3UsOqj5irj5gfZhmqMvwfHPSpyfZ/csz/cbZv3SllwxnXN2c8G057NOa4dxV4DZV7j1R6jV6Rd+VK67OFzw5Kb8aJzps52QFwloFzwcC5aGSVmm3uBtLL/PiJDhoZ29uG6mWU4g1lqf+7Vfk/i2dm7+ieZAivBuOXjRyLRkkw+N99y/39t3zrPY4UK28bG28K7LWf4vPNfsU3+4Xf2ZDfWrN/9x3422/hr/cQCDeLLzvN4WXYMrRWFHtbhowBaBC23pbwpoNeMORPgfy+xby/I30Anl5lH1PqHVqvt0zq3Fd9yE0tsKIDl7TEut5+JUC6EiBd8BPOeJDT7sS8J3fekzvrTnSqnK/y2PkOZJ3BdSPI6xeL61uDc48X74ISTxLSzFyqmQeHkkgkB40ksVA+4kuwQlFavoTT6a18a/T4aFTtGJy2DLJVL6xDDVap2cVq/JQjkS4io/i4gcs2goiejWgRWMuB9AQYiAMhOCsCZx5EoIMkJ4VPhJOYFmVp2HQH2E4MHSDZdCEG2fP4PLE9RexgJVaA8gAHn5gIi39ylO5ggm9mjDI5zDEhyDkuUBNl8IyweIabPcIC3UNNmiC90uTvFKh1DjYoLTqnYL1LiEEerHcJ1ruEGhURZnWkRRNpUIcGKIINyvAgt68kKCAAmSRAJ2AGCjJYTAqDSQFAOodJx5gUhGmDsmwxwA6FKAhoBzPtQNCWDYMIwOYjgFpE/T/5JdZGHkMFWQuZViREY8NMOsOOyaCgEAtGWSgGcjgAgQFcDkuIAVIclpEQibG/FHURbFRCCBAqBNuCgd7GpqcPd1eW/vjx88etn9YWdiaGFoZ7J0cHxpeW3m2s726s7w70jlSW3jicnnUkM+vihfzLeRevFBbdqLj24E5V9f1HD+48vHfz/t0b9+7drHr5pLa7rXdieGplfm17Y/f924+7Wx/evft+c/PD2vq71ZWt9bV37zbfv93YXVvZ/LC4szW1vji8MDs8NzEwPdg33tc72t83NtY3OdQ1OtIzPt4/Ndw9NtY3uTCxvDa3+XHzDx82ft3d+Ly9/mlpfmOwb7Shvvn585d3yyprbj94/ejVy6qXc0NzO0vveps6ruZdLjt3ounx0/n+qe769if37vd3tX/a+f7z9/++O9g+9KCwpyJpuSbxfUPadtPB7c6cD0NXPo3l/zR58cexnA89BzcaopeqTdM3fcZLXfsvKXouKFvPyF8fd6o5JL2XyruVzLmRgj48yH2UIXp+SFF72KPhmL63MGbiVsbY3fSa/MNlh0IuxHldSnAvSHS7EK24EKksiPOsiHW+kaS4kbNhoroAACAASURBVKSoTHC6keR0J1N196DyRqpTVZp9VZr9o0ynZ9mqVyc0dWc0LXnuvVd8x8s8+/NVLaddXhy2vx7NPaeHsrXQMROZZyTyDazSQLvbQYybevSEQuCKKmwo/l4C5P65sL9OXfrfuZPz93U1mcLiIM4FHRaokvNAgZUV9+vvBDZ7XEG7IBrNcABQW9k4/X4P7zdfI1/vw/Za877dx//6O8G3e2Rc6WV7xVW+7CwFNO6zk9nSpCyWBoGNtpjGjq5iMrwO0H2tQF+Ub9Q5hZ7wTOnRquYCXLe8XLZchRs+/CUtsajD1o3cNYP9ql62pBXPenJnPMgFL96iN3/ek9uscCggoBwh+tTHecXi9mOIZirA4b4TmGaPBnFpOoJqIsFQDI5A4TACMfNgfy4YjTFLZcSAl/OmVr4T4LBtsN8IkMx7EnUq+IoSOOqCJIjgMAIOxGF/DNQCsD/E9meztSiow4AAjGXEmIEcRioHT+PzEoTcIALxQujOIFXIsiUYBwTwARnGlKIwiqK2OO+A0Aly8BYpzN5aU3RM+MH0kMwEz6RQx+QQeWKQe7TRK8zsFWLyCDa6BxtdzQEqo9bZqHW2GJRmrbNF5xKsV4QaVSEGZbBeEWJQhhpVYTplWIAqxKgONqm/4rFpJETBITscoqIQBQGoMEBBIBoBgBwmHWPaooA1Bh5AIRsUskVAOwCyhSEAAdg8NkslpPjb7zOJ94RJD5gELA3bRsTaT7LpKAKAAB1m0XE2CIF0FAFIDkhyQB4O8AlQREBCnEXgGJ9Hcjk4BiJciKB8a6uWKO5dvfvjL7/++W//9fH9r2tLH+YnNga6Jvo7R8eHJscmF+bm1uZnVlvrOgrPlxxMPZx18FjO2bzLeReLLxeUFpeUl5RdL6u8e+Peo3vVNQ+etDV3jQ5NLs2vrS1vba3v7L77tPP24/rK283ND+vruxvru2ur2+sr29tbn95v/7iz8fH9ys77lZ2dle23i1urc2vLMyvLc6urC+uTgzPj/VOLkytbS9vr81vL02ursxsbC293Nz7/9OHPv/7w759/+Mun97+urW7PTC9PTy0Ndfa017V2NnQ0PGlqq+2sf1J3t/z2pbO5ZeeO97ys/Xnj49Lg+KNrZc/uVC6NTfz7D3/7z1//OtfV3Fx+dKA8ZuNJym5T1mbrifWOCx+HCj5PlPwyXfxpNHe789B6ffRSjWX+vm6s1LWvUNV1UdN2XtN4RvksW1KVht9KBCvi0co4zsM02bODyqcZ6lfHfBsvBNbnGoszo4+HeWbqpcdDJOeipWcjuDnh3Px4UXkE73qc+Fai5Fq8sDyWX5HAr0jgX43jVsaIK6IF12KEd1PsH2Y6PchwrDni0nDOa+CKqTvf/81J9aMU4ZVgdq6WeSYAOR8kuGwiLxugIhOjLAi4GQhcdGXpeRI6U6fiIgVpPjttWf89kb34QFd9SFRowc/4YgFyRwIm9x8gvtknsjvgjzDj6Qzzd3SHPdacf/ua/S+/w77dJ7Whqq1s5F/vkX1n5YjZFzu43ZSoLrPIKGuWwoYpozKUAMuPCrrYUl1oTB9bhhZmBwY4hF3yCGvURyzpyHda8Xtv+11fly2jai3IecUi2TDzVwLEq3rJsk40503OehGL3twlH96SD6/BWViMAxdI6JlGsmxSbloU9T7i01IgQoSaeECgEIqQYLE8JBaHQkkwgGTo+ewUHnzPWTDm7bDiI17zF6zoRdN+3H4P2T05mu0IhNuDATxQh4NajO3FBnwQzJvN9oZAb4jlC9N1KFPPYZpwRjiHG8Xjh/JJLQdSgjQJk8KjUVA7O3s2Vc4BHWAIBSAqgttxZSyBihB6itzN2tDYhOSYlHj9l888ccGe4UbP0EDvIIOHRe8aZHCz6F1NWoVJqwjUKQO1zoFa5yC9ItSkDjGqLAFys87FEiAP9lUE6VSWAJVBp/gKZR/AEBsOYoNCNhzIBofsCNCOw7LBGSCHTkcZNhjLigNZEWwbAqZw2DQAsoUggM2CSTZTwbf1le75Ir9exFLA1lz6HgywQ2EmzKJjLAafDXMABg/5UssHkhwWFwdwnIVhNJIkRSIRl+ARMIGzOLa/t44KCJ/tnfrwp//a+fGvs7Ob06OLc8OLva1D7S39vd1jc0tv19c/LM5tNjxpyjtx6XDKsRNHc3NyCi7nXSy4mF9SUHjtakXV7fuvnta2N3X0dfYvzW9srO683fiwvrK9vLD5hcW59ZXlzeWlrfWV7bXld8uzm+uL229XP20uvt9c2Xq3vv1u9d3G4sbWwsbbxc31mZWF0dmupv6BjtGFidXt1Y/vVj5sLe1uLu6szGwuz66/Xd3dXPuwNL81M7U+NDDb2T7a2T7aXN/05OHTR3efXLty+9qV2wUXSi6dv3y18MrdG9eGOwf/8v3f3i9vN1Q/uneloPXxk52p1R/+8I+d9Z3Rl/fai5InKmPfvjq01XJsqeXobvvlj33F349e+ThW8H44Z6fnyFZL/NrrsNkq/+Frnj2F6p4C997Lnm25qtfZoqcZnJvpsmuJvHtpkuqDjlVp9tWHFE+Oe94/7HolJeBCpPK0mX/GguUGs89bwPxgsCCMXRaMXQsjKiLIsnCiJBQrCsMKQ9GCULQ4VHAlQlASzi2LFtxIlF1PkN5IlD04qKw9a3h1wqc6U34zinvFDBWa2CUh/KsRsqIgboERzjcil4LwaxbWVW/rcCmHjfk6cMCjwY7TjyL+Ppi+Uh1QkyW5ZCZOeCIe9iKQDn1tBX1tLaNSzBAz9QDV+Fuq+F+/Zfzma+S3X0utbX3pLMs+O89/2yP5+oAQkF2097nl6FPOlibbsj0PsBxt6HI7mjudLrWlOzNQA4CFOXOjTmhiWnyNb3Wum3pyyw/f9RfumF3Ww13XYrzWIjzWAtULfvxlnWhJK5zzJmc88QUv8ov8LS7c6zzoCp/T6Oa4ZFSM+EmuKrFIGRws5ATy4RAJmuBAJAvY8SQQzGX5cKkmHvugAKlRCid9pAte5JyWnDXyB3zQF0rHXDEniMdQ85hyAtBwYA8U1kAsNwx1ZUPuEOANsfwRIABjGVCGHqFrEZ4WJ30ITM0GZAyKgEbFKXTkAEsMAM4oRwYSEB09AJFWHJkd7sLmujGVQVK/MF1IRFSUOTHCPz7EI8LiHmx0DTJ5mwLcDFpNoN7dYnIPNLgadAqDThGodQnUulgCFCFGdbBB9WUZpFeGaDVmP5XRX2nQqb6C0X0obo1xbFDYCgP3cyEbLmDNoVmhFAClUlGGDQfcRyBWXNSGi1K5COOL/BAAEzDDmW/jI/nOJN4Tam/jJ2TYg3vZNr8DqVYgkwLSKSidJoQgHgSIULYYZ3MxEEcZHA4T5TAg1A7BUJIkMYRDwATGQG1/Z5McnLA8uLj9y//s/PD3pYXthbH52aGpntbelpa+1p6xocnlxeXdpZmt19WN57LyDiUfP3Hs4qkzhfnnLxTmX7p5rfL189qB7v6Z8dmV+dWt1beLc+tL8xtfhJ+bXpmeWJydWl6YXVucW12a39hYerc6/3Z2dGl2dGVhYn1ueGV2dn5mZm5sZHywu3+sd2imf2ysva/j5ZuG5y3dzQNzY8ubizvbqx8/bv30YfPHjYXt2Ym52Yn5ns6hF0/f3L/7vLK8uqTwXnHRvdLS8sprt+7eqS69cuv6taqS4mtFhVdv3Lj1rLZxZGz55x//54fdP450ddfcuFZdWj7a0D25/Z9//PP/fj8z0V12vONi8Ny9uOW6jPmmg5uv87ZaLr3rKdoZKfowcfnTeM5uX+ZWS+zqi8Dx2z49Jeq+Is/hK/5DBZ4dZ5zeHBWUJkkLIjhlMfidFP6dFMH9TMeHWerKVOfKFFV5gmNhGHHeSM/V2lzWU0uMwNVAdoUZv2JEi/XsEhNaEoyXhBBFQcTlIPxSEK84XFgUxisKJ8pihRXxkoo42c1keWWyx40U1xtx9mVheFkwdiNScCvW/kaM05VgbqEJuWAkLgQLy0OAcr9v450hgu8lRlhJWu5ApeGvfYnrT4xPjsryLcRRd7ZKzLWxsfuX76hf29hT6SEsetpeW92/UPj/z2/tfvN7zjd71TR6OBOK3WPr/S97yN8eQBiO52Tam866a6hDhg3qvZ/ltJ/uZEPTMGxFdgwXFj8IEyX6SZPLPePnfb3+4k2uBwiWvNirvuiKhTcb7jAX7b4crlsK0M56k4v+gkV/wZw3Oe3BmfPAv4R/l5r/QILdkQp6vJXLBkWLhnNUwvCXIYFctp5gWQRArAhOwJnRKNWEUzyIAwE4kMVHXqhEUz6SWS98Vk9MWgRdfsgNiX0axtbAFD5K4yNMZwzWIJCSxXBGIAUMubEhfxQ2cNiBOKxHmP6gnRoiXBFchbAdWDQB3Y5LoXFsWch+EKewpZBQyBLRaeR3LMHXiL0VqgRIr/3OQYAqUO5rDgkLTowOjA3xDjapzUaNxehl1Lnp/TWBevcgk5fZ6GYMUBt0KrNObvJ3NuvkQXplkF4ZqHUx6+QhRnWk0dPspzL4KQINrl9JWEwek4bR7TAGjQMwOEwGQqFA1tYMpg0bsOVCFAlAkQK2YsBKwLbio/uZmA0AMWCQLURADdfWLLaKkexLEe+PsMfU8AEubT8GMSGIDbFQNh1DKAgB4BiEs2EOgnI4HA4XY/MhSMhkirgcMUfIA0R8SIgyIKrNfi8f97uPHqyvvt/d+cvayh9Wln+Ym1/p7u7s6uju6x5bXNjYXNuenZipqXp45sTJzPSDWUdOHD2Vm5936fnjZyP9wwszs0szcxNDQ0OdXSPdPUMDoxNj0zPjs5MjUxPDk18e6sb6x8b7hicHRicHRsf7hkd7Boc6+/rbuntbOltb3vR0t3e0NDbXvuxufNPX1NT89Omzm7fqnvaM9S2/Xfnxw9YvP3/6659//vsPuz8vTq+2vRqouVV7s/hBef7twpzSgrNXi86VFpy9Unwu78r5/PL8wvL8wsunz104dqo8v/DZ3QdtzX1T4ws7m7u/fvxhe3Gx/lFVRV7Ow9KCnva+79/9+u8//td8T9+zK8de5gdP3o788Cpttf7YZkvORmvORkfuh8H8n0Yvfew/s9uVvVMft/w4cOK2+8g1+WCZ00iZur9I3XLG4XG6/Z0kflk8diUeLU8mbiYL7yeI70eL7iQ6VESJSyIk+cGC0zrkrD+cp0fytOBJo+05o22Bwe6qgVpqpJcEgpeC0fNhRH4YnheC5VjgU2bwbAhyIYZ7MY5/PpabGy26EC08H8bNtaDFYbw7iQ5ViQ63o0RXQwRFQdwcI5lrERYa8UJv6KALX4HISNDZIhdUnwnYbsr50Jj16ih50UJL9eYqxPYH9uBff606QA21gUOtAK/fH5D8617yX39ju4/qYUtm7cWO7oPjvqVo/vVbbI8td699Nuxa6ah96qDOg2GV3QHAxk60x9abY+NrQ4TvkcWLZdHHlCFvfLWLBuWuyXHNi7vsga344qt6cl6Pz5l4CxbppFE44yOc0Yon/IVDXuSABz7mQc568hc9BXXu7g0y4ZgLf1Vn36nlX1QwImQ0XynLTDJCeECcCM0UE1k8NJnDCkHsdJhNEBcuFJM9joI1V/57vWzL7NjpJ7gmZ0ZJST8OJGUxcQZIMCERg+5Mt3ZjWPmwAD8WoAMAAxs0onAAB/TlsNxRmpLFcGYyZHSWiAkRFBA5ABF2HClLTEIwm4UyqAJbO3tbupwBqWFcxeGpEZkHLHPjqbQu3mEefjFGY3i4xTPEwAsOUAdpNWZ/tyCdV4jRN9jgFahT632dTQFuRp2rwU+h83YO8HI2+rkE6dXhJnez3tmkczZpFRa961dSiCmEWCTEQEEaAtAxFh1j0DEajcmyZYNUAqQLQboYpApBKp9N5aM0GLGDIQAF2CIYUpN2AcJ94aI9MUKrECHTDbYWM/eTEAMCQIAJsxkIQoEBGovJBFggACAgGwVRBCBBFo9FxzAWl4Nz2QIhKiDYqK3NPp6YTM5M7eubeL/71513/7Gy/MPy0sbgQF9PW8d479js9Nrm2vb02Mzd6zczk1PjYhKPZJ88l1fytObFQPfg/NTc5MhEd2t73fOXtY+fNr+q7W7r6uvs7e/s7W3v7mvtGmjv6W/p6n7T1l7f2NHQ1PmmufNNc1vdm5ba+tbXDR0NTd3NjV1Nb9pe17bWvmqvrW2oqXl2+/aTmzd72yZWZre/3/7j+63Py7ObE0MzHc1dL2peXS++UXLhSlFu8ZW8kit5JWWXrlYWVVQWVVQUlF0rLL9RUnnzyvXrxdfult+uf/J6uHNwfnpzbXlnZ/P9550ff3y7O9HVVVNZWZl/4fGte4Ot/d9v/Ph58914U/XLorjmQsvSw6SN+qM7rTnbbTlbbaffdZ1535vzsf/ML6O5HzsOrtdHz9boJ+56jN7QTN50n7zuM1ikfnPMuSZTWBmPXolhX43nVCYIbsQKb0YJb0YTpeFYYRhxLhDL8mEc9qYe1zJO+NMOG+GjBjBHx7ykYxUGgJcNyHk9clqPXtChF/WcPCOeE4Cc1rHPGrFzgfjZQM6pQOSMCTmlB05qmXkmuDScVxEpKA0hroYJi0K5uWbyrIV3yYAU+YBZKr4GE/MQudmFf/ugx3RV+trjpNfZvOJgMMWdcBKKbK1wKyt3KhxJQUL2Mt1+s5f7//4O3rtXSkPDAfsLdvw8GyxjH8X3N7/nfLMP+1aYzFKVOPg/cXS9jKK+tgcIaxu5lZ0Fhw0MaTTNIUojMhcr9aMG7+1Ax48G7pI3PueOzHphM374hC8+7keO6UQDPvxRV8mYm3TETTKoFg6qhWNu0llPxzkPx04v9z6105SnbEorfeaOHJfaBvHtvPmsEJwRyQXTJcRxR9EJmSCVj4YSTD1JCxGAJVKix4Vc8iRW9LzRQPE9DzxLRvHkMF1YNKEtlWfHEtNgZwB2hQEfjOnPZvtDsA4CA2BIzwb9UMATYarZFCcaRUqlCCg0nEJHbBhsaxZmg/KoPBRgQ3QOjcK3oTrYMRQMSA2gSpgjB3hqBk/OtncXqI3OHiH+utDIYP/YEOcgncrirw70czX7e5h1noFaN6O/UufnHKh3NwW4Gf3VAT4uOk8nvY+TyV8epFMFBrgYtc4mrcqid/9KxGbyESbOZiIQDWBRIRYVBRkEBDBZFIBFRQA6zmISTABnATgA4zDCAWkYE8SZqAiGlCTVT2hlFu4PEdjoSTsP1NqBbSOAqBiLzmEBJAsk6SyQQYUBGgwx2AgDRZk4QufBVCFM46BULgZzQYQHoXw2DDEP4DjD2099987Dd29//fzjP9bXPm+sb0+NDvW1NM/1j8zPbmxvfZoZnSkvLo0Ji4qLSczPv/Kg+lV/79D81MLS7PJI/3BzXePThzVP7j148fBx44uXra/rut40djc2dTa86axr6G5o7G1sbm+oa62rba2rbat/3Vz7sv7Zk/pnT5peveh48aLlyZPmmpq2F8+bnz6puX2z+ub1uprqmbGlpZmN2fHFzube6vs1165WFuUXXzyXn3fq7PkTp/PPnCvJu1h66XJlSdGdirJ7lRVPq17U1tQ317Z1Nvb0tg6M9IwvTCxvLr5bXXy/ufxhc3Fne3nn+80Pu0ubY+1dr+49eFpR/vL2g+H2wd2Vd+uTA20P8l8VRLdfjZypSlx9cehtffbbpqNvm49tNh9513ns8+iFj4On33UdWW9OXHgVPFcdsFitW6k2zN/VDhdpmnMcH2ZwK+M4pbF4WSy/PEZYHsWvCGKUBgMFIchpE5TsaROtsUrwOpDsaxfjBSV5gUe8gPP+7KIArMSAF+g4F3yRYj/smklwM0RaYRFdMfGKTNziQF6xhZ9rgM/qgFN+jNNaeq4RzA9CLwVjFy1IUSi3OIw8Z+GcMuN5erBEC55w5/py+QJMbnIiiqLtGy8EDpVY6g6LK8PJNCUp5PJsrAkbO286Em4DGb+lyv/tO85vfgfZUHQAmcF2uEQRXKQSR22Z5t/9Hv/md/RvuGFMl/P2vo+cPEoRbrANxdmOEsBkHUYd4kBNMu4SFSLye6L2fGvWfG/hb/szpr3QUXf2qAc66kkOuvMGPQT9nqJuN+GA3GFI6TSscBpxcRxXukx7aGZ93Ke93ca8VdNa5Yxe3urLL3GiJXKtjSTdjwDjCDiZRLMlgrNO9kcdZYkiMoiEDCSQIAQqHdAhDTbnxx7Ss5/4cY66wL6krQi2E9DtRDY0BxtQYctWM9iuEOyJQVoM1SKIFmb7Q7AvBHlATBVAcwEoUrsDIootSaFANnbAARpsC6N2GGqHA1Q2ncqhUAW2dCcKS8WA1Ey2ksV2ZiEKGuZA58shmSfpHKD2NIaaA5LCPS0BKrNWbfRR6300eh+Nzlel85Pr/JyNOjeDVmP0V+t9lQFezgFezgZfZ7O/wqRVGPwURj+NWef5FQ+iEzANgSgASGEBdgCLygbpKMgAWFSARYOYDJjBghkgTGfDDAxmYASdRtAALoMtYYMqHsX3/+fZLh/aThR138+566w1bSkS15/F3RMI8RCH4BRoSwt1n7q7u1KZGjWqQCnu7iECJBCc+rQzs3Sfbefeu8+Lde/+Iz6vvs8jx6bLCVkSwMYnm3jkOBZZTiNL6WQ1C9KzIQ2dJGdSlWwwlgurOaCaDaiZVC0T0DNBNQfU8ehaBk2D0AxsppaDGMS0RL3o4O69/sGxv/75v97P/X166kPA09tVUz3U3Drsn5gd/9jf0X/51PlVy1bs2rr7yeNXbZ2Dfd2D/oGhgGd4sNfb09rTVNNQ/qLk+YMnRTcLn939ufzZs/rS0qaysrrXrxtev2kpe9tcXVH7tqTyzcvKNy/LXxa/fPTg6b07T+/dqbj/sPzu/fL7D8ofPSp5+ODZz7ffPC5qqHjbVNtc9urtnRs/nzp6ev+uA3t37Nm3c++B3ftPHThx9vDpy6fOF164evvytYc377x4WFT6rLipvqun0xfwhkPD0+HQ3MTYh3BoLjQ8HfLNTIx8nBn9PD40MxGY/DLx6evUpwnvaH9FSUtJSX1JdUdjp7+7x1NfWnP/RPHJgvpzOZ2FywJFq8ffbJ6t2BZ+u3n03eap+l0z3cdnOg/Pdeybbfxp7F3+ZFneZGnO6PP04D1X39WEqiPqJ1uld9YKr68UXl0hurpCciWdeiWLfjaHtyeVuSqBnKPF5hjwSy3EJWr8Gj15nwO+nMq+my14lCt8lC16mC18mMV7vlxeslr9anXcswLFkxWKJ6uUT1YpC5eJLy/mnc1inV7EOp3DPpnDPpbNPLqIdSKTdSaXfSiLsSuDeSgNvphOO+Tip0tYYlZseizrWJbowXrT2132ko3yu8uVGzVCFouDwnBwJBsByYyiWBcSlJEoHhrNQxNSiIx8Am9LNHMLmb8NZudFR/MX/hi1kJMCqPbK7Q9UjkKmcg2e5qLC+Rz2SYp1D+jcqTSv2qFOabJZPmSp5zJYI05yj53VbmG1mjitRmGrSdZmVjSblI0GeYdG2aOL9ejUXoPGbzEMJ1r9KbZ+d8KQIy6Qrm1LV/9sZm0T4/J4hCweksZlbxKytgs5ByWSgyrFFoUkV8BK5cBpHNp+EfhSw/baeQNJ9BIX5bSOmiUCxDQyjYbnQZRYMmTCMaw4poVEN0N0A4vmZDOdLIaTRrdBsBkEtQAljkqRU0hCIkFIIrNJJBBHBAkQncJhUAR0Ap9CYhNJQjxZTgA1FMQEMs0QwwQzdHSGEWSpyTw1SWRApA55fFJSUlL+4qSc1IRFyQlpLnOy3ZRkNSTa9ckufapbn+TQuZ36VJc+xalLdehSHZp0ly4r0ZCWaEh1GtITrVlu1w9COpmDEOgwAaET6QwqkwkwaRQ6SObAAAsBGTBEh2AEotFB5j/xi0BQBCJimKlkQQYx0SXHpkgJaULAIIZ1QjiORVbRCEYuxS2BUyWUZB7axqW4eEASD0zmgckcKIUNpXLgNC6SJECyJOwcMTdHwM0VCrJFnCwxI0MGrV+SXltS/uvXf//1+/89N/dLyO8faGry1bf4BsLjI7N9Lb23L908tOPAtYs3aqvbfL4Jnyc45AmF/OPjwcnw0Liv19dQXvfs7pPC8+cuHj9248yZN0VFXTU1nuZmT2PTYFNzVcmr10+KHv98q+h2YdHtwvuF1+5cvXTr8oWX124XX7359Grhk+s3X9x7UPHyVX35u7qKioc/P7h64crJIydOHD5+7uTZK+cv37hcePPqreK7r0ufVFS/rqsva2qpbO9u7PF3B8K+8fHQx5mJX2Ynv02Pf50e/zo7+W0q/CU0NBsanB4PvJ8d+zIxPBvoC437Jz6E388Ep78F/TM+32B7b0djp6drcMzj8TWV1z+9XHtpdf3lgvbry/wPV06VbJgs2zhSsjZUvmms5eB0x5HPfSe/9hyZa9o+V7tuurIg/GbReHFasCil97qt5pjm2TbZnbXCG6tEN1ZLr2dwri0SnckQ7XKwV+uhPDVpuY68OgHeocUcs5FvZjFf5AverRJVrxLWrBbVrZa+yueWrhGVr5e+3SAt2SAp3SR7vUn6coP40brYeytlhcuFV5cJL+QJTi/mHs/hHMlm7UuiHU1H9qTB29MYBzJo57Pox9ycXDksposzVIzDqYIri+MerNQ8WSW9k69Zo5VQIU4kSoChOLFwagTBEImVojACEk4ShbVEU6w/ki3/k5xEEa3nK9eRSNLIeX/8EdSThBuE5psyVyHT+BNBmE6hF3BZxxaajxNs+w3W9Wetizwp9pkMxUgKx+Nmttk5zRZug45brxE3aeXNOkWjRtIUL+zWCgb0Yp9RFjArgg71cIrOk6btcscGnYqBdPXrJMlBNXW5EJ/Lpy7mM3M4rC0ixh4B67hUdCxWsUEpTBcgKWwol8ssFEF1Gq7PIax30i/pCWuFuAQaiQtAFADNAUhqMmTD01x4upPCjF55LgAAIABJREFUtNHZJi7bREdMNNgMQwYAjCcDSiJZQiALiCQOjsAikGEClYyjkggMiCqEKVIQLyKRxUSyHE9VEWAdhWGC2RYa28pkWRh0M8zSUrlqMl9HFVjZMofenJiZlZqbYV2UaklPTEi0GV1WQ6Jd707Up7j1LpsmyaFLcfw3fl2aU5vh1KW69CkOfZrLkpnk/EFCp/AQIhPBsxkULhficxAOHWCCRAkNEdJgPh3mMBA2i8FlMrh0Jg9hSOiAhIZI6bRYLtUoxjik0W4hNplL0kkgvQiMZxP1DIJLSFkkBxZJ8ZnCqCQuJoWLzeQSczjkXA55MQdYwoeWCGhZImiphL5Cxlgt4awU8VZLeKvkjHwZZYVddvfU0anA1F9+/9+fPv15LBQe6u4PNPUOD05MDM8GevyVL8tfPCiue1fv6Rvx+yeHfOOjganpsY9zE5+mgrNDA8PttW1lz0pvnL9w5vCRa2fO1paWjQ56xzze7vrGupKyu9evXj9/9vzxo2ePHr506kThxfO3Ll+8dfni/UuFt85cvnn2yqMbd6tfl3vaegY7+1prGl88ffas6Onzx8VvX5c3VDe2NXZ0tfb0tnsC3aOTgfdzoS8zIx9nRj7OBj98DH/5Pvv75+nvX2Z+/TT1bXbs08zox7nw59mxT1PB9+NDM6O+yYnh2Ynh6RHPaKBvxNs71NPe52nv6G9t621pH2jrC/QMjfT4+xrqG0uftT0523x3f/3lle1XcwIPl4+9XDX6Zs3Yuw0jVdvC9bs/dRz/2nXyY8v+D027Zhs2hSsKJkqWhV/ljjxK6bmWUH1E+Xyr5P468Z010ltL5Ddy5adS+HusjB0meKcZOWijnXJzijKQl0s5letEDVuljVvF9VuEdZtE9ZulJRv5pZsEJZsELzfyXm7mv/xJ8Gwz79F61oM1kp9XSQoLBFfyeBeW8M/m8k9kc45ksLY74H1ueIcb3JrG3JvBPpvJOOFmr1ABSoZokZJ2OJl3Nkt1dbGqcJn44rL4nHgxhsSNQElxcDKRsSiKbI7GyjAxQvxCEQaniSaI/oBm/oCLBeWb5OYDEMMcGRH1B4wCy8hnxZ3n2S/RnVvI8Rkk9iIE2hAZewzU70uxrruXvGg02zKdJfamcHtSpM1WXqNJUBPHq5ILG1SyRpW4XsFsVCADsXSvlu0z8nxmvtcuGkyS9rglbS7BcJK8OUVxzcJZIycu4hNzBNBSHn0Zm7ZJDBwQ0y4qRad1qvVqfroIXsRDNoiEL2RgfTy33iy6YaCvlhGcDKyaQhJTAAYFKwZIOgC0kEE7EbQDSAKdYWQx1TBVCwNaENRQwFgiIMVT+HgKG09FUBQQTSWiQRwGweF5RKKEQlSS8EoSEE8E4vGQlkg3UNkJNI6DznGwWA4QMUJMDciOAzhaiGOlCx0KXZIzI2txpi071ZaemJBkT3BZTS67Psmldydq3U5jssuU5jKmOg0pdm2yTZNs06Ta4pMd8cl2XarTlJnk/EECEQQQgQsTOAwSjwUImACfBnBBshwEJCCVTwN4LEDAA0U8SMShipkUHkLkIWQRg6LiYY2SKKc0IlWATmOTzEK0TYS3cLE2Ni5ZSE4RExMFMS5+lEMYnSiITuHFZHEwOVxCLp+SLaJmiYAsGZQuIuaKScvEUB6ftkLCXBvHWB1PLoinHC7I6Kqs/+2Xf/3yy79MTr0f9Y+N9o2NBeamQx/G/ROetr7B9v4x/8Rk+OPI8NyIfzo8PDc38eX95NeJ4eng4Ji309de21b86Nnzx8WN1fVB33DQE6h4VVZ47sr5I6eunD5XeOHyrUtXb126evdaYfH9opKnz0uePn9w+/Gtq3cf3ytuqmod6Q9Oj8xM+ieHuof6u/r6u/o8PYMBz3DIPx4enpkMvZ8Jf5kemfky9fnTxMeJwHjIMzLcFwh6AhNDo1PD01PD05NDU2Hf+Ojg2Ojg2Jg3POYNTw1PhnyjI4PBkcGgf2BosNfX0znQ0dpTXd1e8a62/HVJefGb8qel5U/elhe/KX/5vLb45/pHF6uubqk5u6jzapr33qKRZ0vHSleHSteOvt00Xb1ntu7QbP2B9y0HP3Xsn23ZNlO3bapizfirrFCR03PN0HRcXbpd9WSd6vZKaWG+5Pwi9pk0+o1F3Ae5vOKl3PJ8YesGRfMmReNP0trt4oodopJt4pdbRM82iZ9ulBRvlj3bIivaKH64SVy0WfJgs/jOBsHNFdzbq4SFBYJLSzgXcjnncvmnMrlHkuk7ney9ibRtLmhLKm9nBu94OuO4m7lODRj5iiUq+qEk/skM5ZlFqjM5vIOLlXYlN4YoXoCNI9CzKOwlKMCOJcTjo6XE+RI8Wo7BMeahKf8XTkmL3R/nukXnLYuKps/HxxFo+ZDsGGQ6CrnXUmxuqiQRoeUwxIdjtTvXOfLfpid+WKr+lM31JjG6HKJ6E7dOJ6yUCaokomaVvCNO2KFEuuKAISVnSM336QS9en6nWdBpF3c6pe1OSZ9LWuIQHdIgOSJ8hoCSywcLONBaPrJFRTmiQK7E8k9pRKtiGW4BKU+IHFDKSzVwiZpxPZZZIIPVXJIQwkooRBmZLKcQNBDFBFOMAMlIJhgBkh6iamEgFqKoIVALIfEAoiDBQjzIwQIMHBVE0UgxCBbFwOJ4GIIMS1ARCGoyUUeGzUTESKSbSGwzwLFAHDvCstFoNhKso9LiQboKZmoQlgXi2HnqJF1azuJMR2aqNdmZkGgzu+xml93ocGjtjvh/4k91mlKdhhSb7v/Hr3XbY912dYpDn5Fk+UFAQvMBLA8m8BAiByFxICIXJApAigRPEJLxPADHYRD5XLKIT5Ry8VIWFgGjaSCai2AVvGijdEGSPCJDhMnmUm28PyYJo9z8GDcP7xaQ7BysgRll5ERZVdEOWWSSMCpNgMoUYDLEhBQxMVFMSlUBThEqTYzJlVNzxdASKZIXB+TGogoUkVsSYyuLHn/9+Ldvv//7zPvv4dDcbPDzqH92Yvj9uHd8uCcw7h37NPX1w8xvY6GPYyPvJ0Mf309+ez/5dXJkbnxoanRwzNM+6On3BYfHPs1+ng7PVJZVnT5y+ui+ozcv33zx8GltWWVXY1t3U3tvS6e/xxP0BIKewJvS+hcvKpsb+2Ynv33/8LcPY1+nA+9nhz6MByfGhsOhwNiId2zEOz7inRwamPD3hcd8/pnQaNgfGOzq6GtrGehoDfR1Twz750amZ4YmJ7xjob7h4W7/cLd/tH9kwjvm7/EMdvZ1tXQ0VTfVvKutrqxrrG9pb+2qavZ19vgHenrbqmoqn5S8uvPyyZ3H92/fe3z7Zsndy++u76o4nV1/xtVxNdFzL2OoeOn46xWjr9aMvdkSLts5XrHvfevRr32nPvce+dh+bK5h20z5kplX7skiu+9qQsNBw5vN8TfXcm+t5t0oYD1YwSnfImvbrujeLPRs4fdt07ZsVlZsFL7czH+6VfRgm+T2T9LrGyW3VkjurVU+2Bh3Z73y5lr5zQ3KWxtVhRuVhWt4d9eLb68RXV7KvZDLuZwrPJfJO5bE2O0W70tibnMhm9MEOzKEx1LZJ5KYWzSwUxyXF8s44OIeTVMez1IdWcT7KUsSJ6FHkxQRWB2RnktmL8VSXQSSgYyOpUbEYhaKsGg4Ak3+Ez6eFncyLvEFQ7g9GhWLg8wgZw1FdAgfv5vszoeTE+kaO4eXppUcTDXsOJy4tCHD+C1P8D0XHnIB7XparZZXFy+okAqqxaLOOKVHJ/Xq6AETNKYQj6plfq2sQydqMYhaLbIuZ2y3K67FJnyYwNkaS80QEtOFwGIeuJoLbpPRdxnh4/G0yyrOERV7iYhkY6HyBdAZdWypGX4Yh+wUwxouhcwiUmASl4qXkDBaEsEAkowQUQNg4qloDYjXwWQtRFHCFDUCaRCaBqQrSLCAALNwEA0HQRguCcXBYbh4ohRHjsMSNQSSEaDaKLCNTLOR2BYK10LlWUG2DaRZQdCCg/VUWjxEU9IRNZ1uhZh2hipJkZKTnWHPSLG4Heb/xm+3ayzWWJdNl+QwpDiMKQ59ik2XYtOlOfUZToPboUyyqVKcuowk8w8CEOBCOA4UxYExHBhgIwgDIdMRNAmIIlMiGVSUCCbIaWQhhGdR0UwADRJQEIBiMmIUnCgnH7VIgMngRTlZ8xKZaCcDZWFEG5hRWk60mh+jFERLuAt1ArJOQNSKsDoxVifGasS4eBFRLSCp+WCcAIwTgLF8QMGnKgWASgypZTRpHEFv5OzYtKKrruE///yf//j+/4yP/hoMfRsPToRHJsZHZqfHPn+Y+uX9zNepidngcGg0EBwbDk8EZ6ZGP02Fv06Pfx0PzwVHxoeG/OHJuenpr0MDQ0+vXj+8YePF4+eLHpd1tveEQzPfPv/j4+yfw8GPs1Off/ny66cPH/sqXjy5crbtXcn3udkvc58mQlNBX3h4cDTg8fv6vUMe75DH6+/pHxnwBj2Dvq7u0YGB8EB/qLt7uK3N29w21NEfHgxPBT++H50Z940O9fgC3d5g/1Cwf8jfNdjf0tPb2N/T0NNZ397d1N7b1tvXOdDXNezpHe3rCY74Z4Z9U13tA021LfVVdZWlb18/e/6q6FHxjSuvLhxtvnGor/CnxhOpTccTRu5kDj5d2f9gme/RivE3P01X7pmpPTjbevJz3+Uv/Sc+DRyd6doz1rw++C5v6Km7/5q245jw2Q7NrQLhzRzuq9Wq1t0Jnfu0jTv4VZuh15sFrzaLXmwWPd4ovLeWf2s1r3AN/+Zawc2VrJsrOTdXim6tkt5crbi5RnZrrfjmOuH1fPr1FYwrKxlnC+BTy5HjyxhHc5gHMmi7sljbExk7zMgeA/mknXg9i3U9U3jMwlkfi1+rpm23KA4lS05kMI/lCFbYFSq2gIjjUCgGAFlG4+/ny09yZFtJiC0ihoFGaTBoacRCDobiEhrOSW03QfFaHKiDmXkU0Y5oxfF5sYcA/TarZeVabepOgfG6wnZVY75u1jx3afqyzOE0XdAi8GiQOinYIGF2KuU+rWHYaAoY47wGvtfMDMWxe9TMBiOnxiKoNfKaE0RdSYqOVOUjt3ifipInxGfxgTwRZ5WYv4LPWCvnnI4lPlDTrsYxlqtgsxRJZ9F3sliXZOLb8dzdcnoShyoFqAICqMTBGjyoIVD0ZI6BwjRBoBkhG2GcHsToAbwBJNkRop1G1kNUCYHMxFIhDEJCM9CRdHx0HCFGTUTFkzE6CtYIES10iosFJyO0VDozic1zc3ipdGYyCJpBREbjcCKpdBRVRoYtAMOEp8lQiIQqThWadltcq5xJaYkuldsqSbNoUhISEm3m5BRDqjMhPdGa4jC6bdpUlz7FqUlxqjOT9al2vcumczgTElNdP4hgiANi6eT5EGEBRMBCJBIM4BEoBqHjIQCFEKPZRBSPhGYRYhBCFEKMppGwMIimIZFi+nwLa2EmD5UpQLt5C21MdAIt2kCPMrBidFxUHCdazowQ0ebJEYyCjlIwY5TsSAVroZQZLWWgpAysGMFKaDgpkyBlEkRMvJhFkLCJUh6ZI1ooFuNSnJprp06Ne8f+8+//9du3/wyNfQn6R0e8Y6OBqdnxrx+mfhkfmR7o9rQ2NgUGBoPe4NjQ5GTo41T4y9T4p9Dw5KBnqLuzyz88PjH1zd87/OjStfN79pU9KxkYHP/28ffvn/78/dNfP0z9MjX64ePM52+fvn+a/dha+ubiof13L57raWoY9fqCvuFA/5C/O+Dp7u9v6x7s7PN193k7egI9vaMDg8G+gaHebn9Xh6epvq+mytPYNNLrCfvGxvxT3o6BvubuvuZuf9dgaGB41DMS7B8a7vX7O72Bbq+/q8/X3TfcPzjmDY15w8H+sUDn4HD3oL+z19PUOtDU6Gtt8rU2eJpqu+qa2t+9a33xoPvJZd/TY94HP3Vcym484Wi66Gq9nNR/KzP8ZMXMmw1TZVunK/e8bzjyS8+5X/rPfek/8aF732zrpsnKpUNFtp4ryrJjxgebxTeWMh4UCF9vVr3doXyzXfhqG7t4Pa94o+DJRv7DdbzbqzmFKznXV3Gvr+bdKGDcWPFP/PIbK2XXVogu5XMvLmddXca9ki+4uIx3No93Jo9/Jk94Mod/JJ2zw03d6aLtcrB3OVl7kmhHF4mOLtLtduk2KHib1Kx9NvbJZNrJZPhAqijdKINgBhHPp4IWJn+9IPaMwlgo0x5DuDkxeNXCCGF0JC0GQ6Pw7ALrIb7lDEWQTwSNOF4BnrMB4m5TSbdl61fvsqadNZquxikKY01XNJqLeulDm6g5TeFLEQ9YGT0msD6e26YV+0xxYat+yqoPmeReA7ffQG9Rsd7F0kr07LcmXo2B35Yg7nTKWhIld+yC3QrqcgEpR4AsE3JWCrgrObTNMt4LA6tUz7sey8iXkN18KJ/F3M/lnJcL9orBJTySmo5nU4lcElVOBDQUUE+lmEg0C0CzwVACTLYxKA42bGPQjCCkZ0PxTFgGwywyCOIRIo6FxrCjURxijJKCiaPi40GyDqYaEMhCp9tZLBdId8NMN5OTxuHm0ulZANVCoYoAGogGeURIDdKsVJoWA3BjQD7ATxbpdtrc610pWYlOrdsmz7Tr02yWJLspMUmf5rJkJNlSnSa3TZvi1CU74t12dXqSNsNlSrTr7Q5zotvxAx+gMikomPAnKvZHCgZFxRNBCh4CYmgwFiBFUTELYEwEAxfFIETTiNEIMZpGwEGUGAhcIIDnmRkLMvioTAHazY82snAaJEaDxBg4eAMHH0ePkQELJJR5YgAjg7EKBlbBRMvoMSIkRgRjxAheiqClDKychZez8FImTsrEiVk4CRsvFkdKBCiVGFqclvTi/pPfP//13/7Xf01Ofg2HpoJDE6Gh2anRT+Mjs70d/bUVNVVlZf2d3b6+waA3FB6emRr9MD763ucZbm/taqlv7u8PTUz+HvROl9wrfnbt9lC3/29//X//9ut/fJ79dSI0FQqMjviCY8Ph6fDsdHi2r6nn7KETezZvun35XOXr4qaKd80VdW1VLa1VTZ11bYPtvcM9A/7O3qGO7mBPT6i319Pe2ttU1/aupKn0ZX9DbbCvz9/jaa1re1tcWldW09PUNdI/FPaNjnlDYd/o1PDEyIA/OOAJeQaC/b3DXV2B9i5/S99gQ894Z7e3rraz7E3v2zeB+spwW81I49v+d8VNb2v66pt8zTUDlU8HSq6H3l4IvTzcc2tdw+mktvPJfdfShm5njz1cMv5sxdTrjXPl2+fqTn1sOfO1++z3/pPfBw597tgSrlw8+NTefdtVflR1fz371grWnTX8OxvEtzaLb/4kuruCfW8198Fa/t01gsKV3CsFrCv5nCsruIUrOTdWcK4WCC8vE17IE5xdzDmdwziRC51dzD2/RHhhqex8rvR8rvRcjuREOu9QEn2nlbTLydqRLF/lFKQboBQTO92qTU9wLBXq1sQKD9ihc0mYM3bCHpcwyRBLYHJQeC4eNMOCNWz1KZ7uIld7jC5fS+VmYNCKGBQTD3Pp8S6GbRMlfiuRmwfQkv6EpJKhbCt75W716kJTxs9aZaESuaqgHBaJD8i4R9X0u05+U6a0P4XXbQU7rdQmk3jArhxPivvgjp1xygNmQZueVRVPuydnFcppd9TMF3purUHUbZF22aX1Zt5FA3+rGFjOB5YKmcsF3JVs1gY2sl8h6EkQ15pFF2Kh5Xx8Lpu6hcXex2HuEdIymTg9Hc0CUQAZwyYRVSSKAaCaIUoiGUiGaYk02I6ATjYzSSSycUVqkM2l0xkgTCVDJAKNQORhSWIsWYGlxNJJWoSsRSg6ENBRIT1INyFsO43vIjOyqIx0iJWOMLMgKINKNlPIAgAAiLASpBuZLCuExOHJTAyFA3GcfOUGg2O1xbXIbjMlWWIz7foMhyXZbkp06tJclky3Nc1ldtu0KQ69265JssWnJeqyki3JLpPDbna6rD/QsFgItxDC/wjiI0A8FiCQADIOoEQB+CgKdiEFHQFho+hENIOEQYgoCB8NxkRTcZEgZYEAnmdmRWUJsRkijIsfFc8mKhC0kobRc8hGLkUNoRXkSAU5UgLgFTSiikWIZRMUDKyEjpHQCFI6WcUixLKJcRxSHIekYBPkLLycTVBwiFoVVqskxYlBi0ZxeNfuwV7P3//6v3779W+TEx/Co+/HRt6Phz6OeMfb6ttryitaaqr6Wts83b2B/kBwcGx8ZDY8PNXbPVBbXddU3dTVORQa+20i9K2rprP+Zdlwr/+3b//yde6v02MfwyPj46HRsZFgKBCcGpv5+v73sZFPdwsfbl+/4fCOzXcun3p68/rjm7df3H36+sGL1oqmkR7/+MDQUEf3YEvLYFPTQENDR11NV311W2Vpy9uXvQ1Vvs721pra4kfP3jx+1VrdPNwXGB0MDvX6fV2DQ73+kf4hT2d7cKBvwu8Z7e8c7myb6Oub6feNdXh6KqoaX7ysefK49fULX31VuL2+993zklsXTu8+eu3UubfPnnTXve2uejJQ/nOg9Jrnycm+u3u993f6720culsQuLt4uChvtHhl+OW60Itd42X75uoOfe44/q3v2Lf+g7NtW0M1qyaep/deN5fvFRWtY99eyb2+WnR1neLyRuXlJbTryzm3VgpurRZeW8G7tIx1Po91Po91YzXvagH3/FLOqWzW0Uzm0Uz6sUXI8Wz4cBZyKpdzcYnkYo7kXIbwVAr3sIu2x0bZY+Nsd8hWOzUOHZ/FxVI4BJZCKdElx7OtbkX8dof4Uhp01YU/4mRmaKQwzIvGc9GQgcxfTpHtwon34cXbKdINVMkKgJyCIWjJPBPNuoRoWRspXYlnLmXSsgGyWkd3bFEsvm3Ova/VnRNRdnNQ24TEfC6rQAhvUSKFdn5ThnIwUTBgQjxmuMcsHHGKZ1LE025ewM6sM9Aex9GuypHDEsYhCXxBRXuq5TaYJH02Vbtd9tbAPhjLXsulLucgeTxWPpe1jk3fzaVfjpd4jaIyE29vLCWbi85nU7dymeuYwCI62gzjZSCGRkEhRJQIj9cTiHYK2Q4ScyEwG0Ey6PREBtvGFuq5MgVDzKHyQCoXj6WhYmgYLBdPlOJJcSSqjgonsCAjAzRCoJECJJAhK5WZjAizmbJlVPZ6Ai0HC9vwkJFAMZJIBpASR4flENPAYNvYLCsdUQEAmwzyIIaZyc2V6PJ0lmyrxelK0KXatGl2vdumT3KaUxzGjCRLqtPktulTHHq3TZtk1aQ6DRkplmSXyWU3J9otPwDR0VT0fBD3JxAfAeAwZCyRiEUR8QvAmEhKzEIyaiEFHQngYyA8ioqJIkYvACKjyKgFAOFHHjjPzIrKFOMyxLhEISqWTZDR0Ao6RsMh6dkkNYSOpUTHg2gRBSeDiAoGQcHASRG0EEKLYIIEISvoGCUDq2RgFQysgoFVMnEqLjGOTzbJcAlKilHBcBhUW9avKX31+uPMh//4t/8Mhz+Fw59Ggx/CwQ9jQ9O9bb3NVdXttdU9LU2ejk5/jyfQPxTyhkOBsZ727qryd02Vde2tXl/g6+T4n8OD4a7K+tbK2mHvyKfJ32bHPs2GZ99PTs+Ew+Hh4MzY7O+f/zoW+v7i6bsdG37auWbl7fPHi28XFt289ej2/TdFb/qb++dGpia8wYGWts7q6ua3JfVvXtaUlvU2N/nbW3obqrrrKnqaGhqrq9+8eNlW3xboD4z6Rwe7B7tbuj1dHn+ff7B7cDY4/Gk8NBv0BTobvS31U96BGY+3t6rh+f3isiclNW8q60rftVRU9Tc3d9fWlD16cHjL3r0btz++fSfo6RnzdnZVPGt5cbuj+OZM/bvJqqeh0vOBZzsGH630FC3zFC3rf5Q//HhN6MXGqbLtc7X7vrQd+9Z36lPviZnOw79W5k89Tus+oy/dKny0inN3pfDmCvn1lbFnslnnl7Cv5AuurhBdzhecX8o5nUs7sQi6lM8+n8c6kcM8ksE4nM48lEE/soh2NBvZn0E8sZh2YSnn/CLWiWTakSRkv5u+L5m+M8lcYDbYY2N5fFYUhFvABIkqPd2US+U6BSJrpsl6JE19LYN20Y2sjmUr8DAqih+NisVBmWTBJrJoByzfw1Xv4cZtYwAFBGIalZdNT9hAMK3HSpaz2Us0jKV5TNFPUv1JreO0VrdLyshnY7O51EUiUaZImClirpYhlwz8Zlds0KoY0wsmjYJRK2/CyRtzc/qdtAozUKimHpBBW0S0HWLWPjHtciyrRC/sSFB4nOpGh/KRnrlVwihgUvJYSB6HsZLD2MGjn5Oyn5mVPQb+z2bWChUpiYtZyoPWCBnpbIIWjtADRDkVzydjBARsPJ7oJFJTADAVBpfT6TkII5XOs7OkcQwJExAQSXwsSYBQYslYCS5GRMQqqRQdSE2AITuNkYggCTDdBtGdED0VZGXD/AKGZBNLsQ1k7cHBOVHU2GgKF0sVU0Adg+Hic9PYIheL62DQzTAoB0EehIgQuhamOTiqXLV5ucOe7bbYU6yaFKs6yapzO6z/7Hlumz7Jqkt1mlIcRrdNn+pMSHGb3E5jkj0h2Wb5AYxGU9HzKeg/EKP/hFsYiV4Yg46KwKD+CEREkBdG4CLmYyLmYaIWENBRVHQMgI6hRaOoqEgK7o8c0v800CPTRfhMGSFRglExMQo6SsXExLPx8UysCopWglFqGloC4GUwXk7HymhoCRwjhGNEME5CI0nBaBkUo0DQCjpGxcTFcYg6IWCSIlYx0SyhJig5WUnWvdu337/zc2dLx6eZD9Ozv03P/hYKfggMToa8E4OdfU0V7+pKX3U31g90tPm6BwI9vqA3NOof7evsral411ZV093hHRz6PDH5lw8Tn31tbfVlJQMdbZ+nf/kw+XFmbGZqdGJ8JDTiHQr5R+bG50LBD5Wl9T+t2rAuJ/fxtWudtbWtjQ3UCeupAAAgAElEQVQNDU3+3uDX6V9+//jbeCDUWd9QU/K6vPhx2dMH1SXvfJ29U4HAcFdnZ11Nd2NDX0dHT1fv0MBQyBcK9Ad623q9Pd7Z8OyX2S9z43MzgcBgS3NrRUnD21dd9ZUhT/+Y19dV3/zmRU1NRVtddduzhy8Lr9x8/exld2t7f2fn63tPbl+4Uvr0mb+7q6268unN6yUP7vTWvP3V75trqx5+e63/6fa+ooK+orz+R8v6H+WHildOvFo7/WbTXNm2j9X7vrae/Np99nPvhX/r2ffn+s3jRVmtJ3RlWyRPVwt+zuNfy+aeyOaczOGeyuWdWcI7s5R7Mpd1JBM6kEo5kgkcyYSOZtKPZLKPZLIPZbIOZiIHM+ED2cCJJfCZHPhUOnAkCdjnZu3JkO7Ojl+RnGJV6diIEEWEfyRRFjK5JJUD1i0hyNwYtosvcmeb7Qfc8kvpvJMOyXqZOAHWK0jxciQxXrLCoNnitu3Pch/OsO9xSNeqmEsEvKUCzRqhYbVGk7c0buku5eIrIvZFufiIQrpRzFzMJ2TyCRk8RgZHmsHjLOIzNkhotwyCPrfufaL2vUU6ZxGNuwReB7fZxnhuQS7pqDtlxDVC6kohcljCOidnPdYIGkwST4K8zxlXYpef19FXC+FlTHI+G17OgtZyoMMyxr14bq1D2WgRnLOwM5UkGxuXxQWzhYiVQ4xDUAYSMZaMl1FwcWSihUxNoSLJCCOJyUpjc500tgkRqRmxHEiBwQnmY3kRZDGNYADxOipeC1IT6DQXk5vCFmRyJNl0YSpdksGU5jIleTRRPsxfCXHXgNy1AGMTAUqNASQYhEflxNH4Lo44VyQr4CncdJ6NAmnJZBmVIgQgAUSTQ4x4unKJOmGt07k62Z6SZtel2lVui8ZtsSfbdSkOfaJFm2jRprksaS6L22pOtiU4nbpEh8FtNadYLT9AMRgqKoKC+iMh6o+YBREx82NiFkagov8AzosAFizEL4yIiZgXs3A+ERMDEXA0PJ4ZgwMx0QBuHpf8RwM9Mk2ISxHj7UK0ghYVy0TFc7BqNkZJj5ZCETJ4oYIWJUcIcgQno6Fl9BgpLVpMQ0loOCmdqISjVUiMmoFRs3AaDkEvpJilkFVBSxSBNjFiUwoLsrPOnTp958bth7cfvnv9bmTs49yHv01OfPd7Job6g77O/uaK8ppXT9vrKvtbW3zdfYEeX8gXGh8Z8/UNNNXVdlZXdbb19/vej4x+/TjzeSbg7al/19daMxOc+hCemw3NjPvDY97R0ODQqDcwNRKcm/7kae8//NPujTnL3j16/mly5sPHz8GZ6S8f/vrty99mJ973d/XVV1aWvnz2+vmDijeP2+u7ggMj04GxYHffQEubt6t7aDAw5A/6BwJDg8PD3pGgPzQ1Nv1x5tPM+GzQH+qvqn9z5+69S+ef3r1ZXf560NMbDocDQyOdzZ6mmo6SZ28vnrp0aOe+B4W3PR2ds6HghC/Q39zaXVPfUVlT/vjZ64eP2uvqJ4LBTz2NoeqHA8UHBp+sCRYXBJ8uG3m0fPjR6kBR3ujTFRPP1kw+XTf9YuP78l0fGw9/ajv+q//0754Tnxu3BZ9md12w1OyLL14rurkIOZErPrKIdzCDfTCNcTiTcTgd2Z9C3Z1I3JWE3ZNM3p8KH8xg//PPsy+DtjcDOpTJOpbFOJ6OHEsBDyQzd6WqNqZYCpKcWrORwZFi8OyFaNqPGCgSEJAELpoynyZ3RzHteG6aOj5naYLzWLq5aKXz1aaUF3lLb6SlX8zMvris4Fz+qitrNtzcuPna6jVnFi/f4Vq6zJSX41i9MnPt0ZyCRymLahJcRUrmVRnnoJCzWYhslgO7VcBBMXSIiWziMLeL6MeVyEuLYHSR5ku2eiqJG7BB7Q5+iZFxNR46GA9vUoErBYT1AvIuGVIo5z2K49ebpIMJ0kCCrN2mumeR7NTAeQIgj01ZwYXzmcAmIXghnvnKyOtwSMotvKNGZpqU6mJQMliwi0PV0/AGKl5DxMZScSqIoEMAK4LY6UwjixvL5arYPDGNzwXFdFBJpcRjiKpoojKGqiJjjRRiAhW0UxmJoCCNpsihxS9FNEsZmsUMzRJW/BK6MhcSZ5A5KXiaC4ckUiEHEdKSGHEMiU2gzhVpV/Lil7LjMhGZjcI2EUANmaImk2UEMpcIcalMAVWcLdWtNZvXOBPS0h36jMS4ZKvWZbL9c8nnNMe5EjRpLku6y55kMbvMRrtd47Tp3AmmtISEH4AoFBUVAWB+JKPmEaKiMQsx6KhITMyPrEgUE42FcFg8OhqNiiRgYgAcBsZiGdFYGB0NERYIwYgENipNiEsSYAzsCCW0QMOM0XOxajZKjkSIwB9F0DwxPF+O4KRwjBiOFEHzRNA8IRwpQmLECFaFxMTR0RoWTsMhaLlELZ+kF1KMYiBJALnELEesZO3yvNvXb927df/c8XOXTlyoaugbm/j28cPfx0OfxvwTI32+zrqaxrKXzVVve5sb/V19Q33ecf/Y1OjE8OBgR3NDy7s3DXXNLV3Bbs/4dHjmy/iQt726tfZ1X2vHqHd43B8e6Rsd6Q8GB4ZHvb7p0PD3L18/hqdun758eN3Orsrmf/3Lv/7+j3+Ev36aHP8a8E02N3W9e1tRWvL61fOiktcPG+reDA+Mh72TYwPBQOfAUHf/qHd42DvS1z3o6/cH/aHZibmvH36Zm3zv6RmsLKt6VlT8+sa9u6fOXzpy+MLxQ/d/Luzs7hifnfWOhXsbu8uLS3++eOP0/sPnDx589/TJxGD/59Gh92Ohoc7O5tcl5Q8eN7x6O9LrGQ+GvV6/v/Ra7+P9A0Xrpt6s+V69/mvpqqmi/OCtvK7CRZ7bS4I/Lw/dWT56b/n487XT77bO1u0a7js24z312XP4Q/PmidfLfDeTa/Zrnqxin1gqP5jF25mM7EwE9riBfSnAniTSDgduhwu7M5GwO4m6J5m2L4W5N525L4O2LxM+mCY+lMo9kkw/ksw8lCrdmmxenJBoj0skSTjRCDOGxEPhuZFoJooghrmpotgtfIGLxHFCquUq65ZE08rt7qznO3L6r+T9eipv9nju3JVV7+9uCRauG76+KnxzXfBqQe2+zBebFt9YsebS2u1Fu/Y07NwQyEscT5AVW6SF8dITMvExheCKjv3YCL9VU6pk5Jtx0lvx/HsaWoWFHswUzubwfSnkJkfkCzPrvIq6SUzOk0HZEmgpF7+dT7igQp4pBRVaSb9FPmaRjRglTQmyq2bBqjhgiYC6jAesESAr2dRtEvC6kVNu4fTYuM917P1qehYfSoehLBpkoRHjSegENC6OjFbBuFgmSc+GEtgMPYslYbHpbBbE5ZHpPBxVhCEqCRQ9BTJTYCMR0OAJCWTISWG48ZwknDgVH7sIp8tGa7Mg7WJQmwPEppMlDgLXhGfGExixJEYciconQUI63yzTrNA69qvsu3iGpVC8FceJxdDUeEhPRUwUahyayEGRISINQXPSWPJ8ZewysyYxza5blKxOtekcelt6kvGf+J3m+HSXPd3lcJmNdr3Bao93WLXuBFOKyfQDEBlDXLgwJmIeKmYhAY8ioKMwC/5IWvAjjCJC0WgoYgGw4A9gzI8QPpKAR0WjovCRf4JRC9ioPylJES4xNUXNMIjIEma0Ap6nhCOUcKQKRsci2FiYqAAIUhJOAEWJAZSMglGR8bFUnArGKegoGSvGgOC1CD6ORY4TwLESWCmhxsmIWiUxRwxkq9ipaumyjLSLZ889fPjw9OmTGzesuXH2VsgT/I+//Pv32b9MDX+fGv7u6QxUlr5tqX7WXV861NEc7vNMDY6+D82ODU12tPY11tY1VNe3NrT0tPcOeULjI7ODPcNVZU0Nb551VZeNdLXODvnmhocmfL5xr3d6aOTT1Nevs9+rSuovn77Z2+L/19//6/PU3z5P/mOkt7e9urri+fPSp49Lnjwqe/G4pfbdsKd7emQq5BkJenxhfyDoGRzpHxr1jI96pkZHvnz9+PdfPn4fHhysev3qyolTJ3YeuH784sPCooeFD84cPrF365YrZ072tNZ/np7w93a9KX7x8M7daxcuXTl34dHd+53NreMjobGhkeFuX0tFVWXxk4HGlgnv6LQvNOPt8beUDL7I9zwrCJVs+li/7WvD+vcVK0JFyzvOZz8/lPb8UFrJscya80uaLue1X8sfKtryvvTA5Ovt0zUH5rpOve8/N9txdLJk3dBlV/9e1YPN4hurBCdz+HtS+NuTBT8l89cnMVbZgXXJwEYXsD2RtsGObHaztqXxtjtox938g27oeDL7qF1wKtW8L92dYTULtepoETeSDs8nUuZHkiLnw+goMQlIoEuWikybxIwkKSfLrNmSlXYiLWX3imV7dm7Zf+Xcpdbr6yZK18+U5f5SvvLjq/X+e8t9jzd03/2p7WxuzZ7Ekt2u6mNLPbsLppamTGRqvCsUFa6Ct9a0UqOmzMB/Z2ZUWjgVFmG5WdphVjYkiCsNrEYD0+cQD6XGV7jEl3TUvXHQTgUnX8xJ5RNXcRZe4eGfSPkP4rSVRmGnUTBqEY7Y+E02XpFTdkQnzWcxcmB+AZ+/TkTbLcDclONrEhgtdmaVnnzaINwihTLouASEoKdTNTQwjkxUYTF2wv9wQ+hktsDB0amZJgFiYNH1NLYOYuogWEulxoFkDQRYADiRhKTikAw800Jg2IiIg0J3QexkEsuBYxmJImuMLBElNKM5ShxdQAC4ZIoYgQ1cdpKInsAAzTxxtsCxmZG2hZayim3OoAt0RFCEIwtxZAmRqiQBcXiyEkuUYkliAttEFDoo8hShJsdpK8h0ZLrNWpdFlGLVJll1TovRajFaLUZHgsGVoEkyqx1Wo91isJp1CUbND2A0mhwVhVo4PyY6Ao+LwaMi8RE/UiIXgAswcCSKFhMFoxbAmAUgLoqIiY6JjiBERgBR81nRP8ZSIt0yKEVN0wowAtp8OThfBsyTgxFKCBWLYJUgXk7Fyyg4ERglBlASKkYBEJQgXongFXSUnBGtQzBqGlbFIsTyKfFiwCChOJVAejycr+NmqjkWGSfDaT997FTRw2cXzl75adOO/bsOVpZVfP/y9e+//2Nu4stoYMo/EOhsbWqred1VW+ZtaRzt6Z/yBt+HZsdHpvu6fV1t7Q3V9dXlVdXlNc11rf2d3v5Of3NtZ1Xxw/qS5731NeGB3pmRoemhoTGvLzjgCQ+Nf5n92t3cV3T7WW+r7x/f//eX6T9PDn/uaWipeV32+tHjkidPy18+r31b2t3cGPR7xv3h0cHgRCA8MTQa8oyM+8Nfpr7+/uGvv335l9HARE151Z3r14/t3bd97cZdG7af3Hv8wY1792/cOXf0xM5NG47t29NaW/15erKvta246PHtazcKL1999vBRS13DaGB4MjQWGBisefO2rbpysKVxpLu7r7Grp7ZluLXeV/888LpgpGT9VOWu6eqtoyX5g09yWq5mlhxMvr5Ff+Mnw887LA/2OIp2O57uTaw6u6T7501jjzZMvt4+U33offvpb71nf+068b5iy+ijxZWHdK+2qx+sUxUuV57KkOy0MTaZoPUJ0CYXeaudtMsBbrVStifCO5OR3XbgVDLzhBM5kSbam6rakpmQ7TIplBKIy4kGgHlE4jwMKSKSGh3BQMVIiEACU5EndWznCXOE0nytZUfK4jMpS44tXn0iZ/m+ZasO3jm4rfrmT613lvf9vLLzSn7FkfTK00srz66uPZr9bkfSy22uN7vSWtenDqfpA05BdyqzMinlrdP62hJXrOc/0zCfa1mv9Lwyo7jBLKszCesMjCYD0m5h1dm5d3XgQTFqgxhaxaUvYzPWCaGTscBjDe2NTlSsj61O4HeaBcMWwaCNW2Hh3rCKd6hFixj0XIS3nMnYKoAuxYIvDUilEXmrB59rKCe0vM0iKJOOs9NIJgZoQCAtQNGTyTYEZaNDZoYoDo7nUXUw1QDAJpBphpg6AImnQHEAGA8geoBmJiJmLGjCgHo8aCaBFgB2IqwkCt2OpRnwHCOGb8Vy9XiWksyQkGEJBYqjsZx8UTafncTjpCo0q2VJP0H2AqIhlSIzkmEBkSTEEwR4vIhIlBGJMjxegsdLSCQ5EdAQWSaS0MGNyzJZlyU5FjktertVkmzRuG36RJvZbjPbrKb/xm9L0FvNOotJm2DU/ACgMOSYaHTkgpiF83HoSEL0QmLkfDAmEpwfA0dGw+hoEBdFxUVQcZEk9EJ8VARhYQwlIoIVPV8LY1MUSKISiGVHcuE/SKEIIeVHEWWBHEYpaVgpgJZQMTIQJweiJVSUGMBIIIKcRlTSCSo6WoVEaWhRKkaMgo2NFZB1IkqiBFiuZmw18wus4lQ1W8tH3AnmYwdP3L/74tzZOz9tObpp446LFy/39Xb+9uvXD3Pvx4ZHA4Pe7va2luqypnelHVWVvpbWcL9vZmRyKjQ9Ehjv6+hpqKorf1X+9uXbmre1fe39Y/6JieHpYE9nf2Nda1VFe02Vp7V1qLdvpG9wpG8w6A1+mv4U6A8UP3xeWlweDkxOhz4Mdg01lTfUllQ1vK3taeoK9A4GBnwh/9BkaGzMGwp5ghOByfejn75Mfvvzx7/97evff33/vau+/emdhyf2H9q9ecvmtevXr9qwbeOu/TuP3rl6+ealC8f37928avXxfQc9Hd3f339qrWl8dPvunSvXH92+2/CuKujxzYTCQY+vu6m1q6FuoLW+p76y5uXLNw9ftFfUz/V3zrS/HX6TP1O940PDkVDpT+33cyquuJ8cdl1Zb963jHuoQHxqTezZ9ZpTq9QnC9RXN9uLDi7y3lwz8WzXl4oT35su/N5z5Tfvpfc9R4abtvrvZLefcdTtN9XuSni1Tn8xXbjPwtyewN2ZCO2wUXdbqTvMhF028m4X5UAicC6Tcy1TeThdmZcoN9gUdCU3BqFgSCQ8lvBjFH5hFDkmGkFFs2NQEixooqmWSJzbaIpVtNg1XNPm2Iy95oJDuXtuJK06q0k9kJe7f8+WbSe3L72za/nDnct+3pz6dP/i58fWlB3MfrMrrWR3etXezJZ19r4kidfMHHSx3iZKX9jF9438G/Gcm2reA63guUFUYhKXJ4hqjZwWPdJkBN8mUO8YyYdk6E2shctF3FwWfQOLeVXGe2sWvXPwXpvZxVp2nY3faeMN2rgdds4zK/ukWbBGJUhhMZbQuCsQ6IgIeGHi1Nm5ZTroYRz0s45xVMPfJASz6cQkBtXGhI0IaASpFgSycelmDlfLkktgDZOiByhGCmSmMKwAoidDWiKkJtLVZKYGYMZT6SoKrMBR1WTQBIIWBHawmG6I7iAiRjLTBHEtMMdA42rpHC3M0oNsG12czYtbLZAXKOLW6mzbpI51eLV7oSAWyxSSyTQKSUomSkgEMYkgJuCEWDSPgBUDZCVE1QA0A4mfgCiTFcYcY0K6yag1GQX/xO92WBz2BJvVZDfrXQkad0K8y2pwWvROi96RoPuBgEIR0NHoyAUxEfMI0QuJUf8ffnpkDBIVQ4mJIqAXkrBRVFw0FRVJjYrAR6AoEVF8TLSZRXHLoAQhTs74kQv/DxkSLaDMF1Dmy2loBQ0rBlBCSrQUwqgglBRAiwCMAMKL6QQFg6Cio+OQ6DjGQhUrWsXDqoWEBBEpSwZu0fNOOJWrrJJMNcskpCUbDbu27rl44d7hE7c3bju3fuP+LVv23ii809XVNTM1/fnjl7nJ/0PVXT7HeaXrws+eSWxBM3P30/3008zMpBYzs2xLtsAWW2BJlmRmZscU2zGTDEJbbDG1mGWOk8lkJ7NnH6563w/ZNXVO1foXfrWqrrXu634/OjD+urGx+dmTtqdPB1pbp3r7Z4YmpkamJoYnu9o6Xj5++eTuk4YHDY1PG9+2v52bmHu/+GFpYmy0u7Pz5cvXz1/0trwZ6RkY7xse6x2ZHJlYnl2cGvXcv3n//InzbS/b5ibmhnqG+toGhzpGZ4bm3y98+rL68/vlj39+ClqdXl6befd15e//+Ol//PPn//X3D79PDU42Pn5+cvfuutLS8m35VcXby4vLtuYU5uWUbt9ef/bYnjNH91aVFOVtzDp/7PTK1NKX5U9NT15cPXvh5qUrLx48HuzsmRvzzI5ODHe/7Wxq7eto6Xj16Mn1y9dOn316+9Ha+OQ/50dXX12fvJf+uaXqU9u+vh/y7h4IvVTjPFRgq0wx5MezSlP5NZtV9TnG6k2GihRtZYqhbpPz++1hrUdzZm/v+vTs0C9tx34bPvVl8sjSRP37VwUT15L6jwYOHQ4dOBD1uCTwWKKhIkBeFiYsDeSW+LFKnLRiP2ppAGtHGH9PgvJgil9mgFKn5hCEjO9Y5H8j4n3xBAyagELQcEgOHs3HocVonArDdJDl0WzbRroii6XNoRuzAHeGaWNBzrGrcRVn5GE7VP67ghK2JyalF2/cdLyk8Oaewlfnd7Rdqeu5VNxxqrDvbOnk2cLRyojOcEGXkT5qEzwNIf/gRz5hpO/Tco+Z5Jftmtt2+R0zdN8lbLRDHVagxUG77kfaZcUVKDDZAky8iJsiYNVLeC8Nyj4/dYObf8sO3DNyWvx5Xf68t25+kz//gh9UYeFlqPiRfCiTA5bx2ec14CsXv8XFvWNknTZCx53qWrN4q5ydDFGjeUAIl+1k0h0MShCHFSDm+otFTpHKLDBreHYJ6BBw7VyuDWD60xh+ZKaLyHZSIDuLb+PwTTyBnsGxs7l+XE4gjx0i5EdC/HCOIAiUBEvlQTJFsEIRJFeGCORhHFkcqNsktBer/St1rlKdayvfEIfg63w4QiKLx6KATIqeQdEwKCoaSUbECrFIiIgV08lqJs1AYxsJfDNZ5g/ponTWKLvV5rbIw1zGP/EHBfr93/hDA20hAdYgtznQz/QNCgnHoxEYuA/W24uMgJERMArMm4bw5aIxDASCCPcloOEUPJqBRzHQvjS4F84bSYcj1DRSoBgIlNCMIFzOWi/heKlBnJSBkNDhSjZGxcFJ6AgRFSZjonQAVsXEiRlYARMvAvByNl7LwRhAtIYL0/JQOhHeIiW7ZZR4FbPAJtodoi0I0Wz2V6Y6NRvDA0ty82pq9pfVHM+vOlZYeGBLdk3+tppjR863NXeszK99WPxpfnT1bfdgZ2t7x6vGt63NI10dw13dgx39g91Dw12DnY3tb160dbx68/pFc2fT6+Hu/snBsdGe7qHOrv437f3tXcPd/SNvR4Z6hvs6+od7hycGJ2YnpttetXx/7tKrpy+WZhamRj0LE+9XZj59XPrl89rfP63+srb809ry5w9rX//x9fd//vKf//3X//Pbx3/OjSy/fv7m+9MXasvKd5YU1JQU7Sgq3lFaUV5csTkrLzsnv67uwMXT+88c3VuSl1OwOa/h7rMvy5+mhyee3X1w88L3rx48GeromRuZmB/1jPcOdDe1NT9u+PHG5ZsXTl09fuTa6bPdLe3/+PDhj4k3E1drPT+mf31d965xb8OxtEN56ppMUcVGZWGSelscUJTELU+XVmdqdmzSlySrt8XK86LleUmm/fkR93dlvz1bvvZk/38Mnf3nzOmfpw58HqxfbNw2djNh4krM+KWk14cTzuX6lYXK84NkBUHSoiBhaSC/JIBXHCguDtMURBhTg616KUhnkJBk0noicT2BvA5HXI/Ck9F8MlpAwIhwODmWpMUBDoIomCALpwvSeLo8rnEzYI+zbtxcdulSas0Rrj2dpN0uCcgzBCdHRG/cUVh5+/T+zodHB54d9TzfP/Hk0MKjI5/u162eTh/cqmt3Q91q4Ytg9I9u/GkzdZ+Oc8gku2BT3LDwb2ppD9y8F3Zuo4X1wEo5biNtN+JzlIQtYlIom7BZSLqk4b61yHpt0rs26KaN/9Iha3PzOv34r13QAwd4xMrepmImiRjxELsYZJzQCJ/4SZsc3Ecm+iUDcMAkqTarSvX8LVIgiceI5bHDuBw3m+Fm04L4QKCIGixlh8rFwQq1v0LvkpmsYqNJpFdAUSIwEuREsDiRABQOCcOE0iCZLECgCBQrwvmiUAgKFQmjRbJYoSpWbEzQmqK0xhi9OU5nTlIYUwT6DL4lR+xXoomskzu2CdSxFMgMYwhhdC6BJmQQBTSSiUrSUckKCkmCx0EYFBeHEZIJCixZhWHK0aAKJbBRpaFKQ0yQMzjazxTi0Ie6LaEBrsAAl9vP7u+wBLtM4X6mED9jkFPvb9P4WVTf+KJgaAwcA/fBe3vTEHAmEkmBeZPg3kw0goyAEeEwKhrDxOOYOAwN6U2B/ZUA82VjUSaQESzlOCGSmg6XM+EKCKPk4iUslIiBkAJoKYAS0mECmq+IAVexMQoAJ2HixAy8hImTATgViNZy0QouXM3HGEUkm5ThJ2OEKhipZm5eoKQ4Sl+eaN+5MXRvftr+ysL6qqqyyrrCit01O0/XVJ0szt9bWbznytnrvS1dC8PzX2Z+mpl6P9Q/0dnU2tbwtPNVQ29ry3B3/9TI9Nzo7GjP8FDnwEBHb2fT6/ZXzV3NbT2tbf3tXcPdb8f7hsf6xyYGPZ6RqcmR2cmR2bE+z1j/+NzEfH9n/60rt54/erY0szA/Of1u4efPq7/9/PGPnz7+8fnD3798/O3rlz/+9ss//vcf/+vvH3+dH5trfdby/alLB+t211WUlRdsrSgp2FlZtqO0bHthWdHWkk0bNm/N3Xbw4MFrF4/uq63MSkmvLq4a6x3/7dOvfW/aH9+58ezH+70tb6YGRmaHx8d6+t88b3xw/daNc5cunTt76dixCwcOXj9z4W1H189Lk+9fXx87kz3x44ZPrfWzD+uvVoaWxrC2RVGKE6DiRFlJDFgUCxbHQSUJwpIEcX6sKCeClxUGpiWaspOslenuc0VxXWdLv7Qe+33w9Nfe/Z/HDn4YqF1oyh+/l9Z/JbHpaNyFbY6yMGykgmQAACAASURBVOG2APH2SPmOGFl9jHJXhLo63FASbs/wM6nUWjKZikJhUEgcHIGFoyneWPp6LJOClhLREjxGhsOrCHQjGXQSITcWdDI5kRJ1jsiQxzYkGhM3FJ86nlRewzJFwnmJdH0cZIvR+G9I3lB5cO+ee1d2N97a/fbp4aEXZ6eenV65V/P+zqbFi+ED2cYWFf+FHf3ISblqB06YOCeM0GWb8EcbdN9Mb3CCT2ycW0b6KS25Vk0sUpKzJeTNPFIUC10rpzTYwF4776mJfVHPvmWRvnbpXzuFHQ5hs5V328zZq6NnC/EpAHYjm7pfSL3jkLWFqJ7awYta8j4dsF0rypQKN8qZKSJ6PI8ZzQPCBZxgATtIBARLOUEyUoicHqoEwlX8UJU4VKkIU6lDVdpgTbyfMtEsS9FIUhXSNJkiWa5OUGhjxJYIqSVWoIzgiMN4sliBNlFkTpY5N8hdsQpnvNqVrHOmK20ZYnO60JopcuXyg7axNXFUjpFAE6LoEJIqwBBkRLSKTLTicWocTozD87B4EIXmYDBCPF4Bo8pRLBmWq0BxjXiuv0gR5W8PjXZZg+26IKcx0GXzc9lcTuuf+CPc5rAAU7Cf3t+udlkU3/hgERgcEovwxXt7M5FINgZDR8LICB8yxoeE9KEgEEwUnonEUOEwKmIdFf0dFePNI6OsfHqQBLCyCSoqUskiKLk0KQsrZqCFdLiIgRAx4EI6TEDzFtC8RSyElIVVsAhKJknOwMmYGBkbqYBQMhCl5OJMAqpdwrSJ6VYZxaGjBTiAtEBRbrSqJtN9tCTpWHnWrqItpbnZ+dm5Oypr63Ye3ll+cGdJ/cl9hx5evTzQ+PLDuGdh7tfJiZXe9u7WZ09eNzzsfPVi4E3X9NDU9MDkaNfwcOfAYHtvT/Prrqbmrqbm9pcvXr9o7nnTNdw7PD4wMTkyO+dZWph9vzj7aXZsZWp4fnZsaaBz+M71u88fPl+YmpvzzPw5L/zp3W+fP/z94/tf37/7urT4YWpqaaLP0/T41fenz+2vraksyt9Rsm1X1fY9NeWVO7bX1NRUVe4sLijLyczLzNhQVrTt9PF9l88cKc7N3rox98a5Wx8XPn1d+9DZ8uL5o2vdTW0jXW/Hevr72jqaHzfcvnT18okz185cePzw2ZMf7j35/oeXd59Mjoy8m+j03K2bPJXgubdl6XlN7+WiM9tc1Qnc6mRwRzJYHM0piwTLIsGSSE5RBDs/nLU1gpUXzswNZ6ZGKdIj5JnhitJEy7nShNbzJbNP939oOfZl6MjX4UPvO6snH2f3XE5sPBBxNd+yN0a4O1p4LF15coPyQrrqQqLudKLf/oSwLW47T2jxhVN8vNG+3gjvdXC4LwGFBDAYIQ4pw2MUOLwKR9SSmGY6x0VmO3B0M4nlB0ozOMp8mjJTHLwpteZAyNZKtj2RCoYwZEFMQ7TEvzA843Bx5eGj+6qvHq18du1g28Pv+x+en7xVtvIi411rkudwYEeQ7JWB3mAF7liBS0bGRSPjtovzzM156QKaLYx7ZuZxHa1KRtouppeJOQVCZhZIyRYwrhjAt/5Qi5tx3kw+aeTcMUtf27Vv7NJ2m7TJLL5tgg7pgCIBPo+N3SFgXVUznjr4L93CGxbGfh15uxbYrIASeZw4MSVWSIvkM8J5rDAhGCqFgmWgv5ztp2EEaNmBOk6gjhuk5Yfo5JF6bYzJlO4KTXVEJ9pSo8yZAeZsiyVTY02TWxPFgbHygCShNZ6rjYUMSUJbutC9SRycxQ1JhAIShe5kmStVYk3m62JBTRRbG4XXh2O5BgIFolI5JCYPTZPjyTY6NYwBBBOoJhRBjCSCSBKAIHAQeD4SL4NR5XhARoOUeMCApDsZojC9OdBlNwTZtP42nZ/NZLeZHHazv8MS4meOcJsjAy1hbmOwUxdo13zjS0BhiGgswpfo7c1GoSAcjolGUFEwHM6LiIFRkWgmDEP1QhDWrSMj1wFkGIvkK6QhrXxqgIhpAQhqKk4NUJVcpoCOFNCRfBoMovjwaD4CBoxP94ao67kMXzELo2aTNABFycDL6GgJGyGGECIOSgHijHyaTcQ2iRhKEUmqwstMRLeJFGKhpAVBxfH6ylS/7clBBQkRefFxmzenbM3NK8otLt9aWl9SeKAi7+KBiufXT01O/jIz9X58aGygo7W35cWb50+aHze0PmueGZzyvB339I15+kZGu/tGunuGuzp7W1s6W9t73/T2dfR1v+ntedM/8HZifHjBM7o0Pbw8M7IyN7460ut5du9F28vXq3Or857/quKbn3k3PbU0MT7XPzDa2PT6zt1HJ/efqi+vrSjM31GSV12WW1dZsKdm+56a8sqa6sqaneUVNXnZRWmJGZszMo7srXl69/LJg/vyNmbtrzkw3Dnxy7u/TQ+PND2709Z4a7ynf7ynv7+to+Vxw70rNy4dO3Xj7MXmR88G3k4Mtw+MtvSOdw+/W5pfHG4cuFawdCF+6tHWqQfljUezzuS6TuTqz5Xo923i5wfhK0N5OyJ4VZFQeQRYGMbMD6MVRNKKohmZIdycKFlenDYnRluYYDpaEP3q9Pappyd+6j3689sjn9rrZ57kD36f8fpQ9IMi+8UU2febJHfytXe2qu5mye+lae9tCLySmVgZFiAA/XzW0detw3h5w9d7wZAwItabTfQWYxAyPE6NJ+kIVAOJaaYBNirDQiDrUQwDhZ9Ek5RQlCUcv/zAbXsNaWU0WwYX9KeAFoIkjO+qCtn4/ZaiMxUllQcrCi/sr/vx8vnWm+dHbpWtvM74NJb+/kHCQmFAl03RYpc8MoPX9eTrFtJDN/OFm9Vgo7TqyLeMtF0aaoGEWiLg7JSIy0VQDkgtFUOPzdKRAOiRP+Gwg3DSzn3kULx2KN9Y5J0WVbNZfs8iOWWEqqWUGhHlpFrwxAw8NQN3jfQzemqNjpKrYaVJwSQBL0JMjpbQo0SsUB4zRMgJk/MDFBy7hGY38Z0WgZ9F6DaL/I3iQIMy3GyMstm2BJlyggJygxKzgrMTA7cFBeaYAjYq/FPE4QnKiDRJYBrPliJ0bRQHZAlCtgjDtzAik5ghiWx3Is+RCBljAEUwTeSkCKzeIp0vnYcj0lgMgMEWERl6GitCJMoVypIYoD+WKkdRQDQVRJK5cDwfjpN64/g4moDJkRGZWhjFRhaEKCxBZpcp0KpxW7UOs95qMdhtpn/hD/XTBTs1gXZVgE35DQvmy0EiWGgEBeZNgPmQsEgyCUsmYdneMJqXD8nLlwRDkREYCgJBR8IAjK8YidNRaE4eyyWgWbloE8vXyPQxsXwBJgYCEGLAVwF4yZnfyanrJBRvMQUmoOGEdJwEwMs4eBEbzWfBhSBCLsSpOUg1B60C0WouRgsRtAKSXkQ1iGl2HcGip1isTEeAyBkmc4WL3RHiwBhRbIwuLcWZkRyQlRJalJVYtCmuMCOyOi/5/oULC2OTX778PrX4S8/Q4pMnzQ+u3u57/mJ4wDM2MDkxND0+ODXePznW5/H0T04NTs+ML3iGZ4Z6hrvbenpbuwc7+oc7B/pfdw939o529032D490dg93dI12dIx3dX2Zn383OjjV1THc1tbz6tWTm3cunzh3ZNfhXRX1FUWVO0orqspKqiqK6mpKd9dV1dbsrKrcWV1Uu6tid9GWwvS45LTYhCN7dnU0vWx4cLu2oLIir7T54asvi19Wp5ffNLW8bn412NcxOTY++Lbv1bOXP964ff3ytT/3i/d3D3xaere89HFwZG15+td/zi2svDw4eDna80Pc6LPKsdt5r3e72sp0owfDXtQG7kgSpgQycl20sgh+eRSvKIRZFMYpioDyw6CtYbxt/qq8EFlOpDAzjp8ZLyzIsO7fnn5tf1Xf1QPLjac+th9YbCj1/JD59lhkW42hpULystLwsNpyrcxxNtd2PNF8ITnw4oaI+ggrm8VZ9+36v36zft138O/+ivLxJiPhbCwawuGFeLyMSNCSSFYK2UGm+lFoLgrNSeBEMAQZLHEOS5GtCipxb9hpSixnWzMZ9CAqTc+GQlTWev/kS/F5u7cVbqkpyKwoqzxSf/DuycOdNwuWWmP+0xP/996UoSsRQxnZTVZtk4LUoic/MTEeuaBXAexGC+quWnFAyy3X0qsk1GoFmKPmxUPsjWzhQRm9z489Hki94mTtUHN/MGk7LJIeJ7vVLmqx8ZtsvOdW7gMjeF3NvqyGLuslP6jpN+zCk05phZ63WcFJETFTBIxNUk6akBjLw0XJ6REG0E9Nt8sJfiq8vwLjMAvCHIoIiyxMJ4wySSOt8lC7PDRAHR6kiQ3SpYaYMsOcmSEB6cGh8f6REe5Iv8BYQ2iMLCIZcKfx3YXywHKucxMnMJFrCwX0wRxNCKhw0rhSKl3IZVlF7DCQ76ICDl+MjEQRQGwOiyEA+LFsVbXIVEHjhOExMgJegyX6e6FsMKyEygLRBDGBqMLhtASCmUp30SE3RxWsdMe79NoAiynEZQ92O/wdJpdN7bYpAuzSCIcj0Gp22vR2p+4bsrc3HQ5noJBUFIKChlGwcCIGhkN6M719aV4+ZG8YCYYiw5EkGIyO8OVgfFUEkh0EAsQcJ59s4WCsXLSZjdbRERwmjsfEiAGkjOEjo6+XU72kVLiEipTS8VI6Xs4mqrgkJUSQgRgFhNEICXoeVsvFqkC0koNScbAqCK/hk3RCilmB1StwOi3FaGGbHFyTk2NxAQ432+6CgoPlYSHamDBLSqxfUpgtKdSUnRxwYffOsc7OX3/6bfXDbxOzX8ZGlyb6xucGxidGZ6fH5mfGF6bH5qdH5iaHZmaGZ2dH5hamVpZm1pZnVhYmF/8cuZ0ZmpwaGJvsHx7vHZjsH57sGxjvefu2qanp/v3O588HGhvbHj5s+OGHm2fPHqmr21m6vbqktLqkbGdJ5d6q6n07q3ZXl9bXlO6rr9m/e9feuj17q/aVbS3fEJ+Rt3HL4V17Wxueewb7H9y8XrW14Pju/VN94z8tfZ4c8LQ3tQ/0vh0b6h/o6OxobHry450fr1y/c/XGo1v32l+1zox4VudW5+fWJj0ff1r4/XfP+NS96reXoqfup409rnz7/caOff7DB/w9p2Ie7XCWRnMT/Zi5/qzSMP72MKgkhF0RyauM4W2P5pZGgcWRsoJIYX40Ny+WkxMDbotXVG4I3JuXcmNnbue16oVXuxYaSid/zPJcTho9FTJ8xNFUbbtbbj6/zXh0g2F/pPZItPVokn+Rvxxgguu/9V33V5j3epzXdwSYDxOFAHEYIQ4nxuMVRJKOTLaRqU4y1UmiOAgUGxFwA4JEjjSLrdws9y+0plQbEnZynEUMVgCNoQEgf4W5yi/+bEJuXV7+lh1bNxXnb6sprjhXW9l4OWepLfH3sZi/9aYsN2yaqyvuiHW+0rHa9LRWB/jCD3rmBJ5bKFcV0loFUKqg7hRTdyrAbBWUKODk8CRnVaxhP3DMn3HBwdquZF81KV9bhO1OVpNV0GzltdoFLXbRU7PghoZ7Xs07qxVf1LPO2wV7TfxtCiBDykqTAMl8ehqPngIxYniMcDEnUA7ZpWyLhOGQ0v1kNKueH2RXhFnkgWpBgIrv1vD9TOIglyrErYkM0CcGGtKCrOnBrpSggJiAoAj/kJDAGGdItCY0lu9KFDlypH75gDmJaY+gKwNokiCmNAyQBNC5eiaoFwpCpKJkpSpTIs+kAGEMlgEExCy6HBSmQ5qDXPUOMisYhxdQKGoaKxJDjYbh1UgcCY7hY3FyAl5DIplpTCcVdDClbpE1wmlQuq1af4fJbTe6bFo/uybYTx8RYIz19w+2W+0Wrcms/obgiyQhkBQUkoJCUDFwKsaXhFyHg/0bw8eb5uND9oGTYCiiL5zk402De3ExMDOTHChhB8s5Fg5Gz4BbIJKJQ5STEBCTKGDixQy0lIaQkX0lFJiEipTRsRIySkpBK+gYNZug4eBVHKyKg1WDOAMfp4NwGgirAtEqDlYBYpVcvAoimMRInQitkeI0KppWy9BoyDotyWwgacx0ox20OIQupzTAT+E08f3MvOgQRV1W0rPvz69NzXz5+NvS4i+zM59nJ997hhf+xD87sTjnWVrwLC94lpc8y8uTK3OepaWZtfeLHz6tfP4w/255cnFxfG5pYnZxfMrTNzQ1MLIwOj4zONzR0HDl+PGjtbXXTpy+fvLMjdOnLxw9fKB2R31F0Z6a7Qd3VRypqzu2u/7orur9O7fvqyk7WFe1p3pHZWFJbkbe5pSsrRvzzh8929/e9Xl5ZX584sbF8/sqS368fHFh1DPeO/LmRftwz9ja4vuJYU9va3Pzk0f3r1/78fvLD25cf37vfk9L6/zY+OLc6tT0woxn7de5r1+7WoeubB24mrj4qmDqcU37qcTuI8HzV2JHzkReylNuDQaSnOytwbyiUGFJMK8sCKoKg6ojORUR1NJwYmkstzgGKI6mlcQyimLBgjhJUZKxNM2/Lif+zrHCsee7l5qqZx9mz97OWLiRNHs56vWuoB8KjYfSFbvjFbUh8n1R5l0Jjo0OPoXIWvdXxPq/on29yL5edBQCwqJERJwCh5PiCUoSyUih2MlUJ5Fsx5EsGIKBwtCB/DCuJIWjSBc6c/TxNZq4/dzA3Uyum8pWMiG7zFjiF3siIacmd9vm8uwN23I35Wdm1eRs/PFYxtybDb8Mx//cm/T3twW/PKsfr0546RS+UtG7HWCri/vAyL6r551QCMrE1FIxZZeAXicDs2RAAo9eIJbcMXAn3YIBF+uElVWgYF4yyVpswiY744UZarJAb2yCdpv4hUn4g4Z/RiM4ZpAeNgJ7zWCxkpUuIKeImKlidjKXnsAiJ3F58UJRiEBogwQmgcAo4luEkF3MNWv5LoPETy+2yrlmKccsBy0qnsMk8bOoAq3qMIcmyqWN9jNE+ZnDXbZQP0dSUExkSIQ7OFzjiJKZU4X6NKoskKS2M8XhbFEsT5bGlydwpWFiZbTakKnWFRgMdUbrPpEin8XxZ1FlLJoOEmaLDKfZsloyKxhPAqg0OZubzICyMRTHdzCMLwpCY6R4nIpMMlLoVgpgoYmcXH2Qn1Pjdmn9nVqXTWU3K1xmZZBTHx5gCXfZAh0ml1Vvt+u/IWIIRDQWj0QSEL5klC8N401HraehvmXAfGgwGBUOpyD+Cz8L4SMkIB1ccpCE6S+mGpgIFQ2mZ+O1TLIYhxGwyCIGQULDS8gYKREpIaOkNIyMQVBSEEoKQkFFqBloNYBVAxgVG6ME0BoQpeVitTyclofTQgQVhFdy8QoQZxKi9Hy0VojTSCgaKVUjIeileLMCr7JQ1SaaSsfQGThmI1erJOtVBLednR2o3r8t4829Hz/Orvy09tvi3NeZ6S+eyS//wj8/ubw4ubI4ubI8ubIytTrnWZqdWFyYXFyZXV2ZWloYn1scn1udWliZnJ0ZGpsdHl+emFwYHe959erUnj1bEhNrS3ccqt177sjRSyeOnTm85/j+6iP7yg7tLT5RX328rurE7ppj9VX7qsprS4tLc3O2pKZsTsnaXbnr7tU7E31jX1Y+fF37MD089uCH29fPHGh8dGuovf3ulds/XLg51jfz29f/Nj4409f8qun+nYdXLz+8euX57VvNDx70NTfPDgwsLX6Y9MxND01+7h9feXp9+ErO5MMtK5218492tp9I6DsTNX8zsWm/Y3cSsNnNSHXytoaJisIkFaHi6mBhbShvZzh7RySlMoq0PRbYHsOoiGFWxHNK4nnb4mU5ScbcDa7cjPhjtbldD3evdR5YaSxdeLBp6W76/M3kgaOJN4ssuxPEddGK2nBdfYy1OMYUbKCj4dS/fANf9xesrxcd4cPBokR4jIJC1OIJSiJJS6GYSRQ7kWzHEs1ovB6F11DpYjbHxuGHs6RxkHWTIqpKHnMECjzBlgTReQoGZJDo8lwxBxKzq/K2bi7bsjE/N33rhvStyTEnq+LGG7N+mdj0tT/1b/25/5ja8+FuYUea/bGc8lpLbTGzbilZF2Xi3SqoQEQpEVD28YFaESdDSInnEiplgkYLf9pP0GFn7TKwtkjply3SVqfwhZP9zMx9aQZbTfw2s6jBILimFRzXSQ5YlBU6RpGKsUlITuSRk4WsZD6QCNBS2NRUsTBZIQsSCfQgR8vn6YUCA49jFnCMar5RydNKORoRoJNw9HKuXs7VKbgmldyqkdv1EpdR5GcS+1kkbovSbVUnufwTAwOjggJcjlCtPoonCaMI7DS5SSBNFMuy5JpCuWabWL1JYcnW2ktVph1q3X6T67hcX0EH/El4iEFR8SWbpZbToPIwHYoiUhkECkRlJXAEZTR2vC8aQGFEaLQIi5URiSoyRUtiGqhCG6gJsjpVDpfG7VK77AqnWe40Kdx2Y7DbERFoDXaZXFa9zaj9hojF4VBIDNwHB/MmIrzJCC8Kaj0dtZ6O8KYhfKlIJAWFJsPhNLgPhIUrqfhAEdUtJDsgrB5AalhIFRMnpxPFJKKYSZQwiDIaSU4iyIhYCRkjpWGkLLyRgzewcVomWsNE6wCsDiRoOXgNG6cBURoQo+ZiNBBWw8WreQQNn6QVkM18lBZCqnk4jZCkFZG1AoJBiLVIcEodUSLHCoUoqRivlhPVErRBjnYaCclm1rZI49mq/O7HD9555t8vfJ2b/To+/dPM5NKcZ2l+cnlhauVf+Jc8y+8WPy1Or857FhanllamlhYn5hfH55Y9cwtjk/OjnrmRicWxicWxibHOzstHjyaHhhZkF1aVVh3etffs0cNXzx+/cfn45bN7Tx+runRk94n6HQery+pLiouysoqysnaWbj9YW3fv2t2B9v7V6eW1mZWZ4SlP//h433BX85uX9y53Nj5qf9FwYu/hw3XHulsH//3r/5geXel8/vT57R8eXr384sfbrY8edjQ0DL95Mz80tLTwZXJiZrzn7XxL4+zdY/N389+3Viy+2TN9s7jzRNzAhdjhK7HXK5SlkZRMN3ODvyQvXFAaJa2Nku+KkNaHCOoieDsThFWJwtIYcWmMuCxOVhyrzIqUxYZIQ0OVQVEG/4CQDakx10+WLnae+KV/34fmouXH2Yv3t0xd2Hi/wm9fsmxPon5vgrMs0hptF3IBL7g38S/fwL2+xf+JH40QYZBSIlZNIutIVCOZZiOSbTiSFY03IvEaJEFFpQhpDB2FZSfzg9iGJGlIqSRsP+h/kq2Kogl1dK5eqt7iH70/NbcqvyCnLDurJC+tMGtTZkxMZXZY693Mv02V/m0s531H+tfZ7f8xuGvh6KZX/qIGBemZknpVAhwXCrcrgC0CYgmXupcLVAmBFD4+DcIcUAm6nYJJJ6/BBGzXMjdIKFft0nZ/6UsX94mZ/cIMtloELVbpQ6P4nEawSy2s0Em2KGkbxZQkPiVFwEoTQnFsRhyLtkEAbtLx0o3iEDlXz6NrRIBWzFbzaVo+VSUGFUK2VAjIxRyFBFRKuWoJVyUGtVKxXiHSqwUGLdeg5Rh1oFXPtxvFIXp1rMMY67aGOf3NuhCI52LyzJDSLhSniqXZKnWZQlcm1ecrrQUqe5lEXy7RVuv8DissFVTAhcOxmAwpX5Ymtx4SaE+zhYkUJgdP5uKpESx+KSTOoQEODE6CRovwWBGFJKfQVBSWlsa3MuV+Yr1Ua1ba7eoAhyrApvS3aQKc1gB/vyC3IdDP4G81uUyGb3BIbwx8PQ6+Ho/wIiB8cTBvHMwbD/eho3woSF8KCkFFo6hIJBuFEBMxBhY5VAy4IJKVgzFzsQYQq2CipXS8lEmRMXByOkFBI6rIJAWZKKVgpQy0hIUycjEGEK0FUAoGXMlEqdk4NRunZGF0EEYDYpQclBxAKAC0CsLrhBSjhK4FESo2QgFi/yz2UUF4LRdt5mGUUrRMCBdzfeVcpEGEtsmx/lp8uJkUb6VsCZHsSHafq8jvfvBg1TO/tPBpdGpt2rM4O7H4582/PL22Ovv+/dyH93MfPix/WZ3/sDS9vDyzsjq9vORZmB+dmRmamBka+xP/7NDI3PDo3ODgo2vXsuLjszbmlRaU1VfXnT569P7tG80N95/ev3rz8okzh3buriysKS6sLi6pL6u+eOzM6xfNnoHhtZmVz0sfF8bnelq6mp80tb9887at921b7+tnt9sa7j29detQ7f7D9Uc6m/v/+Nv/XJz+8Pr5s2d3bj+78+Pr5w1dTY3dzS3DXd2zI6NLk59nJ6Y93W+mXtyZvbf308vyr131E8/rR8+nd5+M6T4X3XQi+FS+rDCCtjmInRUk3hrBK4sW1sWI60N5OwKgHWHy0hhjXrQxI8icHmJJD7UnhNgCXHqdUSbSiQQGKSC1qfTWkq0pfc8O/OE5+/e3dSsNRfMPiyYupjzZ6T6coTyQat6bFJjlZ1AKKOuQ38B98Ov+gvJZR/T1osK8mAhfCOYNYZBSEtVIplkoNCeR6sASLUi8DklQoYgqAkmCJ2uxNAuOY6crwyDXZp57B9u2j63JoAptVLZZLMtyR+zesK2mqDi3Ii+rODulKCsrMzYpOyH4+0MJy/3bf58uXWtPW+jf/J/Te/5orB3KD3mqZ/8opF4SAodEnC0icgaIKwZpuzhAGZ+VLMRli7DfG8QDbt6InfuDjpmtZqaIKbecsr5ARbOT/9TCeW7lNjpFL1yyH0zi/SpuoZiTKeFkiKlpAmoqj7lBxNsgFCYAQCKbtVku3mLhpZjAIBVDL6GqJHSlmKbgExVcvJBDF4AMsRiUSCG+AODzWTIhqJHy1RKeWs5TqSGlhq1QM5Vqpk7NNWuFVo04zKGJ9tPFuP2sugAAMNEAHVdo4UmTBdLNclW52lCtNJWo7SVqW5lEt11kLNYF7FE5d9DAQApZAHE1Anmy1FIvMp0GRKl0loxIEWAogSxBgVyzQ6HMIxJVOLQYjxVQyVIaXUFla8hcExGyAHKVRKe3WPWBu4fJHwAAIABJREFUDl2QQ+tv07nsJofDZnfI3A5NoN0SbLV/Q0WvJyO/I6PWU7BwAhqOhsPgvjAkHEFGeJERPiQEjIJC0tBILhatpBBsID1YwHZwyGYWxgRidCBWykAIaUgxkyCjI5UMrIZB0tKoaipRTsNKGQgRy0fNhmk4cCUAlzFgMgZCAWAUAE7G/H/wy1koOQejgggaPkkFIuUclBzEKfhkBZ+sAHEqNkrPQakhXz0faeRjzDyMQ4AOluNjjeQUGyXShtsUDBVEqHYmB1zfVdH34unC1MzS2odpz+L02PzU6NzM+MKCZ3l5em1t5t3azLt/BX6LU0tLnoWF8bm5kek/A7+ZobHpwdHpgaGp/sH5oaHWR4+2b9mSlpqVl1tYUVZ17ODRx3fvdrU0NT19dO/alVOHao7vq7108tTjWw87m3tWZt799vPvP3/6ZX5sdnJg4k/5Ha/a37b1djf3dDV19zQ+efXgzu2Llw/XHThz6Gx369t///k/5qcW37x89fLho7bnL4a6eoe73/a394y9HZodnVwZ+7w6tTA32D7ZeG32Ye3nV6Wf39QN3a+ZvJg0eD6h5Vj4DzttB3IURbHcLcGc7GBhfiS4PRrcGQVWBTHKA3k7Yh0lSbHp4VEB7minM9xoDVabg0R6B0dhZMm0LJkaKwqg8g0RIYEPLlT8fezcf4wdXnlVOf2wYvJKfPPB4BObVXuTDJXh9lCFkEpCf4P41tcLvf5bJMyL4OtFhvswETAQ5g1ikGIixUSh26lMPzLdhSVbkHgdAq+EE+UovAZDMqOpNjTLQhDZ6ZoIwJDN1JUx1VvJ/CASw8oXbQoI25W5rbq0NLdya2bRltSCTVs2J2SlhodV5Pq/ebD5b5Pln/uzF9o3fx3a/mt35fTR1KeBmmt88CyfsV9A3CQgpHNxhSCjhg3k8+iJYmyBFPvALBkJ5vc7wPNaVpoSSBKT7zqlo0HqFhu/wcZtsHGfOPk/OoSnjLxKObBZxEoVgRuEjEwJJ1PA2wjxM3jCVC4/VQBlqWRZVkGsBvCTMfQyllzMkgoZUogqAvB8Fp3LovEFHL4EAiAmm0OX8EG1WKAQshQSQKZkilQ0vpwsklIVEkAjBeVavt0mCbRJI/zsDlMQABgoNA0L0IKKWLY4Q6gsVpurNdYytbVQaS4UawqE5m0K/zqZcyeTFw8AFoU0RKLKlJh3yewnmYJ0Ek2Dp0gxNDtLnGOwH/R3nWSzrUS8BIeGiDgugcQjMuREthYD6GkSG19tN5ntATZzoFXjZ1LbLXqz1eT0l/n7aQIsJn+d+RuI7M0meDHxvnQCgoBBIhAIOAKDxBBJiO8I8HVEuC8ZiWCiUTw8Wk0nOiCmG2RaWSQTE6sH0CoALqb7QBQfPg0hpfsqmWgdg6xnUrV0soKOkTJhImCdiuOj4SLUXJSS81/CVVySnI3/86lPzcWouRglGyNjo8VMpIiBUPHQCggj5xEUQopSQFGAOCWAVLMRatZ6Kx/tFpOcPIyTgwgRoxJ1hDQTIdSGTXRTc4NF2yP1tWnh52rLG588nJz2LM69W5ha+bN+e2p4dmp4dnpoZmpw2jM8Mz+5/K+0f3FiftmzsDg+82faN9k/PNU/ONHbNzsw0NHQUF9SEhefsikzpyC/dO/uA0/uPRrpGRjq6u142dzR9rSvq23OM/V+6fOXd7/98bf/+fXz7yODE71tnT0tXb2t3WO9o8uTSwvji4MdQ/2vh4bftLY8fnzn8rUTe4+eO3K+9UXbp7XPE8Oe5pevnj952t7yZmJ4fGJ4fOjtsGdkcmF68cPYz5/n15bHuqZbrkw/qHzXkP+huWbobt3qrY2TV1Oe7w84U6St3ywviuNvDmJnh0BbI1jbIxk1UYyaUEZdtOJgTkp9fumWtCJbWJ7Cmc7WxVKUoVRFEF3mZsucPJkTr4wlQHajwXpmd87n/lP/berMh7bdc09rV++l91+Iu1BgrItV5zo0OgbF19f7Gwxy/be+3/3F19cL6+tNRPgyUAgQCecSsFIC2Uim22ksN5XpxlNtKIIWRlDACDJfrBFJcqDpLjTLguLqCWIXVZHIVG+lK4sJ3FAC1cHjb3SH1GVt21Faml25dVPplvRtGVtyUrYlhcZsiNbdOhX1ebj8t4miTx0F862bFps2e85lvIhxXRGLTvPou3mwjULCRh65hAdUsYFcHjVOjCqSYJ6ZhKNhUK8LPKlhJShZSWLyfZdkIlD52iJ8YYMeWzk/WsALJvYeDbNAxsiUgRsUgiwRe5tClC0SZbB5GSB/o1CyQSrZqJBsNIvDJCyrkKmXcqUCjghii0GATyeLOACbQWWDTI6Qw+AyAA5DxANlPK6ERxaLyEIZmSsjsMU4Do8g4FGlPIClYMp0bJOWE+wwOm3BEGRnMk1slp4hC6Pw4ziSPJmuTG4slOm2iJWbeOJMrjFX5KgWW+tZ0AYeGKFXpcg1+VLzAbX/STqUgSXosCQpimoApJscAWdiox5IJEE0ihKNAFAIGgJFx5IFBECDAfQ4vostc2q1dpfJ4G/SuM0ah93kcNmtTpGfUxVoNQcarN8QyTg8DkVGI2koFBWJJCBgKKQvAuULookMJIaGQZPQvgT4t3wi3AaS/SGqA8LrmOu1wLdGLkoNUBRMuoRFEdCROi5SwPCCQF8xhJLSEEoaWsrCMkg+AuY6FR8nZRMENIKKC6oglpCOEzGxSiFeJSLI+VgpBylhIxQgWgGipQDCxkbZQLQRRJohpF2ItYJwG8s3gIdJE9BiBaRgIT5CwwhWkkJEuHQNc5OSka4jbLExchysgiBpbaLr4KaEH3ZU9F65ujIztbY0Pzs7PTw+MeGZmfXMzw3Ozr2dmuh7OzU4ND00PDUwMjvsWZ1a+rzw8evyl9XptbWZdwvj89NDk5ODY7OjEz2tbacOHooOTshKzyvYVlFevvvhg+aVha/LU19WPJ+/fP6PL5/+8eXTHz99+vcv735Zm383Mzw90j3U0TbU3T46MrCwOPv5/erPSwur42ND/f0dbzu6Hv54//rFG6cPnzu89/jT+y+mJubGRjydLZ2dbV393QPjI1OesZnRkclJz8LS0seRd//70/uvn3qezd2pXbxbufi0ZvZp+VxD6Upj2cAPG54eCrm03VKbLtoczExxs9JDhPluQ1mIsjwQrI2WHdoSfOvo3hvn29KTHkaGXXb7H1AacyFFFCQJEEuCZIIQKSeMyovCcV1knjwrLWz+1Yn/b/zq58b6+Re1S/fLB84m3ivT1iaIUwMtbCZ/nQ/2L17r0H+loL6loL+j4rxY6PVM9HoWHs6lYkUIrIrKCmRy44iMYDTRgCeoSTgDAW5E4zQonAJDkmPoChRTjQZMRF4QTRoLyFMAeQJdlMiRbrEFlG3KqSzZXlhYuLksJyMvMy01NTU8MiI6yra7LGjg8Zb/9Oz42VO43J05dD+x6WDs9fTAY0b1IT5wHCJX8BiFHEIBSM7lspN5YLKQVaegvzByR0OIA0H8czZlMERJE6FeuVnjLtYrHaNNDzYaeLcNggNGKN8CZVt4RXJwBwjkKwQ5AnYWh54J0jfymalSIFkLJZmFaWZ6qIKl4UEQyGNyARpIBtg0iA3w6Aw2mcai0Nh0gEnjUMgAlcrhcCQQkwwxqBCDxqXRIToDYlAhJpEH4CEemcrBgXK2TCvVqg0apRuA/NGsADJTRIGskC6TpS3h6Ku1frs0lgKJLJ6r3yk21fOUeWx+FouTI1Rs5siSZIYKmfskU5aPpfhh8UISRcDhhertB0PjWkPdhziAPwyNw1EoRIqEgNfQKRouRwqxVXxBICSNkeuCbA6108q1G2QuS4jF6DAbTWaT1mRSfINCw9BwHxzMh4JA0FAoMhqJRyOwOCQFgSEjUSQsioiBUVDrxSSkg0MNYlNtXIIB8DaA63VcpJxOEFNIUiZJAmANIFLI8OKzfcQgUkqFaehoNZsA0uEi+l+VHISMiZHQcEqAomCRJHSUnIVWchA6CKPnYTUgSguiDDysVUCwCYkBfJy/EO/kYZxCTICE4C/EBPBQESJ8ipiWJKfFaRhJNijOxIpVUzN0jHQ5OVVP2OJk5bo524IEZdHailj7noyYy2X5rffuzA8Nfn23ura6PDs9NzU2PTM8PT8yPzvsmR4cH+sZ7Gvr6m3pGO7sm+wfnR32LIwvrs28ezf7/v3ch4/zX35e/XVpYvXp7edJkXGpCWmbN+WWlFTdv//i/cqvn1d//7L428Ls++WFT6vzn5Zm3i9Mrcx5liZHZkf6JuY8a4tTH1dmv6zNf12e/TA1Nj3Q29P5prnpScOtqz9cPnP55KFTxw+efvbg5cjgRF/PUM/rnq7X3QM9QzMTcwuza3PTazNT7+ZnPy58/D9r04vzL695blTO36tcflm/3FL3vqN+9VXpwPWMpweCL5dZd2+Q54ay09zAhiDBtkBlSbi0LExYm2A8nBd3/+KpR7cH8/Oa4uIeh4ZfMjt2iFSJPHGQSBws5ofxgRA6NxjPsRNY4nC3ueV8+X++PffvnQdXGqtX7pWPnUl6ul2/J16SEWDh0vleXphvv1sP/5aM+I6C8WLhYBysLwfhzUL6AFg4D4VX0ZiBID+RwY0hMZwkqpFBsTGILhRWjcap0EQFhq7CsfQYlgkL+BGhMIYgniGOAaQpQlWeO6h8S25l2fbCkoLN23OSczclp6WlRMVEhoWYCzcaH52JWm7J+X2y8peRkvFnG+7W+p9IMB9zGQ8rBLsAbAWPVcgh5HNI/8K/W8F4aQZHQ8g9gbwjZpmbS0oWIRv9gcUQ0YC//I1d+swivKDlVClpBRqgxCgoVwrKucA2ETeHB2wGGVl81gYxkCxnx2o4MUYo3kT3V7AUEAiyuTSATmXgqRQ8k0zmMkhMEoZKwNBIeBIRi8GgMBgMkUyiULFEEoZIxP95SGQshYYmUxFUKhJDgVN5dK6YKxJIpQILKAiii+NodBmeZqAJE9jaYomj3hSyX2MrEiqT2Opygb6ap8wBhVkAmA2KU+jCMJm+VGo7AcqKSbQgDJaHwjCJNKNEXx4Y/yQp9p5KtZlA5mPwFCKBT8KryWQVjSFhM+Vsth9HFK3QRTicZruVZ9WLnWa71WCzGk02s85m1nyDRfmiYV44Hy8yAkZFIUgIGA7pi0PDcL4wHBJGwCKIGBgd6yMno10sSgiTZgIJBg7MwPXRcJAiEppPwEkYRAUXbwJQUrq3AIDJ2EgVDWFkYPRcogRAK2nfqRneWiZSx8RqGTg1DaVhoIwcrBHwtXNRfgKck4dxcFFuAS5UQo5U0KNl1Eg5NURMDBBhQ+WkaCU5Vk5KkJLS1Ix0IzvZzE6wA7EmeryBmmFkpivJ8SrsBhst00XP8mPkBEO5waKtYaryRPvxwvzm69+vjQz8tLz4fmlpcWZhenJuZmp+cWJpcWJhdmR67O1Q35vO7pbWjsamthcNHa/eDHYMePonF8dX3s9++fXdP78s/v62Zbwga1NqQuzGtNTi4tJbN+8tzn14t/DzwsTHqaHxmeGpyeGp8cGp8ZG56cm12ZmPM9MfPq3+srbw08zY6kD3RNurrmcPG+7eunnrxve3Ll+/cvryuSNnju47evrImYZHL4Z6xwZ7Rgd7+gd6BkcHxmcnFpdmPi5OfZz3fFyY/PTp/T/me7rHbh/x3ChbeFK92rZvrWvfh57dC4+29l5Mergr4GKRZXeaYlswmOnmbAng54XyC8J5pdGKqpSAutzU62fOPLo3uKOyPT6lKybhmX/QcY0uRyyNlUiihIIoDjucCfpRAAuBJlYJ+Ae2xs8/3vOPniMrDSVrN7aPH49vLDMdTZTnBtqUbBnKi+j1b17e35J8vqMivJkoOBvpy4b5sBAwEIsWkKhGFieUL0rnilIYnCAC1UAmmhlkJwqrxhI0KLwSQ9YQWCYM3QQjm9B0F5UdTuOGQtJUtaEoOKQiL7eiuryobFtmcW5szqbYjPSk2LjIQD99QjD/UJGx8VzkalveL8OVE6+2nCszlocIdvlr95tlFRC+nMcqAMl5bEIOl5nK46QIGPvUzGYrNBRAbvWD6oxCG5+UJEY2OZnvwxRT4ZbWAM1Nm3CXglIgxG6XMeu1ohqFqBgC8vmcXIi1GWJmCoF0OSdWxQ7VAsFGTpCeYpTQ+SwGg0anUAkkEoKCQdJQODoZQcR64VDf4dBeaLQ3DPatj+93cIQXmoTyQfv4ouFwLNoXjUQSkDgaGkXyJuLgcIwvnkGmsZhsOshja/micKEuSy4OoFIteHoIVbxJYK3QBNXKHYVCXSZTUQipi3mqbL5sMyTMZfFiSByHWJutspwVyCsp1AAMmoNAU+B4Pl2abIw4mZ7eHRh4nM8PJWAhAppLIShIFBWRJmfSlTSmE+BGyzVxdofbYZdajAKbSWkxGK1Gg92id1h135DRCDzcB+/rTUbAKEg4Ee5LQPgSkTCSjw8JASNjYESsDwPnKyZjzHSSH4NqBMk6LloD+sgYPgICkk/AiRl4JRdvYaMVDLiMjVSBaAMTZQWwFoigALFGhreR4W3noP14RDsHa2YibWyUm08IERFCxcQQESGEjwvmYcP4+GgJJU5Oj5PTo5X0UCkhQIQNk+Fj1dQkFS1RTozVkBONjFgTPUJPCtcQ4g3kVAM1UYGLUhOSzJQkCyHOjE1xkjMCmRuDOFvCheURgacLcxvOnxhufr46Nf5+eWF2dnZs3LM08e7dzMePC5/eza4ueqYnhwb6O163NzU0Pn725mXLm5ctnY3tb9t6Jwc8C+OLA+2DdWVbkyKDEmPCCvK3XrlyzTMxvzTzcbxvbqyje/BN12B778jb0amJpYX5L0srv668+2NxerW/a7ThYdPNKw/Onbh0ZP/RIwf2nzp2+MKx8yf2HdtTVberuu77c5c6W7o8wzMTQ7Njg+OTo1PznoXl6fdLUx+Wpz59mP3lp6U/Pv//XN1Xc1xnmuB57YxEIM3J473LPJknvUd6g4T3ljAECO+9JUAjOomUoUqiDCmJpGyJoiSK3nvvLUgQBAgQtCqpqjQ13dM9HbuzsTsxsxfqnY3YiP/F+wV+8Vw8b8Qz+Xj6yO773697vOv1Z8ffeHru7fnzb0wfG7/3Tf3pjaXfL0/f2BVYUWntztJ2ZeoHC6y9C6Wecv1QTXi0sWqgqfGtteu/2HZi7ZpTC+vvVtddLCn7PpFYG/B1elNa7K56valaJ6VpdXGe9+tZ4+Kc+L73+34/997Lg0Mvvhq/t6Hy1Fh4U61ztDgrzR5iAEH1iiLpNSbpNSZ5AatQikqVVqnWQ4iFpN0cH9Xqi8y2ZourTTSWIVQIxvwMlYZTUZKJw0QAIYMkH4eZqAoNwnScFvJYXbbZsSgYGiwqHO/rGl+zbGjlUNtQV1lPW0VTU1VlRUl+ZrAkzThc6/hsedqB93LuH+i6daDjo2XB9iy2JyYvS3WM+6RxszRoZHq05L/jt3LvBXVn0ozXs5jD6caxsClqp2vt4OEYN5/jvJ0f25UT+CBiGHKgg1b0TZfufa99jcPaZ9SNWI29Jl2bSWy06xZ5pRK/Li+ky40boj7KbiR4miAwnMAhClPRIMCqYRwBILVCo0yC1AoYUKpVSSplMqBWojikApRqDQBCCKCBMAJlBZJkQJ7BEQwmOZEXJB0jmbRem63UFelODTQYDUU4nYNpy7TedltixJY2ZIn26Xz9sm/IktLp9vd7fSM6SwmmDVj8DfGMb5zu11kqE0d1FM3DrIyaMuTUrqKK0yUVP0QiwzomRsMWCrNRTAolRgXRJ+iydPoKq7MyGMlPpIXS4vZExBQPB1KjgX/Hz0JqUp2Mq5NIjYKGVDSk4mBAQEFJoZY0AAcDFKzgMZWJgr0sHuKooMz69LBLXGBjkq00bGcoJ4+7tVBch/olOMWIBkxYTIITEhKTUY8MpktQhh7OtxLFTibfimcbkTwLXuxkKnxiiYspsOJ5ZrTIgpfYyFI7VW6nixx0voPKtmEZViTLjhR76IVeutSBZTvgwhSyJEgVpGAlfmJRhKtKIUtsQImProiwZRG8KACUxuCqDGpRFrcoW+zJCy6tzl3XuXjLm0vP7N7xaOLm3PSDycl7j+49m5968Wzm5fPZ58/n5p8/fjQ/82Bm8vbkjZv3r9+4fPrkqUP7j+3bfe74wdtXzly/cOKL999qWFhUWZzb3dX2ySefXLl8Y+r+3J1rDy4fPXrmwKGLx05N3pp8Nv/rkyd/n5n9bWrmtytnr+z87udP3vv0w3c2b3z74w/e/uDzjzf9tP3bH7b98Nl7m9etWPPB+neO7tn/6P6jp9O/PJp4PnHz/tTE9B8fEB/fe/rswYtfZn796+zvj8+efLBn2+zON14cWvP01Lon59+eOfH67Z2dN7ZUHttQ8M144u3mlKEiY1uC703XLy209VfpuxbKAw1Zwx1trQ1tgwNL3n//+w82nFrYMLmo6VbloiMF+VsSibXhyKjT12mwNxj0mXopQ5bSecYVdfvW9Vc9O/Hev11c9/sPb0x9UHNmaeSjastIcSLHmyoiBs1/gBRJXPICLimZVyhFhUpSqvUQYiOYFJoJcEKu0dJs8/bobbUYn4pSIZbP/COSTuB0gmTTUDIGYUGcjjFCFitmGExlPl9nYf5Ib9fwmqV9a0bbB7pKe9oqmuorKsoKi7KjZVnOrgrnms7Ae+2uPRuLTm2v+fzN1O5ioSaFak3RDYZNS8zSgInv1P4x+XX1ZmZjWDyXrr+RqT2QYekPyiEb1eBEjob5h5nOE5nhj+Ku5R6+z4a87uU2+k0fuKzLzIZOkzTmsvZY9Y1modoulHjEXL+YE5Fy04z+FE7WkySKoKAGR1Q0kkxp1JQKgQACUKKqZBhSYoiagNXoH1EghCjUqBIk1BipQQWcMgqcgScNIo3jOMVqRcFg5CWr5LHaCpyBjrCn3e2oF6ViXMhlLAvlUJslPmSMDJnDQ2bfoD3QE4guSaSvMTnKUcFt8VWmZf/Z6VkqcOkiZ5IkiRB0Gq0Td2Z5Elvyyr7Lz/vAY23giSAOm3HSzehSeSkkyXkGucJgLLW5c+KpaZnpvkTEmIh6ExFfWtSfFg2+YkAgHlRTgIKGVAysZkAVp1HpQMCkVJshjRZW05CCwwGJAi0U7CJRr47x6BAb95qZSnZwuFvgnDxu55VRHebTw24z6jMjET0cl8CAQeOSlQk9mWGkcmxUnpPMc+LZNizHRhS4uPwULsOOx01QmgnOtGI5NiLbimdZsLgZDxmRkBkOmuGwBUo48EwHkWGGUx1omgvNdGEZVqjQQ9REtOVeosQOZzrwbA+R7UWyvJqcAFIYpQtjfH6EL03VNha4Wor9XQvT/7S078TP26fvXH82Nz0zMTc7OTf3YG72wczjhzPPZmefz809efTw2fTMi0ezj+7dvX/j6o2LJ6+eO3Ln2qlbV06c371nqKm5siC/tbHhjTfeOHDg0PWrN25cu332yPEzh49du3DlyaOnf/v1H8+e/nbnzszFi3d37dj56cZP/7T+/c82bv1u246f/vzT8YOHb1+9ev3U7VP7Tuzd/uPRvbsnb9x8Pvv8+aNfnz782x83v588fD4/+fjxvUfz96Zmb048uHR1av+3D3e+P7931fOjKx+fWjt3Zt304bG73zVf21J+6L38LWOpqxu93QXG1oTYlyEtK7D0lck9Fc6h1vKRvqG2tr7evqF33/rsi02nF7Xdq2m7U9NwsbRiX3belmjqmy5fv9HZZJKLzPpCk1xA8xHZ4q8py7y5563/eX/rvx78cObT5nNr0jZUy+3ZKQlXmEMNwGuYKklQJguASgcCMgDIKpUMgGYEc/B8UNDmm61tLv+I2d1E6rJQOkzzaaIuV9TlaXXFWl0xy+fgZCpBx1guymizWF26KOc73c1FRcN93UMrx7tWLWnt66zobK1uqFlYUVKwMD+tKj+lpdw12uRbXuf6cCz644d529/LebPNUx9mK21kg1c3atEPWcQOEe8xahvM2gYz8XFEvJCuvZtjOZjh7PJKYSvZ4cJPxKSJ3JTv032jKYZBBzvuZN4LSh8HLevt+iFZ6jCbRry2Dru+xsoX29lcD5fl47NC2rxU2e+TZIkmUQQD1SSaTKJJGKjClIhGxQFKVqOkQRUDq2hESf4RmQyQySCxACKTEFaFa2HKSDJWjpUFDIURghAETmfkBZvOYrFk2nxNkcBIIjHi8tbRUiaqzeBslaZgnzEwaokMWwOjnuhwPPF6bs4Gs6MCEZwmb0ko8zOTu09vyDAbbUZJxEkCoARIsrOu1mD2WwVFn6dFV5qkQhxxoLiTFeKsPqIzZBrlYp2+QG/O9oez09NiGRFHasSZiLoTEV8iEnjFiII6UMVCSgZVMaiK1iRzygWCKkmvUhhRUIsCDKoSCdBAwkZYY4dAM4s7RMQqJJtZpVukPCLvYGEbk+wXYbcesRshh6zxSeqgTpmiV9pNiqCWSjWzERkJGVSpVjBhQ2ImJM1G+a2Y1wh5ZNBnRkIWLGBCAjIckGGXAbHoNHYZcVkxpwV1m2G/BQ3IcMRJhG1w2ARGJXW+i6oOSkVOosCOhU1w1ALH7EiqC0nzkhk+JiNFm3CJgbAmK4MtStdXpNv6qnI3rVl2+ucfZm9eezw9Nz/zeO7h7KMHM7NTj+ZnHs/PPJ6dejT/4NHL2acvHj15Oft0/sGj6Tv35u5Pzd2fmr1wd03veHV+2eKq2pGh4S+++OLw4YPnzp4+f+bytcu3piamn829ePnkl0cPZi+dvXxo7+FvP9/y1eat27f++dDOw2cPn7t88uLE1VuPJx88ufti8vL9W+cvT928/nR66tn046cPfnk+849fn/7TX1/881/m//pk8tGj27dnrl+6f/741SO7pvZ9Or17/ZP9y5+dWDF/du2jk6undg/e+6ru/GeFP6/P+FOff6SGfw2EAAAgAElEQVTG1VFobs829mcbxnKNPXmWgarwaEf9QO9Ie9dgb9/Amyvf3fLersbum7Ud16tarpYtPpNX+nMs40NvYInT026zLLZbaqyWClKbjst+T8D940fD//XSp38/sHF6W9ul93LeqTPWZNi8Ni+KSIpkQqPQahRaSGmAASOkNgFKGQLMBOrWakN6qchq73IHxszeDtKQCzNhhI0I2lytVGh31HlczQapnGMyBD7Bc1FaymRN6YycbfM2lleODwyOjo+2rBht6mlb1NpYtbiqvKasuLooc2GOu7bQ3FvnHqoLLG9zfrLc/+O7WVvHMkYKbDUuvtLBDVv0QzZth47osWibrFK9Cf8kIlxI4+9nOw9muNpdYsRE9Lup0wnTxSz3W0HTYis36NJu8MubA/IGj3bcwvWadJ1mS6fbWG/Xltu5fCeb6WHTvWxGCpcdEH1ug6zlGBijYZCjAJZWY6hGAyAKBa5SEGolDihRUAlDCghJhlAlCCUpCQBBFQichJAAQUM4i6Ayzxo4EAXVOMHyrKBncIuotZhizkBDJHVNYcn6eEa30ZFPauO4LlfvbDd6lhj9g7bAWDixIpH2Zm7OB7K5HGRtZk+JM+N9wdaklcMWk1lkCA2gUkMoSPGgySP56uM572fnfuLxtLFciCRdAhvBRD8jhPWGTL0xX2fKtXuy45H0rEgoNWROhB3pEV9GJPiKVpXMKRdQQBKLqTkc4GCVCCh0aoUALJBwQMDVLKbWUbAJhy2A2qFS63HEJsJWUWXhVB4t7RHZP/B7BNCuA2W92iwp3VpFipjk1CfZzAq3SAVNjEsLmJlXUuTkgBnw6tUBEybr1SZJbZVBpwV1mhGLHjBrVVYJMOlgLa/Wy5DVQZmtmMWEOIyoQ4ZcJsht0AQMUFSGSjziopAh24ikS5q4nYpaiagNi9rxqJ0M29mQVQyadc5UwJ8Kp8WZhVnWtpL4eH3VlrUrz+786eXTx8/nHz+emX409XDu4ezzxy9+efrryyd/+WX25W/zf33+8JfnD399MvnL3N2Xv839l396+d/+5dF//njlB41lDYsrFre3dqxb98bnWzZ9v/3rS5fuTNydfjg1PzkxfffGxPWLV0/sP/Tj13/+buu2vTt+OnfkzO2Lt+5fm5y8fn/q1r2Zu/fnbj29evzK2UPH7l6++OTh5NOHc/P3Xzyd/H1m4i/zD3+dn3xy99K1K8cOXzry86VD28/t3TZzaNOjfevmDy57fmbV84vrZ46tvP999+SWmmMfZX21IriqxdpdYW4vtnUVWAdzjaM5+q5M20h1+mhHU2fHQEtnf1dP5/jg0g3LP2vuvVjbdmlh09Wyhqu5lUfi2Z8HIiv8wV67rd3rbLE76jApG9CHCEn71vCi6R9Wz/+07u7W1iubije0W6uyrDaLHYDEV5MIRClBSRKUJIEKPaiQQZURh5w8FeAYr8DnGs1tzpQlZm8XaypGhRjKRVkxW6sr9vk74tEBq7FGy+cZtJkiF6b06awlk5Kzbb6G6rqVg6NLRobrx4cXd7bUNS2uXrywrK68dFFxZmGatSxT27XY2Vnj760xru817XgzseP1vHXV4eagXOEUhi3ykF3foSN6rbomm7bejH4S4S6kcnfT7AcSrnY7n2oil3i50wnT4YS5y0wUm6klKabPI64tKYa1FqrPTHVapW6rrckhVf+/Yz8zhUu46YSLynAzXpvOwDEshHEYouNhQQQJGtHAxH98VbEgSaVQqFQKpTo5SaNYgCiTMGVyskKFYpQGxJRKBEZICMYhBOZFxiiCBKqhSE5kGR2pkTnSbAp6wo2uwOu5JW9lFg77YhWyPYfV5+ktbQbbiNbVa/cvjWe+mZb+VnbmB6JUrCHNJk+RNfNtzLSQ1rplg5ZBAfWCBWq1Rg2hCiOGGFPd0dXZhdsisXGDnCXyfh0ThlgPQrlFbcxkzddb8o32nFAgMzeaiAUNqSF7esSXGQ2/on5NDb4GYEkaUgWyIMwgEI4AMKRiFUlajVoLq3lIyUJKHlMJJCCQgJlFTDRkJgErpbHSoIkFDDwgcWqTDjaKoEkAbSLs0mEeHebkICuldsqYx0JYJcCiU5u1gFmEnAbGKtJeI2UWIaMWMhlQgw6SRdAsQiYW0HKwxMI2mXZbGbuMWg0alwnyWCGvg3GZMJ8Bi9vILCedZoNipuSoOcluo712zm/nfWYmRaZ8ZsZn47w2Nuqhoi484UWKwtTiTF17gWVlfWLr0rozP3//ZOLu77/8Pj/316kHLx49ev786bNfn8+/ePz3l/N/++3F3/7+l9//+vJvf3n222/P//GP3/7t+csX32z7ur+5t668vrGho7tvePnSFZveff/kkRNzU4/mph5dPnX2/JETl46dOLP3wNEff977474bl29OTTycmZyenpq5P3Hv9u2bV65cOn7oxJdbv/3qix/Onbs1O/Py6eO/zE09mrpxZ+b6nZnb925dvHLu6LFT+/ce+OqzI5v/dGvHtvndfVP7x2fOvv306rsvzy9/dqhr8of6S1sq9r2Z+mGfv7/K1lZs7ik0DeTLvbmmzhzHkiL98obqka7h3t6xrrbR7pae8YFVa5b9ubfzUUvrnZrWyyUNZ3Iqj2aW7IxkfWD3D3rj42Znr9XRLtnLKF0qAhqGayqPf9R/9OPxyxsbZ79o2NTpL0h146wNAWzUf5RgpV35mqxUGgDErISMasiCYykMESR4NymliY56o2+JK75KdrVidFAypHByiWgpdvsHcvO+jEfe1ctFsilN1hewliytpUCS8+Lhhd0tPa8vGRjpaxrorG9vqm1cXFpTnruouLAqv7AoESzPNLZWGzsrnW3llr4G59ph/0erIp+MRleXpbSYdSVOscWhXWLVLzHrG3m6UYQ2hJkf8/l7heyP+dZmM7tQgNcFxE/j0jKfvtImj5lUW/3avem+T6LWQRvbYxRGTbYhyVrlFBc6hSIHm+2iMrxUIkBHgkQoRFiMuCQgOo6SOEGgOI6gWAIlYBWWTKBJMKoEUQCAAbVKoVYrIBCg/gOAJoMkCFA4wFAASygpGmANtClIaZ0YqQc1AgqKLMULktbkcQSyA+HBYObqaPmfYgvXu1PbeGM2a8yRvNXa0GJv+qrc/G9K87+PR9aKhgLc6DbGIo5gHSfFGMbAEQSPQLgSUv9vCJKse0Wl07B2yZkXz15aUvJ52LNKwgtMlB8SvZBgo2WPzhyV9Olmc1bQnxmPJ1IDlliKNS3kz09Lf4UACQrEWA0ugBgHIRSkQSGVBkjmNSotAuowDQerWEQlkIDIQiILSZRGTwAmQmMhASsNmjnNH/hlQWMUQYsWtomwXYAdPGTnQDujMQmgXY9YJdBuAO0G2CahDj1jZHGPnrAKkEVC7EbCokctEuKUMIeIWHWUUUCtEu4ykg4D6pA0Tj3gkNRuC+GQkYAJyfbQBT4uw45FDOqQQWW1kH/gD5hZn5EOWLmAQ/A7hdQUMdXLpHvxojBVneDr0oX+YudbbVlfv73iwt4f5+9NPp/7y+PZ32amn849evz82ZOX87+/nP/tl6e//vL05dPZJzOTsw8nZmfuP3s4M713557xniX1lU3tbX1d3QO93X0rhpds3bzl3MmzEzfuXDxx+uyhY5ePn7x46OjpPftPHzlz5+rd+7cfPLg7defWvTOnzu7dve/bb7/btmnbt199f+LYxampp/Nzv05OTN+/fufhzbsTly/eunDx3NETR3bvO7Tj+/1bPz6x7d27P216sn9w5vCKuQsbnl159/mpsdk9Lbe/rTn1SemO5cG32pydpcamfENXvn4gV9+dLbdn2QZLzMtaGwa6h7q6hvo6RrrqW8f7xj5+Z3dH18Om9hs1HRcXtpwrqD2RV7E/s2BrKHWVzd/t9A06fd0G50LOmI5B4uDCnDMftx3/oP/s29UPP2/Y2BpMTzEjmA5T64UFHKSwqZJNKsCohk1KyAjAVpzwkUSA4Ly0lC7a6oy+EU/iDXugjxUzdFKAMxRqzcUu/1BR0Y7cvC+c7maTOddoyBdsxXpzidlckhlf1N8xsHKsf7i3sbe9pqt5cWtjRd2iopqy4qr8wpJEqDxDbizTtVaY64rk+lK5t8Gytt/z4XDk7YbwcJq92Cc0erh+hzDiMLRomVYOeT+F3ZuhvVli+DrfscjOFeixJSnMuwF2mVuot+rftMBbU3TfRKxv+/QDZrrPKA6YTB2yscBC5VupHBuV5STTPVRqChn1kRE/6bQKkoDzFC7SPE/wDEZRCIJqVPBrIJIEYioIB1EEgFUKtTIZUCmh15SQSoNDAIGqCEJNogoMU5MCJblJ1kHSZgKTGULW8gIvCVq7xR4NBVv8seFQ3vrU4nfimUu83hq9XMgZ8rW+zmDm+4Ulu8vL9uVmf+hOqdfb47I3ZErJp/UuihMZEqERJaZWql5VQUpCqWFASkfLfnesNbf4/fTUN12mGpsuhglBiHWQWo9giAi6NL0hw+FM8/hDaQFH1OuIpnhSQ5FXKBBjIUxACB2CCwjGITCFQhiqYRGAx0AOBxhURWEqjgIEDhJ5WEtqdCQgkxoLBdkYyMxBBlatZZQSq5IFjVWHWLSwmdOYaLWZAawcKNFKs6gxCiqrBDoMqF0iHBInM4RbQOwcaNciTpmwSahdi3gl3CcRXpmzcKiFh106zCUhfxz5c4pqj4VwGTRhC5TvZ4pDfIYdDxvQkExaTZjXRofsXNDKhMx0yMZGnELYLYYdYtTJp7nJwhC1KMHWJaj2HO2yRZ53usu+37Ds6sFdT+4/+O3ZX+dnX049mJ1+ODc3+eTR/dmZ+w8fTty/d/P2jUvXLp+5cunU1evXr188c2HDmndbF3f0dY/09410tnd1t7aPDS35asuXp46cOHP42Kn9h88dOnJ6/8GjP/584sDpM0fOH959bN/PB37480+bPvr8ow82f/LhZzu3/3jl/NWpB48fPnj6cGr+3q37189dvHbm7KUT+0/u37tv565d3/2466uvDn7xwYXv3nqw5+1nh5bMnVzz9MoHL69smD82PPlD/cXPF+7bULBlyPt6vbm5QNeUq+/J1/fn6Doz5bZsR0eJa6yzs7dnpKu7f6Crr7e+bvXI+J83Ha7tuFnddr6q49TC1lNFtSeLqo4UlH6XmbPRGe7yhAZdwW69u0KwJARSXLU4ffLrlusbOy6vr5j7sndTV3bMYYQgDlYyWjUFJlsBpUUDWVSwSQHKIGonqQCB+ynOz+rSBVuN7BvyZawPJF7Xm8t4MSDKuVpzqSNlpKDk58qqg9HYaout0mIp1pkrjZZqt7OqJK91rHd05Vj/YPfinraKzqba1saKhtqSmorSyoLC0rTwwnS5oZCvL5VqCuTqXGNdkdxXa1rb7X27w/d6paM63VAXYlrdZH+K1G03DBj4zR7D4ZjxfJHjo0x7iZXLNBLdXuZNH/O2T7/CbfnUwWzx6d73Ssvt3LBJGDJLnTa5xmHMtlOZDirbxWS5qQw3le6h0rxUmpdKsRv1LMVjuJYQOIQl1BgBILgaRJIAJAlAFTCiQiEVokwGFElKhUKlUoIwiOEaHFehuAqFFBCkQRlaMJGUhaZNNGXkGJnjBZrnGb3Z4I2GqnyhLm98dSxrY17ue7lpSz3uekFXoHUO+NM+zivZV1i2O6dwYyjWarHGdDobb/cQOj3JsxgOwrAC1igUya+qVCoMwEAIgVidzlMYzV2RW/xeNNZvNeZyYgYjhDldkNfFODFNNGTZU3ICiZycUDDN54v6g9Fw7BUC0DAQrIUxHYJrEYRDYAZHGAIlYBWJqElUSaBKElMxlJpjNByj0TGQREMmBrawiJ1FzQwoUWqBUEiUWmZBs4CYeFhmQZkGjIzGzEEGRmMSQIlONrBKkwBaRNwhcSaOcTKwjQatHGwTUQsPW1jILWABiU6RKBsD2ViNV4t5tYjfgIVkImjAAzbaJ0MRC1DgJ4r9dJoVjxjouFnvtOA+BxN18lEbG7HQURsbdfIhNx+0aKM2IeGiikP04gyhMYPpzOHHKqxv1Ec+Gli48/2VN47s/WVq5sXci8mJ6Vu3Hkxev3fv2s27V67euXLx9uULNy9cvHb2wtXTl29ev/F4eu7nHbsHu0c72/qHB8YGewa62trbWzvWrFj99dav9u3cdWT3vqO79xz6ceeub/68+7tdP32764tNX2/56IvNG7d8/KdPt3+769TxS1N3781OPbpx9c75c9fu3nlw98bEqYOHDv7ww7F93+354dufv/9pz/bde7/+5uS3H97Zve7RgRXzh8fnz6x/eeOjX669O3do4M6fa49/WPL9mtyNvd6xGktzgb4lX+7L1/dnaTsz5dYcd2NppK+9r6d/vLu/r7e1eWlX85Z3/7R985Hi5vMFjUdLWg6UNB4urD5UWH6woOzH7MItwYwhh6/X4es2+RdzxoSWEd5oiD/e0Tj7ScP1tcXTW/s39pQH7A4AEgE1x0CsJtkOquww4lQj1mTIBOIuig4ReJBhw5yUwVsqJE9vSto7sex3bJ4Wio0YTDmSqdTo7M8q/KGm8UJG7jabvdVmKxa0FVbzokS4obGqd/nQ2Irhnv7O6q728o76RU01JbWLCmuqyioLi0oSoao0ua1QXFTI1hVb6wo9dQXO9nLTaJNpWYt5pEbqLnM2J7gGL9QdkQYjjjGPZXPQvi/uOJHvfydizdcT2TLR5xU3BvTfRu3fhD3bPbrPfPq1bnHIyo6YdYMWQ6NTKg/IOQE+y8fmBPgcn5DpYTM9bHYKn+lh3WajjqIFnNKRIgvTqALBlCgJELhKjSlAaAEIvIYoX4WSX1MrkpRKZTKsAmgIZUCUAmACgCA1AMIQwdASRRgYSkfiAoEJOMGhlERp3UZXMLzQFem2Rtd7Yp9lZW8tLvgoLX2FLaXd5O4LpL6TKPgiUbg5lDXmCZZajB6J0hI6PcIJKCuAKAFoEI0GSk5OViqVVDICKSA1yuJyqj3el1X2QVruGoutXq8tNki5RlOm3pTBSxm8PtPiyUlJy8vyR9IDsdRwPB5Lf4VDIAFBdCiqhWBOo6HUahxQIRoAg5U4oiJQJU0ADKnhKOCPBA7ScrDMIlYOtfGYhUVkGtASSgOj+f+lZzUSAxgYyMTDOkqhoxR6GpBZxKblTCzrYhEHC1tYyMxBRkZjpAAHCwck2qPDHDzkEVG/nvRqEb+ERc1M3MqFLUxAhhM2pMhHFfmYNCselpm41ZjiIENuNtXFxe1M3ErH7UzEwQTtVMSuT3XqMtxMcYiuTecb0qiWdKq/UFpZaVlXH/yor3zn+6tvH97/+PbE9MT0xO2HUzdvTV6/NnH1wsTVcw9uXpq5e2N24u7sxL256Zn//Ld/3L01uXbV2401rQPdQ0sGR3u7e7o6urs7e1YtW7l106e7vtux/4cfD/6088jOXT9/+9P3277bsvHzb7Z8u2fH/oO7j185d2v63vzUrdtnj5/+6Yddxw6funPr3sXT5/ds/27f998d2vXt3h+2H9p9+OT+U6d37rq6+9Ppw+sfHx6ePbJ8/txbv9z8+OXl9TP7uq9tq9r/btGWpZnrO1L6qywN+Ya2fONArtSXxndkGNvzUlpqS9pbB7r7l3X3dnXWL/7ojRWndh/44v1DefVns2sP5Nf/XLh4d+7C3dklu7NKvk8r2hrKWWb3Dzt9g45QBydnUQg3UhGc/qHt1831p8Yy962qG6kttlq9atKmAGUQkECFA9Q4YdwN4HYFbIYIN0GHCCLEsVFeymBNxaKzwx17KzXv45TICCNkycYMrVwo2bvi+V/Wtl7PL91vcw2ZrMUCW5biqC3Ja+9rHlwxNDzW19rXUdXTtbCncXF9VWFlZd6i6vKKgsLimL8mVe4t0NUUsPVF1sYCb3Ohu6/KPtpoGazTtZbTIwtTevP0LVGsO13bk2rrTpHXhWxfZ7iPFkbfDpnLRLhcjy1PMXwVtO2PuA8GnN97DR96tMtd2kGrrs+oazOJ1S6hJCLlxrRZAS47yOcExAw3l50iFgbkfJ/eZTCLOMFCmESyWpylAJxQEoTy/8OvfhVWvgopFgDKZJVCkQQplRQI0SBEqAFCDcCAGgQBhERFCpEYUksRHIpxKCGgpInTBmwua6DEFh8wJd6zxD8PZWzLK/o8q+hPwZzVgUhDILU/kDXuyeo3h4t1VpekE00sj5ISjOtQQlaDWoWKAdSMIglTJaNUEg0lk2pQ0NB+zlEXzX8ns+RjT3i52bDIbCwxmbNkS4ZkyhbkDK05bvBEUj2RVF8sHopFw7FXOFTDIxotBAkaDacGCKUSVaogpZLEAAJV07iapyGJRXUMpCU1WlJD0hqWAiUaMrOoXcBtPGZmET0NGGlIpkCJ0uhpUM9CehbSsaCW0WgJwMghehowMBoDAxlo1MyzepJ2cbhLICwcKrOwzMIyBdpZNKDn3HrUJSEBIxm2MCk61COiQZmOmfmAgYrKZKaDKgkIRT4uw05GTFTMKoTcdNTNpLqYVDuVZqMSDjpqJ31mJGzh4nYu3UUW+InqGL04RjTFqZ5s3ViJuLra9lZDbNNgzb6P3759+ODjW3d/efR09u7tmdvXp25emLx+dvr2xfnJGy+mJ19MTz2Zmf3bb39/8fy3r7Ztb13c0dPUPT48Njw83N8/2NLU2tbSvub1lVs+2bzjy68O7fz5yqnTl0+eOrpn//ZtX+3e/tO54+evnr1x9fzNi6evH9m954dvv/tp+4+nT567dOHy0f0HD+386fLRQycP7jt15MTl0zdunbtz49ixiUNfzB9b9/zI0OyJ1fMXN7y4/uGTs6vv/9B87pOSH9fmbRzMGG9wdZSa63IN7Xn6/myhO850Zpp6SuJ9bc0drUvau5d0dLX3tzYf2vHd44knH6w7Ulh/JbfmSMHinYU1P2aV7YgVfR8t+dpfvDmYuz4QX+8LrvIEBrSmchK1tpam39+/6q/f9P84lLeqIb8gJ1uwRkA+qEbdyQoTqHKDGidCpECUS4FZNbiHoEMkGeXpVF6bzsp5vKPFFl6Xmvt5LGu93lRtkuOiPk/nag4VflTdebW05qLLu9ZoLbboyzOi9c01XUt6epf1dw93Nfa2V3Z3LOxrrm+oLqqszKuoLCnJyyuJB5ozrEuKjU1FUlOeuSHT2lFgH29wLW93ddfINQV8X5F7oMjSlcN35eqa4tIiJ9MX1L2ba9u1MPanDGuTEWkzU++Fndsjnj0B+y63/iu/4S0HN2YVhy1yq16olNlyD1ceFHJCfKobT3jIDC+bcDLZPqkoassPmJ16E4eghFol4qiepkSModQE9CoEL1AjSQCSDIHJkEYBqZWgMln12mtJiqRkRK3BVBo0WU2oQAKAYECDQLCAQwaGkllOojk9I+oZ3qwVUmxmnSPbFGm3ZKwzp77rTbydlrMurWBtKG9FMJLu9GWZfQWSPwu3WEEOJ2lCx4oEokdALYbKakCnVImASqt8jQYX0LiCh5WMWsMnQyaYz3ZERuLF74dyN3i93TZHpU5O1cpR2ZIl27Jle8LsjkYD8UQkLT0aTw+FX6EhBa1J5gClCACCBmRBmIZgAkJoTEMiagZVaUnIQKMGEtQTGpkAMVJNkoBAggYGtrKYlUPNLGKkIZnUyBQos7CBgXS0RqQBkQV1PMwjaplFDAwks6CBgSQSNbGsnmQtLGLlMQMH63lYFlE9C5kY2C3Rbhl1GRC/hQ7bOY+ecGvRFD3hNzBBPZMw8bkObaFLl+diM+xkzI7HHETMw8bcTNxOJaxkhoPJdLIxG+mTIZ+MRKxohhMt8uPVMbYuzrakanuzzQOF7IpK05pq71t1ic+GGw98tOHOkSO/3n8wf//W4/vXZ+5ceHDz1IObp2YnLs1P3nh87+bc/anHs/O//vafzp+79vro6o7attGBkZElo4ODw11dPa3NbUN9/etWrdn41tt//nzLmUOH71+/dPvi+WP79hzetfvs8dOXz1y+fObKmePndn7z9U/ffHvy6LGrl6+dPnbq2IED106ffHD1/K0LNyauTU7fefrwxszEqZP3D22dP7z2l6Mjz86/8+zK+0+vvD99eMm1bVXH3sn5cmnGm+2x/mpHQ6Fck/3v+PsSzEC+a2xx/nBXb2/Xqpa24a6ujndWrXx0++4//vJ/rV5xrLz+XkH1iYLqnQVVO1JLvvLlb3UUfmIseMef+0kkfVM0siEUWm6xt7BsemlO4c9bX7+6efTtjrKi3HRLJAO3xmEuhGMBVOWGAa9G44aJFJTxqXAngLkxOkwycZ5I8HyCNmSJ9maT/41Y7rbckk9d/h67OaE15AruGlf+quK2ExUNd8Kpm1wpNamh+uqStsGO7qX9bUt6mgY763raqtqaS3vqahoXFVdU5RWX5ednZy3KSh0sCa6pdHYU2zryrO3ZxuEy06oW+3ijtbHIUJZmrM+ytxdZ2/OFjnxdU4ZU7aNb4vzSIuPnNSkbymyDQWpZQLs1L74jJ7Y95vg6qN2aYVvpoMfN2nGbtV6WimxcuV+s9TE5fjpmg+MOLN3DJNx8TsBYEHdk+s1mQeQQiIZUAq4RcIiFIVKNQa9C0Ksa9I/FvlIDqUAQgFQKzWuvKhckqQA1jKgQTAGzGpKHaArACTUmImoTTZk5wcjqZE6nY1mdQJtlzmgKW/3l1niHJdKREm6IxurCsTp3eLHTadDLBk62kkaLRmCTSUyD8yhm5iABU9MoxGo0DADQoIoBXsXRBQwA0ACAqwEkSUWoEStrKrbG+u2Zy/zRIWegzmBP15qCBkvcaE6YLVGXJ+4LRdNS0/PTE4XxyCsMlMRqkjkgWatRayFYC2M8itEozmIaElJSYLKAAnoC0mOAjAFGXINTAEkCHAVKFGiiYBMFGylQTwASpjLSkIVDDRwsUGqGUPKsRtKiHKySWURPg3oa1JEaHYGYOc7EijXJTB4AACAASURBVBKu1tOgltGILCgJiI4FdSRgE3CHjNj0kNuMB22s10i5dJhHT7klMibzGRYp167PsYoZZjrNiidceMKLxLx01EXGbXjCimc56Ww3G7PjKQbAbwTjDizbi5WGqJpUvjEutKRKvdm2nnxqpFQ3XiIvL3asW5T12UjH4c83PThx8pfpu79M33n24Mqj26dnbp2au3v+8d0rc3euPL43NfPw0W9//6f5x798+qfPWqqaetq7+wb6BwaGRkfH+nsH+rq6R/sHlw4Mvr1q9Y4vvjyx/8drZ4+dP3bwyJ5dh3ftPn7w6LXz125fubNn+3c/fv3N2ZOnJu7cu3Dm7Lmjx+5dufTw+sXpu4+fPvzt+czvj27PTZw+PnHg87mDq387uuQv1z54cf3D+YsbJvb0n/24aN+a1E8H4ysaQp0Vttp8uTZH7sqXR3LF4SxxvDz4Rueiofbeod43W1tGBvp7v/3s83/57R//9Pf/OTx8rKJ+qqjidMHCn3IWfhMp2GLL/kif8w6ds9qT+Zkv+lki+nFm2rtu7xArlqR4M3rbKjaNNDaU5VqCEdKXARhjAOnliaCMhhFNCgC4YCIF5QMA6VajLpQKUWwqhyc4LpWW0kV7s9G3NpbzdXHVN+G0pSmuHMmUK3gWmrIGsxr2VrXcy8z/NproKCvobK/vGe/vGO+vG+6qGeys626tbqwraKta2FBdVFGVl1eYlZOR3lycu6Yue0N9sLvQ0V/sHi1zrKy1rW22DFRoKxJCQchammapzTfV5bCt+dquAnNThqE9Rxos1b9RY3qr3rY0l1+XbdlRU7CrIv+b3JRtOeatJSkr3fxys26Fw1VvkQs92uqYvtXHFQTYhA1JOPDMFC7dK2aFzPlxV9wn63BcxCAdqdESahJ4FU1egCeDeDKCJuFYMoIoNJrkZI1SAQKQRoUokpDXlBoQwlENTqkJPSrIuFYLsTxASZDaTFEWRjTQOj0jchRJ0zAvIm5zisudYfXnW73ZXm9qJCUacKfaLKlWEyGKJKPVUnoZFkWQk2DaCcA+LcQQKhgFIRAEQRCG1Qj4GkQuIF7VgMkatVKdlKxMUgAEwDgwSx7lq7UHeryxJlekyJaSJpvDDOuiCZNOtFo8KZFIpCAttSw18gpDACypxuD/gICv0LiSxmBcQ1CQiKk0NARzGMygAIspRVqlZZQik6SnEAOLaTmUYTQUpeYYgKcBnlQxZLLEAEYKcLCgndGYKYWZU0usguGVPKcUyCQttsBEKh085BIRKwcKWpxhIJoAeEKjo2CZQsw05mBJowjYZdxr5nwmwa1n3BIeNJFxJ+2z4DEHk+kWs1xcupVKtWCpdiLNTad6uaiTDViIFCMasjFxtxi2cx4D5nWQASeZ5qUKAmxlgKkNUB0xbiRLP1RCD5dywyW68VLzysqUt+syvhypO/7Byqnjh1/euf6X6YePJu7du33r/u3rD29fmbtzeerelen7d+YfPvnX3//PU4cvL65sbGtpHRjoGB3sGx8ZHB8ZHhno7+vq7u/uWToy/uaqNz798MPt33x9aN/+U0dPHz9y+sjBM0cPXzhx7PK+nw98teWb44dOzk49vnN94uqF6w/vzcxOPX757F/nn/7Xudm/zlw9O71/w9P9S56fXP7g1KpfL3364tR7j/Ytv/FN6+GNpdtWpK7pcPTX6Gtz5JYcc1ua1J8ujBTounONqztr3hgY6e/sHWppHmjveWP9pluTj/7H//jv8w//rbfjaPniy3mLDiUqvw+UfeHI/VROvGeIrzZnjAvBZabYWlf8LU90vcU3pvV0iOFGQ2ZTuKLZml7OOtIJQyohxnA6BqNhCAwiQACB/DiWQlFenHQimA0hXCQbALUxVErH9XmsaZEpMBLO/zRz0d7s+pO50Z5ISlckNm6OLPcUfFXVcaW2Zmd13uqBxrrh1qaxrpbx7ubhzvr+1urulvLOpuKO6traisySct/CiuKsUNaKltyDHxZ8P+JdszC8vj6+rjU6Vu8cqrF3ltmqotqqsKE4QVVmC4uy+epMuiGP7SnX95Xp2vLo8SpuWSk3lk2/Xmz8oDGypSn162LvT1mOvVnOZTrDkCutzR8sNxP1KXxdUFfiptK8eMJFZTr5XCdV5Ceq0nQlMWPELHA8RVAoyqAog0IIgABKRq0WlGpUocSUKlwN4GoQBUAUgDEQxSEMVOCaBTAJ4BQAsyAqoYyooSSIE1DYRBN2njKzuBaHGRxhGI4VJUHPSyad3ixJJp1WFrWyqDdLslWvl7QiL7A0w1A0x/A8K1AEi8KEjmBYiKAAlAZJGqRQFYEoSUxNJ8OUAiBUCkKVRABKHIBwDUVqeMJgDTh8qR5/qtHmITktjFMwTqAkJUomvz+YiAXz0sOvMDjM4CCFKSgsmSXVNAZhGghRIRQIcRjyB34GVfGEWqQBkQZMDKZnUIGBaRrgOEgnIiILsrhCIBQSA0iE0kipjJRKTywwsyojo6RYJc+qdbRawhQGVGEi1BYWsrCQKKI8C3IUoKVBAwMbadjCoC6BtOphu4y7ZNorc14j4zPSYQsdtZNhJ5Pq4tKdfJqNSjXhcTOaaifSPUzESYXtdNBK+kyY30wGLJTPRHoMmM9ORpxUZgpTGuQXhbjGCNObEMdyjQO5xFA+05/LDuVL46W25ZW+d1qyto3Vntz24Z2DOx9fu/rk/oPHkw8f3Llz/8bV6TtXJ29duHfr+qP7j/75r//7rSsPxodWNDU0dnW2jAz0jg0PLB0dWTI0ONDT29/dMzo4tGJ86ZoVSz94553t33x7+tipm9fu3rp+/+K5m8eOXNy/6+Cfv9x+7OCJ6fuPpiampyamX8z/8uvzvz578q9Pnv7ro4fzk6f3Tv60+vGe4WenV85dfu8f1zc/P/X23R8HTm+u+Wl9/scjkRVN9u5KqSFXas2W+7Lk0Rx9fwbTlSN/uKznq/c2Dnb3D7U0v7PyzZ27Tj55+dt//7//28O7/9zasH9h3ZW8RYdSK7b7S7fZczbL8XelyOuG6JAUGjWEltlCq5zBVZaUEa27jU1ZJIQrLWllWn8eZU3D9XGUC8N4SAMFICiAQyEUDmColyDcGOFAMBtCeEg2oOHCEB/HhWxKX65z96TkvJ+1eG9J9/mi/HXpiTfi2e9YY2scmR+V1u2tW/x5a+X4cGvTSHvjks7m0Y6Ggbba3ubKruayzqbSloqFtRXZJWWRspLSnHDBqo6ci99W3fqqfP+fqr9ZnffeYHBJvbGnUm4u0C8Ms9URqThBlabRFen0oiyuKU9sL9R3Fkgd+bqBUnqsTLu0ULe8yLR+kfeT2sD3C/2HS4N7Muyv6/R9tnCLz1PtZhvCukq/Nt9DpnnxdBed6eRzHGSRn6jKkErjpohFFGgCgwAYATACxgmYxmAehjk18L/wYyoNrAJgFYgAMKpBwCRMswAm1BiphlgQlVBKBGkDInAwqMcRC0dYOEJPYSyBUhTFclpRx/Ei80eClv1fb5EXOIalSYomKZbmOIanSQ5HKQYmaJAkQALXEDhI4yCLAqxGSS0A0GQVpkzGVUm4WoFpQEyNYwCDkqyRESwUJyM4pwYxNYRCMA4jGM3pnE53athfnBV/hcVxCoVoTMMQKhpX0riagFWwOpnDYIFAeRxhEJCGNSwKCQQqEKiJwSQSZkkNSwOiiBokXOIgDlNIuFpPAyKu0BJKLZmsxRZYGZWFVlK0SsfDRgGVSY0eURpQlZECzSwispDAgDoGkjnUxGNmFrXzhFvHOE2YXUYdetJjYP0WPmznIjYqZMGibi7VxSXsbMJK/oE/bsMTLuoP/GE7HbJRAQvllTGPAUsxEkEzHrOROV6m3M/XBtnWMDuQJi7NM45mc0vyhOEcbjhfO1ZuWlplX17jWt0c2DxQvfeDlbf3735+697Lh0+nb0/dvX7zwd1bE9fP3716eebOw99f/vP81Iutm79oqF3c3tww2NuzZGhw2ZLRP4b/YG/PUF/vyED/6+Ojr4+Pvrly5eYPN+35ae+Fs1du35icuD1z+czlEwdPXDx1cfLW5P2b9+/duDf3YO757PPZ2X95/vQfcxN37h3ccm/HyNzewafn1jy7+fHfrm6YPbL88lct+zeUfrk8492u0Ogie3uxoTWX68jUjuVbluYZW4JwX4Ft16Z3Lh48svb1N8Y6O7/+eMvtW7O//9O//Ld/+5eJm7+3Nh6qar5ZVHcsrWpHqOwLZ95npsR7UnC56OvR+7olT6/JM2T3LbF4B3SOBsZeRjkKKEcaZU0jTamkPo6wERANgIgfQkI0FsNQP4p4MMyJ4k4Ec6Ckj2TCCBVC6SjBptO6UtHeZk28EavZXth7Krfk09TszZHsTy2RN+zxdaWLPutqe2e8d3BJZ+OSzsaR9vr+1pqepoqOhrL2huKOxpK26pLG6vzy0oy8jJK4M31le8b08ab/Y2Lps4tLDm0tfnfY0VvFNRSy1Wl0aYCsjotl6VRhDC+Nk7XZ2qZcfUOm1Jyp78w1dxaxI2X68VLzWIllZaXj4xr/z9Whk+Wh3em2lXqp0+Jp8Dtqw9q6uL7Yz2ekEGkeLNPDZjuFTAdRGCAXZRlKE+agRZBJktIAOKDCYQ2BgDQGCxjKwzCuUuMq9f/CDyk1oFIDqUAkCYcWgASAECqQ0UAiSmphyoAJLAzxCCSTmE2gTBwlEChFkDTD6bQcQ+MUiXIsKfAsy1A0RdAUwbMcSzM0SdEkQ5MMRbAERuMoBatRHCIJiIE1NAywKCxAGk6ZTCSrIKUSUSajqiRcmYwqVZACBBfAgAZm1CCVrEKSkyGlCoJADIZwCMRwijcazTGfpzwn7RWOYAgIIRGQQgEcXkDjCp4GKHwBT0ACCfM4wmEIg0AsgvIYKRK0gYS1OMgTGo7R6ERUL6I6FuRxpREHZAoUCJVIqwRKKeALrAxgI9UcAxgExCxgJhqSMbWBAIw0JLOwQKhEUq2nQbOA2QTcxmNOLek1sC4z7jBiDgPuNTIBqxBx8FE7HbaiYScTczAJO5vhYDJsdMKKRy1o2IKkupionY7a6VQXF7NzQRPpl4mQmQ6b0DQbke+hF/qY2gDTEmL6UvnxLP3SLHF5nrQkVztaqF1WZRqvtQxX6weqpbWVnk295bvfW3tzz4FnNx4+vf945u6DqXv3H965OXnj5uy9hy8f//KX+b8e23+8aXFja2NDf3fX6ODAsiWjS0dHxoYHRgf7hvt7Bnu7VowMjg31LRnsWzo8un7Num2ffnlg77GL565fO3/t2vlrty7fun3l9rXz1y6dvnT7yu3ZydmZ2f/yy+Pfnlw7Mbn7remdA8+Ojj+/uP7prU3zJ5be+bnr5GeLflhX8PFwYlV9Sm+JpTlH7spjujP4pfnWsUz9YhewrCZ25cBPLyZnv/lyx7qxse8/3TZxe+bvf/9P//z7bzcv/9bfe66+Z3Jh29ms2p3Riq99hdvsGRsNwRWiu1Ow1XDmxQZHu90/aPH2aG21rKWEMuVQ5nTKnE4Z0yh9AuNjCBVCiDBGRng6lcCDCOxGUQeKO1HMjZEBkomSTJSgYzSfyRvKdK5mOTzmLNwYqdueKPssJWOzO/GxLbI6+P9w9V7hjZ3XmqZmfOwqkgB2/MP+d0TOAEESmQBIggQBgjnnnHPOZAVVWVUKLkmWbGXJypItWZKVc7aVrGxFBzmH9jnd4z7dMxczZy5ou8/Tz/Nd/Hf76l3ft/61194VWz19Z1Zmd/dXJ9enBlcn+hfGeo7IH+1tGO6tH+6tH+2pG+lp7GptrI7Uh6yRg+nEV29M/cevT/3mze27LmRWBkzdGdycJA0RoSEEu5Jqa1pqSqCWBO5NG/vTlv6UcajCMpX1TDRps02WxUb7crNrpytwzXD8vu7YI1nffRXuPZt53OMeiDo7YnJrTMuE5GQQVwT4mlI541erPKA+jDsz1nzKXuaQXEjUaE42MAJFc4VFfJFOZDkVIqQ3IL0B6g1AR7E6A1NEUYUGqtAACgB/nBUMPNIbsIFSWCjTyAQUmQcSyxgh61EFlypoGIgIiqJoVoiEOBFyRlE0y7KMBAliVZA1SVaIKCFRhETgCaAhZwA8BWk9z1KYoTFtEChKpClZr5O+cRzp9ZRex+gLOV0BX3icO15g+HqB7usFx/UGrrCIPnZcX3DcoNexjAHQBk5fRAOimDRzPODvqqm8SIIY0ixmWYGnIVsggAKZHBPQ/3m05yNDWoGcDDiZBwrAGiJGVq9xegVRCqEUiVZFShX0GtTZgMFOGKNgMEm0UdRrsPAIfoVQZsLYBMYKKSukbAJjFmgV6lXumMYftwp6l8J6Vd6jcH4jLLUSn4P12fliOy5zSCGXFHGTuAeVe+ER/Ek3qfQI/4Q/4mCSfhJxwrADlHtJ0qfE3WLEIUQcQsIBqn1CQ6nUFhR7QngkgmeS4mKVvF5l3MyYVmqUxVpppcm40KJONeKxenjYYj/ZUXrJYP0texuv3fuDX7zx3i8//OSLDz7++YcffPrTdz977+Off/jFX7768zuvv7M0s9Df2TszMbmysLi5urK5urS5urS5trixOre6NL2xOL27tnCwsbq9urq+uLy9tnPJ6fPXXvndJx547LVnXnn3tXfeeeWtV59++dlHnn716Zc/eefjX/78b7/9+NMvnrn9g3s3v3xo5TcvHn712je/eO2yDx6YevV7Qw9faL1xL3t6IrrY7BrLWEaqLTM5PJuW1muc8wlzf4lw+XLfx6+/9Mev/vTs069dc+7S2y5c++KTr/z6Fz//01e/eO6Jz+bnXx6a/6h94oVM3/3xtptD+RsC6QuO8K7qm8DGOqA1mDxD3siivWRadfZKjmbJlpPdGdlRjc2VUE1CqRxK5VCMA6FcFSsQDHFsgOeLASwBsAzgKBJSolKJxSSWKlVLvdnXbwrN2Sr23Lnz0abzruRZd/R0MLlRX788Pby9Nr24MdO3PNW9ONE5N9IxOdgy1tc43Fs/2F3X35ntb68c6Kgb6mivDucSzuCFvey/frr2Pz8/fOH+uVPz4a5qKRsWa4NqXUhpDJHOhNJapXSk1a601ps29lcZh9PWyVrXfJ1vrs06VW+cypunmu2rnf4LI6n7+iseqC3+XqVzy6VNBN2DFbaGEKwtxZmwVh7ElcV8bYlc41OqPKAhRtoylpq4yWvFViioNKdQrEpzqEgPdXrMsgLgCc0QmsEUjQwMb6B5A8vqGUZHE52Ai4DMAGygsEEvMiyhOJWXVEGUeWCEvFvBbo1YRKgIUJNETQQS4lSCLIpillUJEhnKFtmiEuWIfBFKmBM4A2D1PE9BwAqMAVAGyFCEpiVdkVBwHB4vFGidni6iDEWsrogrLOQLC9nCAkNhoa6wwFB4XF9wTFdwTKc7ptcdMxiOUYZjFIclo2qqKisdzGUuIoAReEaEnIR4AigBFAjwa5C/iHB6wullSKuYVTGrIEbFrEkEJs5g5A0qpI5yu4R1KtKZsMEMDTaJMwu0TWKtImNGRS6BciC9JjBGSJsAZeIMVsjYBE6FFGYKLPwxC3/MgYs8CuPTOK/K+jQuYIZeO+N3gBInDjrFoFMMu4S4ByX8IF4slXtJuRMnHOAo9pe7+HIPiLlhyM6XWdmwA8TdYsxFIg4hZEMVbpgtEZsjWltE7A7jwRieSJGZKnElbVzPmlezpsVaZS4nTVSjkSpuPIt3Go17TY7tev/Jrpqbdleev/3Wn738yu9+9tkvP/r0i/c++uK9j7744JO//PoPX3785eVnL+9t650YGV2cndtYWd5YWdxcW9zZXNrZXNhcm91fmz/YXD7cXNtdXV5bWFhbWNnd2Du1f/r6K6998K77X3ryudefe/nlp55/9kdPvvL0Cx+//f5vf/5vv3rr9U8f+dZH9yz+/InN3/3km1/95NwXL5x8996J527ovets/eXLFRs9gfGseahKG89YZuvQTFpZSDnmE+7ZmtLvnT/45J2f/uqXf33zzZ/de9Mtd139nR/d8/DPP/34D7/47JEfvDc+8cLA/Ietky+ke++NttxYlruupOqCM7Rr9IxDrZqRa2R3rzO6YCqZFJ29kr1dtjWojpxkzUC1gicxnsSgVA7EOIsjCkkgeNTzlyAcQjgMcRKTSmysQnIKSklRyxhdHdbScXts1VWx66laMZWtekJrmeziWN/s5tTi5vTUwljX4kT73GjL1HDz+EDDSF/DUE++v7Ouuz070FHV25zpb2mqKI7XlpbceU33f//q9Fev73z7sG240VUbkqpLjekSUzZkaojILTHSVC51pk39WftQrXU0a51vdG10+Le7SzZ67AuN2lSjdbTJPtLgONEdvr0//UB9+TVJ64pfHS139qaNNaX6tB9mw+ZEKa4JwGypUu2Vq32oISE1pLVYGbEbOcJDoKOwntF4rPFY4ZDAAdZAiQx7BD+mWMRwiAGA5nmKUwyirEcajyWaFigDYVhMsTIvaKKqYGJEwCELHlWwSshEkEkmBNEE0QpBJkVWiUKAKCHFJNkkJGIOYU4QoUSABGgEaCRwssBjzsCzeo6jEUcLukJQeBzoChF7/BhVUKQrpIoK2aIizqAHtIHjDKyhsEh/XKc7VqT7uq7oX4r0X9OxxxmkxzoemTRzPh6faqi/SACFIjKIkBUhJyGOQD3iv4bh/yEBSuQNEtCr2KAKehkVqEKBWdY7EWcClAIMmkBpEmMUKaNgMGGDEVNWibNi2imyDsJYYJGDUFZBbybASqAN8VbI2RBvEYCCGEAXeojOhQs9ROdX6YCR9Wq0V6N9RuYfzg/LHCTkIn93fh8f9ZG4RziCP2Hjj+BPeGHMCWJOFHXAiB1E7CjqwFG7ELHhuJOrCQj1YakphFuDoCfKDZbDkSScr1FW6syr9dblOutMWhmMg6FyOJ8zr9are622/WbnTqPvZFfl1cvjj11/7c9efPmztz/8+fsf//KjT798/+OvPv3iyw8/ffieH86Mzo70D89Pz6wvL22sLG6szu1sLuxuz29tzOyvze6tzu2uLeytLe+ur+9tbO1t7Oxu7O2vbJ07uPiGC9d+/7a7H7v/oacefPSVJ59///W3v3zvy0+e+eHPvn/q8wdXfvHC/m/euuyXr5z++NGlN24bfviKlms3qk6Mh+c7PCO1ppEaZSZnmskLk1XKZNyxUhs/NdTxw1u++/Yb733w2X95+63PHr//wQduuOX+m+/85J23juCfmHm1f+6D1skXqvvuizTfEMpdV1Z9lT96aPNPK448rdQgR6cxOCv5p7Cjn9g6BWOToKaJVo3kFE/KeRJDcgJK5RwJSziKYAjBICEhIkYFIY6ECkGsptUkp1UgrVI01mjWBptvwBWa9cZWLMFhS2A6nFjq65xdnxjemxrcnhpamOidG2+ZHmkcH8gP99YN9eQHu+t6O+t6OuqGu2u6G6s6c5XlXld3TejRu4b/8LPDZ743vTwYyceFdJBUB7VUsVgbVBsicr4MZEpQa0IbyjqmmtzL7Z7dgcCZidD5mci5Cf9mu2WxzTbS6uzMmhcaA1e3Vd5am7g4Ks2HlP6kqaVKqAnpawI4GzJVlODaUpwtkdMeKVMsNKWUXEoKeFlVNhh4VmfQcxStAcEEiQYEiYMcRROaESgaGShMsZjlBQ4hFkIGqHpB1iMLIArLigwlcgxiOAkSWdQUIpoFbJewS0Y2EZgJUAnE2CAIjEiALBGJyAQpAlQJMslQxgxGNJKALAEZMwKiiMgpAs0gAwMoBjEAMogzALqQ1xWwoPA4c7ygqEB3vMBQUMDodTxnAAKFmKIiqqDIcLyQOa5njlHM1yn+OE8MpJAFdpOtvapqrqHhIgz+RcI6zOkhYxAhJ0KaoOOaXKgiXgKUBPQK1in4uIT+RSX/YtGO+SRsAbTM6zWBMqu8RWFNhLIgg0IYq8TZEO3GrBNSVl5nFykT0TtkwaOIXkX0EOwkyEqgilnE60s1tlimfJKhRGNLTJzPyLgVg1sx+J2M1874rHyJDYfdYsxL4h4Q87BlThB1oYRLqHDjCidKOvm4k4u5uJgTpHxShV+OOVHYBiN2FHeKcacYtBqSHj5TgnIlXL6Uag1RXTG6N06NptBMRlnMW5dylomU2BtghkJ4JetaazHvttsPWq0HzfbdJv9BV/V3N5eeuvmm915585cffvK7z3/x5QcffvjmOx+++e6bL75xcvPUYM/A3OTsf4Z/Z2tuc33qcGN+f212d2V2b235YGNtd31zc3l9dX55e2Fta371cG3nwplLb73mhvtuufNH9z747MNPfPDSW+88cMvH9+1+9eT2b3989qu3r/jixYOf3jf6wrU9d53MnZuNbA6WzLf7xhss41ltts44kxfGKpWxqHO7OXvlyvxj99z90ivvvvHRn3/y5mfPP/L4o7fdftd3bn731Rf/9IvPn37005WN9/oWPmyffikz8P14y02R/A3RzDVlidPe0gVLoI3RamlrOwlMIO8kZ+9Hlm5ObuRQAkuVR/xDKYmVJFbLoRwjMIxgEOMySYpIcpyQJCaVRKw9RiKssUK0ZRRLRrXU2VxdrsCEq3TWXjLkC87XZjfnRxcOpru2R/NrY+2z452z442Tw3WjfdnBnsxgd7a/u76vK9/bme9vq+rIpzpy8epS53xf5bMPTrz3wsJVm/n+RmNVsCgd4qrCQrmPqw7i+jCpLaZTbrY+LA1lHYudxbtDJRdPBa9Yil67mfjOUuhEn32t2znZ5WvLWUez3tPZ2BWR0q0gmIlpnQmloYLLxZi6MilXZq4oRtkyoTYgVbnFTAlpqlAzSeJx6EWhsABzBSzF87wCsETzIsWJLCA8FCgaGyioN/wTfswhxEJFhxU9sgCscpzE0jLgMMtLSBQFRSWKWRRsInKIwCYCk8ArkBNllogcEQEhWJIUWTIJyAQ4TRM0whHMYBkqMlQQRaBBEBgJLCsS0gAAIABJREFUFBUKlEFkWEyxAg0wg3k9r/+GgegKQFGhoUB/7Lj+2DGqsIBhizik4w3Hjxu+/g3qGwVcIcUXMMzXKeZrNPd1Vscjt83Vla6ezuYuctA6G2MwsazEUIDVs5yexkW0WCTzQIWMBgvN+Btm/A0jOa5KekWirZCyQ8oJKY/AeiXWobBmmVLkIqOgs0iUTaJtxGDBOrtgcGKDHershLEQ2iZxLg05NWQmnIppFdMlqliiin4FOSXeofBuM3ZZsM3MB9yi3yn4HdjvwCVOUuaWgh457JYTbhRz8HEnSHmFCh9JuFHCjSp8JOrSxzxs2A3K7CjiEBNOJWUXkyYYsctJj1JTLOYCIOejG3xUeynfFyEdCdQa41uiXFuUb4+BrjjsrxDHak19OTSWlxfzxs066069e7ez7HA8dXox98NvX/3OE0/98r1PfvPlb9958/3XX33jF59+eut3r5kdmRzqHlqZX93e3NtYWd1ZWdpbnr14Y/5wY/5gfeFgfeHv4X9jdWtlZX1xcWlhd39192BtfW9r+/TZy6+4+rrbbrr5sbu/9/HDV737w2++98SJL39y8e/fu+RXr5z46IHVt26e+/75ugvL4f2JwOpAyXijfSxnmWu0zdUZZ+P2uQrvif7c5atjd1x92Y+ff+mnb3/y2o9/9uKLP3n++WcfeeD+x753+yfP3venj599/MHX5udfbZ99rnX6mbqRhys67ow03hDMXlOcvuBKXuJyjpodo4pjQnRPIdc4b+kGpibB1EALMV5OIq0SK0kgRXkhDEgYSVEWxzghzglxniShVIHlNFFrJGOtpqRVpUKSyyU1KdtqVW+77B8gxaMlgdl0cnKofXRjqn93tm1ttHFhqH1pZHB4oG50qH6oP9/XUdPdWt3Xlh3szA901OXbknXZeGMyMJjxXbqYeeSm2VsvDE71FtfGueoIWxVka0KgOoirAqiqmNSUyvkQao5LvRnzbLv7xHToOzuJO06W33Mqcutm9rLR0F6nZ6HdPVhv6c1apnPejUzJYMzVE7F2RI2tCa0uLqVCKB7CiajUFLRl/WK1i8sWw5aEpSHpLHFImCmAxwp5g4HnWRFhE4fNFCZ6ntUzPAUADRGNEAMIAwnDE4YnFIcZgVBINCCVRiorSBAjBDjMy8BCWFXmJJOgWEViEaGZMHaZUwROxkAjxKKYLIrJKKqqIGpEkpAoIRkBwtGIYzGCCoQKy0qFgNEBXk8Dgw7RegxpiWcwQ/E0TfQFSP8NzB0TQYFMFSB9IWegeMNxXv8NSB/DUAeQ3gAKiuDXAf6aCfPWMme4K5sfbWy4SDMUGqkijaVkjiGAQYhCggERSgaszOs1rlDjv2EEx1RUKGFKxJwZGizAYIeUC9EugXFItEWhNYUyCgaLxNgk1ibQFmSwC7QT0w5EWTFlhnoLMtgkziZxRsxoiDZixi0hr4I8MnSInFPiXBp0G4FD49wmrtiOQ14l6lVDLqnMJpTZhJBDTLpJwiUkXMLRodyJEy4h5RHjHirmYUMuvtQGw3aScEmVLqnKhis8xkyxqb5UbiwTWsr4ziDfHxVHytX+CrE3KXSXo95y3B2DnUG2M8h2h/nOKrqvghtPgbkUWUprSznrQotnvtN/8Vj3HedOvfLwDz995/333nr/p2+8+8ff/OHlZ5/fW9oZ7hyaHJleXd5YX17ZWV8+WJs5WBk7WJ87WJ873Fg8gn9/fWV7bXlrZWVz4+Dk1u7h+urO2tr2zuHuwZkrzpy9/cL5t+868/b3T3785Mlfvn7mt2+c+ezpnTdun3nuwsDtp3NnJotXuxzzHe6JvG2i1jifM89Vy1NR53VLAy/edPmTt1z13P13fviTtz/66edvv/H5yy++9corrzz1o8eevuf7n738yF8+e+WJB9+YmXmlZerphrHHM30/KG+5LVR/3T/hDwTXXSUrZt+i5JmG9iFWaeakWiRV8XISKCmoJpGc4MUIL4R5IQzFyD/ILwdiCsmVglItahnJWGs2ZkymjMWStTob7Z5Oa/GgrXTKFpxPJ+ba87PTA2NrE90bk01LYw0zQ22T/b3DA3XDA3WD3dne9ure9sxAR7avLdPZmE5nArl0sD7mG8z4zi1lbru859RadWtOq4lylUGqspROl4HqUlQVQOmAkC1VsmViY0ztrrHMdnnPLsZuPVX5/UsS958p/d5u+qqZ4Ml+z0q7Y7TePJCxjFfZZ8rt7UFze8TUFjc2xEg2itMRUhkRk2G5tsRY4yfVPpgtxfVxY03E6rViyBaIOgrSNM+zmAdGFlkZonFEhAQYANIDbIACDQgFRJqXaF6ieUKhI0kMknlBghhDBABQkCryksyJRixaRWIWkEngLQInIyQjpAqySTSpWBVYAVIQ0jxiMQEihiJHI5oCLIM4lnAsKaR1Opox6DlDEWR1GNIEMpgz8DSNWYqwOsIXEL5AYIoQpeN0eqrwGH38X7jCr3HUMZYv0kGdnuhExeBUkDPii/bk6ocbchdJjF5mdTKvl3m9BPQyNMgCrQichmgV6FS2wMgVmoDeCFkFQAKRFdN2zDgx40CUHRqsgt4sGowKZcSMVQI2EdgEzopZO+ZcmHcizob1VmSwIINNoC2EMQu0SWAtIm+XeacKXRp0K8Ctcn4jLDahgJH3GZkyO4p6pHKPHHWSkAWGLDBsRUk3qfBKFV6p3Iljdhh3oL8XAi8X93JBByix8iEbSrjEtEeq9Yh5v6WhxNhcpnSESG9YGIyR8YQ2nTKPValjlcp4lTpZbZxKG8dS8micjMSEgSowVMFPJNFciixWqQs1xqla42hGXW0o+eZY092Xn3jjyYc//em7P//ZL/7bX/7917/8863f/t7M4Hx/5+jc9NL87Nz68tTe+vjWUv/+6vTB2szhxvyJzaWDzeX9jaX99ZXdjZXNzc3DzbUT64u7q8sryxsrixtntzZvveTgrTsPfvbwmV+9cP53P77kq5dPffzw2svXjz18tv3qterNXvdMg3WuyTGTtU6ljXNpdTYpnO7MvXffDf/+0WsfPfXga4/84J2XXvnJi2+9+tw7r7307o9ff+v5p154+v5HP37h0V9/+OJD978+PfVq8+RT9SOPprvvizXdEq2/PpL/blnmam/qvC9+yhHeNwVWRfcUNHfzUh2WKhU1ibQUVJO8XM6TGCdEORzihTAgkf+NfKLWiFpG1LKynJbVjMncZHf22F0DVteI0z9THFruqhuf6JlaHR9ZnWhfGKubGWsYH24f6u8aHqgf6sn1ddT0tKX7O2r6O2q6GlNNmXB10lFfUZyPOAcznlPzlWfWKwfbrKkYWx3mq8qYigCdKmYq/FyFH1QX49oSuaZMa0jYujKO2S7vudXo3efTj1yIP3yp//aT0e+uFJ8bd+302GabLGMZy1DC0lei1JXJzXGtOaHmI7g2DLNhsSYoVQZIpU+u9AvVxag2RGqjaqxEtRoBx+o1hic8DwCHeaDSwGRAMo0wh7AeYD0QDFCioEwjheKPJBoAoYBAA4FDBAgECITHAgdUQZQgljheQ9gqShYimDAyQSgBSQKSilUjMcpQAQbIFLJsEcfSAAEiIAnyAmMAjAFwNAKswNAGhmI5A+D0COiJQBFsQEjHG/Qsz2BEEb4Ascc5TsdTerqw8HhRIV1wjC/8BtIXAkZvYHU6oMcCZTeJ7oqyZH99w3A+c5GMWQkxEiiSuEKJK1T4IjNgrYi3yqxZoExAbwG0DUKrIJoERUGKVQIOETgJ58SMHRosUG9EeqOoNxPOJkO7BO2EtwmckwAPgW4BeETGJTEuiTtaAXKInF3mHQpwmKDbjH0WXGzBJRYUsuCIRYhYhJhLjNqFsBWFrShqwzG7ELfiuBWXO3GlT67yKwmXELPDcic+igBJHx/3gKADlNpA2I4SLqHGJ9X5pWafqaVY7SiRuoPCQFQYj8tTSdNcyjKbNs2mTQvVluVa+1rWsZZ1rGRsyzXWmaw8l9VWao3rGdNGrXktZ16oM83lzGd6/Ce6yi6fbXrwmrMfvfz8H3/+m7/99f/527/9x2tP/GR74aC7dXB6Yn5hfnZlcWJrfWx9qWd3ZXR/dfLExsyJrfnDjfn9jYWDzeUT26tb26uHW0tnt5dPbW1srWxsL61eebD50FUnPrz/8FdPn//L6xd+//I3P398982755+40HfPQf7keGKpzTNb71hs8MxmbLOV5pVq62at8+6TW189+6P/6/2fvP/4Ay89eP8rjz7x3MPPPPXwi88//tqzT734wx88dt/N33/6vttfeuyuG697bGr6tfaZZxvHHq/uuT/Zclui+eZk802Ruu8UV11uT5y3Rk9rgU3iHIdaC5aqJLncpMagWs5JUQoHaVTGoDAvRAGJARLjSfI/e76oZSVjTtSymFQKUq1iajXbBiy2IZt9uNg/nYyvTrb2LQ0MrE30rky2zozlx0cah4baBga7h3v/bvs9rVU9rRXdTcnWXKShurSxytVc6WuIOftrXasjwel+V66KjweZmhCoKuVTxUzSyyQ8dMrNVnpB2o9qg/bmlLc755lod56cDdz+zcQT1yafvTZ099mym3e8V807zo24djucs1nrYMzUUaLkYnJDUm1MKfm4kAvBbJlQ48dVbqGyRK4oRpUlIBMm6bAc9ElGBbCcQdLTiGH+Cb+mA4KOY/UM0UNBByQKG1nBxBGNgaqB1yigUDyhOEjzPAsAQAQIMi+orKiJSEKcDDgNQ5sk22XFShQzEkXOJPFGBRo1wShDGdEY6DGiJJ7BGEgEyxiKiMWQQYiFAo9ljpcYIDICpkVMiwJFBB2ABbROp2MoFlKQL+TY4wxdaNDrCguLvq7XU7pCoC8UGYqwNEdTekrHMXrFprgz0aqRpobxhtqLZMzLmFWwTkWFGiw0Q70FsFYAHEbGcdThA+DAopOoFlHTiGKWeJsI3BLyiLxLYO0CbRNoi8RYJeBQsVPBDhHYCe+WkF8WfBL2y1yxCgIa9CvQLfMuiXPJwCUDlwV6LMhnhSU2HLIJERuO2YVym5D0ynEXCdtgyMyHLaDchpMOknSQqA1VeJV0sbHCqyRcYtItpTxywiUmvHzMzYecMOhAEQdOuFGNH+cDpN0vdxTL3aVCX0gYiYmTCXU6ZZ5NmpdrrMs11qVqy2LavFRlXk5bVtPW1bR1KWtcy5k366ybWct6rbZWq23kzVvN9nO9zv0m626r/8JC+xM3X/nFG2/85Zd/+n///T9+98nvv33JtQMdw2PDU4uLiyurs9ubU+urA3tLQ4ero4cbkyc2Zg42Zg835g+3Fk7urOyf2Lx4f/Wyw43LDnZPbm6d2Vy74/z2K7ec+tnD+7994dyfX/vWr546+dbdS09dM3THifzVi+UrXWULzb7FBs9CnWs2bVuocZ/oSHxrvPGOMycev/7bT9zy3R/eeM0DN3737htuuuO62+684a47rrv7xu/cfMVl111yeOHCqcMrz+0dHFw/NvVy1/wLzRNPZnt/UNF2e0XLrRWtt8TqvhuovNxZdY09eam5bEd2jSClHgrlCJVi6GPEkAGXFvEBPR+gYYjHcUgSkCSgVPGf0n7uH8orpqxqbjba+8zOMYdrIuAbqymf6axbXehpXexvXR5rW5pqnxxvGuxv6O1tHhjoOJrq97VXd7ekOurjLblQa22wtba0o9bVmLQ2Jex9eddou70jh9IxqryUrSwBlcV8yscekV/lA5liXBsQ8kF7W6W3J+sZarCu9Nuv3C556KrUS7dmHrgidNfpwE3rvmun/ed7i1cytr6w3Fam1lXI+aTUkJIak1J9VMgEYI0HZzxiJqxVBnBFgM+ESTqslnokVQIsy6LjRZxezzAU4niVBmYKKwzG3N+zvcIQM5TNUNYYqFC8SgOVA4RhAcMyDMezgHBE5SUzpygCkBAnA1bD0C5LLs3oUFQbkWTeKbJmiVdlJIpAwAzGtChyGgQi4AnkiMATgccCB46uFYwMq9KA0BixAmJESCFUyKHjFE3pGb0B6nhBj7AecIV6WlfA0EWUQacv5KgiiaNkjkUsS7MMBJzmNnrqE1VjzfVTTTUXSTyrIMZE9DZZ51ANTplxCNAKoFNjHBJtQ6wDQhcSnKJok4hZwZoILCJ0StArIp8MfTL0KsirIYcGXCbkNiKXzLuOXtczCiVGwS8zJRpfakR+hfeInEfk3DLvlkCxBfpMvN/Il1hB2I7DdvT3QZ1TiLvFhEeKu0jUhiJWWO4kaa8adwgpj5wuNqaLjZU+tcKrpDxy0i2Ve0DUBcIuFHYJMTdOuEG1D+YDsCsg9ZRK/WFpuFw6+pPnTJV1usK2XGM9svqFCuN8SluuNK9V2zYyjvWMZStn3a6zbeZMaxl1vVbZbbCcbHOeaDadaLMdtLhOdUe+szbw1C3f/vClF/7nH//6H//9/3vh0WfX5td7ugdGx8cWlmc2tmbX1sf3V4YOVocPV0cP1scONyYPN2dObM2f3F7YO9g+vbd2xeHWFYd7l+xsfvvU2pPX73764OHPnzv5h9fO/eGV8589svfyzdP3neu4crVib8S30Fw81+CezTmm07bptHO9JXHZbN8N+yvXnjz41t7Gua3lyw82zx/untzcOLFzcPH+mTNbp3bWtxcWtmYnNxYnx+ZnuienTw2OPtU9+3zr+JO5vgfS7XdWtt5W2XJLNPed4orL3DXXuyoutwW3FfugoGShEGNhwMA5ddBfBHyFvN8ASlgcgSSBpUosVWI5/Y+0n5WMOdlUr5gbFHOD0VZvdnWbvaNW34y/ZKayfKInPzHTNbU20LQ00DQ/3Dw73j463NLTVdfVkevvbhroqOtry/S0VnU3JdvykZZMSWttoKOurKXamI3JTZW2/gZPR1bMJfRVZVTczZS7maSXS/n4Si9fXYzqQ0pzzNQSN7eGTT2VzoGsu6/WMtyobY+5bjyd+tH1TQ9fVf7Dy+P3HkRvni290OFdqzD2BklzSG6okPMJnE/gxiRpiAk1AZj24tpiLRc2VhXj6mKQiyiZsClgF2UMWJqTDQxiGI5jIMspFG+msJEXZSyJvEhoLLFEQ5IRSiLNEwMrM0BCvMAzgKEBw2IWypyo8YqJN0qIlxCvQF7D0C6LbqPq0hS7RFTgFVmzwBKB4zBHQ5qGFMS0CHiJoSFjAICGmOUFmhEoWqAMms5AigycnmFoyDKIpyAsYoRCCnA8T3FID2VGlGgC9SxHGSBgBJ4GBsgXKbxe5hjIcwyEWCSmEltxc2X1WGNuqil9kQ0RuwDtMuMyUR4L4zYChyzYiOQysi6ZdwvAgwUPIW4FO42808xZjMSuEZck+CQcUEiJkQRMYrFZdJk5rw36rNBr5DwaGzDDoBUHrbhU5UMmFDKhgAp8EutX4FFRiNqFUiMXUJkyCx9x4LALhZww5EZhF4p5SblfKveSqAvFnCjpFasCaqVPq/RpVX5jdcCcLjZVeNWkW055lIQXxtww5IRhF4q6QNzJpH1cfSnoLCE9QXEwLo5WyONV8kRam6iyTFTZ5qpMy7X21ZxzJWNbqrasZezbec9ug+9k3n2Qd+3l7dtZ01atulOnnWyyfbPNsddsO9vtP9PlO9NZcqYvccPW2IPXXPLB80/833/+8+8///Km79wwNDTS2zcwNTO5vDa/ujZ3sNq/vzJwVAIO1sdObE4dbs4cbs5s7+6c3N68dG/7ir2dy3bXbrts84179/749P5v3/7m79+45BfPnnjr7pVHrxy8fi93OBWc67LMNrjn6uyT1caxCm2xvvRwpOXStbkr9rYuPXFw6YmDU9srJ3dW9jaX15cXdta3tzZ29xfWVxYW5+bWZqY352dGZ2c6RiZ3+0Yf6Zp5rm3iqYbBhzJd99R03JFuuy2ev640/S1f9fXu5KXW0lXF2iOpWUFJ8mJYj0oKgbsI+HQwwOAgEONYqiRKNflfTf7fbV8xN6iWRtXSqNrzVl+PvXTKVTobjs82101Odfav97UvDzUsDDfPjLSPDbUP9Lb0dNT3teYG2+sGOup6Wqq7GlNdjYmu+lh7rrQtV9yRL8lXk5qE0Fhj62pwNlTxNeHC6mKqys6Wu/iUF1QX40wJqQ8pHSl7b41roMY9mjKP1zjH6jwDOUdXjTrcZN6ZLrvqMHPfpbFHr8z88FT65rHA5fWOzYTaHyb1YdycJM1J3JRA+XJQGwZVAVDhwxVeKVNCqn0wVyY0x0y1QaPfiEWG5fW8kQVHPT/ieIXijXp41POLggI4DBkk8FjgEG+geQMtsgBhFgIGsyxheJklKidrvKbxJhEIMhJViDQMLSJ0aoJDhTaJ1aBP5EyYhQJvEIAOsQZIs5CCHCcyNGYpCBmAKRbpDcRgkFnaZKBIkYHVMxSLKB7TDAAURwws5gREY0EvEJ0o6omgR5DmAUMrHEX0EBepgt4osIRAJBFRky1xX7gtXT1SVz2RT15UarYVGxWvyro1ncukd5k5l1FyqprXAnxG7JfFYkn2y6LfiH123u9mPU6Tx6q6NckvCwGFlGqkxEiKjcRj5Xx24LcBn4n1mdh/+DmOmFDMJkatpFSFxQpfZsIRuxpzGqtcSsyCyoxc2AajHjHqIyGfEPQLiRIl5hfDHhx2oahHSPqlioBSWaJmSq1VfuM/4U95lIRLSnmUlB8fwR9ywoiTjznoKi9dXwra/KA7KAzGxdEKcSwtj1YqIxXGkZR5psq4nHNs1HtWc86jFLBR59qqc59t9J/Mu3dqLZsZbTur7edNJxtMpxvMe83e052BUy3OM+2+k+2Bc2PZq1YH77/y1DvPP/Xffv/bF59+en19c2hscnJ2bnF5aWll8XC1f3+lb2+5f39l6O/wb00dbEzv7Z88vbN72d7eFTvbV+yu3XNh4/0Hdv7Lcxt//OCSr14/9d5Da09/d+R7JxvOLySW+52DLdJM3jqTM49VSuOVxo2u1NnF4dNri5vzC4vT06cPdk/tb57Y3zg83DxxuHv69OndncOL1zYPtjc2dw63ti7e3l7e2BqZXjrVN/pQ9+zzndPPtow+mu//Qa7nntquOyuab47WXl1Se4Ov4lJHybJq7ZK0DNEqOCVWJJQVArcOeSmhhBcjSE4QJU2UalGplYy1R62+qGUlY/4Ifs3Sotrz9tIBT3ShuHy5snphoHN6bbhndzg3318/P9w6Ndw50NvW09nS19U40tUw2p4b7Mx3NVW31cU7G8p7m+Jd9aH2ukB71petwZkqqTFra8vb6lJMTdnxrJ/OOlHKi2qKxWypkg+rLXFzb7VnJOcfyfmXsvbFvHuusXg072lLm5oqpaFm++pY5LaTwUcv5B46nbm+33uu2riT1IbiYj6CWpNCR6XUWoHrImxVCZ0q5hIeHLajajeo8YKmoNSZtOXKjB6RwzoD1AFcoOMNBo5jMA80BpoMSDQAQPOSqAFeoCmeY3iW5qgiHWugMA9YRANICxynsNDESkZe0XhN4o2EE2Uoa4ioCJgE3ibzNoUxkyIVuglrRAxHoF4W9CIyCByHWchxMseJkCMCjzHFQl2RxFBWxDsB1BgecJCBAiWINI8gAyQGQAZjWsQ6Ao5hcAxiHeb1vKGwCB3/Gvg6hY7LMm0xIpNJUqxGk9PiqgqWd2cyA5nkaCZy0VEsL9H4gMqVGkHYKoQsOKByxRZcbMEBMywz8WVGNmLkEma+wgKjThJxCEErDBjZYoUOqEzIDKI2XGrjyux8yAaDVhg0o5CFRKxK3GaMuqwxty3itJRZtYBJLjErQZsx4rSUebmgmw262ZCHi3pB3I8SPlTuhUm/FPcIcRdOecTaEjVfZqoLyFkvyZbCXJlQVyblSqXagFTjkypdpMIppPxawqvEXCTkhGE3F/Fx8RKQKAO9pXx/EA6H0Xi5MJuSFquV5Yy2Uquu5KwbdfbNvGMta12pMa3UmDZqrTt558lm7bDJvNdo3W10bjU7t1odm+32jQ7bqSbl4jbz2U7HmS7f6c7AqZ7Q2cHUpWOZH5xaef8Hd77/xNM3Xnbt9MTy6MTs/Ori/PrM9trW5urK5urM1vrY7sbo/sbYwebk4fr0ma3JS0/tf3P/zDc39m45vf7cTSsfPbb627d2/vr+1V89efq9G5ceO9V7/Vrj5li0r8na1+7YahBHwkxfiXJ2qP/x79762C33fuvg7NLY1PRQ78xw39xo3/rc+M7yzMb82M7y1CWHGxfvHpzZ3j2/u/Wt/eXL9xdOb61tLZ5anP5Wz8IrXXMvtU8+W9vzQFXXvdV994Tbbi5tvsmbu9lRea2l7LRsHxfNWdEYRyTKcLEiQ6DIEDAwZSwfgzhJpLQoV4tyNbA0QXMDMderlnqLrclqb7ba2s22NlA8oRaPl4bGGionxponl/qHl0Z75sdbJgfbxvqah7rqBjqyA52Zf6i6r72uty3d3hhprHU31lhas9b2WmtrjbUzobSl1ZZ6U6oClpUZYqVCwiXVuiwtfr7JRXpKvFMV0aVseKW+ZK2xbLU+uJ6zLzUHptpLexvMLWm2tRq019lb68vWp4pv20k+sVz+1Eji3t6yM83aSA2oCTKxhFKV0tIhPhdks16qyq6r9Qhpj5RzKjUO2BpTurO2ihhRTEV6ZDgOoV6vN+hZliKAUQXOSIBEIBIhx9FFHGZ4BULMEZpRihihkKILDQzDQR6IkCMsTVhaRoIsapJoRFARsVHBJg0aTUh2EOIkwC7QJtUlc4pSCK0F2GWQrAyReYQAFAAvIigjJHG8QNGCnlJpzsIjgWagnuX1AFESoARWz7CGIo4rAjpG5EXEYlrPM4xgYEihQdDRIkXpGb2OGFgLJ9o5xcTKVtHitQcykUhjKtaTiQzmQheVmmGZBZWaYakZBq044hDDdhK04mKbVGwjJTYSsglhK4pbUdKOUg4c88oxl3jEf9AMQhYYswvlTjHsQhE3iblI1EkiNhKxSTH7WMXTAAAgAElEQVS7Vu4whhxiyCEG7aTMJpRa8dHQPuyUIsVi1EciXiHqI3GfWO6XEj4x4RNjXjnqkWIukvTK1QEtW2rKlZiyATVTImRKSG2pmAlINcVy2idXuKSUU6wqsSa8SsgGAyaqzKKPu9maoJgvVwfDZDgqjcflqaSyUKUt15hWay3rWfNqrWUta13LWlcz5pUa02q1aaPWul3nOGiw7tfbdvLO7Zx7O+/bqffuNnl2m10nGs2nWm2nO9ynOnz7Hb79zpKDnvCJgdjZofobt2buvfzcjecuPbm1Pze3MDU/Pbsyu7m+tbmxtr2xvLMxu78xcWJz4uzu9LmDucPNuYv3ti/ZO7j6YPuhK3fef+Dg96+d/tcPv/nls6feuWvl2SuGbl6tPTFcttDtHW4yjzRa5irgaFQ8O9z86t13/vadjz9748MXH3vugTvv+/b5c5cc7K/PTs8OD84OD04N9kwN9ixNjixNzqzNzO4vzZzbnvvWqZXLTu4ebJxZnjnXO/9i9/QLnZPP1fU/WN17d7r37nDrraWNt/rzt7irr7MGL1YcE6K5TtQSiEQZLqqnS/V0KcUGWT6GhJQoV8tqRlYznJoDSg6rOcmY18yNZlub3dnj8PSLnmF36Wh1aqq/cXquZ2J5cHBuqG1isH5ioHW0t+EI/v6OmiPy+zvS3a2Z7pbKtoZwU9bdXGtry9k6srbWGnNXytqYMNanLVUJNRkWa8q0+mJLT6h4NOUcirvnMqFTfdVXz9feuJG5bi31renw6UHfUptnpNHXnXO0pFBHFRpscgy3le51+64e9Nw15HtsqvKhpdylQyWDNXKlH8XDJJvSslGcLeNqPPpqF1MbkCo9Qs6t5YvltqS5pcoc8nMiOa5ndYUsYBgGcBjxsgCNIjAKvIhZHrEUZBmAeFaEEAOVA1YWygzHGwyUgQM0L3CczPEKD2QkylglghEDSRI0VTAbkWbGio0QhwgchJFETeRF1YAtOsGiE2Qd5PU8QwNA85hDIhAUQBROUBisMVhjsMRBgUJAj6FB5A2E1XOsgeJYA2dgBZ4ADtN6nqYQpcc6HdbrBYpiGB2N9ZyRFcws0Thik01+pzcTizVXlvdm4iO1kYtCLqnMQUpsuMxBjnZpgk4x5JJ8NrHYRkrtYtBOok4Sd5FyJy534nKPHHdLUSeJ2oWYg5Q7xXKnmHBJMTeOu8Vyj1TukuJOsdwhJ11qhcccdHKldqbMwYZcfMQD/6mYX476pKhHjHrEco9U7pGOvr0ddssRlxxxyTGXGHdLCY+U8imVPrXCL1b4xZRPSvmkpFdO/ONBMa8ccYtRB445+AoXyPqFpqDSHtHGotpE3DSVNC1UWpZrrGsZ60bWvllnX6s1HWk9Yzqa6u3krHt5+16Dc7fetVPn2836d7OBg1zgZEPJmabiUw3W0y2Oi9vcJ9tc+62O7RbHVqtjs8250Vy60xG/dLbjxhMr3z6xubM4PTs1Or8wtbW2vL2+sruxure+uL82e2p75vzh/IWLF04fHpzZ371wavuuy9ZfuW3718+c/stPvvm71y9+7/tbT1w1fPth/enJspk203ijOlojDifAkB9vNsSfufnaf//1b//HX/72u1/+6ddf/v7Ln/3qk59++M6rbzzx4I/uuunWG6665vKLzxxubG4vLW+vru4uL+0sTp9Ym7r0cPnKsyfOnzh3sH5+aP6Z7vEnuyafaRp9uHbg3nTfXZGW74Ua7yxtvs1Xe6MjfE5zzkrmhiP4WT5GcSGKC1FchIVxJFaKao1srFWMdYjUEDkraQ2quVWztFsc3U7PkKt41OcfqIiPdTVMz/ZOrQwNzQ92TA40jvTlR3sbhrvzR+T3d9T0d6T7O9J97VWdjenOplR7fbA152nLOrrqHJ05e3uNpbvS3xBz1sUdmbApU6a0hk3jFa7d5tipoeqzY7XXbbY8fEXfS7f0v3l376u3Nj1+oersvGeiSWuvsDbHbfVB2FMJNvpcJ6bLruuJfafTcde47/Hd7I/OdF5YrhzO2WsDllQA5svVfISkfVSVy1Dt52uDcspHajy4MWLsqHZlYprLRCHuOEszDI0RwATLMjFqxCIhBTMYUAxP6TALOQ5QgAMAGAFyQmwEAPEUYAXIIMJAlcdGKGlQUbBJFuwEiCrRzJLFQswWQbUR4pSgnbBIgAQClccmjmg0EfSI0yOaxpBCkEKIxhIrqpys8YrKSjJNFF4SGYIocgQ/p0ecgedZwDAcAIhjEa3nWR1kihBTANlCAXIEsYLEEhOQzEi0CqLHYgoWezPJeHM60Z+Jj2ZiF5UXa2G3WObAIRcJucjRIeZTAlahxIaPyC/3SAkPSXhwwo0SHqncLZY7ScIlVrrlKo9S6ZYrXVLCjVIescIrpX1y2idXe+WM35gNmFM+EnfBmBMkvUJVQK4KyJXFUmWxVBkwpfxa0qdW+LRKv7HKb6z0aRVetTJgqQxYKorNSZ8ad0txF0l4pAq/miqWk34p4ZWPKsU/FXeLSa9YVSzlS5SWoNoZUntDSn9InSy3TCUscynLYpV9pcaxXuvYyNo3c46tvG0za9nMWrZy1r28/aDBeaLBdaLBtd9i32ty7DW4D+q8J3L+i/PFlzQWX94SON9oO99kP9dqu6TVdqbFdNis7jbKO43iyU7fqQ7f+YHItbPZa1Y6zs13Hcz27y9OnNiYO1xbOFhdPlhZObG+emp75ezB8rlTS3s7hye3Vq87M//0DSufPbLzr6+f++uPz332xO7rN6/cebr90uXE+rB7ol0by4sjcX60jF2qiNxzev8P7777tz//22efffXeB7/4/PPff/HZ7//rH//2t7/8j7/+7r/++ovffP7hF+/+5N2Xnn7p6R89/aMHHnjw7jvvuOHaG646d9O3L739+mtu/+6NN164fn7tmZ7Rh7vGnmgbfzw7eF+6745E+53lLfeH2u4oyd/qiX/L7FmSLa2SMYWlKI9iBj5i4CMUiHI4iaQqotYe3fCpUq3Z1Gi1d1lcvRZXv9U94PaN+EvHcomR7rrxqa7x5cH+hYHmiZ7caF9+eKBxqKtusDP3v5Hf21bR0VDV2ZBsrw+21Xnb6+zdeUdXztZeY+muKmtL+FvK3a3l1v60ZaPdee1C9KGL6x7+9sjzt06//8jq508vffzY8E/vb33ppuofni/bmbD11pD6kLEpaGsO4tVW9aa9yIOXVjw5n31qK/HmdxreumvwmdsGbj5bu9jqbgtY036YKxNqS1Clh0m52epiVF1CEl5Y42XaK6xdtb5UmWYWacLSIiMQWgQcJFg0SppR0mQkYpbnDQag06MiQBs4Hc2wNCMznJnjFY4BPKWIFhHKEks0IJqQbESaKlg1yS0CZBRVi2yximYr0WySbJewVWSxyBIRKAI0YlGDisSrCGgQmgirQoPIFiJYJBBKVjijzGqEkmVOEhmCaRFREqQlQImAEniG0CzDcoBleZYGvB5AHcI6IuolERhFoCpINRPVQkS7LPodpmiJK5OKNqcT/TWJ0ZrERZmguSqgHu3GpHxSuVtIesV0iZZyipVuudqvZAJKtlTJlSq5UilbQnJ/Pyv1pWpj0NgcNDWWag0lamNQbQ4bW8Om1rCpLWxqCxvbI6auiLk95m4ss+YDpqagrS3qaou6WiPOtqirNfH/k/WewXGWab8nu6fedwBb6vTkfjoHqVuppZa61TnnbnXOOUe1crIsy7YcJWdsYxswYMAYG4zBxjiBwYQBk0zGgEkzDExg5szZc85W7W7V7gfN8M55t+r34ap6Pv/u/1VX3ff1CH0KgVfe7lMIggphSNkRUgiDckFA1RVUd/vVXR5Fu1PKdUhYrkGOS8FzSDj2Abatn2XpY1j6aFYx3dbPsPUzhmTcoUGWV8oMShlxKSMnZ5bV7IaWV1FyampOQ8sbNfDHTfxJC3/ayp+xta1ztq+z81fTftEl3Ozp2uLuWhrqXPCzVl/1LLraNzoESy7BTm/nnkD3fg9/v4e/39e2J8DfFeBt93M2e2iLLmyjl7c9LNgd69oVF+3JKA/Uhw5NZg/O1vauby7PNrdOjCxNTS3NzCzNz25cP7F+XXPT7PzKfPOpvY0Pnp78443Fv9/c/t21DW8+Vr2wnDs4YZ7NiSphVt6Np3RwdhCZMnc+um7x21fe+L/++Levb3/3+lsfvv7Wx2/d/Pydtz9/542PP37vq0/e//qT97/89vaPf/r9X//683/7+5//x0/f//jjt99+c/uzTz5499Zbb3742zc/fOONWzde3bjxWip3Jpy66M9fsSSfMsSf0IdPmULnZKHHB4ZO9Kjv43dPM/kRGluP0RUgIlsLDK4FBlshBRnTQHQTyrKiLCvKtHOYDj7P29YR53WluJ3J9u6UuD+jVBQzrnw5mB1JJpspbylqToUMiZA5GXUlgqZ4wBjzG+IBfSJoSAT1Mb826tOEXbrwkCrslARsHSFbW9TRHrbxgyZORNcbM/SmzJ3D/u6VYdmzeyy3Tge/uxR9/3zh9ku13789eudG9benguf2GR6aFy+XOWU/PaDEfFJuUtc57us4vl755iOudx+xvLbO8smD3r+8Xf/9B+O3rpevn4ocHJPVVEyHGDV3A4Yu0NSLmnpRfTekEpBUApJfBmScHXFHr7yXycLIVDKFRsZwAkppJSMUmIZiDBTFIQgjkRECESEQ0Xso5BYKgUimkACslUxvJWFEEggQmRgXB2l0CsqBqVyYzgToOMCiwTw6CHEwGp/G5uGsVfl5OMzBKAwmQqchNBSiIxgTZTKpbBzlIhCLRmYiLVTK3RD5Xhgm4CiJDhNwYC2KEhCMiKBkFCVjCAVDyDhMogFEOoFEJJFIABmEyQhGRKkEKoNEZ5NYKImOkWlUiIbDVDqCcKhIJ4c+0MkzKaUenTJm0mZNurviGkFU1RaSc4Myjk/C9A4w/FJWSM6NSPlxeVtKJcxoOzJaQUbbltHxsnp+Rt+e0bdnDYK8QVgwdpSMHUWDsKAXVKw9DXtvw97TsPfULB1Vc3vN1F4ztdft0oJBlNV2lUx9VetA2Swum8VV60DJKipaeoqWnrJFVLH21q19NUtv1SyqmHoqpp6iqbtg7MibOrJmQc4izFs7MnphWidIaduTGl5CzU5qOEktO6Xj5IzCrJ6f1XByKmZJw2zoGGMm9qSVV9MwGjpW08AaN3MmrbwZG2/OyZtz8hZcbeud/AUHf9HVvsXTsc3Xtc3TudXdscHHWfTzF32CjZ7ODUPCTW7h1kDncqh7f1C8N9C3O9i3OyzeFR7YHhZv8vcsuDtmXV2bwwPLaeVKRrVSMOwf9h+ZKR1bP7Z/YXrP3OTO6fHts1M759dtX5jfsjCzcW7s8OaZkyujr5+Y/OHawi83t/342tK7p4cv7I08us6/s6YejwvyTiymooTFlJqx58ho4dbF1/7nd3/5+49/u/XeZ++++9l7791+/cYHr11/7+qLb75y7eb1q2/fePndD979/LOPv/n41u0P3//881tffPnpV19/eefrL7/9+vNvvvv86z9+9eXfv7v9wKFXy6VTwdgLvuwrlvhzxtgTltiT1tBZefgxqedxse6osG+B055mcMxUhhLGZC2gvAWUE2AlGdNBdBPKtK/C5bi4bQG2MMrqSPC6Er39SaM267OVqqFYIxZrpILVpCsbNccD+qhPH/GZoz796h2+mF8XD+jiAV3Upwl7FVG3ITakDjnFfqswaOVF7LyojRe28FKmnoK9p+HrWhlVvHDE98WV3M9v5b9/NfD5peTHFyMfvBC5cSpweq/1wKxqfb6r5qFFtFhoEM/r2qeDfQen5dePuz89E3z7kP7qvOqDx5w/vl/6/pPmnfeGf3p37OaJ2H15sU9ON/YARhFiGWCZxAyNANBwCU4RNuFnT8R6k06RpItOR0GEDCAEAF1LIa4hAcTVVRdkHCRQKUQqhYSTKfRWEkIgUygUBABpRJjeAlKJCARiCAXFAIQJwVwE4yIYA8AQEgoSUCYEcDGUh9E5GINLpfNwGhdHmSiFx6ax6VQaimAQjMNUOsrAYTpMRjEiFWlFobUw1IoiZBwmUUmtcMu9FKiFjBIpKIWCUigoCGEgjpDpAJEBkshAKxGlwAyISqNQaSQqE2CyARZOxqgAFYUxDEGpGMKhU0V8rryny66Q+LTKiEkXN+vumhjqn3QPjLvETVtPzdRRN3c2LF0NS9ekqXfWNrB+SDrvlsy5+qZdvbPu3nVe8bSvb8YvngsOzAcG5gMD877+VTYEZRvDsk0R+VJkcHN4YFOwb1NQtCkoWozI5nziWW/fhvDgpphiISRdH5QsRmRzQfFsoG/G3zvn613n75v39a3z9s55RPNDvXPOrmlHx5Szc8bbNePvmfJ1jnuE447uMXvXqE04amsfsfFGbNwRG3vExh61CEYtghEzf9zCHbeyJ2yMKTtj2sFsGpijRtaEhT1t56xzcde7eYse/kYvb8nbueTt3OLr2u7v3hkUrQR7V9ka7N0ekmwNybcEVJv8ik1+2VJYvj2h3JYwb4maN0XMizHrYtw1H3VPB50jXsuIzz4ZHZrNBeZK4XWV2EI9u3G4vKlZm29OrR+dXBwbW5ocWZ4b37th+uCmdfdvWXh6eeSVYxNfPDvz841NP7+945MX5y8fy57Z7tpTN21Ii8dDbUUjHBcTi8r2PY3866ef+sOXP//lu7/+8MXvPn3/sy8+vP3Z+7fffvX91y69eenCjVeu3Xzzxq33bn766Ud3Pnz/8zduvHP92hvXLrx27eKN6y+99cZrt3772ifvvvrB7bdv/uGTm+dPvz02fCoUvejPvGWOXzRGT1miT1gDJ+WRRwe9TwwYHuzq38wT5lg8O42lRnAZEVMTUBUBVRFRLUAzIiw7levCeUMcvp8jjLC7Uzxxrlua0eoyQWe24M9X4r5y3J2PObIxezJsiQeMYbc+6NCFPdqwRx3xav5Dfr8q5JFHPbqYWxWy93nNfL+ZE3XwE872uKOt7Owd9Ys3ZAdObh9659nSnVeHv7pRfOe8/7Pnsm+c8Dx/n+HhLbptI4rRZF/KzfUYgYiCVtRz54Oi/c3+J5flN0443n5g6NIGzeUN+htHLTcvBj94JfvlG7W/fzTz/bXGkxu0IQPH1I+s7udWCalaPujrpU965IdH+rcWJXFrWw8fRCESmUgCWlsRYiu5hQK0EiFSCwKsoQJrqUArjUKmU2AumYgRWynkVhSE2GScRaBhBBpIYUJkCg0A2QjEgyEeDLFghAagCAXlIAAHhdkIyoIwDkbj4TQWjtAQMpdK5+EMJoZTYQQFIRxC6CBCJYNUAkoloBjxHwkPklESESK0AnArASMTMZCEUFpgChEFEISMUwh0OhmgEihMAOEg9NW5AEamoSScDkI4BKEIBCEghiF8Nmuwu8ckkfkV0pBOHTbpAmbDXdsi6p1x3faoZpNftuAeWPRKN/oGN3gkW1yDO32q3WHNcli5NSDZ4hdvDUt2xmVL8cGtSfmOpGJHUrEjLt8ek22PyXYmFFsjsh1x+UpSsTut2JuW7U1L92WlB7KDy+n+rbGebXHRnvzgvqJ8V1aynO7fkx9czitXsoqdadnOtGw5JVtOyXbGpTtikr2xwZVQ/7ZAz7aQaEe8b0dSvCUm2hjqXOfqXOfqnHMJZ51tsy7OjJM17WBOO+hzDuGsvX3GxpuysafsjGkXY8ZNn/Myx82MCQtz2sGaG+IseLkbA21LAf6WYNtyRLwrIt4d7d8TG9gXk+yPSw/EpAdi0l0R/e6YZVfcuRxzbok4NkesS0n71qxjfTo8mwxNxkMT8fhYMj2SyFXC2ZwvWQik85FMJp5NpTKZbL5QKBUzhWI8n4mPVHKj49XG+pHqtsnKwYWRx7bPn9239fWj0188vfDz1Y1/en3pmxtL108OP7bNeWxavpCUjHp5o252Q4+VpNSNAcuLR4/++evv//zT//z+qz/e+fS7bz/95qtbX3z+zqcfvPbBjYs3Xr/xwbs3P/3wgy8/uvXVh7e+ePutWzde/e1rN976+Oadd9/6/N13bn9464f33/nu5vVbH1x/5cs3r77y4rtzY6ej0cuBzLuW+DVj9JQ5csLkeVgWfkTmOyk1He+RbGvrLHHaXHS2BsFlZIaeSNO2oJpWTEumm2GOg9rmpgn8bEGQ25MUSEvdmrrCWHfZi2lvZjiUKqed2Zg1HjRFguZIwBoLWCNDxqBDE3KrQm5V2KOO+jTxgC4e1ER8ypBHHnfrokPKgFXkNXL9JnbUwU8NCTNDwoa7dy4u3d3UvHg0+cmLE59dG/vo6sgbz+bfeDBxdrvx0ET/xqKoEuyKOto9NobVTMnrePMB8eGm6vHN8rMHpVce0F3bZX9u0vrKdt/L9ztfOeW7+ULh4yuV373W+PT57JGp3qit3SrD9WJc2gb30gk6Hlwx9B4bSZxZ1O6pSaJ6poBJACitBEILkbAGBYgQAQIJJJC4FiH9BqPcg1PWrsrPp7QghLtJrfcgZIALMLgkLtbKJrWyqBCFjcE8DOJARDZA4qIwD6excSYXpXAQiAnBDABhoziHRmPhCBUisgAaD2PzcBYDpVJBkAGDbATmIBB99aU/CUVICESCATIMUBAQwlASAQcJGNQCU+4GyWsQgIJQMAqB1gYgTCKFC2J8lEmjUCECDJEQUiuMU1pRgEgBWglAKwgDHBZb3jNgk+tiakXEoA6aDR6z8a6VqmxnWbojL9ma6d+S7N+aku7MqvbktTtzsu0Z6fbMwHJ+cKU4uFyQrhQH91RkK6W+5WLvSqlvb7n/QE16qC47WBu8ryo9VB44Wpcda8gP1aQHq5L7G7IjI4r7m/KDJeGhaufhhujIiOzosPZoTXl/pe9IRfjoSP9DddH9pc5Dhc6DxZ6Dpb4D5b79JfH+rPhArvdAvmtvnr+v0LavLNhTaF/O8BdjvIUIZ12QOeOjT3tpM17mrI+1LsCZ9rBmvNxZL3/W2z7n65jzds15u+e83QtuzSa/YSliWYpYNkXMm6OWrQn7zszQtkx4aya8JRvflEtvzGXW5/LrssXZXHGs1BwpNBrZaj1dbWRqjUyjkWnU0/VyrFmKNUuxZiHezCabmWQznWpm0iPJyEgiMpKIjcbio9H4aDgxGkyMBBMj/lgjEi6mE+VCuVkcHh1rlo8t1H97cObT840fb2z4y83l715aeuvJ8ef2po9M25Zyska0u+HlVnRQSUJe5+x/ft/2P3x8+3/88v/88Zu//vzdLz98/fO3t3/85rPvP3v384/evPX1u5/fuf3znc9/vP3xndsffXn7w6/vfPTDnQ9//PbDn7+9/ePXn/3w+YdfffreF5+8+/kX73/+5a3bX3345Tev3Xzy6LVC+aIt8ZqtckOXfljtOeAJnVVFj8n9hwds+0TqrR0DE1xhDGfpQKybxpbQuGqEZwI4ToDtxbhRLj8taM91d5WkA2WjpuK1VxP+Qi6cLESDpag3nbAlY5Zk2BYLWKMeW2TIGRlyRV3uittR9bqqwaGS31nwWYtuY8VlrLlMIZ9syCa267tc+s6AuTNqFWacgoJXMBrpn88MHJzSXD4Uvn1x8s7LC68+2Xh0ObBzUrFhrGukQUskyF4n6FLDASlaNbdv8bGemFaf32N9+rDhzAOGlx4bemFRem207/ndfW88ZH7vhP/jp7LvPVm6cCR6YKO+kmJqVYBaDA/QqIPEdhsyMKnXPb3J/taj+qcO9DfikKxzbQcOt4NUvIVIalm7lkhAiWvQVjLaAlOJEE5ppYH3MiASG6bRKTCdAjMBhAWiHOAfcClo+xpWG4HBBegshMaEMSZI5VJo7WQGA0I5GI2HM9gozkKobBTnYDQ2iqMoC4YZIEhDYBpOZTFobBqViSE0EEJAEMZAKg2iUQEcJMJkEgyCNJhyNwa1YCAJoRCpFNLqi3uMdDcHwekggkEwhqAojEBkCtxKwgiUNS0oiUiHADZG4TBBTge9XdXZ55Qpgnpz2GQKmdR+g+Su3Q3p3rpsd1W6UpauFAd3FeX7Sur7qro9ZeXukmJ3SbGvptpfV++rKfbVFAcaqgPDg/c1ZYeb8iOjygfG1Q9OaB6c0Dw4pn5wZPCRCeWjk6oHx+THRgaPjQweHR08MiI93Og70uw7Ni59aFL50KT2wQnNA2PSo6Oi4+MDx5q9B2vd+6vdB+p9+xsD+xsDexuS/SXFgbJ8f1Wyt9K7u9K7tzawuyzZme/fmNYupjQLCdX6uHJ9TL0Q1ywm9RtThnUx3bqYbj5uXJ+wrI9bFxKOhYRjIeGaT4TXp6MbsvEN2fj6bGwhF18oJBdL6elsYiaXnM6npwu58UJ+tFBoForDhWKz0GjkavVstZ6tNXL14XyzkRuuZxuV9Hg5M17OjBez44XseD43nsmNpbOjichIIjISj45EYyPhaDMQHfZFG95I3R2oeAPlWKKezY/msuWRTPTYfPqdB8d/vLH5pze2/e7VLR89O3P5SP7RRfe2knTCx6s78KoRrirJ43r6gZLrzceP/PmzT/+Pn/78pz/+/Ze//Pc//fm//vFPf/vjn/72ux9++u6r73+487sfvv75h6//8MNXP/z+zu//+O1Pf/7+L3/5/u+/fPfffvru55+++/nnb3766c6PP9/58U/f/vjLDz//19/96f/94xefvXlreeX1UOG3lszrhtQZTeioKfiILHRC6nlEbH2gW7NfMLDI7aow+AGcbWawLFSGCabbEaabxvG3t8cGujLqvoJTX/aYyhFHMe3LFyPpSixcSXjKMXs8Zo7HzLGwORqyRP2WiNcS8doibmvIqQ0N6YJujc+t9rjkXvug3yINmSVWS4de22ZQ8ewagd/YFbV3ZVydeW/HiL9zY2Hg4Y226w+l3j1du3I8fXSjZbE2MJ3tbKbpxTQY8hPdVsCroab17Pmo5OSC6jEQrEgAACAASURBVKVD7lcf8V56zH7tjPvWufjrO7Svj/bd2Cv+9OTQu48FLtw39MBm29KEvpQSGdSAiLW2B2/thwBfp2Bj2HRhOfPps82Pz6V3zQtiQ0BfO4GHISwihN7bQl67lkAigmt/g7SQkLUQtIaEEO6lgffSQSKVCEFrCEgLCScCdDLEpiCrsMgwZw2VQ6CyACodQegIwoQRHkRrh1lcKs7DaRyMyoBgOgixEJSDUTkYFce5GMpCYBoC06gIA8cYNISOwzQKgIAUBAUwBkinAzSEjEMUHIYZVIRARUgIQAIJBJBAoFJINIhIBdYyKDCNDGEAhIIQAoAwiYK2knEiAAI4CjHoCJcFcXkwV8Ro03b1uGSDUbM1ZjVHLNqgUX7XfaODB8cUh8aVh0aVh0aV94+oj4xqjo0ZjowYDg/rjozoHhg3PjChPzqmPTqmPjauOTalfmha8/Cs7pE5/Yk5w4k5w+NzxsfnjI9NK07OqZ9cp3lsTvXojOKRafnxadkDE5IjY4PHJuQPTasenlUdX6c8vk750JzigRnZ4WnVgXHZ7qZ0ZVi6MqrYNa7ZNa5ZntDtHjbvaVp2Dxt3NrQ7G/qdw9btNftS0TZfSM0XUuvyyXW51Lpcal0uM5/PzuezU9ncVDY3nctP5wozufJMrjybr83mayO56irNfLWZrw4XqsOFarNYK+cqlXy1VKiWirViqZYvV7LlcrpSruXr1VytmqvVcsP1fLNRGKvnR6vZZrkwVSxMFvIT+eJkoTSVK04m82Px7Eg8+g/zI9FmMNzwhmruQGXIX3a7qy5/1RcbjsYa5Uh6RyV+6b7qt5fnf7l54IfrOz84O3v1WPGJrb49TdV0iFeyQnUNualDxgysDT7pkYnMs4d2XHrykYtnnnzzjZsfvPfRxx9+9sVnt7/76tvv73zzzRdffv3ZF99+8e23t+989+XX33/11Y9ff/v7r7774Yvvv/v0d3/46vufvv7h5zu/++mrb3+8fefHz27/4fMvf7799f9959XfffDmEw+9Xqq+6UnecubeMqWeVwcfk/nPDXrOSR1P9+kf7ZYdEPQt8LrqvM4cpz2NsyJUup/Lj/b1pPTSrFdbSFhKpUCmGEgVA7FiOFCOeQtxezZqTIU0/qDWH9T6Ahq/T+31KN1OmcsuddokOnOP2tytNHfIzEKFSagwChQavkrFG5RhAwOoXEIzKnluU2fE3pMa6sp6e2ajwp1VyYnNtucO+E4uO1YmpBMpQSXErQXYeT+cDgBBJ8lrRMIG5mig58jM0I2T/o8upG49H3nt6aE3n/V+fDZ0c4fyt83OG9sFbx/Tn92l3zourecHIkGJUSPo4IEiyhozj17QivY3ja8+Ev3meuPTS42z+3yZOFWrILWxKAwIRltI4L13gy33Ugit5DX/BreS4BaIci8BItxDR9bSICLUQgbvbYXXEjEChU6GmADCpiBMEsQkQWwyzgSpTBihYSCOAjhMYYAQC0R5NIxHw9gYvPrbCxYKsTGYhUJUjI2hDAymYzAdQ2g4TKMhOA3BAQoKUTAqgDMhFgNkYmQGDDBgkIlTISoGYRAMkUCICKAUEIcBOkRhkVE2iLMQGh3BcQhjQFQ2iPMgGgOlcjBGG84VYtxuGk/GFVj6er1Kadxmi9tMEYs2aFTe9cCs+sE5zUOrTKsemtYcn9E+Oqs/Pm16aMr48IzxxDrLiXXmh2cMx6f1D88YHpnTnpjXP75gfGK98fF5wxPrDCfnjacWzE/MyZ+cVz61oD61qHlyg/qJ9coT8/KHZ6X3Tw0em1I/OKt+eE7+8MLA8Y3SBxdVh9cb9s54lyddW0fsm5uOpVH35nHPpnHvxjHP5hHv0qhv84h747B7w7B/cTg6X43PFOPj5eGxUnOs1BwtDo/kh4ez9eHscCPTKP0HzXJ2pJwdqeRGq/mxcna4lGnkM/V8pl7IDRdyw/lsI5utZ3JjmdxYpjCaLY6mS81UuZkqN5LlainfWKVcGKkURyvF0VJutJgdyZZnUoXJZH4imZ9IF6eShcloZjSUHA5Hm+FoMxQZDoYbgVDdE6wO+csuXyngqQ8FGrZAxTeUmI0lntsyfOfChl/e2/zDK/s+fHbxyrHqqR3hg9PGjTlR00MvWsCahjZi7Rh1ycZCjplSerJWadbKzZHa5tmNuzcvH1k58MTBB889/MTlU2cvPXX2+ZOnLp67cPHc8y8+99yl8+dePH/u/LPnzj717OnHz5586JGnjp84/fBjp44//PiRY48cPPjoffedOHjwub1L54/sPrrjgan6hVzuo0T5K3fubW3kkj502RC8bPC/oHackeqO9cl29krWifonuN1VKjeJs0MdnTGNLDmkjyWc0UowXvA7015rwm2Oeo0Rv9bvU7ncUqtTbHNKLY5+k63PYOrS6NvUarZCSZMr8AEltVdO7ZSjnQqsR4X3yql9EqpIjHT3kru7yX0iWCNjuQzCsK07OdSV9fZsTAt3N6VH5zUHZ2UbK8LhCKMUZFWj7WUvM+eGU24oZAZ9ajRhZC9kJE/vDn/4cu6b39a+fq304ZXYBy+GP3nG9/6K/L3xjrMbBI8v9mxqdmbjAqerQ6XgSzsYinZ2apC3I2t8flfyg2eKt69m37+YOnNwaCoj0GghoZCMowBKgeGWVmjNb+C1d4Nr7gVb716VH26lYJQWBtpCg4hw6+oOe4gJwUwIZoEwgwIySQCDSMEhDEdgOhWiU8k0jITDJCpEpoEUFgawqSCbCq4WHBxiYQAOEhAQRyEaBtNxmEaFcBzCaDCVjuAIiGMgzgDpLJDBBJg4mQaTaCCZhqEgTkXpKI2G0GkQjY7gdARhoTAPwIVUdjuNw8EYLITGw5hCKrsDY7ehkICKdeKMXjpbwuLrOrrcUnFEp4iY9RGLNmzWBI3Kux7faPwHC/oT89rH5rWPr9ec3KB7Yr318XnLE+vNpxZtpxZtT6w3PrZO//i84fEN2icX9U9tMj61yfjUouHUBv2ZDYanF42n1iueWlCe3qA6vUnz1Eb1yQXFo+ukD88OHJkbfGhO9cic+pG5/hOLXY9u6X9wyXBwg3v7TGXTZGF9MzvbSE03MtPN/ORwfryenanHp4cTU8Ox8WpkrJoYr+ZGysV6rlgs1FYp5Ov5XC2XrWZS1UyqmkjVE6laPFmNJ6uJVC2ZrqeytXSuXs02ytl6KVMrZ+vlwnCl2CwVhwv5ej47nc9OF/JThfxEIT+WK4zmCqPZwnCh0CwUmvn8ajFaKIzmsiOZ9HCqPB0vTERzY7HsWDw3Hs+Nh1PNQLzujzT8kYYvXPeF695QzReoev0Vj68cDTZd7oJ9KFoIhY5OFj55fMNf39z5482FD88tvfLw+OmV5NF1zu0V+XiorWSn5i1I1ijJ2jRRm83n8Ll9cZs/YYukA6VaLJbLpsq1TL2ZrU/kmxOV0eHScDFTKmbKpWy5VChWKqVqtVoq13O5WiJdiQXjqWg6m8jlEplMLJUJxzLhWC6aGPF612W8G2vphdq26eqzlcLVYOqyK3HVE3nGF3vGHzk95D1usezVaBZU8gmlvMHrS9DbPHSutbPLJpda9UqtTT/otcuHTP12Q69J32sw9uktYrWlb9DYLdYJVbp2pZo/qGD2SzFxP9jbR+4VkUSi1r4+Yo+I2NHT2tlLEokhsRjuF8HiDqCnB+zupPR1wWoJw6nlh62C1JCw4BNuynWsNPtXxiTzRUEjQquG8HqY3Yjwyl5G1gmnrFBABfikaNbE3Fbpf+FI4L1rmc+vl29fr3z1Wv2bNxufPB99c5f8cp25e1Q4kWZGvFS7laGSUyXtra5e6rqA5uy24Lsny99eHf7ySvnGycTJ/b5t04q4B+kUwUwagJAhjAShpFaU+Buk5Tfwb+6GyWspLQTyGgpChnCYhEH3IpQWhAxxMCobxVgIyoRgBggxKCCdDNBIFAKJCABkDAUYOIVFI7NoAJMKs3CUgZBZGLDKv8qPAlQqRKOjDDpMxyEMpyBUMkglgxiI4hDGBGksgMYC6AwKjQrgCAXDYeAfa78QJhthsmEaF6PycaoQxHtwdhedw8foHJjajtK7MGY3yuzCwW4cEdHp/Uy2gtdm7u72ygaiemXYrA6b1WGzJmLR3nVmu+vMdtcz21xntthObzY9tcl4erPx6SXT00uOM5vtZzbbz25zPLPVfnqz6dRGw+nNpme2Ws5usz673XZuu+3ZbdZzWyzntlie22o9u1n3zCbtM5u0Ty/pTm/SPLFefnym/8Gpvkc2DjyxqD65oDm5vu/kkuDksuSR7UOHN+Q2zUzPT4xNNYZHqvVmdbhebVTKjXKpUS8W6+VCrZyrFDOlYrZSKhcLtUy6nMzmktlcKldM5YqpbCmVLSUzxWSmnMzWEplqPF2JZ0qJbDGZK6UL5UyxUs1Vy5lyOVMu5yrVQq1SqldK9XKxVsyPlQrjpcJ4OT9ezo+XcmPF7GghM5ItNtP5Zio3nMoNp/MjqVwzkW7GU8Ox0mQsPx7JjkbSI9HMaDQ9Ek0Mh2N1V7AyFKq6VwlUVs13e0vhQNFtC+bC/kPrSzefmP/l9T1/e2fv1y9vvPHY1PP3FR/a4NvZ0M7Ge8sOTtqAJ3WYz2IaMlmNepfGFFQ7UipPVhMqmDJ1uSeucSes3ozbl3V7M0OBjD2c0fpjTmfE6Qw5hoJOb9DpjzoCcasvYXanTI6wzRVxeuJOT9zpjjjdEbc77PFEUg5jwds7ER/YmPcvZIdr4YloYCEY2ZsIriRDO5PBLRHPnM9cc2qSNkXQKvdKB/S9XYpeQf9g14Bc1D3Yx5X0UwdlqGqQrZSyBqVsqYwjVfIHVHyRkt8l40gk2MAAKu6DRD2U3i5ybxe5t4so7iYNCNeKhWt6hGtFnYSBHlDWjcg7kME2sK8TFwlQsRDVipluDT9ubct7+LUgf7HUtbEmms63l0JY3o8Mx5jjCU4zSKsGGCU3NWfHoiokoWKOeYUHJvuvnXD99vnob5+J3DqXv/Pa7Pfvb37tTPbUwuC+MJDx4MbBu5XitUYZOqSm5Wys+0Y07zxS/+WdLX9+Z/b21fz1E6FHt7m3j1uGM2KHuVXYjjNgkNoK0skADViDAf+Ott6N/WYNQmkhrWkh3kNCyBAVIkLkfweJ96IUmIHBDBikQwAOkGkUMo1CppPJDAqFQAFAkELDQA4O8XCQS4U4VIRDRdkYzKEiLBRabfuZCMhEQDpEoUE0BsJgokwWQqODGJUIYAQK2krGQDINAJkAxAFgHkTlY/TVJTosGGTB0OoNIj5M58O4EMd7Wax+OnOAxe5js7uZjA4a3kWjiRnMfjpTzMb6WFg/kyFhc5TtQpOoZ0gmCWjkUZsyYlFFrbqE3XzXuZXQ+ZXwhd2hC7sDF3Z5n192nV92nl92vrDiPb/TfX6n68Ly0Pll57nttnPbbc/tsJ7f5Xh+xX5+2X5hxXFx2XFx2XFhh+3CNuv57dZzW0zPLhnPbjU9vWQ4uaB6ZG7w+Izk8S09p7eonl5Un1nffWaJe2ZFcmJH+PDi2PzM5PT4WHO4Xq1Wy5VaqVzPFWvpQqWQGynmm4V8NZsr5PLFXKmaydcS6UoyW/gHmeI/KScz5VxmOJepZ9O1TLqczZRy2VKhUCoWy4VsI5+p5zL1fLbxzzxvZgvD+XItX6rnS/VicbhQGC3kRvPZkVx6NJEfjuca0XQ9mq7HMs1VoumRSHY8lB4NJpqBaCMUbYQjjXCkEQ03bIGSLVBy+EtOf8npLbrchSF3wTWUdzj8UYdjZST2zsm5v7yz4++f7Pnxzb0fnN36/OHCo1uDy03NdFxUG2rLmDkJHSemYTnMdpPeZjR6jJaIzpZQD6VUnrTck+oNFvvdOY23bPVXTZ6SzpNXBQrSQG7IU7S7c1Z32uxJGH1Jgz+n9xe1vpI1UrFGKpZw2RIomP15sy9n8Wct/mw0oE55uuru9lm3eMYlrdr6kzZt2BnIOpNZZzzjCMRN1rBG5ZcPBGSigEzkl/B9fRxvD8fVxbZ24epuUCIiisUtajGoFEPyXkAqokj7QKkYkoqhgX5ooI/S30vu7yGLuyjiDkDcAfV3opIOtF+wpk9wb49wrUhIFHeB0k5ssB0d5CN9XFYvmybl04297ICan7Fzaj72WIQ5mRXUE7yUF4s4yTk/MpXmrEuypgNwPUSrBai1IUZez6hbhZsz4uMbpS+f1L9xZujm6fBnFxp3Xt/y9pXFA1uH5rOihgVzycm2PnJEzSlZO9clB57c4b71QumXj2Z++XDHp5dHzx91P7BZu3VU2sz0xHxcpWxtJ4fOoUCcVrANBOnQPQj5f8cI9zDWADDQQiEQKa0gTIYQsBUCfgNR1mIgisMAFaLQQAoOkP/Df4ACojiG4UwMa0ORNhjmQxAXwTgIzsGovw78aAC4CpVMYaJMNsJko3QmjDMAhE6BGRSYQYFpCJmNAhwE4IGgAEU7GIwOFpPPonfgcAeO9uD0XjpbRGOJcLqYQZfx2Wo+W85jSvmMAT6jn0cf4NJkXIaazx7g4v0cvJ/NlHL5KmGnWTwwpJT7tMqYXRGxqCIWbdxmuevCrujFPfErB1LX7ktePRC7si90ea//0l7v1f3BS3t8L+72XtrrfXGP58KK48KK4+Ju1wt7HBdWbKu8uGJ/ccV+caf1wnbzhR2Oc1sszy6ZVzuC05sMj69XP75e/eTWjmeWZGcXFGfWdTy9if30zoETW+OH1s/Ozo5OTNQbw+VytVCoFguVcrZcTBeL2fRkPjeeyzXTuWo6V84Uq+lCLZ6uZHPlbK6cTpdTqVIyWU4kSolEKZGoFJLD+UQjl6jlEpVcolRIl0rZcjlXyRYmVkkX/0GqNJEqTaRruXStkK6V0uVqplhP55upzHAy3Yzm6pFMPZSqhlLVcLoRzTajmdFIesSfGPZF655w1R0oe30lv7cU8lfCgarZX7D4CjZvwe4t2N15hyvncGbtjozOZC36HE8vFX+8tuHvn276/UcbP7y0+er9C0/uCh+cNc+nRRUnN29hZ83taaMgqRPYLHaTwWozux22kMkSMLli5kBW502J/Q2xo6gdqjs8oyZ7RWUtyFzFfnfBOlQxuQpaR1rjTKqGUhpvUeWvqQMNXbipCdbU/orSW1K58yp3Xu3NaTw5+5DYb+/I6QUjyo5xJbehRTN6ekjTlTWqM/rBpFYUU3LDg3hYAkcH4ZgMKfS0lHqIhW4g2QH42snmjlZ1T+uguMUkJhh6W7Td9yo6fiMX3q3ouEfVtUbT0yIRtUpEREkPWdoFSDpgiQDt56P9fGpvx5oe4dpuYUtXB7mnC+rrQPvbMTEP62GwRTSGlM2w9HIjWn7BwWkGGVNxesqLB+3AkKk16KTU4sx1hfaFFH3WR6oE4IYfGx5iFA3MUWfn9uLA8c09Lz7af/246t2T3juXxj+5vPnRg+Wwu92hpPrleEJFn/JKj4xEjzWDD007fnu68M37jTsfZ9482zxzILZrXLNY7ZnMMXNRJDCEa5VoN5PWRgKEBKgTBhjQv4HEuzDCGg4BQ8BWFIRQgIpQYARsxZA1VISEw1QaAq6ymv90gLLqP4TSMZTOQqh8CBaAsBBGBRhDgHNYCJWHM9roLA5GY0AoToFQIgVqIbIRJgtmMGGcCVJZEMaBqXyM3o7TeXSgjQ62UyltCKUDh3tY9C4uQ8DG+xhoP4sm57dpBJ2qNqGCzVNwWJo2jprHlLHxfhYm4dEkPNoAmyrn0DR8Vj+HKmZTe1ksCV+g6hJZpHK3RhMw6aM2WcgsCxpVYZPhrssH05cPpi8fTF47lHr5/tT1w6mXDiau3he5vC9yeV/k8v7Q5f2By/t8l/f5ru71XN07dHm389Iux4u7rJd22y7ttl7abb24Yn5hxXBhWf/8dsP57eYXdjqf22o9s6g+vag4u0V5arPsqS3qJ5ekpzfxntvGfG5FcnxbZMf60fGJ4ZHRWr1RrlQq5XK1VKwXC41Cvp7LNVYpFJrl8li5PFYsjuTzw+lsc5VUZvhfyWaauezI/59CfqpYmC6XpsulyXJ5olRqFovDxVK9VJjL5acy2Yl0djSdG0vnR5KFZiI/nM5NJdLj0cRwNFGPp+vxdC2aLIVi+WyokAgWA8GqM1A1+yp6b0nnyWs9GZMzZXBF9e6I0Ru2BWJuf8LtiNq03sxg5/5R783n5n94b8+3b+6+fXnHzUenntscOTzvXCr2jnrgqrk1b0TSjr6Qy2o2OPXmtM6U0plSekvSaEubHVmzI22yp8xDRZOrYHTmDY6cwZEzOvNGZ97kKujtWZ0to7WmNZbUKlprWmfLqN1ZtTurduW0zoLOUdLbSgZryWipBAzKkJofV6wtqu6qaP8to1kb1BBdOpJPgfoVsF8GBAZJYQkl3A+E++CoCBvqu9cpXmMXtVi6CcZOolZIUQsAVTuoFa3V9pBUHZRBPnmQByiFgLKDJBeskXBbpTyCtI04wCf18Yk9beReAdDXCQ3wQGkbPNAO97WB/QK4vxPtE8KdPLJYeE8fnyjmQNoeasLObYSZw0F42AM4rBSbgeI2wmk3PpqgzWXh+TS0Lo6MeihjAbweYOe9rEqIu6EqemCz9uwB24UjQ6+eirz5XOaFE6mlpiai5vgl3Iisba+1/drO2KuPje2ZcWyqSa48HPn27emPro9f253dO6wZSQmLWW46RS9H26cDijmrMSJnS5hr2rB7aSgRhsgoBURaKGwSCq+9G16zBllLpLaCDDLKhiA2SmRT19DBVjrYygQJLIjIhUkciMgCWlnkFjYZpAMgFYZQDKTiMAOHeVRUiGECnMOGMDpAZmEAm4bSURoG0CEySwhT+TDGRnEWjc5lstoZ7A6c04WyuyB6N0IV06kKDkPFZcqZDAWdo2IIFG1iRZtIyReouRwdj2XksS0cjpXLFbQDHXyKiItIeDQFn6Ns48v5bVIuX8TidrE4HSxmF48tE3XYVdKgXhnWKKImZVivihi0cZPlrquHs1cOZa4cSr10OP3y/anrR9IvH0q+dDBx9WDy6oHY1fsiVw6Er+wLXN7nu7LHfWWP+8oe1+Xdzku7bZd22y7vsa3Kf2Gn8cKy/vwO44UdlvPb7Wc3m55aUD61Qf6/yL/Ufn479/ldsge3RresGx0dqw83q9VquVwul0qVUrFeKg4XC41iceTXwdtqncs1MplaNj+azY9mciP/iXxu9FcK+bFCfqxYGC8WxkvFmVJx6l/kHy2VmqVSs1iYzBUmsvnxbH40UxhN55uJ/HAsW48lRyPxZiTeiCbqsVQtlqpGEuVgNJeKlKKhsi9YcfgrZm/Z4C7qXVmjM211xMxDcYMzrnVGrJ641xsP2H1+o2NL2njl2NhP7x/6+daBjy4tvvHE5MV92cdmrItl6YifVbKQiiYgZWSEzf0ui81o8K/KrzUmdeaEwZoy2TMme8pkTymNcZUpoTYnV93W27Orp4DWmv5XdLbM6leFM6N0ZJSOjNqe09hyOmtOb83prTmH2jQk7wkNQhn5mqK8JSkn+mSkIQXFIwE9EopHQvJJCL7+Vk8f0dNNdncBdlGLrafV0k0wdrXqOklqIUklIMnbyYqOe+WCFimP0M8i97PIgzxA1kaQ8Nb0cwj9POIAnyTmU3r55C4euZNH7uCS+njAQDssESADQkTSgfZ3oqJ2sIND7GkjittgCY9q7MGSdmYzyix6gZjxXrOWaNcDIRtejrDG07SpJDgRIo/5yBMRylgMroWoOR9cDqPra+zDm0RP7pU+f7/2hQe1LzyqP/ew5cDGwbE4u+qi5k2UQ9H+c9tCJ/fGxzN9NT/r2QNDX12feutcbce4ruBj+y2UqB/NhKjNSNuWtHF/NrwxZkoo2k0d9D4GwgXJTDKZ1UpsByCM0IK2tKAtJGorSCdDTJDCgltZ8BoaRKSDRBpAoINEFkTmIAAPBngwwIdQFgjjqwsA6CiXQW3DsTYE5FMZbARlwSAPh/l0Kg9ncFA2B+F3wngnShPQGHw6zqNR23Csh0brozMGOex+Br0fxwaZuJLLVHHYai5Py2/Tdwyo+J0KDkfJYejbmGYBx8Tn6DnMXiHSx0cGuNgglybjsuQ8rpTH6+fyuhnsTiZbyGR0clm/yh/RKqMmZcSgjhp1cZPlrmtH81eP5K7dn3vpSPaVo7lXjmauH0lfP5x66XD6pcPJa4cS1w5GrxwIXtnvv7zPc2mv+9o+92r+X95jv7zHfmm39YVl04Wdxgs7jS8smy/ssJ3bYjm9QXdyneKpDfKzS+rTS4OnlpRPLknPLHVcWG4/t1t5dCm2OD023KzU6qVyuVgsFouF6j/kzzdLpdFV+XO5Rj4/vFpks/V8cTxXGMsVxlZPgdU6XxxfVf1X58ulyUp5qlqZrpRnfjW/XJ5YbSIqldFSaTxf/OeQv9hM5xuxbDWcKgUj9VC0Fo7VI/FaNFGPJCqhWCkQyYcixUC4NBQs231li7tkcmQttpTFmnDagzZn3GBPGp1ZhzfrtntDFn3Vazq7O/LtK9v/z2+O//DWyuunxy4ezp/c7Dk0LBsO87J2KG0CslZGxCiwqQe1aodCE9FZ0lpzSm1MaExxnSVpsKUN9qTBnlQYYipTQmNJ6WyZX5Pf4MipTVm1Kasx5/4TcnNGbs4oLGmlJamxJLTWuM4a01ljWqXLOCh3SbgxKZyWAtEBireP4uoD3H1kj5jk6ScMDbQ4xWtsvS3mrlZDB8HUQTQKCXohUSMkqAStcgFB1t462N4q4bcM8FrFbOLq+qZ+NjDAJfdzCCIOUcQh9vGAvjZQ1Ab18MFOHkXIofS3wRIBOiBA+9uRAQE6IEDFbXAPh9LNR8V8uqKNPiShF4fY1RAeNreaZf9mUcMuHRx14NUofSKDTyXhqTA6GaA2Q8hwEC15oKyLXPGTN1boD23qena/9NJ9pgv7Nc/dTrbDKgAAIABJREFUp3jxAcvZ/aaH1ssONEXb0+xtwc49w/LFpjxup5c99ItHw1++NHfpeDGZ7LCYAJuOmBrCqgHGZESwXLY8MJ46MBpuuuV+qUDVhndhlHaYyAHX8hECjUSiEkhYK5lKoNBIFBaFzALWsoA1LBRiwAANJNMoJCYEcFGYhyF8KirEqDwYZkIgG4PbmbQONk2Io3wYYOM4h4pyMaSdhnbQ8A4q3o1xRHhbH0oT05hiFquHSe3AwS4cEDMgOYeq72QpuLiUicnZdE0bRyfk6gVsnYBhEvbo2wVqHkvNx7XtuF5I1wkYGj5DIaAp2nAFF1ewaXI2Xcpl9vPYfVxON4PdwWAJmYxuPkfR1+VQD4YMqpheHTVrwkZ1xGiImS13vXS0+NLR4ssPFF95oPTKA4VXj+VfOZp5+f7Uy/dnXr4/89Lh5EuHYtcOhq/eF7x6IHD1gO/lA/5r+7xX9w5d2eO6vMd+abfthWXT+R2GCzuNF1csL+y0P7PJeHKd6vFZ2ar8Z7bITi0pT26WnN7aeX6l85ldmvs2JWfHx2uNcrlaKJTy+UIpX6gUCo1V53+1PZutr/q/2gLki+O/+r+qfaE0UShNlIoTpeLEP9N+olKeqlVn6rXZWnWmUp76p/kTlcpktTpVrU5VKqOFcjNXbGQL9XS+kczWIulyKFkMRqr/lL8RjlVD0UogXAqES+5wwRUo2H1Fq6dsdhas9qzDmnSYYy6732aNGM1pp6vq9+Q9en15SH54KvDp5dG/fbTrr7f23To/d+2h8jO7Y4entEt5YX4IzdjRtJ2RsHV4DRKjyqhU+xW6rN6a0ZpTGlPyP8mvtqXVtrTGntE6slpHVmPPaOwZtS2tNKRVxsyvKA1puS4p1yWl2qRUlxjUxxWGiNIUUln8aqtPbfUOKpxKqcoiFfoHaVEpEOpr9fSsdXUTPL2Au4/sEhMd4hazeI1etFbd3aLsatW2UVRtZFUbWdFGGOS3SttaBtrWDrStlfIBCQ/sZwN9TEDMAgc48AAH7mdD3RxSN4fUwyX38sD+dkQspPYJMFEbIhEgA+1wfxs0wAMlfEjaBssEqEyADgi5sjaOqYuT1rUN+zhpO8ki/3dV/z1WBdWlQWJ2tBqijiWo41F0PEgb9zEKFuqIhzsT6lgfFm6Jt91XFDwx0X1uveiZSc3JEenDw6InpqQnxqQPlgceykkOhbuXwvytpZ7JfE/Oy1ms9F97LHv9yeqOCaPJjJnU5IABLroYVRe94mGPJPomS7pmQRdx9dgVXJWI1ssF2ugEFnY3Dv8XnEyhkshYK5FKIDFIJDaFyAEIPKCFi6NsDGbAAAOkMCGAg0Cr/ndiWDuC8BFYQEW6mbQeNt5FR4UIwMVRHh0R0LEOGtaJId0IJkZxCZUpw+lyJkPBYcg5tEE2PMgGlDxQ14bohJimHdPwGToh19DJN3RytUJcLUCMfL65nW/uYBs66ep2TNGOKgRUVQdDw2do+Awtl6nhMJUchpTL7OMxunnMHiank8nuZLN6BXz1gMipkYUMqrhBE7Vqw2ZN2GSIWix3XT1WfOnB8qsPVV97pPba8eqrDxZfOZp7+f7Mtftz1371/3D8pUORlw6FXzoUfulg4Np9/iv7vZf3DV3a67q4x3Zhl+X5ZdPzy6aLux0XVlxPLRoenVE8tk751Eb101s0T28dPLVF/vjmwdPbup9fEZ1a1u9ayIyPTFfrpXK1lC8WcvliLl/J5Wq5XCOb/V/kX/W/WBwplUZXzV+N/dXkL5QmiuXJX83/T/LX6zPV6tSv5tdq09XKdLUyXa2NFCsjuWIjnasns7V4uhZOVkOJSjRRj8QbkXgjFK0FI9VAuOIPlf2hqt2btXpzJk/BPFQ0Ows2e9plTXgsMbct6LRGLYaYw5wI2wN5l3b/mOOD01P//fby3z/d9fW1xVcfqT+/L3N8g2NzoXs8QE9ZwKydnrS1+/Uim0Zl1Lt1ppTGWtZbMzpLWmNKas2JX+XX2xIqa0JlTSgtcbkp+q+oTWm1Ka0yppSGpEKfGNREJarwgDIkUUQkypBEHZRqfIM6z6DeKTM4ZUZ7n0IvGZRqpEK7jOYdJHrE97hEdzu773X0wDYR2dxD0HXdq+pao+hcI+sgyjpIch4g41KkXMoAl9jPI/byWnp5LSJ+i7QNG+BBYg4g5gBiDiRmI2I2JmZjIg6xh03qYZN6uZT+NniwHR1spw62U6V8spRPlrVR5O2Aqh3UtEM6IaLvQE1igVPcGVF01WzC4SFGUHuPWvRfpD1rdCLAqYLSLmojSm9G8IYPbXrwcT93PiLaV9WenPOcm3c/P218bnTwueHu5xptl6bUzzYlJytdp2pdjxXbH07wHom0H3Gw9iTa9tZ7Fyt9U2nRvhnN04d8exeN4aE240BrUANVndxRN79kZ8ccTK+HafEyLGbMZmI4jG1WJV8iQATovRzo3xnk/w0jQRiBgrW20okEFpnAB8jtAKUdoHCpEAcDuSjIRUE+AvIRsB2DBRjcgcKdGNJDxXrpmJiJi5lYLxMVMRABA+piYj1Mau//R9ddhcl1pnmC906TQVJiwInDHOcEMzNmRmRkZEBCJAVzJAssW7JlkW0xk0WWZMsWWmBxioxlF1dNb01Vd83TM9s9PTt7sXf97NVehK12d+8+z//iRGTe/s77wft9AUM6EDCBEhsMOlHIRsBOEvJQiI9BAhwc4EAfJ3ZzIhfd6+MkAQUZkLNeGe3kUQcP2Hihh8b9HBFQ4H4l5pZJbFLAKoVsHGqjEAeFemjCxRAOGjcxqJaGFRSsIWglQSkp0qiUeS36mMc24neO+1wjYU8q4E75/cPB0EsPT1SXT1afnml8cab5/Ez96QeVx8cLy8fyD4/kf/Q/tXxkYvnw2PLhseXDo8uHRh4eSD7Yn2j7v7M7entX+OaO4I33A3d2R2/tGPh4g+fsWttHG1yXN3uubHVf3mr8eLPl/DvmT7epr76vPbfNv219fmZmfaVZLdZKuVJxulCezleyheZ0rjWda5VKs/9mqp9rtBf/XuDP5mdf4C9XV7cr/4u0x/z12tpGY7FWa4/2F2u11fXa2lp1XbWytlabL1ZmsoXm5HRjfLqRmWwOTzTTmVZmsjk20fhRfj05XGv37YQHsqFYLhjN+6OFYCTX1z8V6x+P941F+zLx6OSgP53wROpD/fsW0t+cm/mXX+76lz8d+Mev3vv+4prP95UuvJ3c2bQtjTKVOFIIictRdjKk6rfrfA6Pz5twByfswWlXaMoZnHQGJ53BcXd40tM35Q6Pu0IZW3jcGspYgmPmwKg5MGoJjllDGVt43BkcdwQydv+Y1TticqUMjoTOFtdYYjpzVGeOai0RraVPYwtpbAGV3a+y+5Vmi9qgMes5rxEJG7vDmpdDilfDig63TOiS9Vi5lSbmVQPzip56TU93GpgeI9ltoLoNVLeO7FGT3SqqW052y8luPQlo8F411qnBu7REtwbv1WBiLS7R0506qkNPdujJLhPVY6WENlpko0VWaoWdWeXlu8NKUUQFROSiqFw0oBCPmKmCV9MMa+tBqhgQJu2velV/Y+U7farelBuspcn5CbY1TMykyA05zd4F9+0dY08PTH93NPfz/Zmf7Rz8bmffL/f2/eZg368PB39+MPDdQe+vTwS+P2R7skX++SJ1fqL3UIE62JJvqSjezCrfb2l2Limbk1SfGx+39M5EyDdGlauTilwfnQoTgTBo9HdFbR0jYXQ6pk77FGZaxHT+lazzFb7jZaBDBHT2SDo7sO4OStDJCbtlQoG8R0gJVrHiLh7sVUACBSRQQUItCuhxUAUDWlhiRCArAtpQyISCBlyiJ0EdLjISoBlDLCjiwDEvjQekWFAKO1jAyQI+FgxxSL8c71PgPjni5mE3JQ5wcEiOe3nMwUI2qcQuAx0K2M2RLinm4iCPDPYpULcct0txM4noKNjEoHaWcEhJO0uYGFRDQQpaosYpOUaoaMqqVQUd5rjP0cY/3OdJBt0Jvy8VDL70+FTjyenms7PNp2caT0/WHn9QfnKi/ORE+dGx0qPjxUdHC4+O5paPTD06PP7oyFi7/j84kL5/IHFv/9C9/UN39g7c3h25ubPvxo7wnb2DN3fEPtroO/u68+Lbvqvbg5e3ei9t1bfxf7JNe/ld7al3fO+sLdRbG0v1cr5cmi4Up/Kl6XwtW2jmCrO5wmwbf3uFv138f9ilLy8WSgsvKn+htFCurq7U1lTKS+15fjs/lPfqmnp9oVqdq1Tmq9Wlem1to76+Vl1XLq2tVObzxbnp3Mzk9Mz41PzY+Fw6M5ccmRsZr6RHK8nhUnK4khqpJ9P1eKIWi1cGIrlIpBCKFAORQjCSC0emIv2Zgb6RUGg6Hp2ciA7PpeLH1k59f271//XFlv/nV9v+4csdP7/0xr19rU/fmjjY8m+cUs0kmfIg3eonGlHFpE/bbzMHXSGfN+HwJW3+tM2Xsfkydv+4I5BxBsedwXG7f8TqTZsDw+1YgiPtWEOj1tCo2RM3umJ6R1Rr61eZQwpjQG7wy/Q+td6t1rsVOpdc7+L1Tk7nYrROWufkVTq5QqNRyM1KyqEU2WUdLq7bw0MGXmyQCnRsl45aqSVXafEOHd6jx0QGepWe7tRRXWqyW0UK5ISQJ0Q8LtZgQiXSoUBe0xArdVSHlujW4iI9CZnolVZmlV3a6ZT2uNkeLyv0s6KAVBzgVwZlqyKKrqRGmNaIUirBiEo4oZUULaI5PzsT4MpuMOvuGrGvHDD09KmhuA2aDGH1FD0zys4M82vHdXsW/RfeT395OPv1wcmv9o9+tTfxzZHUrz6a+tublb+93/z7u5W/v1f78/3aP31R/T+eZf7rncifLge/O2r/bKv97JuG3Qua9xv6nXX+nZykloCGg4pWGFk3LF0/Lm8MshkfmfDQMT8+EIRaUXQmwWejsoiNksGd0Mq/Znu6mc5uUacY6BRA3Z2EoEMq6pSLehW9IkW3iBOsUEq69JjIiIr0sMAIC20E6GYxK0vaSNyBIy4M8RCoi0StJGwgARchcRGQA4UdKOoh8RBPhOWIXyZyyARumTDIQ/082s8RASnh5kgnR/koNCDFAjzqlkIOVmLjQLsctctwu4KxcriFBe0c6JXjfhnjZWgnTio4TMsRJp6ycoSZxQwUpCYlChLgQUQKIUqKtOnUfW5bIuAaDbgm/O502JvwexJ+f9IfeunJmdazszNPz7SenK4/PlFZPlF6+kHl2clq+3n5WLGN/+GhzMPDow8OjTw8OPzgQPr+/lQb/919sc/3RG/t6r+xI3x3X7yN/8P1rkubg9feDf2I39TG/8k27fG3fRtXFyvNtwrVYrZYmMoX2vhzxVa+OFcoLbyY579YAiiVZiuV+VJlqVhebBf/dtmv1NbUGuv+VXttbTs/fGzMVatz5fJMtbrUqK9r1NfXqutLxTXF4lyuMDedm5uaXpyYWhwbX0qNLg6l51KjxUS6OJQqJNLl1HAjmW4ODlWjsUo8kh+IFPoixWB/wd+fDfRPhvtH+vtTnkA2GhqvpEb3zee/Pv3G//31rn/5xbZ/fDTz6xubHxxd+HRT4eRCYnvWsjrFVuPUdB81F6ZqQX7UqRlwOAcC8XAo7Q4mPH0pi2fU4hm1esfs/rF2Sbd4UiZXQuce0nsSBm+yHb0noXMPaV1xlSWgNPvlRi+nc7EaB6O20yobrbIpNWaF2iJTmaUqC6O04AoLJreiCivDaaWMTs6otVLOwMFGRmimQBtDazhIzQEaTqhjevRUr57o1WOAEZHomRV6epWG7lCRPXJCyONiHoekGKzEemTIShn6ipp6Vcd26JgeHS02spiFftXJrfLLe0MKYZ9CHFUAMYVkUAkndL1xTfeQuiut7hlR92SUPTkdULWgdcuqlkNUtUnydkHW1T3u7B61weM2+WSQme7DyoNkMyWdG9a8MW3dMes+/lb4bMv58aLv+obw/R3J56dzX11r3r9Rv3q1/OXlxSefzt2/UH5wcXz508i31yN/Wp7488P89x8PX93t+WCT/eym4Lk3LYfn2M0F9dJ46I1x+Ya8Ys20rJqUTgX5bEjTjJvXjTu25bWrR+VxN6SWd4kkr3QLViAwCAiE4i5A0iVEerspUQcPdMlF3cpekbJTrJasNKE9dkpsI0UWpMeC9LgpICTDvCrOLaVcOOrD0SBF+FncTsN6QhyioQCBuBHYASMeEg/KiIBM4mA7bIput1IYVsL9PBqkMReJ2RjazvM+kgowpJ9F3RzolEEuBe6QU0aWMCkos4ww86hVCjlZ1MuQPpoNUDJeRioUpE5OGTlcTyMaUqImRCpSxIgklFgiJ3CbTt3vsSeD7jb+ZNgbD3gGfb6hQOilLy7MfnFh9umZxvLJ6tOTtS/Ptp6fbjw+Xl4+Xn56svbsVP3JicrDI/l7B6cfHpp6fDS3vG90ed/wg/2J+/sG7+wduL174OaO2I33B6/vjF99P35l28Cnm/s/fSdwaYvnylbHtXdtn252f/q28cpb3LV32E+3eo5uLGxc22rMl2qNcrlayRcquVztx7W9RqFYKxSrxVK9VGoVizP5/EwuO1PIL5SKS+XyQrE4VyjMlkrztdrqRmNtvb6mWl2q15eq1YVKZb5cbtf5hUZjdbO5ptZYW62vqdTaWVeprStX15bK67L5malsc2KqPj5ZH5+sZyYao5na8GhlYLgyMFwZHK0kxmqDI8XI0HTf4GQ0MRXzTycGCoNDWf9AyhcdGkiMDg6OR0LDOVtqpj+6Z2bgq4vVf/7+7f/57ZY/33v3t5e23z9avfTe+Jm3Envm/PMpvtxPNONcPS6rDMqG/Bqfz+MNxKyOoMHq1PhCyv6YyptUu+MaV1TnCGntAZUjqHD0y10DCrtLYfPLLf0y0wBv6pcaPazJyJqVnN4s1VkYtZVW2UiFhVSYSKWeVGqlSictsxCcDmNVGKvCpVqSM1G8lVC5KJmOYQkFI9TS3Vq6u61aJ31Vy6xQk50qoluJCZSYQIX3qskeNbVKja/S4T0mUmwlhDa0y4ascOArLMRfONmXPewKF/2qi14R4LpCsp4g3xvhVkW4VYOK7rRONGqUDOvFab1g1CQu6rG8FppSi6c0vVmDoGgRFuyCgr1n3tK74ATmPWDDJak5oboLrdqgogHIezsKvs56WLw0SKxPSjckZW+lVZtH9IemHYcLseMLo0c3xE7uHjl3tHFi78KhHXMfbi3cP71091TjzLb0gbXxg+uSJ99JXzk49eTU8PKZkfunUtcO9H20zXbhDc3FNYqra+THFlSHWurdBeXWDPl+nj226N3bGlhMeEYHlV4HrFH3ctIeHOzAujv4HkDbiyCAAAN6cNEqWrRKJu7SAAK9BDRJECfc60aFPgLwEYCbELsJsYsUuynAJ4U9DOihJSEGjvJ4jMMHGDRCQCEaClCgn4F8LOSTwm4p5OZhNw87pCKPHPQpUDcP2xnQSsIOBvNwtEOGumSYT4b7pLiLQW0sYpFiZh6384yDZ9xSxs3QToayMaSRJQxSQs8AJp7QM7SWlOpYmYokpaiEx8UwIkYRiKcYh9YYc7vTXnvaq0+7FamwPRFwJPy+dLDvpa8vLnx9ceH5+Zknp+tPTte/ONN8dqr+6FjpyQf1pydrT0/Wfor/0eHp/4j/1s7BGzvin+0aur4zcf29+NXtsavb+q5s813d5ry63Xp5q/vKZsvVd2TXtkg/2uw5+Gb2jaVmbbZUrhaK5VIuX85mqz+O7ZulcqNYqpd+6L2dyedn8rnZYmH+/w9/rba6Vlus1Rbb/qvVhVptsV5fajRWV+trKrXV5erSD7OD2rpSZU2xvDpXmJ3OtSanG238Y+P1kbFqeqQ8MFwaGC4NDpeHxsqD6UJ/fKJvcDyWmBqKTQ9EJ8LR0XB0NBrLDMVGkn2JhDc6F/EdmMs8PDHz56eb/vm7rX9+9Pbvr2/+5sON9w+WLm4e/mBt5N2SrRUlSwG0McDNxOWlEB13KZxOp8kZVhmdMr2Ft7s5b0hq6ZOaQ7zRKzM4ZUY7Z3TSRjdl9NI6I6Ozs1o/owlRKh+htOIqNa7mCIWOkBtwmQnjzBhnxngjxuswmYaW2XDWgNAqmJKjjBJjNSitg0kdzFlwqZZhKAUt1lBdWrKzPZ5XEy9riNc0RIcG79bgvRq8W4N3aYgOA71KR6wyEF1WSuikBA6iy0ms9NEr/dyKsKKzX9XdL+/uk3X18z0RWW9E1ptWC5PK3rRaOKYHxo3gmF40qhNmDOKSAS3ooKxWnNUJc0Zh0SIsOoQlp2je3jvnEs26RHWnqOYQN53QjA1qmYFZZ8+sU7Dkk6zvw9/sp9eH6fVh9o0+6da0Zvu49+B88sx7I6f2DO/YmFgshWvj7l0LoXtn6t/dXH3vbOnKwamLu8dPb+87vsV2bGPo7Ht9V48P3bmQvH0qdnmn76MNro/Weo4vcccXlefWW69vD9w7EL25b+jAUqARU8b6OJsZkMs7aaoDFL0Gd6ygu3rkXRJS0kNJuhjJKl6yUgV26qBeCyyxwbAHFXpx8Qv8HhLwMqCPhfxS2M9AfgYKMXA/hw3IiAiHhWjIRwA+GvTRoJcBvSzk5RGvHPXIEAcLOKUSpxR0cYhLirk53M2RbinllGNOHnXzqJvFnDRioREzi5p43MaTdo50saSTIRw0bmEwI4vpWVRDAwYppqMpLcloGV5FkhwGygiAxiAORw28Mmh1pgPB8X7fRJ9tPGwa7ncmAo641zPkDbz09cdLX3+89OWFhfbg//np1rNTzScf1J+ebDw92XjyQf3x8fLDI4X7h7IPDkzf3z/1cF/mwb70/X3Ju/tid/YO3N4Tv7U7fmtX6rNdQ5/tSt7cmby5M3nj/YHr7wWvbXdd3W69+q7n2lbbta2qK1sV5zZ597yeWzffqLQKhVI2V8hnc6Vstvrjkv5MpdoqlX7Ii9N17WX8SmWxVJovFufK5YX/iP9F6vWldtryS5XFUmWpXF1drq4tllfni4v54tyPxb+Rmai1y35quBRLlwZSxYF0fjBdGEhOR+MTkcHMwNBEOJ4MR9P9AxOpofzI4NRYOJ7r65sZGji65P3ybOsfn7/3v362608PN/3iyrqvL6y9f2T21o7J828MHJzxvDOpq4fwggdq9nGzMUXZSwzZZWazmdPZcaWeUGhwnQkx2FCNC1NaMIWBUmgZlZ5UGzGVEVQaYJkSlRtwhQOXOxHOBkn1ICcHeRaWKmFWDbM6hDUirBFmdTCrhqVKkjFhpBYhFBilIBgVwWhQQiOBlSBlQBk1y7IKBtJQvRqiQ4t3afEuFfyKGl6hRTv1eI+B6DGQHXriVT35ipV5zUqtsFIr3WyPj+n1050BdmUfv3JQ0TWk6klpRcNacVIlGJL1JhXCYTWQN2PTBnhSJ5nSg1kTmDWB00bJtFFcNCJFI1Q0QgUjUDALS1ZR1SGpuyWzzp5Zt7DlFjZdwlmXaMkNrnfBbzqQTS50owPe6EA3urA33MRaJ77Gga11E60g3OrjNpc8Z3cPn9gRX120TEUUEyHp6jHukz2pn91ofnO9+vXVxrfXW08/nbh7LnxmR+LI5uDhLd7zBwaufTBy7fDwxffiH20e+GAdf36j4cGh2O+uFn57M3v7eN+2WXm2X+ywIyplN0m+hsCviHtfBla9THR2Mt29tLiDBVbxkteU4Aod3GGGu22I2IGAPlzkJ8R+QuwjxT5S7KWAAAuFOCREQ2EGDjFwkIaCUqRPQYTluJcBnTjgpWEfg7hpyC1F/HLCryS9ctwpg21SiZUBHRziUVBeJe2SUTYWcygwGwc7GMQlxRwMZiQhPQObeMIiw6wcamMROw1baMjEQDoW1LCgmpRoaVRDEkqCUFOMnMA5FOZxiBWJFTBi4eRhsyXt842G3CMh60jInA67h/zOQY877vW+9Oz83PML88/PzT37cPbZ2Zl2vjgz8/x06+nJxuMTteVjpUdHiw8O5+/vn7q7d+LhvsyDfSP39iXv7B38fE/s9p747d3Jz/cM39iduLE7dWtX6ubO5M0dsc/eD7XxX9luv7rdem279tJ2zcm3/TvW5Fa36tVGMV+czuZz09niT/GXK80XC34/Zr5cXmjv2JXLC+3n/4i/Xe0bjdVt+bXaYqk6X6rOF8sLbf+lylKhtJArLGTzMy8q/9h4tV32U8OlwXQhlsoPJKdjialofDway0RjmYH4WDiR6h8aSyWymcFsJjhUDPo3TUVOrhv/+SeT//h0/f/4cusf72z42UcLT8+0Hp+q3dg3cfWd5KnF4N6S9e1hZSuAVz1YKyybj2oW+hQjbq3OoEcUepDXIHIVLNeJOB3AGSWsGmIVGKsgZUpSqUVkGoDXgIwckWpw3oLzNlRqgRgtyMhBhodoJUyrEdqA0CaENiG0AabVEK2EMR1K6HBaQ7JaSqojGC1K6GBMhzIWgtGyjEwlJXQsYKQFRrxTD680ICuMaIcZ77GSAhvVbaNXWemXrcxfeaSvuOmXPfTKoLSzj+vu41cNyFfGVauG5B1D8o4RlSCjFWfU4hGFYFwDFE1Ew0FXLHjBABcMYNmMVK1Y1YZUbUjRDJYsUMWGlG1gySwqW8R1JzjjRWdcPS1P74xXMOsVL/kk633QJh+y2YNsdpAbzchaA7holMwbgBkT0LKCCy6sHJCUg9ibRfPHB8eObYsUB6kxN14ZkC+l2eMbArePp++dGnl8fvrbq5Vffp7/7cOJb2/kb51Kn94eOfxm39GNA6e3Ri/uCl8/FL65r//OwcTX5/O/v9382fWJc7sdq4vocLBbLu8miFdByV9JRH8t6X0Z6nqN6OmUCoXS3ld40SsqySta8BUj9JoF7rAjvS5E5MNFbf8+UuyngAAtCbBQUAqHSbCN30tJfCzkl2NeOepgJTYScEsRD4c6GcjFwj5qH1nRAAAgAElEQVQF4VeSHhnmluNOHnVwmJPHPQrKo6AcHGamQIsMM7OwlYFdUsIuxQ0UpKEgHYcZecTEIRYWNlOgiQYNlETNSFSsRE3CGhJTkrgCx+UEzmMog0AMAsmFgA7F3XJlzGob9ntHQ+7hsCsdsicD3rjXFfd6kgH/S0/Pzbfz7MP5p2fnnp6ebeeLM3NPT7aWj1eXj1YeHSk/PFJ4cCB7d+/kwwOTDw6M3tuXurMv/vnewdt7hm7tTd3aM3pzT/LG7tTNncnP3h+6/m7k2ruBNv7LW82Xt5ovv6u/sE137O3wttWFhVa9Ui/ki9M/rfzF4g+996XSfLvCt/G3Z/LtIf2Lhzb1F85fyG9/2Z4FFCtzP6S8UKosthcLp3Mzk9ONyenGxFQ9M1EbzVRGxqrDo5X0SDmeyg4mpweGJqKxTCQ2EouNxmKjAwPpwcT40GAm3ZfOBKLVSGBbvv/q9onvL8z8r2/X/Z9fvfVfbq355tzMk+O15WPF5eMTN/YMXNkUPz7nfndSuz7OtwJEMyCdi6iXYqb1aXMmZFbp9BKpBpJpCYUOZtW9hEJAqgW4QozzEMlhrALnVRCnAVi1hORhRoWyWkxqQBkjTGshSgVSCphWw7QWpowIbYYpE0QaQFItIRSARImgGorR0ayOpDUYocIJPUGaSKmdZAwMLVNyjEVOuuSwhxG48ZVeusdD9bbjpXu8zCqf9FU//0pUtqKPfa2PXRHluwZlPYPyzoSqY1jfMabuHlV1ZTSCaZ14WieZ1gBFI9J0si0HU7MQZRNcMkI1K9ZyErNuasZF5i1AyQ5VXFDVAVasQNUKNJ3wnBdrugRNl6DpEc56xQse8RqX8A2HcKNDtGAAZrTCuqa3bhBWTaKSWVS2iatuqODprQThzRXTzVOTx7eEJ9ziKTeyNq3eXnKffit2eXf84vv9F9+PXts39PmJ2L3T4e8upX55dfrr8/kbu4bPvBE8vcH56U7f7ROh+ycLtw/lr++funYoc25P/zurNemYyKx7BSNWIvArkPCvYcHLhGAFJVjFiLp5UKgWvKoXrzBBr1nh16zwa06kw4MKfLjYj/X6sV4fLgiQoiAlDjJAgBYHaHGAlARpyEeDbgpw0xI3DztlsJUFbCzi5HEnjzsYxMmiHp7w8ISTRe0c4eBJl5x2KUinnHDIcBuHWqWIkUcMLGSmEQdH2KS4nkaUFKikIR0HG1jIxEBt+VoKUDKAggVUFKEkcQWByXBUikA0DFIgRACQTAToMcKjkEcshoTbngo4UwFn0u9IBQNDPm/c6xryuV969tHSk/MLT8/NPzu/8OzD+cenZx6dbC5/0Gzjf3yisXy0sny08vBI4eHB3P390z8c/tufvrs/+fneoVt7Ezf3pG/uHrm1N3Vjd+rGjsS1dwd/Ouf/dIvu0hbDJ9v0Z7cZDr7Vv3mxOFdvliv5F8P+XK72Yydvo1CstXt1fxjwl2YrlR9SrS6082Js/4L6Tz+21/+q1YVCuVUotwrl2WJlrlRZLJYXcoXZ6dxMZqI6PlnLTFTHxqsjY+X0yA+JJ6YGhyYH4mPR6HA0OjwwkI4NpKORZNyfSPoGpoLBxeHwkaXh5WPNv735+n999MY/fbX5z482/vzi/DdnWl+eqD05NLV8KH1nZ+jS5vjhGceGEX62j6gFyEZYPj9gWBqyzY9a4iGjTKORsGqCNzC8DiEUQlTZDat6IIUQkkoQDsZ5mFKCtEZEakCCBwk5TCkRSo3SGoTSwqQGxDUQpYFIHUQaIcIM4iYJrpfgGgBXSkA1imkpxkAxWpxUobiaIA0Ma2ekDoo20bRKycvsKjaspQaUUIzvHVT0xmSCKCeMSAURqSDK9cTkXYPKjmFVd1LWleC7UjLBsFIwohKM6nsnLYK8BciZxTmzpGgGSxakbEZqNrLlYhs2qm7Dqxa0YkbqNnTGRc66iRkXnrMJi06g4gJrTqhqk9RsklknsuDBWw6g7hDWHMK6S1B39NYtnU3DqlnDyrJBUDYIqlag5UFm/EjdB1V9QM0vqbt65/vR96q6uyczx950Z6xd9SC1LWfaNxO+uG349qHMZ/tSn+0bvXNk6vMjqav7PHf3R746NfyLjzPfnR/56kz6yamRW0fSF/cMntiaPPJ2atea6KZZx0JVkU6AWv0KhPgbDOkg4Q5ctJLuXSETd7WjgHrtki4X3OPFu714pxfvDOA9YVISYZAALgjggiAhDJCiEA0EGcBPiXyk0MuAHlripiUuCnAyEicjcbASpxS0y3Abj9l5zC5F7VLUwSAOBnFQsJlGbVLCKaNdctohw+085pChLgWu42CjFDWzqIVBLVLcwKAqBpVRkIZFdAyipxEjjegoWENBCgrkaImKpOUYJsNRHocoWERIxAQAwSKQFInkOGqW0V6Dot+hH/LaEj73kMczEo4k/P6Y2xHz2F764uKaJ+cXlj+ce35h8fmFxadn55ZPtZZPtZ6fmn/6weyTD5qPj9Xbxf/RoeLDg7mHByYfHBy/f3D43oHU7f2JW3sTn+1OXd+V/o/4r2x1XNlmubJF+8kW/YWt2g+2mvZujL61WJmpNgvF6VxhKpvPvcBfLM4Ui81CsVYqLhUL84V8e21vtlKZrVRb5UqzVptvp15faKfRWGx38ryY5/908e9H/K0X4/9cYXYq28xMVNsZzVTSI8VkuphIFZLpYmwoExvKxGKjkUgyGknGBpID0UR/KDbljTVjsW2lxMWt0z+/uPQPTzb/96+2/f2zzb+58/avbmz86sLCt2fnvjpRfbp/4tme4UfvDZx/q39XzbA6TtaCSD1MtyKqZtTQjJpGBjinW0bIFRCjpVk9Q6hhiAcRlRAxiGAdAKlAWA4hMghVAphWjOlQUokQMoSQYZSKYLQkY8ApA0oYEEqPkEaEtMC4FcatCGlBSCNC6WnGxrA2RmqiWT3F6GjWyErtHO/ieJeUs/G8US1T2RR8SEUm1XBGLUlrulKq3oRcMCQTD8nECTmQUorSamFWK55UiTIK8YQKmtBCkzpJziwpOqCSEy67kIoTKTvQqgtvuumGi6o5iJoNbzjIup2oWOGqDWk40YYTrdqgrEOQd4lKLknVIanZwaYNnHMgCy6iaZGUzaKiWVCwC/K27rx5VdG0qmbtrNsldbtkxg0tBtHVYXQhAC74gEW/+I0g9M4Qs6+sunc4cex1e94l2jCiOzjnPrY29PH26M1Dg3ePDS+fyn1zsfXd5dpXn4zfPzr24Ojw05PJn32U+fVn5a+u1D85lNnxZmDDnGV90zaT0xfGpIkhwOR8DeVfFjE9KNjJQD1SUadc0GEABHqwVyPp1iICPywOYUAfKQ4TghDeGyZEEQoelJL9FNBHikOkKEyJQzQQooEgJfZTIpcccbASOwO4pZBbCrkowEUBfg6xKQgTh5hZuO3fSoIWQuKkETNDWaWUjaPtMsrGEzYes8tRhwLTcaiJx41SVE9CBgo2cqRGinM0pGJwDUPoGdLAkHqaUFGYjEJYClYQDIdiHAaymJgABTggwiQILERgSMJSqFqOW/XSoF075LcPB4Mj/nDSHxl0+wZc9pjH8tKzj9Ysf7jw6Oz88/Orv/p43RfnVz/7cPHp2YVnJ+fa+J8cbzw+Vn10pLx8uLR8uPTgwPSDg+MPDo7dP5j+/EDy1t7U9V3JazuHb+1N3dyTvrkzef29+LXt/S/wX92m+WSL7twW7fEt5t0bBzbOV5vlejY7lc1PTuey09liLlf7cWO/WSzVS8WlQn4hn5v9t/gb/07+C/z/jn07L/AXKzOl6ny5tvBT/O3KP5qppIYLQ8l8PJEbSuYHB8fi8UwsNhyNJKORocFoMhZJ9IWiG0anD86U7uye+f3Vtf99ecN/+2LTn55t/c9Ptn99bdM3lzc8OTP77GTti8PFp7vGv9wx9nx7+uhaz9aianYQq/VhzZi8GdNW+jRZv8rtAVQmDOY4iNKwtI4EeVDEIKgGJJwgboFRPYyoIVgFIhoA04kxA8lqcVqJknKcVtKcnuUttNRGUBacNeGMBaNtGOXAaSfBOijOTvFWvTasVvpkvJXnTHKZRalwqBRepdyrlHsVSq9a5dAqdGae9fJIQiGZ0khGtatG1F3Dyt60XDysAEeU0KgKzmjgshHNa6FpNZLTYjk9njUiRRtacxM5B1B2QxU3WnYhdQ/Z8jMtD1WxYTUH0XTTDRdRsSFlK1yxQ2UbmDeJpp09Oaew5BJXHZKaQ9KyQ7N2dNGB14xgSS/MGgRZqzDrEOQdPWWXsOEHZp1w0y6esYsWnKIll2jR3rPo6Frr7Flr6X4njO3PcctHEh9vDr2elB9bjF3amrr0XvSjrc6Pt1uv7vbdOZx8cmr6+0vF339e/PJK5ctPK19drH/5UevBmdqF/ZltG7zzs9q5Kl/IkPE+QdC3yuF9mdW/1EX/pw6qCxF1MEAPL+hW93ZZQbENERthoZkQBWEwjIL9hCSMCUOoIIyJoyQ6yNIxKRihxWFKGKaEIUYUZsUhRhSkhW41buEkVqnEK0e9POIixR4SCPOYVUnopZCeAe0y3M5jJlJixgEXgzpknJ2XWqWUlSOsHG7jMSsPWziJToaZFKRJimswQI1LjByplZE8AyspQk2TeoY2MoyeodU0KSMxhkRkGMPCiBSVsJgYl3SjEhEOorAQ6Rb1SGAhSYuVcthhkEacxqTbm3IFow5/xO4acNmH/PaXnp9benp24enZhefnlr44v7qN/9mHi4+Pzzw+PrN8rPnoaOPBkcr9w+V7h0r3DhXuHpi4s3/81p7Rm7tHPtuZvr4j9UN2Ji6/G72yPXz9veBn7/mub7Ne3Wq8tsXw0Wbfp5u0VzbxFzbb92wYWZwvFSrlqcLkVK46na9lC/VsoZ4rtnLFVjY/k83PlApz7fxwpLcyV6zMlKqz9dp8vTbfbCy2mks/Ta252E61sVCu/euhnVyxlS/NFMqz5dpCpb5Yri3kSzPZQnNqqj6eqY6OVIbTpXQqn05PJlOjiVRyIjaeTA0G4u7wYDgVHRu2p6fdiTcmcrc2jz7eW/zluTV/vLHlT3e3/e2dLb+/s/m3dzd/88kb315c/fxU5dHBieeHp78+WHmwNXdpafhQ3fDOMD0XAhshuhLRjYRMHodeZ1QxOjkm50FGKiF5kFTClBIkeACTIpQaJlUwroBxBUaoCEpDUBqSUDOkmZc6eIWbkTkpzi6VOZVyj1rhlXEuOe9WyDxyhVeh9ClUfqU6oNIENXKfQRPWafoUqrBcHeHUUakmpjAPq01DOl1Eo/BrlSGzPuLQ2fvV5LheUNS9ltf0TKrEk2pgQtczZezOGXvzeknVhtTsaMEIZLXiigVtOpmGg2446IZb2HALWx6o4YKqNqjhIFsutmolK2607iMafrrqoXJWeEIvmdCDU0Y4bwFzZkk7eQtYtMFlB1pxYtPOnoylc9zQlbcADSfaciEtBzBjF1WNPTVTb8smnHNLFn3gQgCa94OzXmDOLFrvR7YOS8+sc9w7GL+7v+/e/sB3Hya/O5v+6nT89l7XR9t0F3c4ru4buHMy/+3V1//3x7O/vt1cPpP/+L30nrV9GxqOxrRqPEk4012mgRUK798wxr+iFX8tpV6Rga8pRCvkol5VT6e+Z5Vb1NWH9vST3R78VSv0nwKQMIwCIQzwwgIPKgzSUIhDAxwyyFBRGouySB+H+GiJnRBYcJGVBD1S3M1iNgoykZCFQZ0KxqFkrTKq/ZPWJgYyMYiZISwsbWYYI0l7ONTLY24edbCQlQLMFGBlQLsUtnKoUYqqSYmKBjVSVE6DUgpUcJicxZU0psRgFQxqUFhFYRyFoJhYBkIKFNVRrIqkaQlCABAOwpJesRjsFok7MVgoYzCVnFYoGZVeYXIaA+5gyOcPej0ep+WlNvjn55Ze5OnZheVTs09OzD4+3lo+1lw+1nx0rPboWO3h0fKDI6V7Byfv7B+/vXesjf9fsyt55b2BK9vD194NXH/Xe22r5epW4/WtxotbfZfe0V7aJPvwLduO19MLs+VSpVwoZady5el8re3/p/ir5cVKaaFcnG83+eVLM+0CXqvO1WvzjfrCC/bNxmKzsVhtLFQbC5X6fLk2V6rOFsqtNv5soZktNPOlmWJlrlSdL1bmcsXWVK4+OVkbH6+MDJfTqWIqmUulppKp0UQynejrj0QiA4l0PD4x4Bwadw1sK2Wv7X7jVxfWPzvS/P7c6r+7s+0Ptzf9/PLabz5Z+OLCzPcfrf32bOvrD0rfHJ/+5sj00z1TV9cnj5d82yfY1+NEPYRnA3zcpTDrOVbO4HIpLuMRKQ8SPIDKIFQJYyoYV8CoDKV1CKXFKR0tNXEyKyezSnkLz1kUnFut9Ks0QV7lY+VumcKrUQW0yoBaGVQrg8p21CG1tk+rj2iMUaO2z2aKmY0xrX5AaxxSGobkxiG1ZVhpThpMcYMuotFEtNqoUW33q9mMEapbhWUTUDDAOQOUM4uLFmHRIiqa4YoVqDugkhkoGEV1BzbjoVpusumkGi5JwyVpeZCGE67aoIYTb7noqhXLWsRFB1Rx42UXkbPCU0ZoyghnzehP5ResUNEGl+xIyY5M2rvGjKsy+s6sSVSzw3U72LCJGjZBwyKsmwV1q3DGKZn3w0shbN4PtrzidW540SVaCoh2FeX3Dw395mr2l5fSv7mS+uNnpT/eqvzmyuTzD5N3jw/dPJq+dTx3/0zr/rnJ68eGT23rf3fRuVQwZEf5gSji9At521+y5r+kNX9B8X8ppf5Ghr2qglZpJZ06icAI9NjE3V5JdwjqCaKdXnSFC3nNC3X5kR4/1uvFer2EwEuL/CzgZcR9BBzEQT8B+CnARYpsmMCCi6wU4GJQJ41YSdBIgBYGdchpm5w2c0T7gh0jjZgY1CLFrRxh40kbT9pp2MEgDg5zcFh7qc/MwmYW1tGQjobUpETNQFoOUzGwjILUHM7TqIJCVTiiRiA1jqgoTErCKCqSgZAMhtU4JUNxUgwRAERACCKWQLBALO4ExV0ELKJwCUmCUhmhMslNBrPFZLZZjTar4aUvL6z5+uN1X15Y8+TM/OPTc88+XHxyZv7BiebTD37Ef7z++ETj8Yna8vHqw6Plewcn7x6Y+Hxf5ubukRu7hv81u1Nt/Fe3+69t97zA/+lWz5Ut+kubZKc32rauTs02S6VKuVTOtS/hnM5XsoV6u1Dniq1sodmW38ZfKs0WyrPtyl8tz9cqC43aUrO+utVY06yvbtSW6tXFcm2hbbtQns2XZtrJFVvT+cZ0vtH23/7TVK4+MV2dmCiPjZWG04VUspBMZBOJiaHESHwoGYsFw+H4YCQ/5J9KO/rfnkrdOTD/q0sbv/94w9cfrvnN5bf+y63Nv7q05tvzre8vzvz8k9Yfrr7xi7P135wt/+FC7efHpu9tTZ5bCO3P298cZZpRctzHRlwqi1FDSKUighKzPE4rMUqF4moE1eGogcAMFGlgSD3B2nDGynJOpTqg0/dptCG1JqjThPSaqMEwqDPFFbqITNOn0PRrtVGDdkCvj+t0g1ptTKONaXWDWuOQ3pw0WFJWc8xujZvNcaN50GhNakxDCn1MY07ITWm9NWU0D6n1QzJtTK5wOdWqtEXWcMJVG1I2Y0UzWLSISlZR2QaULFDZKqg5xFU7ULUDMx5s3k+23GjLjTfcWM2JND14w41U7JK6C2560IpdMmkU5KxA0YEU7Oi0GZw0gJMGaNqEZE3AT/G/yKS1e9TQMarpnDKIShaobJGUzcKSqadlh2pmUcUoqNmAOS+yEMTn/HDTDawPwPPOnqa7a8MwevfQ0P/4cvHPD6d+fTX4u0/zf7zZ+G+Plv5wZ/aLjwu3jk9e2j9x5r2R3W8F31m0zudluTQ+GIEcboHc1EGoV0Dk/4YSf0Hjf80hLyvh1/RwhxnutiA9dqTHgwoCqDAECQKSnoCkx48IQrjQi3R6kU4v3h2ghUFG5GOEXlrgYQRBCvRhEi8u8VKQl4bdNNQ+YO+kEQcFW0mwXfltPGnhSSOLmRnKzFBmhjCzmIlBzCxqkSJWDjUQkIlCzCxm40m7jGr/c7s/V8/AWhrS0rCOw5Q0IiNAFYPyJCwnESUGqzC4fbcXg4MYLGRFYg4EFSjKwSgJSEgJTEAICoAwIgbEPaCwGxMLEEAAgj0ILqZ4jGE5Kc8pVLzWoHzpi/Orv/543fNzSw9ONO8fbzw5M//kzPz9441nJ+ceH2+1a/7jE7XHJ2oPj5bvHcrdPTDRLv5t/Dd3j9zaM3pj1/DNPemr78fa+K9uc1/dYm7jv7TZcXWL9tJm+YmN9k2Lw81GpVSulku5yWzp3+L/wX8+2yrkZkqFufYmX7m2UKnPV+rzP23ga0/y2y29L9i33x3tvMA/nf/X18pktpaZLGcy+ZGRXCqVTQxND8WnhoYm4/HRwXg6Gh/qD432O8aGXUNvZ9MPD8/+/vK6L49XPttb+e7ixt9+tvmb8wtfnW3+9vLiH2+u+9OttX+6ueF3H8/8/eXZf7g89+2+0Utr/B80vPvzzuqIbMhP2IyEWqtg1SaY1QGkCmK0DG1gaauUcXK0m6Pdcsat4j0auZtTBFmZX6EKG0xxszlhMAzq9TGzIW40JsyWtN6aUhnjCn1MbYwbjAmjMWEwpgzGlN6Q1BqTOlNKZ07rLcMG64jRFDWZBwyGAb1xQG8ZVOr7OVVArg3zhqTWktaZ4ipjgjUkpOqQWWOJWYwFG543o3kjkDcIC6bekkVYtIjyFqBgXlW1C6p2Qd0pmg9gc3606YYbLqjhoqp2tOEiGm6sYpfUnGDDA1YcoqxFnLdJ8jYoa4HG9aIxjSijBSb0YNYiyVok02Zg2gy0n3NWMGcFJyw9I7qOUU33pF6cM0N5I5A39OaNPVULWDYBRaOgZBbVHJKGG256kIYHXO0WLniES33Q6yns2q6Bf/p66e8eZb65aPn+/PQvPs7/7rPZn11qXDuUObktvnt9eF3ZmCtoh9N0X0jodXeaLStlqhWo9DWAXonBqxioUwl1GsFum6TLDna7EIGbEAXwrhDR3YcLwpgwDAuDsCiMgv046qd7vGSXj+oOcqKwDAhIhT6mNyAV+hnITYidOOihEJ8Ud7NY+2qNduW307CVQa0sZuWINmYzQ7QLvpnFTAxqpGEzi1qkmInGjRSmpzGTlDTLaLOM1kkJNY1qacggRXUMoqVhHYMpCIhDJAoCURCIHIfbURCIjIBZTELAIlog4ECJAkV5BGEgmAIhTALBIgACAUgswgERDQIkKIaAbkDSDSI9MILBKETSGK+gXnp+buGL84uPT898frh050h5+VTryZnZhx80np+efXyi8fBo9eHR8sOj5YdHi/cO5T7fP3Vn//hP8d/aM3p779j/J/4rWwzXtxovbTJd36y+vEV1bIPzrcWxRq1eKtZKuWz7Kt7pfCVbqOaKtR/9N3LTzUJuplz8YT+/2lhqD+l/eidHtbr0ouGvfSdPu3VnKtucyv5wNPgF/namcvXxqcroeHF0bCqdnkwkpuKDk4OxicHB8fZ+vj+YjvqGxzyDb08lHh6q/+Ha4rfHy9ffGrmys/Dlh+u+Or/2weHaF6daf/hsw9/d2vifr6z+2aWlv735+v98uOnvP52/tyl2qubYNW17Pa51BUi5HoJZBGIVGGfFGDtOmmnSzEudCs6r4sMqvl/NhbXysEkVsmr7NIa4ShfT6eMmc8psThkMQ3p93GxI6A1DenNSa0kqzUMKU1xjThgsKaMpqTEk2uy1ppTWlNKYU2pTUm1KavV9Wn2fWhvS6vu0pohcE2BkTl7l5fQJlWFQpe+XGwc5c5rTx3Vab9DkHDMSGQM4re/N67vLxu6yWViyivM2Sc64omzrqti7607RnB9ueaCqXVRziKsusmRHKk6s6kJLDknJAVTcQMkpKtjBgh3MWcFJIzCmFYyoBGMa8bjuB/lTJvGkUdRO+0UwZe7N6LpHNb0Tesm0AZoyAJP63klDd04vKhiBokmSMwqzBkHWLCjagaobnrP3LvrAdQPkUhw787bvTw9n/3B/8mef+p6fytw9lL55YPTC+8kdq30bWvaFsnE8STlihMErUptWarSvapSvydgVNNFB4d1KVKJFQSsCuiCxFxT6QUEQE4UpcYTo7CO6wmRPHynuo8AIhfbhaAhF/ZzYTfe66V4/Jw7KJH5W5GOEAanYRYttmMCKSBw44qAwO4nYKbGDEbfn/E4WtUtxmxRv79LpacRAi40MYGZhM4uaGNTMUDaOc8hkdp4xM4SOQnUUapASRo7UsriaRnUMYuRwLQ0rcVBNwmocUaKQGkfUBKrEYBkG8TjEEZAUB6WoRIpKOACQI7AcgVkQpCQAKQFRAEDEYlAoQcSS9t3+NAggQA8AdABgJwhDEgiAMYCgoZeefTj/7MP5Ryebd46U7x6ttPEvn2o9OzXz+ESjPc+/fzjfln9r3/jn+zJt/Dd2DX+2M31779jn+zI/xX/t3cC17Z42/mtbDJfe1l57R/HJZuWhDZ43lyYbjVYpXytNTE5kC5O54lS+1MafLzXbKeZny8X5WuXHLt36YnsNr1RZfJHij1dxtU8B5wqzL/C3e3gmp38AP5mttdOWPzyWHx4ZS6Uz8XgmNjAeG5gciGai0dFIJO33DI/3p97Jpu7vKf399aWvj01+vCby0eLojV2F23vL9w/U7x+oPz7a+vbDtd9dWPfVmcVHZ+f/cHfrPy/v+MUHjfOL4V0lz+KwOW4lYBUOyimQk6OcgeadPO9V8R611K2U+9WKsEYZ0SljWkVEr+w3acMWfbg9aDeZU0ZT0mhMGAxDBsOQST+k0kU1pkGlZVBujsnNMbVtSGcZ0hoHlfqYyjCoNsbVpiG1aUhpGJQZYpwuqtT1qfRhpS6kNoT1pn6F2sPJHSqtR64b1Oj6lRo/b4hw1lRl/9kAACAASURBVGHWmNRoQx59IGGgRwzQlLGnYupqWgUNB1hzQiUXmDOsKlm6y9aemkM844XrTrBkEVbtQMWJ5C1A0QZWXFDBJi7YxCWHpGAT56xAzgpMm4EJgzijE45pRO0Fv0kLMGEWj5tEGaNwzCAYMwgyRmHGKJw0Csa0PaNq4bhOMqEHM1rxmLYno+ueUIumdeK8EZzUi8fU3aOa7imTsOSEZ+zAjBua8SPVILB31vrNJ9Xf3ap8d2n00x39xzd49r/u2b7omSsY8+Oq4TTrCwg5W49Uv0oqf0UhfVVDr9TiHVqkR4sIzChoQ0EXAvgQcRAR9iGCCC4YIAVRojeMdweJ3iADhDikn8NCFOJHQA8vcTBCG9XrpAQeWuShRV5a5KVFDqnISomsBOKkaBfN2EnURorstMAjxV0M6mRRB0fY26drGdTIYmap+IcLTljURONmhrIwUivLuRWsnSONNGKgYCONtN8UOgpWUqCagZU4KEPEGgI1kLgOR/UEoScwFY7wOCQlYZaAWEwiRSUyDFLjiIYkZDBEiAS4SEhIxDgIEhAEC2FMiJAikBQBhEiAirthSRcEdSIQDENiGBKhqOClZx/OPj07s3yq8fCD2qOT9cenm49PN5dPNZ580Hx8ovboWKWN/+7B7J2DU7f3T9zeO9bG317n+3f4r77bd/294PV3vVe3mC9v1l95R3d1k/r6FsXFdxT73vCsX5pqNuZK+UYxMz6RzbV/hCNbrOSKtXypni/V86VmpbRQLS/WKj/s3pVrC8XKTLEy027U/4/s/x3+9q/3ZCaqk9naxHQ1M1nOTJbHJkqj48X0aC45PJ0eHk0kRwYHxwaimWhkPBoZj0RG+vrSiUhycTL+yVtjvztT+f2p0u13kucWBy+9PnVxQ/Lm9uy9PbVbO6vX3y9f31n/bE/zs90zT06t+8XHb39zYuHCusEtU5bZUXO8X63QQiJejavMvNYlV7m1Kr9F3281RCyasEbXr9FFdbpBnW7QoB0w6PqMhpDZ6NcYYkZr0mpPG0xxg2HQZBoymYaMuphCG1Qa+xTmft7az1v7Vdao2hxR6cMKXZ9C16cw9CsM/TJjP6cPS3UhRheUa8NyXVChDaoNYb0pLFc5ZQqr3ujT6KIGfVClcXJaH22MU7q4StPvMfTFDXzahGbNvQ1797xDPOdCGm6k5IUKpu6SpbcNvulCKlagaBJWbVDJKcpauvNWYckhyZnFWROQt8A5M5S1iLMWcdYimTJJJo3A/8vXWzbJcadtvo44sRuxz9hSdxclM2dxVlZWFjMzMzVzq0WWTAIzWzLJJNlDz4xJJlkeS4aZnSfOi/OhzovyaCdOnN2IKzqyP8Cvbr7+Qw80UpGxF12gvlBPNXU9xrZ7pe1eGSqGnnNlkSB03EDLaWo4TjadJ4YOYOgGRwo0cAEdp6HrMva95kkA3tWxnRC2EYbX49CVufLpy+27706+fr3x+qO+Szv2c+uu/amnXeNjSVAJnuSV/4ux/jdR+g8b97CLOKFiS37M4McMPmQ5ghsjuDFKGBKkKUOb8rSxRK2UieUiCWQpS5KxxAUwLqNJCU2wUIywhEQsxCMBFgrQYISB4ywaZ5AICQZEk58HgzwVE+QoL4UYIsgAIc4YYtAABQcYZBH5fTyhCaQu0SErFZRJv0j+lvYzhErjKk1GRTLM434O9XOozqM6j3pZWKEAKwnbadSKgzICqjTp4xiVpDwEqZKEg0BlChU5XGAxjoQFHLLhiIvC3QxpxVAaMDMQwCAQiYA0BpMWgjITtBllTABjNlGgkURXCMKIAQABAyRiJlHjQ//4/dGvHx/8cmv/148P/v7J4S+39n/6aPf+hzs/vbf103tb929s3nt37W9vz394e3r3rcndtyb/Dv/tl5oP4P/61eb/L/y3Lzu+uir/+bL99YvRC8eT3b1T/0f4dzbXjxf8L4r8Rc2/tXu8ONRZXT+1QH2hf4f/wa1uf7jVG2wOxpv90UZ3sNYdrHX6q63urN4aVxvDZrtVb3TK5Xax0Cvk+4V8P5/r5HKtYaN4eSv//fPN/+eNzs9XWnevzn58+eDb59dvHqR/enXj5zf2//Lk8PePj/54ZePmE/MbF6b/983Ld1/ae38n93jFvpbiSkneHqRBFSNsUVlJuzwZxR7XHMmorxQOlDVv1qNXPL6aV2uo3rrXW/VqBa8v4/Mlbe6sN1ALhJqqVlbVkt9f9/vrmlqyKim7lrXqOcmfkwN5e6Dg8OWsSsrqySwketKCkuI9KU5JckpSdKQkV9LqSjk8GbealB0B2aarWsKj5n1qWnGFRWeUchcIR9HuKCS0StlrbfuIqd+0FzKcjvwG/1oMXtfNG37Lhg5sBaDdML6hQ6tey1YAWw2vjHwPT/SV1RAw8VnGGjT1YRMNm+rAzA/OA8jMj0588NiLDD3w0AN3FEPXY+x7zYv43/UYm86luv3EwG3s2FdaNmPHDrQcQN1mqNpO1uwnBi5w4AL7TqDrNHed5o7b1FeBoQZtevDtALkVwXey1GMD9xtHiXfP5V7bCZ9fozabUK8AVbJIIGiU3P+DVv474/3vAvOQk/8PL7OkIcs6bAijxjBmCCInk/jJOLmUYFaSgiErmoq8qUIul9ETRRLK0lCChyMiHJLAsAhEWHOUNoVkMiyRYR4P0kiMw9MinWSJMA6pzJKXMftZKsRLYVb0E7iPMPrpZT8J+XDAR4KLmt/HEz6RCtq4gMjrPK2xpMbhPp7QBcLHoxqHhBcS0IiIRUQswCMaDXgIk5VGHAxmIyArCnkZys/xHoxwQoiHwB0EKjOYLJCCQHAkLKCgDYOtKOSiCTuBCigsEZhAYCQCkghIATQL0iJICyAmQBCLWBjCxFAm1GiiIIBBLTRifOjnjw9/+eRosdj/y0cHP3+4/8tHB/+4eXj//d377+///N7BTzf2772z87c3V+9eH35/vff1td7X13rfXO9/++bg2zcH31zv33698/krzb8+V/rsxdKXLxdvv5D+/JnIZ1e8n1/x3L7i+dNV15fPuf/8nP/lp/JnDsa7s73pZLO5OpzOVqez9elsfXVta31jd2Nzb319f3V1d2/7zPbm8eb60cba4aLhv9jSWeQF87Wjf5l5HUzm2+PZRn+8PZ7tzCY709HWdLQxnWwOJ2vd0WzU2xz3t4b9zX53vd2eN5vTenPaaM2atX690q2VO9VSt1LslPPdQqaVTdZnlcKl9fqNs7V3j1M3zuRvv7j+07X9b68Obq3r//Ol8ZcXSn85V/j2av+9/eS1zdDvL9T+cqXw3L5/2JWDeV6ICqQqCh634guonrTDGfeoGT1Y8UVq/njLG2s4/EVbpGQPl5yhsjNQcmklxVfW9KoeaHqCFYdWdKgVj6/l9Xe8vppHzSueLBkYEnqX0tqsty54q1ZPQXZlJEdi4dsjKUnZnbIqadmVkRwpXk5apagkR52ulFNJc7YIbQ0IrqjgiTNqhHOHBUdEskV5McyIEcmZdeuNgBop+13zALTj/4/DyMnzaexCAr/gB0/F4N2Aactv3gsjBzFiN4xv+tENHVkLwKt+aNUPrQXgmQ8Yq6axaprr4CLtnweQRbe/6zR3HOaBAnVcjwxV48QHjlR44Eb6Lrxrxxoi3LCZGzZzxw50HXDLCjQES0sCB06860GaTqDhMDVdpoZzpWY/0VKWhn7LWMemOrAWMu5ngOM6eapn2+wok6a3V4KLWTAcMysBo9W9JIm/U9jf6ezDOn7Ch/8uSP0uzi0l2aUYcTKKLMXglRr2uyaz1BJMVd6UZw0ZzpRizRFqJcgwYZZMcESChWKMOUwZg6wlwAJhkdMoNCjgERGLCWSEowIYEaV5lbZERCxjpdMCEaPhIAPpPOwRID9LBXgiJGJhGfHzoJcCNYoMcmKYkIIUq3O4VwQ9VlCRQEVEFZHQWSbAcwGR9cuMT6ZUGVck2CVBHhZzELAdw1w07aJpmcAkHJRJwIZjLppy0ZQNx2QUseGYncBtOMYiJoGEBZbgaYohSAaiOJCWIJ5BwH8JYhCIgZGFQAiBTaATZnwQ99Df/3D8jz+e/ucfz/zPP5z++62jX28e/vLRwa83D++/v3vvvb0fb+zde2f3b29t/XB9/v21wZ1r3TtvjxbML34Fvnqje/v1zhevtj57ofL5S+UvXy5++Xzqs6fDC/i/uqr+59POL551ffKM/txjmVO7o63x9ni03pgPRuPpaDyfTNfmq5vrG7ubW/sbGwdra3tbG6c2148ewL+2drC6cbi6cfh/gH803Z5Ndmbj7dl4czbdGs82+pPVyWhnPNweDbYGvY1OZ7XZnNYak1pjUq/1atVutdKplLrlYqeY7+QyzUyq3sxm93qFS6uppyb6E5PQa0eNG+e6b2xlX5vonz7Re+8g9/Zu9qNzjedWY5fH4df2ipe24hsdbzZt80Qcss8lujWXEgn6Mn69oHmzur8cijYC0WYw0Q4m2mqo7g6X1XBFDVXVYEXRKx69ovqrXn9D1LOcmuXUoqjVJF9D8FZ5b0HQ8qy3znjKjLvEKyXZXbQpBZs7a3em7GrGqqQkV0J2JmVn0mpPSdaEIMWc1oTbmfZ6cg5nkpcCvC0kuWK8I8g7goLsl8SAVQzbhIhdirkcGUUphEKZakSbh4hd/8mjiPF8GnssRV6IQEdRaD9k2Q2BhzH8ME7uRYitxepeGFv1QxOveayaRh7jyGOc+YCNELpI+2d+eB7AxhrUdZq7TstAgXpuw1gDpjqyyAUGbqTnRNo2sOU0NR2mtsvScwEdO9CUjC3J0rPDPRVtOoGKvFyxLlVtJ6u2R2r2E3XnI30VGngMY+3EPLS0ljRN0mgnRVbiVDm0nPSd0NWTLveK3XbSIZzwcUsxYSVCrYSIEzHqkTS3nONW0uRyEjOkMXOZPNFgTTXBXOJMWcaY5iwx1hKhTUGGCLNYnIMTHBBnTVHWGGRNfsass5iPgeNWMiZjERGJcLhOIGGG1VgwLKBxHkuwaIxBIjyq87CbsfhZys/hQQENSYifBz2ExY1CHowIEGyApnUO10XIK4OqFdZspM/OBgQqIFB+kfKJlCZRHol0C5hTQL084aYxJ0E4SNJBklYSlwnISoEOknAztMIyDpKwE7iDJJwUaSdwGjKxGMCRKEsSFIYzMMFDtBXiGARiUZjDEA7FWARlYGwhhCBRABEBwmHAH/rnn8/+13+e+6//PPdffzr7gP9fbx7e+2D33nt7f3t39+7b23evb9y5Nr3zRv/Ote4PN6Z33h4tAv5CX77W/vK19pcv1798pfoA/k8vqwv4//q044tnXTcv+y6fT2+v9+b99VF/1pz1B8PxcDQbT1YfwL+5ebixcbC++psevK43Xd2bzHd/mwisHi48PCez/fFsazRd7422HsA/n2ytznemq1vD2fp0ujce7wyHW/3+Rre71mrN6vVxtTqsVjq1ardeHdQq/XKxV8i1c5lmJtUoZCuDemmrk9hsBNYbkaNR+dysetiLn2uHnt+pXxynHx1nnlgr73fiO634qWGu187k89FQJKgF45o/5/eV4v56IdyNhWuhQDUWacbi7VC4EYo0A9G2Fqz7A5VAsOoP1vRAVfVX3b6y21dW9JpNz9h8eZtWtestWW+Lvpbkb9pCbbtasSolyVUQnXnZVbC6i7KrYHUWRE9ecucEZ0awp0VbVrRlRSktiCmBjdrkhN2eFoQozfplW9yupHlrRHRGRUdEkiN2OeqyJVVX3u3OO905NZDJhrRZiN4LGo9jwPkMeT6NnY0CexFgN2w5iCJHSfIoQe1Gia0gvhnANkLoVLMM3CsD98pQMYw8xrkOboaxsWae+CwzPzzzo2MN6rksPRewyPwnGjbTiYmGjVRk6IEHCth3A13V0nGb2i5jVwG6TnPLZmzJho7N1PUgDYepLC0VxUcq1qWGc6VmXypJ/zFQwIHHMFBPjHwPD/wnW0Fj2Q9mNbCkLqfdyyHHimYzeoQVlVoOUcspzphlzBnakGWXC5yhyBnytLFAWIokVGTNZQ4qClCGBeOsJc5BUQ4MsWCIw8IcFOeABGdM8CsxzhBkDTpjUHFjgAVSDjJuQ8IiEBGRAAWHGCLAI0EODtNQlIbjPBaTCZ2H3ZTJzxI+BvUxoM5CPgZUcMCNQgqGBijWz1J+ntBFxCvAXgnRbKTfyYVkPCDiPh738oRXpBWBcXGUnVkMCAknQVgxzIbjdpp0sriDRWw45qRIF009gH/xwcBmFoUYHKZxhIRRCsRYAJdAmoExHiNFghYJlkMpFqYZiGIgCmMYBEIZCyYYkIf+/qdz//jz+f/686P//NP5f/7x3D9+f+bvt45/vXnq/od79z7YX8B/582N76/P7lwf3Lneu/vO7M5bk6/fGNx+rfdAX77a/erV5u1Xa1++XPziueSnV0OfXfF+cVX96qr65XOOL59RPngq8NhxZnW1M+3NRv1Ze9IfjibjyeqDtP8B/Gvz/bX5/sK9b4H9aLYzmu1MV7emqzvT+W+Pdo0mu8PJxnCy1hlsDCdbs8nOfLKzOt1eW91dwL8o/rv9jU5vvdNZXcBfqQwqlV6tNqjXh7XaqFTq5XOdbKaVzbTyxUGt1ug2C4NGdtSoTTvdWa896BTH9fRGvzyuZUeN/LhVbpWz7UquXS5kq/VYthyOl2PReiLSTkbamUinkOjHIs1IqB6LNCPRlu6v+HxVXa9pWiWsVyLBWiTUCARr3kDN7Ss7tKLNV/a4kqo7o7pLblfN5mzIjrrV3XR627w9y9lytC1LW3O0vcg4KrStStgqtKfOKHXWXedcNd5ZEexlwVYS5CIv5QRrTrIXeDnLyimbUnL7qlZ3nnElBWdKcqRkOWGzZRyuvN1dkF05SQlGVcdIJ/dD4OkYciZNHSWg/eDydtC0G7YcxNGjJHkQI7bD2GJpf6pZhoph4F4Zq6apZplqlpkPmOvgWDNPdWAeQBaRf7HeO1KRkYeYeKmpRo696EiFhyowVIGhah4FgK5qWjT/2i5jy77ctK607caWy9J0mms2Q0k8WbOvtBVLW7HUHYauy9hzG/qepZ53qaMtNX2GitdS9kJ1xVJwWNI2S0yCIiwQwo1xwphnLCUWrLCWCmescMYyayjRpjINVWk0L2A5Hs3wSIKFF4d3i6u7EA+GeUuMMyT45aSwEudXgqzBR69oxEqIM6cdaEQyhQRT3IaEeCjAIBEeDbFwkIHCHBIT8ZhMBHjEywABntBoyENYvBSo0YhGIz4a87OUX6QCAhUQSJ1HNRb2cLBXJDQbHZJRvwB5WdjDYqpAeUTezQl2hlUY1MMSLpK0YpidINw86xFpF4/xCCRiiExgMoFJOCrhqExgVhIXMUTAEAaHaQwmYZgBUR5ABQvKIiSP0QLOCBjHwjQD0QxEszADkyQMoySAchbsoV//eHahf/zh7D/+cPYfvz+zOOz5+ebB/Q8Pfnxvwf/W92+v3n1rdPetwXdvjr+9Pvr6jcEDffV6/8tXu1+/1rr9au2LlwqfP5v4d/i/fcF2+1nP+0+Ezh/nZ6vd6WA+Hcx7k8FkOp/NN1bXttbWt9c3dhfWXQsDn4V1/2+zutnOcLo9nG6PZxvj2dZ4ujee7o8me8PxTn+01h/N2/31wXjz3yP/ZL7Zn6y2hhuN/lqjM2+0Zo3WrNmcNmrjWmVYqvYq9UG1Pi5Xh4VSP5vvpLOtdLaTLoxzpXaxWqnWa83GoF6bFGudXLNarlbK1Uq+UMqVyrlSNZ0rZwv1ZKYcLVTCmWokXkvEm/FoKxqpBcOFUKTgD1V9/kogVA+E6osens9X17RaJFiLhurRcDMYbmjBuqJXHFrRqpUUd9LjznhcRaejbLNVZHvJ5qzY3RXSkScdRcpZot011tPiPB1W7dFKh1CatNJkPS3WXeccZd5a5MQsK2Qke4EV05yU4eU0IyREOWlzZCVrShLCNjGqiHGFi7qZkMJHVDmhOtMet5pR5YmG7gYsB1HkIEHsxsDNwIkNv2EnbDmIo/txfCeCbgaRVT8y80Fj1bQI+1PNsjjvXfA/1syLDb95AFs0/MZedKJhIw8x8hBjFR970aEH6ivmgccyVM3TMNzXLE3XctO51HSsNOzLLZuhbTfWHYYF/1XrSkVebjrNbTfQdAJ18ZGG9ZGG45G660RNOVlxr1TcxorLVJFNBcGY5c05Hs6wcI6GigzQEOEaC9U5sMaZKoyhSC8XKWOZhqoslhHJFI/HOfh/Xd0KcEREwiIQ5k0xbvlf8BtDnFmnTWHGEuUscaslwC4F+ZWkiwjLqMaCURaJskiER6MSHpbwoICGBTQsoCER8zGwl4J1FgvyVIAjAxwZFMjfTDg4PEDjGoV6adTDY4pMBETYx0EqA3lYTOUZVRQVXnSyosKgKkcqNG0nCAdJujjGxRE2GuJgcMH/gnwJR60kbqdJEUN4FOYwhMZgDkN4FJFgzAZhLEJyKPUg5tMgtYAfQXEUxkgA5UDioZ//cPbn35/56ZPTP31y+tdPzvz6yZlfb53+9dbpn24d3P/o8P4Hhz++t/+3d3fuvrP2/TvjH94efnNt+M214ddvDBYf31wbLuD/6tXml69UP38xv4D/86vaAv7vXpC+fsZz4/HouePKbG0wGa7OhvPRZDidrc5XN9fWt9fWt1fXtv/1bsfOgvzFiH4w2eqPN/vjze5kczhZG042Hhhv9gab3cG8O5i2++v90cZ0vP2g4TcYr7YHk0p3Vu5MS81xuT6q1Ea12qheHdUqw2J1UKoNi9VBvtzPFrupbCeZaScz7XSunyo2U6VKrtwslyaZ3DicbfrLlUS5HslXQ9lyJFcPZ+vhbDOS7fgT9WCqGEyUwrFqOFYPRqp6KKcGk0owZvPl7d6c21/y+KtOb9HtrWh63eur+UJVPVzzRxpauObxV52+kk3Ny96i6E2L3ozgyfOuvOAuWD0FqycjKXFRLQmeouAuiEpRVIqyuyg687w9y1hjnDXOW6OiFBY5XaJVmXBZcZdL9FkZxca6FcHr5txuzq1JHk3yZEQ1J3qrkt6QfDVeqfDuuk1tq8F6WBsGhA0d2PEbt8LAWgzejILboaUF/PsxZCeCbAahVT801cCxapnr4KLan3jNU82y+Lvqh8aaeR6A1sP4Av6Jhk40bOxFF5n/Yuw39MB9N9h3AyMVnoTxrgY0nCt1h6FhN9SsK3WboW031ewrDaex4TBV5OWisFQSlyuyqWo1t8SHG9aTdcdy1bVScRvLjpWKbaUiLxeFlRyznKMMBRos01CJtlRoc503VxmwzoF13lxiVrLUyTxtLLBQkUPTIhln0YXZZpQDo5wlLoBJCY5IYEQwx3ljgl9JcMYYawmxYIBBkgIa56C4YNHpE0HemHRRIRnXOCRGw1EWiYhY2EoEJczPwSEeiUtESEL8HBzgiYjER2UhJLB+DtdZxClbFB700oifwAMkoTOkKhCKTPhYTGNQlUFVjvQKrCoJHkFw8ZyXJ7w85WEYF007KcpOkzIB8ahRIjARRyUCk0lcJnGJwGw06eQYEYY5CGIQiMMQkcRsFOHAcSeGPSjyWYRkEZKF6cWvAIGRFELgZpgF8If+/udHf/7D2Z8+OX3/4+P7Hx//8vHpXz4+/fOt4wX89z48vPf+wd/e2/3h3fXv3xnfeXvw3ZuTb6+Pv7k2WujrN4a3X+t/8Ur39iuNL16ufPZC7rNn4p89Hf5f8D/H3r7qvvF48uxxY7o+no7W5oP5aDQaT2bT2fp8dXO+ujmbb05nG5PJ5nS6tdjJGU62BpOt3mijO1xvDlYb/Xl/NO+P1hYmHL3BVqe33u5N271xq7fWH21MRlvjwcZ4sDYcrLZ741q7X2iN881Rrj7IVnr5YrdU6lVK/Xp5mKv2s5VeqthO5FrxbDOWaUXTzUiqkUk1MvlaPF9MZmu5zCiWGGrJpqdY1vM1T6rkTZa0VNWXrOupli/R0iJ1bzSvxUpatKaFa2qw4tGLHi2taAlOy7BqStDysq/Au7OiK2t150VHTvBlZF/Wqudlb1ZQMrwjydrirC0JOkKwPQLJIVQKMdaI7IrIdo0VbDZHQLbpoqhIvNPK2x2szcnKTlrSZTkgyyFZjIl8gqfTPFUU6arMVt1C1S20VKnrtXY9wkizzgLOiSbvBG2bmriniWeCttN+cVehdrzkYUTYi7v3w8yB37AZODELm6dRaD0C7YSMW0HTbgzciyNbIWgtCM51cOIDBx7TehCZ6+Ai4V+0/aaaZS0Aj7ymeQBaC2GLmn+x2z/0wEPVPPCYRl5woqFjL9p3wX0XOvIQAx1te8CGy9xwmOp2c1UyVCVT3WqpO5Yr1qWSdKIkniyJy0VhpcgbS4KpZz3Zsa+03Oa6B6h7gKrLVLOuVIUTNZupxBuL1EqFBqoMWKYNRXKpQD1cZcC6ANVFS4FdyVAns4wxy0E5Hk0KaJQBw5Q5ypjjvDnOmxOCKS2bIyIcFcGEYImzphhjjjJgmMVCLJkWiASPJEQkwBgDnClqJ/wirgtkgoIjFBTk4ICM+SXUx0FBDk4IeFCE/BzsZ4mQwIdFIcDRfg4P8IjdbnYJFi+NhAgqQnFhjtME0iUiPob2MbSPYzSB9QqsR2QVgXEJ5KLmd1OUm2EW3X4BtfCo0cHSVop4QL6AIRKBOVh6AT8LQxwGSxRuowg7jjhgiIZBGgYZBOIxXCRIkaA5lKAhlEVIDiZJI8yBxEP//Otjv/7p/P1PTt+7der+x8c/3/pN9z7au/fhwQP4v39n7c7bo+/e6n//9uy7NycL7L9+Y/jV64MvX+19/nLni5dqn79U/vT57AL+L572fXFVvX3F890z9O3LrncvJo9PNSYbv8E/HA4Hw/Gi5p/O1ifT9fFkbTzemEw2e8P1/mhjMN7sjzd7o43mYLXWnVba495w1huu9gab3f5mp7fR7q61upNWpZMbJgAAIABJREFUd9TqrfWG6+Ph5qi/PuzN+71Zoz0oNzqZ5jDXGGZr/XSpk8m1crlWOd+tlQYL8mOZRiRVi6QakVQjlKgF4/VkOJ9M5SOpVDiWT0Y74XDXE6sppbInU3bF8+5ESYmVPbGalmh4wzVPsGILZO2Bot1ftfqqNk/V5io6HDmXLUnrGdKTor0Z2pMmrHFcihJ8DKFDsCuMuCOYK4rZw6gUgjk/wugoHYClECIGUdZPMbpdDvucIc3qdjKc22p1S4KLYzwsEeCJhEzm7XTJwTRVuq1SfZWaeMg1L76v0+ei3ONJ+ShCnkmwF9LiuRh1OohdjNFPJblHA9hjFeFMEjmfgC/liEt57HRk6SD4u1OxpTMh4XQAOvI/vBV8ZBoxDqPgPAJuBw07UWA/AS/gXw0Aq35o4gP7ivF/N+obqsaZH1wNohMfPFSBRc3fd4MjzTBUjSOvZerDJl5i4CYGLnLs4bpetKVADRfQdEINB1iRLBXRXJUsdcdyQXg4y/6PkniyZrNUZaAsmsuipSM90pRP1hzGqhuoKWDdaalISxX24brTUpaMJWalylianKXKGsvMiSLzu/Ii+ZeBAmfIMEtp1pgV4LSAJjkkQprDpCHGGJO8Kc0bMoIhL5sjIhKTkAQPxllLlLJEKCTMkhGeT3FkksPSEh7mQZ2zBCVMFwhdYhMUHCIAjQZ8AuyTUJ2HgwwUY5CgCPhYi0rAXpLwUYzOkCGRittpp2JWrKCPxSIUE6eFMMepHG7nQB/D6SzvFwSfyGkSowiUW8CdPPZg1OekqH8f9Tk5xkaTi/jPozADARwCySRuw0gBQTgE5nFEJnGZQCQYEM0rFGShIAuLQiKJ2znGxrA8hlMgxFgwHiIZEyIj9EOL6/2/f3L611unf7l5/PNHpxf68ebR/Y9P/fLJ0U+39n74YO3OO+M77w6/vzG6e2P+3duTr68Pb7/Rv/1G/8vXe1+81v381c6XL7a/eKH5xTOlz66mvrgcvX058NVl7Zsr3h+ec//1avzls8WjrdpsrTYYVYft9mpnNhhOh6PZcLI2mm4Op9uDyU5vtN0ZbDZH8+Zo3hrO2+NZbzzvDKfN3qjRHvS7673O2mCw2W7Pu/2NwWi73py2++uN1rzeXG12Nlrd7Vpns97brXV3ctXVZHWYrg7T1WGy3I/nO5FMM5puxjKtYr6by7aT6UYk1Qglm75kXY3XlWg17EsGfZlEtBXyt7xaw+tvubSKFmm7vE2nWnd4q3a9YvdXZb0heBuM0sTDCUiLwN4IqacIbxK2RyA5gtrjrEfDZA8h+hjJSzIiSdIcIQm4U2QpiaWcHOsThCAnRGk2w0sVq7PBM1WGbAnU2C1OPfzIQQzt2MxDjmzgzA5uKuiOB9r3gI9Fqatp/qkofjHOP5YQHkuJFzPSxZz8aE5+NCefz8tn88T5IvVoiT5fpM7k8OMMepxBT2exwwRyOkMcJdGDOHyYQPai4HbIvBsB9tLkdgJbj0CrIfNq2LgaNq5FDKvhlU0/uOkHNwLgRgBcDQBzv2XqM01000Q3Tv2medCyFobWI/BaCJn5wYnPMvQZB5phoFmGGjTW8bGPHKhE1433VENPXe57VwaaYeBbGfhW+trJvnZy7AS6TnPVZSwqppLXUvKYSw5TUVrOS6aCbC7KQEGy5EUgJ1hygiUngAXbcsVlKdmMRWm5ZrNUJVOFMzYkoCQZS5KxIKzk+eU8v5zjlrLsyQxzIsOcyLInM/xKljdmBHOGB1ICkOTBNI2nRThlNYdFc4hB4zSZoZAsYQxJSFCEAwL0QH4e1DnAKsEKD/sY2MchXgnzWomIjc5ITMAKBq1IyIaFrJRfJDWW9FCEmyACDOZnCR9DqxTjpCg7Rdl50iVRC+u+qEiGJTLAYz4O0VjYy0ABjnWjgEoCYSsWseF+kdR5VmMEHcFUGFMRQiVYhZJshCjjokxKAkhwCMrgIE2aaNzII4ADIRSEA3kIYJYQ8ncUsSwQmIAzJALClodJiGQwSiIpK0VaCcKGkVaUsaM8CAswhJOoUSKXfoP/14+PH8B//4NT9z849bePDu/dOvr548P7N3fvvrf2/buT72+M7r43/v7d2XdvT755c/TVtcFX1wYL/j9/tfPli43PX6h89mz2s6uJz6+Eb1/Wb1/y3r7k+eJZ163LsSuni5uble5qvTGqN7ud4WB1OlsfT1YH49XBeLU/We+NNtr99Vp3Xh/N6oNptTeudEe17rjWHdc7o1p7OGzP+81prz1r1Ue9znzYX2/WR53OrNsbt9vjTmdSbw3LtX6lMaw0xrlSN1moJQu1VLGeLtSSuUo8VYwlC9FEPpFpRFK1UKLmj1f0aNUbKavhkidUVKI5RyCjRCpWvSiqBdFXoJUEq6UIZ4ZwJQh3lFQitBqh1RjpjuPOOC8pNOfgOKcseiRB4Wg7TzpkVvHLjF8QIrItZXVkrULFJXZUpe329jR5oMlTv2Mn4j2KaYchz2HAeeR37kY8mwHndsB+EHUeRGxbfnpTI3YDzOkIfzYmXkjLFxL8hTh9uSA+X7VdybNPpPknssKTOfHxvHghy5/NsKdS1FGSPEqip1LYcRo/TuOnUthREj1MIEdJdD8GnUphB3F4PwYdJpD9GLQdMu9Fwb04shOFtsLmzZBpK2zcChs3Q4aN4MpOGNwKWtYDplXdMPMbZn7DPGCcB03zoGUetMwClnkQmAUsC/LHmnkSsIz9wNAHDLzgwIsMVKzvwXsKsdjq73vNPdXQ9ax0lJML9e2mls1QtC3l7Ms550resZKTl3P8iYJsLlotC/hzgiXLm3OCJS8CGfFk3rqSl5ZLkrFqNVdEc5EzlFlDQTAulOcNWXY5wyz9S8sZZjnNGjOcKSOYM4I5JZiTvClN4ykBiouGALOiE2CExFMUkqVMEREJC3BYgEM8tFCQA4McqDpIXSYiAhESCV0mfFYiLJEpjtQli18G/BLkl1BdwBbnOhpLRsSF5Sbj4ziFZZws6eQJp4j7GFRnMT9PBATSL5K6QOgC4RXwoMB7SNhDgwEZ00XEw6EqR3s53ktQCk4oBKXQjItiZZyUMEomGAmmBATjMZBDjRxq5BFARnArymAshjFmgjzJoAYWRjiY5hCUQU0iQYokJtGoRIMSDcoMZmMpB8tBAItYUAowc8jKQ4sb3l9unfrl5vHPH5366cPje+8f/fje4Y83j+7dOvXTzaMfP9y++97a9+/Ovn938sP7kzvvTL99a/zNm6OFFinAF691v3ix+Onz2U+fSX76dOSzp4OfX9U+u6x89qTzT8+pNy4nHj8uzzdrzXmjNGlUBoPmYH0wmQ4m0/541hlOmr1RrTuudia17rTVnTQ740Z71G5PO51ZrzPvtmed1nTSWx22p4PWpN0YDrqz4WC12Rh02uNOr9vqtFuddqXRzJXKhUq1XG/ky5V4Nvub0plYKh2NJULhqD8QcqdLrlTRmcjbwmlZj4veiKCGRSWEe8OIM4A6w7A1iNiDuNMPWxXE7uadEcEZEN2a7FFcqkfVvKrm9Xp9Zaev6PBUXd6W6mup3obL2XS7Bj7vts7u6/Jx0Hk6YD/rFy7FHM+l1MsR5bE4fzHGPRkXns5an8vbn85IT0XoxwL42YzzOGk9nZTOZeTzWelskjmbpC9k+ct569Wi/emK41JBvJilnyixl2r84yX6iRzzRI55PM8+VmDP5ajjNH4Qh3dj4H4MWeggjh4l8YUOE9huBDiIw3tRcC8KHiaQgzi8GwH2Y9BOxLQdNm6HjTuR37QdNmwGl7dD5u2QeSNoXPOvzAMrq0HDatAwDxlWQ8AC+4luGnlNQ9U4VM0jr2XsB0a6ZegDeh5LVwF6HmigYiONGmrowAv3PGDHbem4TR23abHw23GYatblonQiK51Iyyey0okMfyLLPVKSzGXZUpLMRdGc5415zlzgLSURTPEnk8wjGX6pKJqKoqkkmAqcMUOcTDHLGc6Q5Y0ZzpBilpP0UopZTrMrWRrK0lCaAdKsOcUZU9xKUlhJCitJGlvAH+KMIQqOUkSKQVOMKc4jcR6JcXDsX4OAhXQHHbXSaZGOi1TISvmtZEQg0iwRkMx+0eQXLX4R9AuQX0AWm/khCQmIqI/HFw/pKALlEjGnAKs07mUIjSW9POUTGU1iVIFSBcovcwqDejjYK2EuFrTRkIujPCLvYlknwzhZ2sUxNgoTUIuAWmQCsqKEjKISDIiQSUTMPAJwGMJgGIrCJGmRGMBKwlaUEUGOAwkWBgUU5lCAxYwMYWRpM8MADIsyLI4DBGnGaAvIg+BDP988+vnm0U8fHf704dFPHx7d/+DUTx8e//Th8b2bp+/dOnX/o8O/fbDz/Y3VO+9M77wzvvve+Lu3R9++NfzmzcG3bw0XH7ff6H7xWvuzFzJ/fS7x12cinz4T/vQZ/6dPq3++7PzTE7ZPrmjXL8Yf26+uzRvNcaM8qJe7vWpn1uy1OoN+e9hv9HrlRrvQaJdbg0Z/Wq+0m7VurzEadWaT3vqkszFozLvVSas3bHT6lUa7VG81uoNqt5+rNbLVerZey9SquUY9VSlHsqloLh0vZMOZZDCd8icTejzmi0X1SMQbDCq67lK9WNCPB/2krpOqh3A6KZuDtjk4u4sUnBTnYHlFFFWHVfW6NF1RgppSCaRrwVgrFOpG/OO4tprwbST928nguWTifDp+MZd8spx8ohR5LK8/WfY/3Qy/0dLfaPqutfTrNe21ouN62fVW2f1a1vpiVX6uxF8pMJfz9FN54vEcdiENnk1ZzqSp4yRxLk1dzDNPltgnisylIvN0Vbic454uS09XxSeKzNksdiaHnC1ipwrQ+TT8aAY5n0XO5pDTWfgoAx6kLLsp834M24uie1H0II4fp+kzWfZ0hjmVov4d/kVGcBCHj5LoQcSwH17ZCy3vhZb3w8b9sHE3uLITWF7TT24GVxa5wEbEuB42rAaXx/ojs4DlAfkDj2HgMQ08pqFq7nvNA80y8II9D7iAf+TDZgGm7yV6Kt5R4LYbaruBrgfqa/DAh7Tc5rrDUJJP5qQTC+WFk3nhZFE0FEVDUTTleUOOM+R5Y1EAKjKc5k7GyIdT7FJBMOZ5Y1E0FwUgSSwl6ZU0a8zy5gxnSjGGB//mGTLHYGkGTtGWJGtIsstx7kScfzhBoWkRztqAjBVOilRSYBMcFmWNi/d2Ejzym/0uA0YZMMZCuoCFWSzJEkmeDFupkJWKimSGI4NWU1C2BCTzgn9dAHwc4GXMGmf0MCaFAhQG1QRSk0iPhLlFSOVITaA9POnhSVViPCLt4giXQGoSqXCoIuIeibDRoEQCDg5XJNYmcjaBtfK0jcMkEuBRg4wbnIzZQRI2FLWBgBWwWCFAQEEGhwkcIiCMRSEbAbgJwonwNkAUAYoHQc6CMADEwiBLQAyDkAwKE4gFhVkA5wFcAAkJJB+6/9HhvQ8Pfvxg/8cPDn784OD+R8c/3zrzy8dn7986c+/m6XsfHv7w/vadd9e+e3v63duTO++MF8A/0NfX+wv4P30++dfnY58+G/nrs8G/PKP/+ar6x0vOT56w3bqoXDuKPrlR3hk1h716u9todPq1xqQ5aDb6jWq7XmjWcvVartbIN1vFdrfQrJWbzWq73egOW91Joz2p1Ublcj9ZLaZqpXApGynnUs1KrF70F1LeTMwdSyqJhC+d8SaTrlDIHQy4Q7pVU2yaT1a9glsRXYroUmSnIjncot3FOgXJJdncVrfL6nXJIbc1qTrzPk/Z623owW4gOgwlZuH4Rjx+VEidraTPl8oXy4UnaunL9fizjfBLzchr7cQb7eRL/dzLw+yr48zrs8yrk9hLk+Cr89D1zei1tcRr49Dr0+D1WfiVge+ltufltvvFpv2FlvP5pu1KTXy8yJzL4Wfz+PkycaFKXSyTF0rEE2XqUo29UuMuVakrFepqlb5UZJ6piVfr4uNV+nwRP13CjsvY6Qp+Ng2cTQPHacupjOUwYz7MmPcz5r3swl0P2o1AB3H0dIY6m2POZOnjNLkXBRfw78eg0xniOI0fJpBTKexU3HgYXdkPr+yFDHshw27AsOM3buuGVW1pK2jajlg2Q6b1sGkjYl4LGcf6ybHPOPYZx5p5rJkX9/mLvZ2exzLwgiMfOtSQngfsecChhkwDZFchOgracsEtF9xygW031PVAPRWuK+aaw1C2LhWFEwX+kaJwoigsFaXlorCyUIEz5NmVAmcsi5aqDBZFU4o6mWKWs7wxzRrzIlCQ4BRjStDmNAdmBTjDQykWSDKWNAfmRKTEcwWWyjBYigbjlCFOn4yxJ+PciRiFpkU4bwdzViQt0kmBjQpYgDPEODjOIwkBjfPIg8gf42AvA4QoME5CMQYJiKhPQoMCmmDRoAgsFJLAsAyFJFjnLBpj0gSTwpndDOhhMZ9I+a20JuOqCHt5yi9zXpFWBUqzcqrEuDjCIzOqiCoc6pEIj0TaaVSmYCdPKBJpEzkrT8scITOISJp5dNlGGhTeYqdxO47YIdgOQHYIllFEIGGGhGSCk3BUgo1WALRZaBsgyhAjIIgEihLEixgnUJxA8zTFwxhrgWgBAEUQkWBKRuiHfrp5tOD/3oeH9z48/Onm6V8+PvvrJ+fu3Tz740fHP35w8MN7u9/fWL/zzuy7tyffvjX89u3+N2/1vn6z+9X1zlfXO7evtb94vfnZq/XPn08u+P/Lc5E/PR38/WXt40vKrafcnzzmffMoenm9cmrcWe03hoN2fzhodSetUb3cKqWKyVghkSxlk5VCrJAPplPeUsiTDym5kDsT9WQSSiqlxFPuWNrhdythr83ndAQVNa7bwx454OI1m+BWZEVVdN3r1zXdGwhq4ZBP113BgDfgV/26J+RXI0EtEfanY6FMPDxM+idJfZ7UN1P6fsZ/thB6vBx5qha/2kq92C++2K++3K+90Cm/2M5dm5TfnBWfHxVfnuRfmaVfmyeuzaJvzmNvzRPvriavbSavb6Wubyfe2Im9uh16ZSvwym7g9YPws2uxS2PflZn32XX/lYn+WNd9sWO72JUuFcQrVduVqu3JsnShyF4scY/X+Ccb4sUqcbFKPF4ln6yzT9bZp6rMkxX6yQr9WIV6ssE9UWcvVJlHK/SZMnlcxM+UyTNZ+HQGOkoB+0nzXsK0kzTtpM07afODNH4vZjlKwccZ9FQaOUxCi1L//wP/URI9SJj3Yots37gVNG0FLZsBYEMHFjZemyHL3Lcy1VfWw5aNCDAP/pbqj7ymiQ98sMw7VIGRD50GiFmQHOtYX4U6bktXAfoq0HIjLTfSdMENF1B3WupOU81hrDmMZcVUcRoq1qWqcLLCn6jwJ0ricllaKQpLRWGlJBqKwkqeXSlwhpJgLouWsgzkeWOWMaZZY4o1ZwUwK6NpEU4yYJqDMzyS4ZEUC6VYKM3BWQEt8UyBIzIMlqTAOGVJ0OY4a0pwxjiLp0U4J5lTrDlGoWGWDPCIJhjCAhyV0MUC/6LgX2z+eTkwTENRCgrTkMZDbhHSeCjIQDoH6Bzg58GQhERtWNSGhSTYzwMBB67LmCYSPpEJWPmgTfBbaU3ENA4L29iARGkiEbSzupXWJDLk5DURUXlEE0hN5NwM6WRxRSTcAuZkSTuN2yjMRiEyAYm42UqBLh61MbCVhK0YaodRO4w6McxJIi4KtpG0jYDsqMmJgi6EtcGiAFMsDFph2YqIEsqJGCPgDIuxFMLhCC8BgARBAoJwCPrQvVtH9z8+df/jU4s5//1bZxa6+/6pu+8f/vDe3g/v7d59b+vujdU770y/e3vy3TuDb97q3b7W/vKN1pdvtBbkf/pK7bNnU5+9kPnshdRfno3/4Wr440v6R5d8Ny/rH17WXjkOXVjLbQ5K7Wa20soVO5V0vZ4qRcPZkBbzesKqEvYqYZ8z6LPpKu9jWS/DqCzvkQTVLqseWfVKHq/bIflUp8suKm6b7lNUr1PzuVWvMxvx58K+aiLQTIf62eBaLbHXzm43Ewe99FEvczzInR7mHx2XHptVn1prXN5ovbpee3W1+tq89Po8f30tf2Mj98F2/uZO4cZB8sNT+Rt7hXf3S29tF19dT13byby2nXxtI/3GdurabvzabvS1ndArW8GXNyKvbMZf3tBe3tBe3PA+t64+vaY8vaY8ve59ZkO7PPE/OXJemjouz5yPD5yPduzn2vxxA32sIj1Zly81bZca1ksN6UrLeqUlP1UXzlaIc1Xy0Qr5aIW+WGEuVtjHK9zjFe50BT9XY85UqOMifrpInsqg+wn4KIkep+BTafgwCe4ngZ2kZSth3kiaN5LmnejSduTkduTkbmz5IGk8SpsPU6b9hGHR5N+NALsR4FQKO5XCFiXAbty8EzVvRyzbEXA7jGyF0A0/uuaD133gdhDdCMAzr3niNa8HkY0QOg9AE59l5DUtDHlWg/hqEJ/qyMgLzkP0QhM/3lehRXnfVcxNN9hSoLYHbnvAlgI0XKaaw1C1r5RVc1Ux1R2GprTSEpab0krdaqrbzWVppSIbKrKpJBoK/HKOWc4xy3l2pSJBZQnKc+YUY8rwQFqEUyKctWKL1y+THLL4eKACh+VZNEVDCRJIUGCKgdMClpWIhEBmJCQnmVOMKUoiIYbwCbAirAREOCSjYSu22Lf1cYBfgIIS4pfgCA/HWCjIgR4BcMqARwB0DghxWJBFgywaEbF/vb2FhQU45KIDdtYns7oo+iUpbJVCMh+UmQCPJJ1szEGHZDzqpEM2IiBjcQ8ftRMBEdcFUud5L8OoHK0JpJsBvSSmEIhCogpDOilSJjAZx60UaeUAmYFkEpdx0o6RCk4EKCzKYhKGOWlY5SFdID0Mb8cEDkEJxCAghIjiMoHJBCITiISjMoLLCGlFIRsB8QRAYqaH7n986qdPjn/5w5lf/nD259+fuX/rzI8fHf/wwdGdG4d3bhzevbH/w3u7P7y//cONjbs3Vr9/d/bdO4Ov3+wusP/8tcaC/L++XP3s2cxnL+Q+fzH7l+dTv78S+eip4EeX/DevBK9ddj15oGwPg/VKMJT0eJOKM61LMd3mkxx+q0O3Sx6ZsrG4xFAOQfA4fRqr+7iQbouH1Ww0VIgn8rF0IZrupBKjQq6ViHVz6Um1NKoU583aaqt+cdo4Pyg9OihcHOSeGmZf3Ki+udd4Y7v66mb+9e3i9Z3ym7uVd3ar7+7V3j9sfnTUfvdM861TtbcOSm8fFd47Xbx5tvDxo8VPLhRuXAi+/1j82nHkzbPp189mnz+Kv3gmcfUw+NZO9O392DsH0TcPQq/vBV/aDjy/GXx+I/rqhvuVdfcLa85n586n5+4rq54rq+qlNfVK1/n0UH5uKj4zEp/syk91bU92+bM1y9kmf67Nn21xZxvshRb7REe42KTPldHH2uLFlnChzp+vsucq3IUKf7EqXaxKh1XydIM5LBGHeexUnjxMYDtBYC8M7ceBgwS4nwB3k+BOCtxOAhtJy0bSshs/sdB+cukwvXKUMRymVw5Sywdx+CAO74QtC1uuwwSyE7Zsh8zrUeN61LwRBTdjyFaM2IzSa0FqpuNzFdj0o5sBbFWDZj5oI4SvB7GJD1wNwhOf5QH862Fy5kdHKjwPsvMQPQtSYx1bvNK78O1puMwtBeh64b4PGehozwd2vJaWx1TVwYYXaCuWgd0ysJkHdkvHBXUUuGYz1WymqtVYlox5bilLL6XJE2nyRFkEazJW4MEUY8oKcEqA4hyUsREJFo0zyL8rRsMxGs6xYJYBkhSQIIEEBWc4MiexBauYEMicFSvawLwIJVkiwlE+AXYKy34JDlrRsB0PWlFdhDQe0EUoICN+GxoRkRgHBwRIsUJOG+SxwQEZiYlshKdDHBHmyZhExWU6KuFhAfXZGa+V9gqsxgu6KIUka0gWI1YhJmMFVci62agNjzvIoIT4BSilsGmFCUt4gKN1ltNo1scxukAotNmPwRoGaTjqY1gPw9pIWkBJHqNFziKykMgQEknZccpLUHGazDOklcbcAqLbUF0m3Awj4SxLoCxt4TGLlQLcAqLJ8P/b13l1xZGl6br+wEwVLk147yO99y4y0pEYAQKEB+FNGjwkTkhIIEBewiUgqaTq7pnpqprqVsn0zKxZ54edi6jRqTNurfdqR9w++/PfdguAiwadBOjAYRuJmGmIowwYXvPN//lh5d/fLf3b24V/fb34r68X/3a1+Lk6/+mi/OF85uPl7Kfq7F9Pxz+c3P71dOTD6dBfXvR/eNb34VnfXx93//Ko45fD1p8f5n86aPzpQfZPh01/fJj74SD9di96fddfveM62zKfbprurYZmR50dreak6gxFfS6P0+m0e9x2n9+pxLwtarBd8bSFrDf85q6ouz8VGc8G55oi8zcSi62J1XblTlf2fm/jXk/u7uCN3YHmOwO57f7kdn98dzi2P5E8mk09nos9LSSPZ9Tn5caTpZaT1fzlVsvFZuP5UuZsMX26kDpbTJ8vZc6XMqcLqVfl5PlG5qySPqukT9dTJ2vqyxXlxXLi+VL86XzySVl5UlaelhNPy4knpeij2dDRdOBgxrs/7Xkw5d6f9jyc9T2c9e1Pe+5PuvZGhL0RaW/YfG/IcnfQfKdf3Olnt/uotZvs5i3xTr/57oB9u8e81iEsNFPFHLbVRO20MJt5cqOR2mnhtpu5So7aaKSXWumFZnKxmVxupZfyxHwWnc+iK81UKQ8UG8FiFipk4FIKK6p4MUkWk9RcEphSDNNJ47QCjMV0Q8G6oXDDWAIop5C5BDATM8wlgNm4cTqqn4kZCgqo6evhVEQ3GW6YDDcUkrqCYigl0UICnwiAk0FoKgzd9tZrbv9tn/62Tz8WhrS9PYM+45Dnu2EfMBKmR6LkUAQYDOmGfcCol7rlA/uCSH8I7Q9A3W59h6Pmpr2m01F701LX7wGHfFiXw9huabhpN97ndHqkAAAUvUlEQVS0G9ssuna57oaprlWubZVrm+WaZrmmSa5pkmuSQq3C1yh8jcrXpITaNF+b4mqSzLd5rq5RqFe5uihTE+XqkxKoSmCCNWZpKEUYU4QxS0NZGkqTQJoEsjQUIxoU2hBnDBGyIUrpFB5URVjhQT9VG2EaYowhShqiNBBl4AADOkmjk4f9ZtwvYz4BjshoXMa0fT5JOx0SUA9u9OBgiMbjPBfnhQjDujjQyQIOxuhgjE4WcPOQV0R8Euq0MjaRtAt0wMwHTWxAQMISmHFiASsYtjJxsykmc2EJ8QuAR0DdPOeVYY8EuUXQIyFeGfXKuEtAHBzkZ2p8dK2P0vkY2ENiNgSzQqQNZuw0ZcERCQbMsNGBg34W0x72FtGaiBnO2cA2i27QAfeakBbM2ARDvRQ8INLdAnODI24IVJtEtItwlwkZdOi7raBKG8ME9M1v5L+Z/5frhX+5XtDg/3he+svp1K/VmY8XMx/OJj6ejX06H/14PvLh1eBfn/f/5VnfL89u/fL45s+Pbvx81Pzjw/yPh43vH6Tf3U99fz/55l7sejd0ecdX3fFcbLsP50Nrw/aZm7aJdt9EhzLWpozeUMbbkxNt0VKXst6X3OlLbPdEd3pje0Opg7GmvbHIwUT8aCZxPJ14NBN/Xki+KqdPSulnxfbnpbYX5Rsv5pteLOReLqZfLadPVlLna6nqev5kKXO+1ny50XKx0fR6N3+5k7nebLrayF9t5C8rjZeVxup67mIte7aS1mh/thh7uhB9Mh95Mh95uhB9uhB9XIo/KsaOi+HjudDxXODRXOBoxvdwynU443s47dV0NOs/mvU/nPbuT7rvDQr3BuV7A+a7/bbdPuudXmm7h9vuoTe7hK1ucfuWtNklrbVzyy3MYhO12EStNRGVFmqtiVhtJDda2PUmZjlLrOTIYg4tZJFSDi03YvNZtKCCxRS0kEGLjXAhixSzSCGNlFJIUUWLKlpK4gUFKCjAXBKYU8CphHE8apiMA9MqXE4hBQWcjRtn48aZmEEjXLsCvkr7qqmo6otJsKxic3HsK/yjvoZ++9/f9tZrL2pPxbGxMDTg1ve5dcPemmEfMBQkh8L4QMjQ66vtddT3WaHeANwfQvtDaJ8f7Hbru5x1Xc66bld9p7W+12XsdRlv2vTtloYOm0F727vd0tBmrtfUaq67YalvtdS3WupTQq3K16S4mjRfm+Vqte6dNP1tK9/QJDak+foEV5fgdaoEZmQ4KyI5FklToFbYS5FAEjekSCDHImkeSvNQgjVGKV2U0sUYQ4IDEhwQ4nURXh9njTHKGGPAmIBFJDwo4m4GCkio1qgbFKCQCId5MCJAYRkPCIiPgT0U7KOxIE0GKMJPkh4B9kmoX8YCJtwvYz4J9QiwR4BtPGbjULdAhS1izCpEZSJhRtIO3G8BgmYqKksxmYuasKAEeUXMzXNOHnQJkFuEPRLmkTAXjzlYxEZDfg7w0HoXBbgpxI6jZggxgagMETaWNlOECYNNKGDDARcJeWjES0NRXJeXkRsy0CnqRqzIiIT20cgQQzezeJuZb5LFlMimJC4pEnEWjDOG3hDf5hEiPO6msG+0qZ4vV8Uvl+Uvl+UvlwufLsofz0u/nEx+uJj+VJ39eDH1+WLiS3X8c3X04+nwLy8G/vlF38/Pe3960vXjk44/H7f+03HTPx7lv7+f/P5+8u2e8vpu/Ho3drUTu9yOVrciL9cCj8ruoznPi4XI6XLq5YL6qBA9nA0/mYm+motfFCNXpdB1KXBVDlwuxq6WE6el8GkpfFaOnC1GT5eiJ4uhV8vhs7XY9VrH1eqN6/XW15Xm1xv51xuZ643UVUV5u51+s5OrVlJXm7mr7ezlVvp6N1XdiZ5tJM82kueb6vmmelpRTtYTmjTyH5fDx8XgcTH4uBx+uhB9vhR/Mh95VAocF3xHc97jWc/xrOdo1nk0ZT+YdO9PuDQdTLoPJt0Pxp33xxwa+fcG7Hf77Lu9tju9lu1bwnYPt9Mjb9+SNruE9Q5+uZVeaqaXmumVVnatlaq0Mast5HITudbKLOepchqdz2CzKXA2Bc6loXIGKaXhYhIsKEBJhQppopDG5lJoUYWLKlxSoZIKlVSgnADKSaichIoJsKCAReW3e0Ej/7egIGbQLPxURPefyJ9LAJqKqr6gAKUkOhvFxv3QRADU4B9wfHvbWz/qN0yEwOkEPhaG+l26Hmf9iK922AcMBoiBINof1Pf563od9bdMxi6PsdNtuOnQddjr2q017dZvO2zfddlqepy6Ww59l62hw1p/06a/6TC0W/Ua/JrarA1t1obW/4C/SdLlxYa82KDN87SIuia+Ps/VdfC6Fq4+x9anuYYUr09xxqwANktYWsRUHkkwYJwGIoQ+QugTDJgWsbwJzwiwwgFxxhCj9RFKF2MMCg+GBX1MBBUeTHBQgoNjAhYWiaCIh1g0JuERAfUxYFCEwzIalOGQCdGCcy+HBAQsJFJhgQ6whJdCPRzoF5GgjP32Aw9p8gi4TyJDMhOR+ajMxGUiacZVCxK0Qb+HPyTDXhFzcayTQ90C7pVIn0x7pd/q/3YG8wukm8YdBGIjMQuGiTAswrCM4CJDSBQuUohMwWYasjOIk0VcHGrHaryM3kPX+1hdTIaiAhCljRkJj7OUIothUXKzrJvnXCxhJwA7ro+a8aBE2HDAhELffLkqfr4sfKrOfboofq6WNJ//17PiLyeTv1ZnPl/OfapOf6lO/u1yQoP/55PBn14N/Pii95+edf3pcdufjpv/cJj/4WH2/X7y3QP17Z7yejdxtZOobiUuNpTzSuLpZuzZeuhkLfh6K/r9Tux6I3S27j/Z8F+vKK9X4u9WQu9X/O/XfG8rvqtKsLoe+GE59f1S8u2y+q6Sfl1JVdfiF5XE1Xbq/Xbr242m67XM9XrqdSX1ZkN9s6m82YxfVkJXG9GTldD5evyikjirhKvb4bMNz9PFwPPl0MvVyMvVyPPlkKYXK+Gn5cjjYuh4LqCZ9MMZ3/Fc4HExdFzwHs6696ds+5PW/Unr/qT5YNy0PybfH3P8Xnuj9nu3bXdHrHuDlr1Bx96A816/526fe7fXttNj3r4l7PTIOz3yVre40SmutrHLLcxyC7PSylZuchud/HIrOZ/HF5vJcg6fS8GFNDKXhjTyF3LYQg6bTyPlFFxOwbNJcjZJFFW8qKLFFFRSgVLKUErpFhLgsoosqnApBhQT4EIKX0jhRQXRntOajup/b96/oq7p6/lMzDAb183E9HNxZDqMjHqBiQA8HUbGA8aJoGEqDIwHgbGAcTwC3w4C/S5dv0c/Gqgf8YP9PqzPD/cH9UNh/ZDX2G+Db3mAbrfxpkP3H0v76rUJ/+EA3Oc2dNt1nXZdt9PQ6TR22PVt1oY2c0O7Rddu1bdb9TesuhZzfaOpNifXNEu6JrGhWWhoFhpuCLobgq6Fq29h6jrYhhamLs815EVDhjckaV2a1jfxiCqiqogmBSTOgmFSHyb1cRZMSVijjKU4MMEaFQ5QOCBK62OMQRXhEG+IiaAqYykJVwQ8zKBeGnKQYJzBVImM8mhAg9+MBcxI0Ib5ZcLFwTbK6OWQmJVN2qWIzHgZ1M/DQRENSVhQRP08HBCQsIzHrXTERMQsTFRmghwZYvGERKgWImPBI040bGUikhgRmYiMfoXfxWIenvCJlE9kPDzlYn9TQJLdLKdN9ZgIQsIwCcNMFMnQOEdjHI1xJCyQoIAbRFwv4norClopRGYwk0jZzJyZI0wk7OEpG0E6aE7EKALCaBTnUIxHIAk1yjRgZmABNZow+L+H/+N56cP5zKeruS9Xhc+XM1+qk1+q458ubn94NfjzyfBPrwb+/KLvH592/+G47d3Dpnf72bf30+8eKL9Z/t3E1U7iclvR4H+103KymT9fT1+sKKcLoZP54OlqtLqtvl5LvFmLvFsN/mHd/8dN//st/9vt4Ovt0J8q0fdrgXeV4Put8OtN/8W6+6zirO54X29ErtZDF6u+8xXvxarnct1zue6prjur64HLSuh0KXi2Fjlfj56u+S+2AifrrperoVdr4dNK9GQ98nI19Hw58Hw58GIl+LQceVIKPyoEj+cCR7P+wxmfpkdFz9Gc6+G0/WDKcjBlOZy0HE6ZHk7K+6OO/VHHwZhzf9Tx4Lb9/ohtb9i6N2zd6zft9dn2eu33elx3bzl3uy07XfJON3+nW9rpErc7hUobt9pCL+ep5Ty10kSvtNMr7XQpj8ymoUIWmcsgMymokEVLabCcgRZyyGIWWcqhSzl0MQPPp8C5BFFQiKKKl5KoZvNLSX0p2bCoQF/hn4sZSwpSUpCZKKB5+F+Z/320/9/CPxmunQw3TEfAySCiZfinw8hEEJiOgLMxeCIEavCPhsAhr3HID4yHdLcDUJ8X7XYbe3z1Wsw/YEc0+LU8X7dL1+/RD/mBkSA0HiWG/FCf23DLZexxaxeEod2ma7fqtZ6fThfY4TA2Wxtyck1a+HutyNfI1jaytc1sXTNbl6dr8uR3nby+jde1SsZWM9QogSqjT1G6HAMmBDgpoUkJjfNQhDGGaUOMAxMCnBURLS+oCpAqQDHGoFn+oGCMinDKhKdkQhHwIKNN1EJxBkuJZJxDAwwYEuGICQuZkJAVC5hIFwc7SKOHhWMWJukQ4mYqyCMBDg4JaFjEtGH+II9EZSJhoaMmLGGhYyY6xOJBBotLlGqlklYs4kRDFjok8CGeCktI2IQETKRfltwc7uEJD0+4WMJBY3YKdzKkm6ODssnD8XaattO0jWGsNG2laRvH0gzOMgTHEiKHSxxq5hArh1p5JADxPkRwYZKDMtkZswXlLSDlQnmGJnmex2kGxEiYJEmaokiUZ1CcJEiaQlGcwOhv/nZd0vj/XC19rpa+uv2/Xsx+vi58uSp8qk5/Oh//dD7669nwX170/3wy/NOLwT8/6/2HJ11/PLzxfj///V727b3U2z3l7Z7y5l7iq9uvef4nldBpJXq2Hj9bi71aDr9aDp9VotVtpbrhvK7Y31ZM7zekHzaE9xvS203Tmy3zuzs2TW/uWK62TReb/NkWf7EjViuuasVV3XBebrquttxXW+7LTUd1w/5mM/52K3mxmrhaT1Ur6vl69HIrclrxVzeU6oZyUUmcrcVOViIvFoPP5v3P5v2P5gKajmf9RzO+h1Oe/QnXg3HnccF7NON+OOU8mLIdTtoOJy2HE+aH46a9Qcv9IeuDYdv9Ieu9AfPdftNun7zbJ+/28Ls94u4t850u806nabtT2upkN29SO13i1k2+0sasNFMLOWwhiy/miOU8VcrB5UZkRjVMKYa5NFRII4U0Mt9IlDPQfBaez8ILGXghAy/n0MUMXFaBQhIrJJGiipZTSDmFlJNQSQGLimEhCc2rcDkJFeLATMwwEwWmY8BU9P8B/3ub/18D/q8XwUSobiJUPx2BJ4PIqBeaCKAzEXQiAI75dZMh43gQmAiBU3FsIoqM+MGRIDQR1o8G4T4vetOh63R91+evG3Drey1gl8vQ7TR0Ow1dzoYep67X1aBt+xgNIyNBaNAH9nqNt1zGbrex06lvt+m0Vp8uN9TlhtpdQKtdnzfXZeWa/8nt75aBDtnYZoZarUiTBckIYJoz5jgoxgBJAVFFNMFBMQaIMUCcBeMsmBWRNA+pAqS1A8RZo2b8IzISk5CEhKkSGeOJEIsGeCJgopMilbaySRMVk3DFTCTttGIjk3YqYRXiFj5qpqMyFTORSQutWinVSsVlQjFTKRubsrGKmUqYSK3gF7egqoNO2tiozAQFMijiAQHycoaAFfTLRIBjgxwZlpCoBYvY2IjNGjGzYRMTlCi/QPp4wsdRQZENy3xIZrws6aIwJ0O6WdbJsg6GcTK8wLM8R4ksJbGkzBFWgbALuF3ARUbiWYHnRU7gGY4lSBrHSYpgIRwgeALlSIDGIZqAKRhB9Rimg3AKpQQAk2DS+v/F/H+7mv+a7f/1YvbT1dzny7lfzyd/PR39eHb7w+nQL8/7/vn54M/PBn580vPnR13/cNj2x/2WH+43vt/LfL+nfr+nvt1T3tyLvb4bvr4buNr1Xd7xnu76X2yHHlVih5X0w42mo62Wo+3Gw63s0Wbi6ZZyuhO72AqdV3xn696LjdDFZvjFSvB0PXJWiZ6thU5Xgxdrgep68HIt+HI5+moldrIaP11LnK4lztaV80ryYkO9Wkter6fOF9XqSu5qPXe+lrraUi8qsau15OWqUl1JnC/FzhajJ/Phl6Xg84L/aMb3VYfTXi2kfzDuPJh07084HozbD8bsB+O2g1HrgxF5b0jcH7IeDNsejtgPhm0PBi17/aZ7ffJev+leL3uvR7jXI93tNu92me508TudzHYnsd3Bb3fwW+1cpZVdbaK0MbvlRnI+Cy82oqU0WExBi434Yo5YyOLLeWoxDy/nkcUcNJ8BFjPgSiOykoEWkoaCaiypUDkFz6fReRUpJ9FyHC7FkJIKFZNgQQXnFHAybhgN68Yi+gktjE9CBQXUUvoa6v9Lwm8q0jAVNszG0JkIPu5HpkL4TASfCIAjnrrxgH4sYNQSfhr8wwFwNFB/OwD1+7Aul6HLXdMfqB/0GHotYL8PHgygQ0FsOAAP+sDfr/ca8gNDfkDb293p1N906NqsdR0OsMMBttuBVpuxxWpotujzFl3eoms063MmXaOsy5v0zbK+WdY3Sbq8UN8uGW6YjU1mIGMypk1g2gSnJSjNQzHKqLBQkoPjNBCnAYWFFBaK00CKAzX4FQ5IsEYt2xdnjSEZDolQTEAUAY+wmI9B/QIRMnNRmUra2KSFjstEykJlbEzGQmatVMoipayiamIViU6KhCrhGQuZs9FpK5uxcTmHkHMIWTufsXFpK5uyMDErnLDjCQcdtTBBifIIqIs3Ojm9z2z0y0RYFDS3P2JGw1YmbLXE7UzUSoVMeFAighIRkumwiYmY2aAAeWi9kzR6aNTL0i6SduC0FWPMoiCyDEugDAIysIFF9CykY6C674AaPVoLU7U49S1K/B2MfWuEahoMNayhxkxAJhIXUFiEIQnQSYYaq6GG0/8dC9SjOiNixP4v1H8DWI3D/P4AAAAASUVORK5CYII=" alt="" /></p> <p class="MsoNormal">L’invecchiamento, come una serie di condizioni cliniche(malattie cardiovascolari, autoimmuni, lenta riparazione delle ferite, depressione clinica, demenza, Alzheimer e attacchi d’ansia) sono associati ad un primo incremento durante risveglio e da un attenuato incremento dopo risveglio. Un’eccezione notevole è il disordine da stress post-traumatico(CAR attenuata e curva bassa durante risveglio). Sembra che soggetti sani possano modificare il proprio CAR in risposta alle esperienze del giorno precedente, prevedendo quelle del successivo: infatti il CAR è attenuato nel weekend, dove solitamente le persone hanno meno occupazioni. Tuttavia recentemente è stato riportato che una miglior misura di uno stato psicosociale positivo <span style="mso-spacerun:yes"> </span>non dipende dall’ampiezza del CAR ma molto di più dalla variazione circadiana nel giorno intero.</p> <p class="MsoNormal">Il CAR dipende anche da fattori non psicologici come sesso, tempo di veglia, luce, volume dell’ippocampo, feedback dei recettori dei glucocorticoidi e genotipo. Il simpatico, tramite in nervo splancnico, nel periodo immediatamente prima del risveglio riduce la sensibilità surrenale agli aumentati livelli di ACTH, mentre subito dopo il risveglio la sensibilità surrenale all’ACTH è incrementata in risposta alla luce: una funzione, questa, <span style="mso-spacerun:yes"> </span>mediata dall’SCN con un pathway extraipofisario(retina->SCN->surrene, senza passare dall’ipofisi e senza coinvolgimento di CRH né di ACTH). L’ippocampo inoltre ha attività permissiva per il CAR pur avendo effetti inibitori sull’attività dell’asse HPA: probabilmente l’ippocampo agisce prima del risveglio(perché il sonno REM è associato a marcata attivazione ippocampale, che porta ad un tono inibitorio della secrezione di cortisolo, mentre il risveglio è associato a spegnimento ippocampale)</p><a href="http://t0.gstatic.com/images?q=tbn:ANd9GcRCusHGNgaE2SkCDx7EC1AuHoT1s98m66m18GWo1D3WWORhleC-OB31IvPz"><img style="float:right; margin:0 0 10px 10px;cursor:pointer; cursor:hand;width: 190px; height: 265px;" src="http://t0.gstatic.com/images?q=tbn:ANd9GcRCusHGNgaE2SkCDx7EC1AuHoT1s98m66m18GWo1D3WWORhleC-OB31IvPz" alt="" border="0" /></a><p class="MsoNormal">STATO DI COSCIENZA</p> <p class="MsoNormal">Studi di EEG e imaging del cervello hanno rivelato che il risveglio comporta un rapido ristabilimento dello stato di coscienza, ma che il raggiungimento dello stato di allerta è relativamente lento. Tramite PET durante il risveglio si è notato che tronco encefalico, talamo, gangli della base e corteccia del cingolo anteriore si riattivano rapidamente con uno stato di “inerzia del sonno”(15-60 min tra riacquisto di conoscenza e raggiungimento di un’allerta completa)forse dovuto alla riattivazione più tardiva della corteccia prefrontale. Il CAR è coinvolto indirettamente: innalzamenti acuti di cortisolo stimolano l’eccitazione psicologica e riducono la fatica; lo è anche direttamente: In soggetti privati del sonno l’esposizione di prima mattina a luce intensa induce un immediato innalzamento dei livelli di cortisolo.</p> <p class="MsoNormal">AFFATICAMENTO E MEMORIA</p> <p class="MsoNormal">Un elevato CAR è associato a diminuzione della fatica media in un periodo di 3-4 gg. Stati di eccitazione o anticipazioni di giorni impegnativi prima dei 45 min post risveglio correlano positivamente con il CAR. Inoltre alti livelli di sonnolenza sono associati a bassi livelli di cortisolo 15 min dopo il risveglio in lavoratori d’ufficio sani. Da uno studio con un soppressore della sintesi del cortisolo è risultata una significativa perdita di memoria di immagini e testi appresi 3 giorni prima: il CAR può essere importante per l’avvio delle rappresentazioni mnemoniche nell’organizzazione della personalità, delle identità e del self, quando devono rimanere preattivate per esperienze maggiormente acute. A sostegno di questo, il CAR risulta attenuato in pazienti con disordini della memoria dovuti a danno ippocampale.</p> <p class="MsoNormal">Il CAR ha relazioni anche con il ritmo circadiano immune(disregolazioni endocrine si osservano in varie malattie, come il cancro): il cortisolo inibisce i linfociti th1 e stimola la risposta th2; forse un elemento fondamentale del risveglio è lo switch tra risposta th1 notturna e th2, dominante al mattino.</p><p class="MsoNormal"><img 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alt="" /></p><p class="MsoNormal">ATTIVAZIONE MOTORIA</p> <p class="MsoNormal">Stati di sonno associati a inibizione di funzioni motorie(atonia del sonno) sono fondamentali per assicurare passività fisica durante i periodi di attivazione dinamica del cervello associati agli stati di sogno; essa è indotta da proiezioni discendenti ai motoneuroni spinali dal tegmento pontino caudale dorso laterale. Il coinvolgimento del CAR<span style="mso-spacerun:yes"> </span>potrebbe esserci in quanto incrementa l’eccitabilità della corteccia motoria; inoltre anche in altri momenti della giornata un picco di cortisolo potrebbe facilitare il movimento volontario, probabilmente facilitando risposte motorie appropriate a nuovi pattern comportamentali, es capacità di provare nuove abilità motorie(Sandi 1996). E’ anche vero che il cortisolo inibisce la plasticità neuronale della corteccia motoria (cruciale per la consolidazione delle abilità): probabilmente l’esplorazione ambientale avviene di giorno, mentre il consolidamento delle abilità, durante la fine della giornata(livelli di cortisolo più bassi)</p> <p class="MsoNormal"><span style="font-size:100%;">Conclusion</span>e: in futuro è possibile che differenti pattern o caratteristiche del CAR possano essere riconosciuti come biomarker di differenti funzioni associante a diversi sistemi cerebrali e disfunzioni neuronedocrine(SCNmediate, funzione ippocampale, asse HPA)</p><p class="MsoNormal"><br /></p><span style="font-size:85%;">References: <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Clow%20A%22%5BAuthor%5D"><span class="highlight" style="background-color:">Clow</span> A</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Hucklebridge%20F%22%5BAuthor%5D">Hucklebridge F</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Thorn%20L%22%5BAuthor%5D">Thorn L</a>. </span><span style="font-size:85%;">The cortisol awakening response in context. P</span><span style="font-size:85%;">MID: 20970005 </span><p class="MsoNormal"><span style="color:#FF6600;"> </span></p>Vobbertohttp://www.blogger.com/profile/00580279520012953526noreply@blogger.com3tag:blogger.com,1999:blog-2650750594787397971.post-75407295355552080272011-08-28T17:41:00.000-07:002011-08-28T17:41:14.947-07:00Regolazione della crescita laminare e compartimentale dei dendriti nella corteccia matura<!--[if gte mso 9]><xml> <o:OfficeDocumentSettings> <o:AllowPNG/> </o:OfficeDocumentSettings> </xml><![endif]--><!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:HyphenationZone>14</w:HyphenationZone> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>IT</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:EnableOpenTypeKerning/> <w:DontFlipMirrorIndents/> <w:OverrideTableStyleHps/> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true"
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<div class="MsoNormal">I dendriti sono degli integratori dinamici degli input sinaptici che giungono al soma del neurone.<span style="mso-spacerun: yes;"> </span>Le loro proprietà al riguardo sono strettamente dipendenti dal modello di ramificazione dell’albero dendritico.<span style="mso-spacerun: yes;"> </span>Nei topi la forma finale dell’albero dendritico si completa nelle prime due settimane di sviluppo post-natale, periodo in cui si ha una notevole quantità di impulsi afferenti e formazione di sinapsi. Successivamente la struttura dendritica su larga scala è notevolmente stabile. <br />
La via di segnalazione PI3K/PTEN regola l’ipertrofia dei dendriti nello sviluppo della corteccia, ma il suo ruolo nella corteccia matura non è chiaro. Per esaminare direttamente la <span class="hps">potenzialità</span>, le dinamiche e i <span class="hps">meccanismi molecolari della</span> <span class="hps">crescita</span> <span class="hps">dendritica nella corteccia</span> <span class="hps">matura</span> <span class="hps">in vivo</span>, bisogna generare dei topi con delezione condizionale del gene oncosoppressore PTEN (αCamKII<span class="atn">-</span>Cre <span class="hps">+ / -</span>; <span class="hps">Ptenloxp</span> <span class="hps">/</span> <span class="hps">loxP</span>; <span class="hps">Thy1-</span>GFP).<span class="hps"> La delezione del gene</span> <span class="hps">aumenta significativamente</span> <span class="hps">attorno</span> <span class="hps">all’ottava settimana</span> <span class="hps">dopo la nascita</span> dei<span class="hps"> topi</span>. Vengono poi ripresi nella loro interezza i neuroni degli strati corticali II e III di tutto il cervello di topi dell’età di 3-4 mesi e vengono ricostruiti nelle 3 dimensioni. I dendriti apicali dei neuroni dei topi PTEN -/- sono molto più lunghi e tortuosi dei dendriti corrispettivi del campione di controllo. </div><div class="MsoNormal"><br />
</div><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiqz5bqrYHpyFLCe_IXaScz9RGlMT9UoioW4dQrj2QQA9ZNoLfLgX80zJJI77HgfdsbaBVCVV_JUiny5YVuKvd9nLbW8lFYa3s-JmmwlZl-V0F1MbJHnJWj1yEwzZPzE6nAWzJhSHa59w/s1600/nihms185282f1.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" height="117" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiqz5bqrYHpyFLCe_IXaScz9RGlMT9UoioW4dQrj2QQA9ZNoLfLgX80zJJI77HgfdsbaBVCVV_JUiny5YVuKvd9nLbW8lFYa3s-JmmwlZl-V0F1MbJHnJWj1yEwzZPzE6nAWzJhSHa59w/s400/nihms185282f1.jpg" width="400" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Crescita compartimento-specifica dei dendriti</td></tr>
</tbody></table><div class="MsoNormal">La lunghezza totale dell’arborizzazione apicale è in media di 1,6 mm in più nei topi PTEN -/- , con un <span class="hps">ampliamento</span> <span class="hps">di circa l’80</span>% <span class="hps">della struttura</span> dendritica <span class="hps">apicale normale. D’altro canto la lunghezza e la tortuosità dei dendriti basali degli stessi neuroni non sono significativamente modificate dalla delezione di PTEN, né si riscontra una differenza nella densità delle spine dendritiche tra i due gruppi (densità</span>: 7,3 <span class="hps">± 0,8</span> <span class="hps">spine</span> <span class="hps">per</span> <span class="hps">10μm</span> <span class="hps">nei controlli</span> <span class="hps">vs</span> <span class="hps">7,5 ±</span> <span class="hps">0,9</span> <span class="hps">spine</span> <span class="hps">per</span> <span class="hps">10μm</span> <span class="hps">in</span> <span class="hps">PTEN</span>-/ -, p <span class="hps">= 0,29</span> <span class="hps">n =</span> <span class="hps">1798</span> <span class="hps">spine</span> <span class="hps">nel controllo e</span> <span class="hps">1989 in</span> <span class="hps">PTEN</span>-/ -<span class="hps">)</span>. Tutti i neuroni <span class="hps">ripresi</span> <span class="hps">in</span> <span class="hps">topi PTEN</span>-/ -<span class="hps"> hanno mostrato segni di</span> <span class="hps">una robusta crescita</span> <span class="hps">dendritica</span> <span class="hps">apicale.</span> Per esaminare la cinetica della crescita dei dendriti apicali vengono ripresi ripetutamente i dendriti in vivo.<span style="mso-spacerun: yes;"> </span>L’attività di imaging inizia tra la settima e l’ottava settimana di vita del topo quando l’espressione corticale di Cre subisce un brusco aumento nei topi Cre +/-.<span style="mso-spacerun: yes;"> </span>I dendriti apicali degli strati II e III della corteccia dei topi di controllo sono stabili se ripresi a intervalli di un mese, anche se piccoli allungamenti o retrazioni possono essere rilevati, non ammontano a più del 1-2% della lunghezza totale dei dendriti.<br />
In topi PTEN -/- i dendriti apicali dei neuroni piramidali ripresi tra la settima e l’ottava settimana d’età non sono significativamente differenti da quello del campione di controllo della stessa età né vi è alcuna differenza nella densità delle spine dendritiche. A distanza di un mese però i dendriti apicali dei topi PTEN -/- crescono di centinaia di micron, ampliando l’arborizzazione dendritica dal 24% al 62% per neurone sia dello strato II che dello strato III della corteccia. </div><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhFyACxb9LzX6BxSU4_lCJkw93gyyg9xlRaI6xCGn3jdROC-K8qqnBeRpzmBuase8I0o-PJ51UdgVqFmz0gMkM13X6bvCoh-LvPViK14qHsJA5-26JbqpQ6r5dsnB8n94e-_Lbd-YwaDQ/s1600/nihms185282f2.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" height="385" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhFyACxb9LzX6BxSU4_lCJkw93gyyg9xlRaI6xCGn3jdROC-K8qqnBeRpzmBuase8I0o-PJ51UdgVqFmz0gMkM13X6bvCoh-LvPViK14qHsJA5-26JbqpQ6r5dsnB8n94e-_Lbd-YwaDQ/s400/nihms185282f2.jpg" width="400" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Dinamica della crescita dendritica apicale in vivo</td></tr>
</tbody></table><div class="MsoNormal"><br />
</div><div class="MsoNormal">Questa crescita <span class="hps">si verifica</span> <span class="hps">sempre</span> <span class="hps">dalle punte</span> <span class="hps">dei dendriti</span> <span class="hps">esistenti</span> <span class="hps">ed è caratterizzata</span> <span class="hps">dalla presenza di</span> <span class="hps">sporgenze</span> <span style="mso-spacerun: yes;"> </span>simili a filipodi <span class="hps">sulle punte</span> <span class="hps">di cresc</span>ita. La densità delle spine dendritiche non diminuisce significativamente nei primi 150 micron delle regioni appena formatisi eccetto che nelle porzioni più distali con l’aggiunta complessiva di 220-404 nuove spine per neurone. Queste nuove spine dendritiche sono molto labili e si formano e disfano con una velocità doppia rispetto al normale, situazione simile al primo periodo post-natale in cui i circuiti corticali sono raffinati dall’esperienza. <span style="mso-spacerun: yes;"> </span>Le regioni dendritiche con una densità di spine minore di 2 spine per 10 micron vengono retratte. Questa retrazione è associata alla presenza di grandi rigonfiamenti vicino alla punta dei dendriti che sono simili all’aspetto dei “bulbi da retrazione”<span style="mso-spacerun: yes;"> </span>descritti alla punta degli assoni dei motoneuroni che poi scompaiono.<span style="mso-spacerun: yes;"> </span>Così l’innervazione sinaptica, o almeno la presenza delle spine dendritiche, è richiesta nel mantenimento delle nuove spine dendritiche come anche nello sviluppo della corteccia. <br />
La carenza di PTEN porta ad una maggiore attività della chinasi mTOR e a un concomitante incremento dell’attività della chinasi S6 con conseguenze traslazione delle proteine e crescita cellulare.<span style="mso-spacerun: yes;"> </span>Iniezioni giornaliere di rapamicina antagonizzano la segnalazione di mTOR corticale in vivo e impedisce completamente l’abbondante crescita dendritica che si ottiene con la delezione di PTEN. Nei topi di controllo invece la rapamicina non ha alcun effetto sulla lunghezza dei dendriti poiché agisce solo su arborizzazioni in crescita. Per dimostrarlo si rilevano immagini in vivo dei neuroni per quattro settimane dopodiché, quando la crescita dei dendriti diviene più rapida, si effettua il trattamento con rapamicina e si continua l’attività di imaging per altre quattro settimane. Appena una settimana dopo il trattamento la crescita si arresta e le protrusioni simili a filipodi all’estremità dei dendriti scompaiono; anche la densità delle spine dendritiche sulle nuove porzioni di dendriti diminuisce. Il trattamento prolungato di rapamicina comunque non porta a un accorciamento dei dendriti nelle loro porzioni neoformate, mentre una volta sospeso il trattamento la crescita riprende in modesta entità. </div><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjrUcOl0xuHO8nFKbcfSXB9yKpHBd5jPMuP3Foyt9DumAGuKhBjSbnYIZ6DsLE7iiKz9pen4ZzM8JHFcX8vj_83AYTihyg7Xg28Ct2hw6SuCiz0KM4hI7NT2iBTriOlimZJw_qyB_-AJQ/s1600/nihms185282f3.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjrUcOl0xuHO8nFKbcfSXB9yKpHBd5jPMuP3Foyt9DumAGuKhBjSbnYIZ6DsLE7iiKz9pen4ZzM8JHFcX8vj_83AYTihyg7Xg28Ct2hw6SuCiz0KM4hI7NT2iBTriOlimZJw_qyB_-AJQ/s640/nihms185282f3.jpg" width="316" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Effetti della rapamicina</td></tr>
</tbody></table><div class="MsoNormal"><br />
I neuroni piramidali dello strato V della corteccia dei topi PTEN -/- non mostrano alcuna differenza apprezzabile nella crescita dei dendriti apicali né nella densità e nella cinetica delle spine dendritiche rispetto al campione di controllo. La rtPCR e le colorazioni immunoistochimiche confermano l’assenza dell’RNA e della proteina PTEN nei neuroni piramidali del V strato corticale nei topi PTEN -/- e sono nulli gli effetti della rapamicina. Quindi la via di segnalazione PTEN/mTOR non regola la crescita dei dendriti nel V strato corticale. <br />
In sintesi : i dendriti mantengono la capacità di crescita su larga scala in tutta la corteccia; i dendriti in crescita si comportano come i dendriti nella corteccia più giovane e infine la via di segnalazione PTAN/mTOR agisce soltanto sui dendriti apicali degli strati II e III della corteccia matura.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">References</div><div class="ref-cit-blk" id="R1"><span class="ref-label">1.</span> <span class="ref-cit"><span class="citation" id="__citation1">Hausser M, Spruston N, Stuart GJ. Diversity and dynamics of dendritic signaling. <span><span class="ref-journal">Science. </span>2000;<span class="ref-vol">290</span>:739–744.</span> <span style="white-space: nowrap;"></span></span></span></div><div class="ref-cit-blk" id="R2"><span class="ref-label">2.</span> <span class="ref-cit"><span class="citation" id="__citation2">Wong RO, Ghosh A. Activity-dependent regulation of dendritic growth and patterning. <span><span class="ref-journal">Nat Rev Neurosci. </span>2002;<span class="ref-vol">3</span>:803–812.</span> <span style="white-space: nowrap;"></span></span></span></div><div class="ref-cit-blk" id="R3"><span class="ref-label">3.</span> <span class="ref-cit"><span class="citation" id="__citation3">Cline HT. 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Laminar and compartmental regulation of dendritic growth in mature cortex. <span class="ref-cit"><span class="citation" id="__citation2"><span><span class="ref-journal">Nat Rev Neurosci.2009</span></span></span></span><span class="citation-publication-date">; </span><span class="citation-volume">12</span><span class="citation-issue">(2)</span><span class="citation-flpages">: 116–118. </span><span class="ref-cit"><span class="citation" id="__citation3"><span style="white-space: nowrap;"> </span></span></span></div><div class="MsoNormal"> </div>GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com0tag:blogger.com,1999:blog-2650750594787397971.post-59820978486681926582011-07-30T04:10:00.000-07:002011-09-13T07:22:43.429-07:00Liposomi "cavallo di troia" per il trasferimento di geni attraverso la barriera ematoencefalica<!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} w\:* {behavior:url(#default#VML);} .shape 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unhidewhenused="false" qformat="true" name="Subtle Reference"> <w:lsdexception locked="false" priority="32" semihidden="false" unhidewhenused="false" qformat="true" name="Intense Reference"> <w:lsdexception locked="false" priority="33" semihidden="false" unhidewhenused="false" qformat="true" name="Book Title"> <w:lsdexception locked="false" priority="37" name="Bibliography"> <w:lsdexception locked="false" priority="39" qformat="true" name="TOC Heading"> </w:LatentStyles> </xml><![endif]--><!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabella normale"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; 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Essa riveste grande importanza per la protezione da antigeni di vario genere, oltre che dalle fluttuazioni dei valori ematici, ma risulta un ostacolo per l’eventuale passaggio di farmaci o altri mezzi terapeutici. Generalmente grandi molecole endogene attraversano la barriera utilizzando<span style="mso-spacerun:yes"> </span>un processo di transcitosi mediata da recettore(RMT) espresso sul plasmalemma della cellula endoteliale del capillare. Similarmente, alcuni anticorpi monoclonali passano tramite proteine canale. In questo modo, il peptidomimetico MAbs(nient’altro che un anticorpo </span><span style="Bell MT","serif"font-family:";" >monoclonale artificiale) può essere usato come un “cavallo di troia” molecolare per trasportare grandi molecole dall’effetto terapeutico, inclusi plasmidi non virali a DNA, utilizzando lo stesso fenomeno di RMT.<span style="mso-spacerun:yes"> </span></span> <p class="MsoNormal" style="margin-bottom: 0.0001pt;"><span style=";font-family:";" >Un plasmide a DNA non virale viene inviato all’encefalo mediante un percorso intravascolare attraverso la barriera ematoencefalica(BBB)a seguito di somministrazione endovenosa di DNA incapsulato all’interno di liposomi “cavallo di Troia”(THLs), chiamati anche immunoliposomi PEGilati(PILs). Infatti la superficie del liposoma è ricoperta da filamenti di glicolo polietilenico(PEG) e le punte dell’ 1-2% dei filamenti sono coniugate ad un anticorpo monoclonale bersagliante, che agisce come un cavallo di troia molecolare(MTH). L’MTH si avvolge ad un recettore(ad esempio, per la trasferrina) presente sulla barriera ematoencefalica e sul plasmalemma delle cel</span><span style=";font-family:";" >lule dell’encefalo innescando un processo di transcitosi mediata da recettore del THL attraverso la BBB(in vivo) e una endocitosi mediata da recettore all’interno delle cellule dell’encefalo al di là della BBB. La persistenza dell’espressione del transgene(gene estraneo) è inversamente proporzionale al tasso di degradazione del plasmide episomale(episoma: particella genetica che può esistere autonomamente nel citoplasma o come parte di un cromosoma). La tecnologia THL consente una larga espressione del gene esogeno nella maggioranza delle cellule dell’encefalo adulto(o eventualmente di altri organi) entro un giorno dalla singola somministrazione endovenosa.<br /></span></p><p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><b style="mso-bidi-font-weight: normal"><span style="Bell MT","serif"font-family:";" ><span style="mso-spacerun:yes"> </span><span style="color:#1F497D;">Fig</span></span></b><span style="Bell MT","serif";font-family:";color:#1F497D;" >.</span><span style=";font-family:";" > gli anti</span><a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiBfMosXSk8q_0F381rai7A51hfokaxkl_g3iZdmmXHdoX9WKvBBhRRBTLhMbzT1haWiszv75G_XsIgqs9TdrPPzxpErvMpcM1Nffz4ex8BjrPbnMzcWuPyDh6d4tJ-kp1rLGESrW4bbMyc/s1600/bbb.png"><img style="float: right; margin: 0pt 0pt 10px 10px; cursor: pointer; width: 274px; height: 184px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiBfMosXSk8q_0F381rai7A51hfokaxkl_g3iZdmmXHdoX9WKvBBhRRBTLhMbzT1haWiszv75G_XsIgqs9TdrPPzxpErvMpcM1Nffz4ex8BjrPbnMzcWuPyDh6d4tJ-kp1rLGESrW4bbMyc/s200/bbb.png" alt="" id="BLOGGER_PHOTO_ID_5635101814686122434" border="0" /></a><span style="Bell MT","serif"font-family:";" >corpi monoclonali(MAb)sono specie-specifici, in base alla reattività nei confronti dei recettori sia della transferrina(TfR) che dell’insulina(IR) BSP = proteina capillare cerebrale-specifica</span></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><span style="Bell MT","serif"font-family:";" > </span></p> <p class="MsoNormal" style="margin-bottom: 0.0001pt;"><span style=";font-family:";" ><br /></span></p><p class="MsoNormal" style="margin-bottom: 0.0001pt;"><span style=";font-family:";" ><br /></span></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><span style="Bell MT","serif"font-family:";" >Le applicazioni della tecnologia includono l’espressione di geni tessuto-specifici mediante promotori tessuto-specifici, la completa normalizzazione della tirosina-idrolasi striatale (terapia genica sperimentale), un incremento del 100% del tempo di sopravvivenza di topi con tumori cerebrali che seguono settimanalmente terapia antisense(molecola che interagisce con filamenti complementari di DNA modificando l’espressione genica). Inoltre , in caso di tumori dell’encefalo intracraniale murino, si osserva un incremento dell’aspettativa di vita del 90% mediante somministrazione venosa settimanale di RNA interferience(RNAi). Questo acido nucleico presenta una definita sequenza metabolizzata dalle cellule tumorali: quando queste cellule si dividono si attiva. Si tratta di un inibitore del gene EGFR(recettore per fattore di crescita, protooncogene)</span></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><b style="mso-bidi-font-weight:normal"><span style="Bell MT","serif"; font-family:";color:#1F497D;" >Conclusioni</span></b></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><span style="Bell MT","serif"font-family:";" >La possibilità di utilizzare cavalli di troia per veicolare regolatori dell’espressione genica(plasmidi)oltre la complessa BBB può essere fondamentale per la terapia di tumori cerebrali che utilizzano questa barriera per poter proliferare indisturbati</span></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><span style="Bell MT","serif";mso-ansi-language:EN-USfont-family:";" lang="EN-US"> </span></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><b style="mso-bidi-font-weight:normal"><span style="Bell MT","serif"; mso-ansi-language:EN-USfont-family:";color:#1F497D;" lang="EN-US">References</span></b></p> <p class="MsoNormal" style="margin-bottom: 0.0001pt;"><span style=";font-family:";" lang="EN-US">-Preparation of THLs for gene transfer across the BBB<span style="mso-spacerun:yes"> </span>-apr 2010</span></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><span style="Bell MT","serif";mso-ansi-language:EN-USfont-family:";" lang="EN-US">- Blood-brain barrier delivery of protein and non-viral gene therapeutics with molecular Trojan horses -apr 2007</span></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><span style="Bell MT","serif"font-family:";" >-P.Rosati-Istologia: la barriera ematoencefalica p586-587</span></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><span style="Bell MT","serif";mso-ansi-language:EN-USfont-family:";" lang="EN-US">-RNAi delivery system crosses blood-brain barrier to target brain cancer -giu 2004</span></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><span style="Bell MT","serif";mso-ansi-language:EN-USfont-family:";" lang="EN-US">PardridgeWM</span></p>Vobbertohttp://www.blogger.com/profile/00580279520012953526noreply@blogger.com0tag:blogger.com,1999:blog-2650750594787397971.post-61612593942710766872011-06-21T05:48:00.000-07:002011-06-21T07:45:02.080-07:00la malattia di Nietzsche<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="http://media.kunst-fuer-alle.de/img/41/m/41_00009623%7Enietzsche-on-his-sick-bed---olde--c-1899.jpg"><img alt="" src="http://media.kunst-fuer-alle.de/img/41/m/41_00009623%7Enietzsche-on-his-sick-bed---olde--c-1899.jpg" style="cursor: hand; cursor: pointer; display: block; height: 354px; margin: 0px auto 10px; text-align: center; width: 480px;" border="0" /></a><br /><div style=" font-style: italic; font-weight: bold; text-align: center;color:black;"><span style="font-size:100%;">"il prodotto del filosofo è innanzitutto la sua vita"</span></div><span style="font-size:20pt;"></span> <br />Friedrich Nietzsche (1844-1900), filosofo, filologo e poeta, è stato uno dei più influenti pensatori occidentali del XIX secolo. La sua vita fu ragguardevole almeno quanto la sua filosofia e sicuramente molta della sua produzione ha risentito della sua esistenza raminga e dei suoi patimenti psicologici ma soprattutto fisici. Ha sofferto fin dalla tenera età di pesanti emicranie e a 44 anni ebbe un crollo mentale culminante in demenza con totale dipendenza fisica a causa di un ictus. Si crede generalmente che la causa di questa condizione sia stata una neuro sifilide o una paresi generale dell’insano (GPI). Numerosi studi sono stati condotti per accertare la reale patologia del filosofo, per via di incongruenze sintomatologiche rispetto a tale diagnosi. Dopo aver tracciato la causa di morte, sono state eseguite diagnosi differenziali alla luce delle recenti acquisizioni neurologiche. Per la diagnosi postuma sono stati utilizzati archivi storici e materiali originali, compresi corrispondenza, dati biografici e cartelle mediche riguardanti le manifestazioni cliniche della malattia di Nietzsche e, usando questa patografia, si è discusso delle proposte per dare supporto a nuove ipotesi diagnostiche. I materiali utilizzati sono stati lettere originali provenienti da Nietzsche, descrizioni di lui fatte da parenti e amici, e profili da parte di medici. Sono stati attentamente osservati i ritratti e le incisioni raffiguranti il filosofo dal 1864 in poi. Sono state analizzate sia le fonti originali tedesche sia le fonti cartacee bibliografiche nei giornali di medicina.<br /><div style=" font-weight: bold; text-align: center;color:black;" align="center"><span style="font-size:100%;"><i style="mso-bidi-font-style: normal;">“l'essenza della vita, la forma più immediata di volontà di potenza, si comprende a partire dal suo exsistere, dal suo continuo superarsi, dal suo trascendere.”</i></span></div>I risultati patografici mostrano che Nietzsche soffrì di emicrania priva di aura dall’inizio dell’infanzia e nella seconda metà della sua vita di una malattia psichiatrica accompagnata a depressione. Nei suoi ultimi anni di vita ebbe un progressivo declino cognitivo culminato in demenza con ictus. Morì di polmonite nel 1900. La storia familiare include una possibile malattia mentale collegata al sistema vascolare, particolarmente evidente nel padre che morì di ictus a 36 anni. Da questi dati risulta piuttosto difficile che si trattasse di sifilide. Manca il progressivo deficit motorio e di altre caratteristiche neurologiche tipici di una sifilide da infezione del sistema nervoso centrale (CNS), inoltre Nietzsche visse almeno 12 anni dopo l’esordio di questi segni, cosa estremamente rara nei pazienti con GPI non trattata. Infine, la sua prolifica produzione filosofica nel 1888 sarebbe alquanto poco caratteristica nel GPI, mentre combacia con alcuni casi riscontrati di fiorente creatività in alcuni momenti della progressione della demenza frontotemporale (FTD), una forma di demenza cronica che colpisce le parti anteriori della corteccia cerebrale, tra le più coinvolte nei processi ideativi, ma che può compromettere anche il comportamento sessuale e morale, manifestare letargia e disinibizioni varie.<br /><div style=" font-weight: bold; text-align: center;color:black;" align="center"><span style="font-size:100%;"><i style="mso-bidi-font-style: normal;">“Meglio essere folle per proprio conto che saggio con le opinioni altrui.”</i></span></div>Alcuni dati suggeriscono invece che Nietzsche soffrisse di encefalomiopatia mitocondriale con acidosi lattica e sindrome da episodi simil-ictus (MELAS). Si tratta di una citopatia dei mitocondri (le centrali energetiche cellulari) dovuta ad alterazioni del suo corredo genetico. Sintomi precoci (spesso prima di 40 anni) di questa sindrome includono debolezza e dolore muscolare, ricorrenti mal di testa, perdita di appetito, nausea e convulsioni. Spesso questi episodi peggiorano in emiparesi, anormalità visive (fino alla perdita quasi totale) e perdita di funzioni intellettive (demenza). La presenza di una notevole quantità di acido lattico nel corpo porta vomito, dolore addominale e rende difficoltosi il movimento e il respiro.<br /><div style="text-align: center;" align="center"><a href="http://dekluizenaar.mimesis.nl/wp-images/nietzsche_olde2.jpg"><img alt="" src="http://dekluizenaar.mimesis.nl/wp-images/nietzsche_olde2.jpg" style="cursor: hand; cursor: pointer; display: block; height: 248px; margin: 0px auto 10px; text-align: center; width: 450px;" border="0" /></a><span style=" font-style: italic; font-weight: bold;font-size:100%;color:black;" ><i>“</i></span><span style=" font-style: italic; font-weight: bold;font-family:";font-size:100%;color:black;" > <i>Si è fecondi</i> soltanto al prezzo di essere ricchi di contrasti.”</span></div>Una diagnosi che potrebbe adattarsi a molti tra i sintomi e segni è la CADASIL: arteriopatia cerebrale autosomica dominante con infarti subcorticali e leucoencefalopatia. Si tratta di una patologia autosomica dominante dovuta a mutazioni del genere Notch 3 che si accumula abnormemente sulle membrane citoplasmatiche della muscolatura liscia dei vasi, soprattutto di quelli cerebrali, portandoli ad una progressiva degenerazione. Tale patologia di solito esordisce con attacchi di emicrania e/o ischemie transienti di regioni sottocorticali tra i 35 e i 55 anni di età. La malattia progredisce con demenza associata a incontinenza urinaria e paralisi pseudobulbare (coinvolgente il tratto piramidale, responsabile della motilità volontaria).<br /><div style=" font-style: italic; font-weight: bold; text-align: center;color:black;" align="center"><span style="font-size:100%;">“Le grandi epoche della nostra vita sono quelle in cui troviamo il coraggio di ribattezzare quel che abbiamo di male come quel che abbiamo di meglio”</span></div>Un’altra diagnosi proposta è stata quella di un meningioma della base della corteccia frontale come causa basilare. L’anisocoria (disuguaglianza del diametro pupillare), probabilmente una pupilla di Argyll Robertson, era presente sin dall’età di sei anni. Egli non aveva tremore alla lingua, progressivo deficit di caratteristiche motorie e visse almeno 12 anni dopo l’inizio dei primi segni neurologici. Nessuna registrazione sanitaria o fotografia suggerisce la presenza di disallineamento oculare. Pertanto né la diagnosi di GPI né di meningioma sono convincenti. Si è quindi supposto che Nietzsche soffrisse di emicranie, e che la cecità all’occhio destro fosse una conseguenza di una miopica ad elevata progressione associata a degenerazione della retina. L’anisocoria si spiega con una pupilla unilaterale tonica, e la demenza come inizio di una patologia psichiatrica.<br /><div style=" font-weight: bold; text-align: center;color:black;"><span style="font-size:100%;"><i style="mso-bidi-font-style: normal;">“La demenza è rara nei singoli, ma è la regola nei gruppi, nei partiti, nelle epoche.”</i></span></div>E’ stata inoltre esaminata la possibilità che la massa intracranica potesse essere stata l’agente eziologico dei mal di testa e dei disordini neurologici trovati nel filosofo, e causa del suo collasso mentale terminale nel 1889. A partire dai vent’anni di età Nietzsche ha combattuto contro severe emicranie, generalmente sul lato destro. Contemporaneamente soffrì di progressiva perdita della vista dall’occhio sinistro e delle terminazioni dei nervi cranici, documentate nelle sue visite neurologiche, in aggiunta ad uno sguardo non coniugato evidente nelle fotografie. Nel 1889, inoltre, Nietzsche sviluppò un inizio di una nuova mania, seguita da profonda abulia (mancanza di volontà, ndr). Questi dati sono tutti compatibili con una massa tumorale frontotemporale. Un esame approfondito della progressione sintomatica e dei segni neurologici indica un decorso clinico consistente in una larga lesione alla base destra del cranio, a lenta crescita, simile ad un meningioma dell’ala mediale dello sfenoide. L’ipotesi del meningioma è difficile, anche se non impossibile da dimostrare. Le ipotesi sono tante e nessuna perfettamente chiarificante, pertanto solo studi di imaging sui resti di Nietzsche potrebbero rivelare le sequele ossee tipiche di un meningioma o degli altri processi degenerativi sopra descritti.<br /><br />References:<br /><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Danesh-Meyer%20HV%22%5BAuthor%5D"><span lang="EN-US">Danesh-Meyer HV</span></a><span lang="EN-US">, </span><span lang="EN-US" style="font-size:12pt;">PMID: 20542432</span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Koszka%20C%22%5BAuthor%5D"><span lang="EN-US" style="font-size:12pt;">Koszka C</span></a><span lang="EN-US" style="font-size:12pt;">. PMID:19723969</span></div><div class="MsoNormal" style="margin-bottom: .0001pt; margin-bottom: 0cm;"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Hemelsoet%20D%22%5BAuthor%5D"><span lang="EN-US">Hemelsoet D</span></a><span lang="EN-US"> </span><span style=" line-height: 115%;font-size:12pt;" lang="EN-US" >PMID: 18575181</span></div><div class="MsoNormal" style="margin-bottom: .0001pt; margin-bottom: 0cm;"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Owen%20CM%22%5BAuthor%5D"><span lang="EN-US">Owen CM</span></a><span lang="EN-US"> PMID: 17881977</span><span style=" line-height: 115%;font-size:12pt;" lang="EN-US" ></span></div><div class="MsoNormal" style="margin-bottom: .0001pt; margin-bottom: 0cm;"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Orth%20M%22%5BAuthor%5D"><span lang="EN-US">Orth M</span></a> <span lang="EN-US">PMID:17087793</span><span style=" line-height: 115%;font-size:12pt;" lang="EN-US" ></span></div>Vobbertohttp://www.blogger.com/profile/00580279520012953526noreply@blogger.com11tag:blogger.com,1999:blog-2650750594787397971.post-45585642749223830832011-06-03T12:32:00.000-07:002011-06-03T12:53:01.814-07:00Anatomia del nucleo rostrale del tratto solitario (Parte 2)<!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} w\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} </style> <![endif]--><!--[if gte mso 9]><xml> <w:worddocument> <w:view>Normal</w:View> <w:zoom>0</w:Zoom> <w:trackmoves/> <w:trackformatting/> <w:hyphenationzone>14</w:HyphenationZone> <w:punctuationkerning/> <w:validateagainstschemas/> <w:saveifxmlinvalid>false</w:SaveIfXMLInvalid> <w:ignoremixedcontent>false</w:IgnoreMixedContent> <w:alwaysshowplaceholdertext>false</w:AlwaysShowPlaceholderText> <w:donotpromoteqf/> <w:lidthemeother>IT</w:LidThemeOther> <w:lidthemeasian>X-NONE</w:LidThemeAsian> 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Definitions */ table.MsoNormalTable {mso-style-name:"Tabella normale"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} </style> <![endif]--><!--[if gte mso 9]><xml> <o:shapedefaults ext="edit" spidmax="1026"> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout ext="edit"> <o:idmap ext="edit" data="1"> </o:shapelayout></xml><![endif]-->Non c’è uomo che non mangi e non beva; pochi, però, sono quelli che apprezzano il buon sapore. (Chung ung, testo cinese)<br /><br /><b><span style=" font-family:"Times New Roman","serif";mso-fareast-Times New Roman"; mso-fareast-language:ITfont-family:";font-size:13.5pt;" >Connessioni dell’rNST(nucleo rostrale del tratto solitario)</span></b> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; line-height:normal;mso-outline-level:2"><span style=" font-family:"Times New Roman","serif";mso-fareast-Times New Roman"; mso-fareast-language:IT;mso-bidi-font-weight:boldfont-family:";font-size:12.0pt;" >Le informazioni sensitive vengono trasmesse all’rNST tramite i nervi faciale, glossofaringeo, vago e trigemino: le fibre di questi nervi entrano nel tratto solitario e per la maggior parte si dirigono caudalmente donando branche che terminano all’interno del nucleo. La corda del timpano e le branche superficiali petrose del faciale innervano rispettivamente le parti anteriori del palato e della lingua e proiettano alle porzioni più rostrali del nucleo. Le terminazioni di queste branche si individuano nelle regioni RC e RL, la branca glosso-tonsillare del glossofaringeo (che trasmette informazioni relative al dorso della lingua) giunge all’rNST per poi estendersi anche alla parte caudale del nucleo. </span></p><!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} w\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} </style> <![endif]--><!--[if gte mso 9]><xml> <w:worddocument> <w:view>Normal</w:View> <w:zoom>0</w:Zoom> <w:trackmoves/> <w:trackformatting/> <w:hyphenationzone>14</w:HyphenationZone> <w:punctuationkerning/> <w:validateagainstschemas/> <w:saveifxmlinvalid>false</w:SaveIfXMLInvalid> <w:ignoremixedcontent>false</w:IgnoreMixedContent> <w:alwaysshowplaceholdertext>false</w:AlwaysShowPlaceholderText> <w:donotpromoteqf/> <w:lidthemeother>IT</w:LidThemeOther> <w:lidthemeasian>X-NONE</w:LidThemeAsian> <w:lidthemecomplexscript>X-NONE</w:LidThemeComplexScript> 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normale"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} </style> <![endif]--><!--[if gte mso 9]><xml> <o:shapedefaults ext="edit" spidmax="1026"> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout ext="edit"> <o:idmap ext="edit" data="1"> </o:shapelayout></xml><![endif]--><span style="line-height:115%; font-family:"Calibri","sans-serif";mso-fareast-font-family:Calibri;mso-bidi-Times New Roman";mso-ansi-language:IT;mso-fareast-language:EN-US;mso-bidi-language: AR-SAfont-family:";font-size:11.0pt;" ></span><p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height: normal"><span style="font-family:"Times New Roman","serif"; mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:12.0pt;" > </span></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height: normal"><span style="font-family:"Times New Roman","serif"; mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:12.0pt;" >Parte dei rami relativi a lingua ed epiglottide del vago e del trigemino giungono all’rNST. Nonostante il tratto solitario si diriga in senso rostro-caudale, l’orientamento degli alberi dendritici dell’rNST è prevalentemente lungo il piano orizzontale, e alcuni lungo il piano coronale: tale disposizione favorisce l’integrazione di vari input da differenti nervi cranici. Il nucleo riceve fibre da varie aree encefaliche, come il NST caudale (da regioni viscero sensitive alle aree RC ed M), che permette di connettere le informazioni viscerali e gustative. Un’altra connessione è con il nucleo parabrachiale mediale(che termina nelle aree RC e V), tale da consentire alla regione pontina di alterare il processamento di informazioni gustative. </span></p><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh1IPyjfaAF-SATeVD0vI_QpvBluWOFGQv53pvDLSf5EEZRA2vHPEGFi9g_tnVzyBpheiLWMwUueGeuFAoZ7UgWPOZbJgYpCxwJeP9jVSDSDhAaENQmXMuDyuuuz81ffmshTHq8meIH088w/s1600/ch2f5.jpg"><img style="float:left; margin:0 10px 10px 0;cursor:pointer; cursor:hand;width: 320px; height: 228px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh1IPyjfaAF-SATeVD0vI_QpvBluWOFGQv53pvDLSf5EEZRA2vHPEGFi9g_tnVzyBpheiLWMwUueGeuFAoZ7UgWPOZbJgYpCxwJeP9jVSDSDhAaENQmXMuDyuuuz81ffmshTHq8meIH088w/s320/ch2f5.jpg" alt="" id="BLOGGER_PHOTO_ID_5614082934251574770" border="0" /></a><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; line-height:normal"><span style="font-family:"Times New Roman","serif"; mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:12.0pt;" >Connessioni a centri più alti comprendono la corteccia dell’insula(in particolare la regione rostrale, gustativa) e il nucleo centrale dell’amigdala, tramite fibre discendenti in grado di regolare le efferenze dell’rNST destinate ai centri oromotori del tronco encefalico. Altre afferenze al nucleo provengono dalla stria terminale, dai nuclei ipotalamici paraventricolare e laterale e dalla corteccia prefrontale, il cui significato è ancora sconosciuto. </span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; line-height:normal;mso-outline-level:3"><b><span style=" font-family:"Times New Roman","serif";mso-fareast-Times New Roman"; mso-fareast-language:ITfont-family:";font-size:13.5pt;" >Efferenze</span></b></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; line-height:normal"><span style="font-family:"Times New Roman","serif"; mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:12.0pt;" >Uno dei ruoli principali dell’rNST è quello di trasmettere informazioni orosensoriali alle aree encefaliche coinvolte nella generazione di appropriate risposte comportamentali e fisiologiche, verso i centri superiori e i nuclei oromotori bulbari. <span style="mso-spacerun:yes"> </span>Tali proiezioni originano maggioramente dai neuroni dell’area RC, prevalentemente omolateriali, e dirette con tappa obbligatoria al nucleo parabrachiale(PBN) I neuroni del settore esterno del PBN rispondono a stimolazioni gustative e tattili della metà posteriore del cavo orale, e proiettano al nucleo ventrale posteromediale del talamo, quindi alla corteccia dell’insula. Proiezioni minori giungono direttamente all’insula o ad altre aree diencefaliche. La proiezione bulbare di maggiore entità dell’rNST (dalla regione V) è alla formazione reticolare parvocellulare, la quale proietta ai nuclei oromotori. Altre proiezioni terminano nell’NST caudale, nei nuclei salivatori o direttamente ai nuclei motori(l’unica significativa è al nucleo dell’ipoglosso) </span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; line-height:normal"><b><span style="font-family:"Times New Roman","serif"; mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:13.5pt;" >Anatomia funzionale</span></b></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; line-height:normal"><span style="font-family:"Times New Roman","serif"; mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:12.0pt;" >Un importante studio funzionale è stato realizzato mediante tecniche istochimiche tramite il gene c-fos, grazie al quale si è stabilito che diversi gusti attivano diverse popolazioni nell’area RC, con probabile organizzazione chemotopica. In particolare, l’infusione di sostanze dal sapore amaro (chinino) eccita i neuroni più mediali, che rilevano il dolce o<span style="mso-spacerun:yes"> </span>l’amaro. Comunque, il pattern di risposta al cloruro di sodio(salato) non è significativamente differente da quello per l’acqua. Si suppone che i neuroni dell’area RC che rispondono preferenzialmente ad un determinato sapore abbiano proiezioni differenti, sottolineando le varie risposte comportamentali che diversi sapori evidenziano. </span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; line-height:normal;mso-outline-level:3"><b><span style=" font-family:"Times New Roman","serif";mso-fareast-Times New Roman"; mso-fareast-language:ITfont-family:";font-size:13.5pt;" >Connessioni intranucleari</span></b></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; line-height:normal"><span style="font-family:"Times New Roman","serif"; mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:12.0pt;" >La morfologia sinaptica all’interno del nucleo è piuttosto complessa ed eterogenea. In particolare, le sinapsi primarie provenienti dalla corda del timpano sono organizzate in strutture glomerulari. Pertanto, l’effetto di un impulso viene modulato dai dendriti dei neuroni di secondo ordine, situati all’interno del nucleo. Generalmente questi complessi includono una spina dendritica di una terminazione primaria e due terminazioni presinaptiche di altra provenienza. I neuroni dopaminergici all’interno dell’RC potrebbero essere bersagli preferenziali di questi input. </span></p><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhlY1HWmJM57U8CccMOZ7IHdG0hRWEOOIKKo9aNLyrBUjsZrICtYmuBM4Z_zVAHz4vRug858As17Do7ESrW-YrWRR0mElolqvfZ5gg4WDrGCm7hmjzBcLCj17vlz4g-aQ0bAJvLzhGmH2mz/s1600/ch2f7.jpg"><img style="float:left; margin:0 10px 10px 0;cursor:pointer; cursor:hand;width: 320px; height: 240px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhlY1HWmJM57U8CccMOZ7IHdG0hRWEOOIKKo9aNLyrBUjsZrICtYmuBM4Z_zVAHz4vRug858As17Do7ESrW-YrWRR0mElolqvfZ5gg4WDrGCm7hmjzBcLCj17vlz4g-aQ0bAJvLzhGmH2mz/s320/ch2f7.jpg" alt="" id="BLOGGER_PHOTO_ID_5614081383681608434" border="0" /></a><p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height: normal"><span style="font-family:"Times New Roman","serif"; mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:12.0pt;" > </span></p> <p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height: normal"><span style="font-family:"Times New Roman","serif"; mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:12.0pt;" >L’organizzazione sinaptica tipica delle terminazioni glossofaringee è di una terminazione primaria più una singola spina dendritica. Questi dati suggeriscono che il processamento degli impulsi sensoriali delle parti anteriore e posteriore della cavità orale sia diverso (meno fine per quest’ultima). Questo significa che risposte sinaptiche proventienti dal glossofaringeo potrebbero non essere soggette a forte inibizione, e questo porterebbe ad una risposta comportamentale più rapida e consistente, tipica della reazione a sostanze amare. Si stima che circa il 45% delle sinapsi all’interno dell’rNST contengano il neurotrasmettitore inibitorio GABA, inviato ai pirenofori o ai dendriti prossimali di assoni del PBN, di azione opposta rispetto alle sinapsi eccitatorie instaurate tra spine dendritiche e dendriti distali. Non si conosce niente riguardo sinapsi che utilizzano altri neurotrasmettitori.<span style="mso-spacerun:yes"> </span></span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; line-height:normal;mso-outline-level:2"><b><span style=" font-family:"Times New Roman","serif";mso-fareast-Times New Roman"; mso-fareast-language:ITfont-family:";font-size:18.0pt;" >Sommario</span></b></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; line-height:normal"><span style="Times New Roman","serif"font-family:";" ><span style="mso-spacerun:yes"> </span></span><span style=" Times New Roman","serif"font-family:";font-size:12.0pt;" >Il limite tradizionale tra le porzioni caudali e rostrali del nucleo del tratto solitario è il punto in cui il nucleo si dirige lateralmente al IV ventricolo, cioè dove vi è una zona di transizione tra le aree a maggior input viscerosensoriale e oro motorio. </span><span style="font-family:"Times New Roman","serif";mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:12.0pt;" >I corpi cellulari dei neuroni dell’rNST tendono ad essere più piccoli di quelli delle strutture che li circondano, ed essi sono relativamente carenti di assoni eccetto per quelli che compongono il tratto solitario, il bordo dorso laterale del<span style="mso-spacerun:yes"> </span>nucleo, fascicoli verticali lungo il bordo ventrale e fibre dai nuclei vestibolari che attraversano la sua metà laterale. In base a caratteristiche morfologiche e funzionali è stato diviso il 7 zone, di cui la RC riceve la maggior parte degli impulsi gustative dalla periferia e contiene quasi tutti i neuroni che proiettano al ponte, e da qui ai centri oromotori. Gli impulsi dai nervi cranici entrano nel nucleo secondo precisa topografia dai nervi trigemino, faciale, glossofaringeo e vago, sebbene molti segnali convergano verso neuroni situati al di sopra del tradizionale limite del nucleo. RC contiene quasi tutti i neuroni che rispondono a impulsi gustativi, RL quelli oro sensoriali(tattili). La via di conduzione principale del gusto(e funzioni elevate ad esso associate) procede al nucleo parabrachiale pontino, al nucleo ventrale posteromediale del talamo, e alla corteccia dell’insula, ma non mancano connessioni con aree corticali frontali, diencefaliche e limbiche, oltre a proiezioni discendenti che organizzano risposte comportamentali prevalentemente motorie. Determinare le popolazioni dei neuroni dell’rNST attivati da specifiche sensazioni orali, e come questi processano queste informazioni, coordinando le risposte fisiologiche e comportamentali è una sfida della ricerca futura.</span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; line-height:normal"><span style="font-family:"Times New Roman","serif"; mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:12.0pt;" >References:</span></p> <p class="MsoNormal"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22King%20MS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract"><span style="line-height:115%;Times New Roman","serif"font-family:";font-size:12.0pt;" >King MS</span></a><span style="line-height:115%;Times New Roman","serif"font-family:";font-size:12.0pt;" >. </span><span style="line-height:115%;font-family:"Times New Roman","serif"; mso-fareast-Times New Roman";mso-fareast-language:ITfont-family:";font-size:12.0pt;" >PMID: 21204466</span></p> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} w\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} </style> <![endif]--><!--[if gte mso 9]><xml> <w:worddocument> <w:view>Normal</w:View> <w:zoom>0</w:Zoom> <w:trackmoves/> <w:trackformatting/> <w:hyphenationzone>14</w:HyphenationZone> <w:punctuationkerning/> <w:validateagainstschemas/> <w:saveifxmlinvalid>false</w:SaveIfXMLInvalid> <w:ignoremixedcontent>false</w:IgnoreMixedContent> <w:alwaysshowplaceholdertext>false</w:AlwaysShowPlaceholderText> <w:donotpromoteqf/> <w:lidthemeother>IT</w:LidThemeOther> <w:lidthemeasian>X-NONE</w:LidThemeAsian> <w:lidthemecomplexscript>X-NONE</w:LidThemeComplexScript> <w:compatibility> <w:breakwrappedtables/> <w:snaptogridincell/> <w:wraptextwithpunct/> <w:useasianbreakrules/> <w:dontgrowautofit/> <w:splitpgbreakandparamark/> 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gran parte grazie all'azione dell'ormone steroideo estradiolo. L'area preottica (POA), una regione dell'ipotalamo anteriore necessaria per l'espressione di molti comportamenti a carattere sessuale, è estremamente sensibile all'effetto di questo ormone.</div><div class="MsoNormal">Gli astrociti della POA presentano un dimorfismo sessuale, nei maschi hanno processi più lunghi e numerosi, risultato dell’azione dell’estradiolo durante il periodo perinatale. Inoltre i neuroni della POA nei maschi hanno più del doppio di spine dendritiche per unità di area dei neuroni della POA nelle femmine, risultato anche questo dell’estradiolo; infatti un’esposizione in periodo perinatale all’estradiolo di POA femminile mascolinizza quest’area. </div><div class="MsoNormal">L’estradiolo proviene dall’aromatizzazione di androgeni prodotti dalle gonadi perinatali. Il pathway di trasduzione del segnale attraverso il quale l’estradiolo svolge la propria funzione coinvolge la PGE2. Il processo inizia appunto con un’aumentata produzione della molecola lipidica PGE2 che è insieme necessaria e sufficiente a produrre una densità di spine dendritiche a carattere maschile nella POA perinatale. Topi maschi trattati con un bloccante per la sintesi delle prostaglandine in periodo perinatale mostrano un pattern sinaptico femminile e una ridotta frequenza della monta e una riduzione dell’eiaculazione nell’età adulta, mentre femmine trattate con PGE2 in età perinatale mostrano una densità di spine dendritiche maschile e acquisiscono un comportamento sessuale maschile in età adultà.</div><div class="MsoNormal">PGE2 è sintetizzata a partire dall’acido arachidonico attraverso la cicloossigenasi (COX) e la PGE sintasi. L’esposizione all’estradiolo in periodo perinatale mascolinizza il cervello attraverso l’up-regulation dell’isoforma inducibile COX2 che porta ad un aumento di circa sette volte del livello di PGE2. Successivamente l’esposizione a PGE2 induce un aumento dei livelli della proteina spinofilina e della densità di spine dendritiche . La spinofilina, infatti, è presente in gran quantità nelle spine dendritiche e i livelli in età adulta di questa proteina nella POA sono direttamente correlati alle misure comportamentali (frequenza e durata della monta, eiaculazione, ecc.).</div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgoYdp9Jk3nQ0gKW7azqLiqtgO22Uk3SUrpwgsXPxVZhKJZyEiNi5g6Gb9P2Iw_J114D6g233IEBweaSjfe-PVWSnbsAfJEWT1PkpFMFoF-au98MdpwS8i7wcUxv6l54vK_Psf-BlLJ2A/s1600/pone.0018500.g003.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="265" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgoYdp9Jk3nQ0gKW7azqLiqtgO22Uk3SUrpwgsXPxVZhKJZyEiNi5g6Gb9P2Iw_J114D6g233IEBweaSjfe-PVWSnbsAfJEWT1PkpFMFoF-au98MdpwS8i7wcUxv6l54vK_Psf-BlLJ2A/s400/pone.0018500.g003.jpg" width="400" /></a></div><div class="MsoNormal">Gli effetti di PGE2 sono propagati dai recettori per i prostanoidi di tipo E accoppiati a proteina G chiamati EP 1-4. Tutti e quattro i recettori EP sono espressi nella POA perinatale e sono necessari all’aumento dei livelli di spinofilina in risposta all’estradiolo e alla PGE2. EP2 e EP4 sono necessari e sufficienti per raggiungere sufficienti livelli di spinofilina in età neonatale e quindi un adeguata densità di spine dendritiche per lo sviluppo del comportamento sessuale maschile in età adulta. EP1 e EP3 forniscono un supporto ridondante che garantisce che la mascolinizzazione della POA PGE2mediata sia raggiunta. I recettori sono generalmente (sempre EP2 e EP4) accoppiati a proteina G che possono quindi stimolare la produzione di cAMP grazie all’adenilato ciclasi e quindi reclutare la PKA.</div><div class="MsoNormal">PKA fosforila diverse subunità del recettore AMPA, come GluR1, fosforilazione promossa dalle proteine che ancorano la PKA (AKAPs) che la indirizzano verso i recettori del glutammato. In altre zone del cervello, come l’ippocampo e la neocorteccia, la fosforilazione di GluR1 in corrispondenza del residuo di serina 845 provoca un aumento del traffico de dell’inserzione dei recettori AMPA a livello del terminale postsinaptico costituito dalle spine dendritiche. Quindi PGE2 regola rapidamente e positivamente la fosforilazione delle subunità GluR1 dei recettori AMPA attraverso la PKA e aumenta l’inserzione di GluR1 nella membrana, entrambi fenomeni che contribuiscono alla formazione e alla stabilizzazione di nuove spine dendritiche. </div><div class="MsoNormal">Le spine dendritiche sono i siti primari degli input sinaptici eccitatori nel cervello e frequentemente si modificano di numero e /o densità in risposta a variazioni sia interne che esterne associate con la regolazione del comportamento. L’attività sinaptica della POA è necessaria per l’espressione del comportamento sessuale maschile nell’età adulta e la disposizione maschile delle spine dendritiche è altrettanto necessaria per l’espressione di questo comportamento. </div><div class="MsoNormal"> </div><div class="MsoNormal">References</div><br />
<ul><li>Lenz KM, Wright CL, Martin RC, McCarthy MM. Prostaglandin E(2) Regulates AMPA Receptor Phosphorylation and Promotes Membrane Insertion in Preoptic Area Neurons and Glia during Sexual Differentiation. PLoS One. 2011 Apr 7;6(4):e18500. </li>
<li>Wright CL, Burks SR, McCarthy MM. Identification of prostaglandin E2 receptors mediating perinatal masculinization of adult sex behavior and neuroanatomical correlates. Dev Neurobiol. 2008 Oct;68(12):1406-19.</li>
<li>Wright CL, McCarthy MM. Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling. <a href="http://www.blogger.com/post-edit.g?blogID=2650750594787397971&postID=8568782932248588944" title="The Journal of neuroscience : the official journal of the Society for Neuroscience.">J Neurosci.</a> 2009 Oct 21;29(42):13274-82.</li>
</ul><div class="MsoNormal"></div>GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com0tag:blogger.com,1999:blog-2650750594787397971.post-86548834219406931652011-05-10T06:22:00.000-07:002011-05-10T06:22:49.869-07:00Anatomia del nucleo rostrale del tratto solitario (Parte 1)<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:HyphenationZone>14</w:HyphenationZone> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>IT</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:EnableOpenTypeKerning/> <w:DontFlipMirrorIndents/> <w:OverrideTableStyleHps/> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true"
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<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;"> <span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: IT; mso-bidi-language: AR-SA; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: IT;">Pur contiguo con la parte caudale del nucleo, l’rNST è funzionalmente distinto poiché riceve afferenze gustative e oro sensoriali primarie. Infatti campi terminali oro sensoriali dei nervi cranici si estendono per varie centinaia di micron casualmente rispetto al punto in cui l’NST si porta lateralmente al IV ventricolo, funzionalmente quindi l’rNST si estende caudalmente al suo limite tradizionale.</span><span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: IT;"> </span></div><div class="MsoNormal" style="line-height: normal; margin-bottom: 0.0001pt;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Sul piano orizzontale, l’NST appare a forma di V, la cui punta corrisponde alla porzione commissurale e gli apici all’rNST. Su questo piano, il tratto solitario è chiaramente visibile insieme alla parte laterale del nucleo. Nelle sezioni coronali, l’rNST è situato subito lateralmente e ventralmente ai nuclei mediale e spinale vestiblolare, medialmente al nucleo spinale del trigemino e dorsalmente alla formazione reticolare parvocellulare. </span></div><div class="MsoNormal" style="line-height: normal; mso-margin-bottom-alt: auto;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj6-juzPNrOa8sS5JFrAkQEwH8Ehlkqa8RE7JMUCW_h6ZvmaHpxUQczVHd59UmF2rsVrqm0TiyzjOElzao1YYWQpNQQVbxGV4pPbX7kRdjpRt6Sh636q0ZMsu0rIhoHxsV-kLYTXNYRIg/s1600/ch2f2.jpg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj6-juzPNrOa8sS5JFrAkQEwH8Ehlkqa8RE7JMUCW_h6ZvmaHpxUQczVHd59UmF2rsVrqm0TiyzjOElzao1YYWQpNQQVbxGV4pPbX7kRdjpRt6Sh636q0ZMsu0rIhoHxsV-kLYTXNYRIg/s320/ch2f2.jpg" width="289" /></a><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">Istologicamente, l’rNST è distinto dalla regione circostante per via della dimensione relativamente piccola dei pirenofori. Tale distinzione è particolarmente evidente lungo i margini mediale e dorsale. Sono comunque presenti alcuni neuroni giganti, particolarmente nella metà ventrale, simili a quelli dell’adiacente formazione reticolare (rendendo quindi difficile delineare i margini).<span style="mso-spacerun: yes;"> </span>Il bordo laterale è maggiormente distinto nel tessuto decolorato dalle fibre mieliniche per via dell’abbondanza di queste appena lateralmente al rNST. </span><!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:HyphenationZone>14</w:HyphenationZone> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>IT</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:EnableOpenTypeKerning/> <w:DontFlipMirrorIndents/> <w:OverrideTableStyleHps/> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true"
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</style> <![endif]--> </div><div class="MsoNormal" style="line-height: normal;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;">I neuroni dell’rNST non sono omogenei né disposti in maniera ordinata: il nucleo è stato suddiviso in regioni per differenze istologiche, citoarchitettoniche e di connettività. Studi recenti, utilizzando una combinazione di varie tecniche come impregnazione di Nills, argento ridotto, metodo di Golgi e tract tracing, hanno consentito di designare quattro suddivisioni nel topo. Tali suddivisioni corrispondono anche a distinzioni funzionali: di conseguenza, tale suddivisione può essere importante per chiarire i meccanismi di processamento sensoriale all’interno del nucleo. <span style="mso-spacerun: yes;"> </span>Recentemente alcuni ricercatori hanno diviso l’rNST in 6 campi che non riflettono specifiche caratteristiche anatomiche ma facilitano la discussione sulle differenze funzionali delle varie popolazioni. La suddivisione mediale (M) è la più piccola, lateralmente al nucleo vestibolare mediale: contiene neuroni piccoli senza neuropili e alcuni neuroni parasimpatici pregangliari nella porzione ventromediale, che andrebbero esclusi dal nucleo per la loro funzione motoria. I neuroni M non ricevono fibre dirette craniali, ma sono connessi all’NST caudale, probabilmente per collegare informazioni gustative e viscerosensitive. Il campo rostrale centrale (RC) è immediatamente laterale a M, medialmente al tratto solitario: contiene neuroni piccoli e medi densamente impacchettati e poche fibre mielinizzate lo attraversano scavalcando i nuclei vestibolari. L’RC riceve le maggiori afferenze dai nervi cranici e contiene la maggioranza dei neuroni che contribuiscono alle vie gustative ascendenti. La suddivisione rostrale laterale (RL) circonda il tratto solitario all’estremità laterale del rNST: contiene neuroni simili per dimensioni a quelli di RC ma meno impacchettati. Vi è un significativo aumento delle fibre mieliniche che la attraversano in direzione dorso-ventrale I neuroni RL ricevono fibre afferenti dai nervi cranici, la maggioranza delle quali trasmettono informazioni orotattili. RL contiene anche alcuni neuroni che proiettano al nucleo parabrachiale (PBN) nel ponte. La suddivisione ventrale (V) si trova davanti a RC e RL, facilmente distinguibile per neuroni sparsi intorno a molte fibre che decorrono in senso rostro-caudale. V contiene la maggioranza dei neuroni che proiettano ai centri oromotori del tronco encefalico e altri che proiettano rostralmente al PBN.<span style="mso-spacerun: yes;"> </span>Infine la divisione dorsale (D) descritta nel criceto, una sottile striscia situata dorsalmente al RC: contiene neuroni molto piccoli e sparsi. </span></div><div class="MsoNormal" style="line-height: normal;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"></span></div><div class="MsoNormal" style="line-height: normal;"><!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:HyphenationZone>14</w:HyphenationZone> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>IT</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:EnableOpenTypeKerning/> <w:DontFlipMirrorIndents/> <w:OverrideTableStyleHps/> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true"
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</style> <![endif]--><span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: IT;">In base alla forma e dimensioni del soma, al numero di dendriti primari e alla morfologia dell’albero dendritico sono presenti 3 principali popolazioni neuronali: ovoidali, multipolari e allungati, identificati con iniezioni di rafano-perossidasi e aggiungendo biocitina all’ago per valutazione elettrofisiologica. </span> <div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjm-RsAaBKmBYklWeFaMOfUHlMuTeXlS8eqYYpg8B8_RTJTxuCCsyWSoXuwbgvzu0npaElKkkzrt-fbDmJgftnV52W865UgtcIunkpiEw446VhKkSxYSJuTN69YuGY7js7ngGH9nT2Ulw/s1600/ch2f3.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjm-RsAaBKmBYklWeFaMOfUHlMuTeXlS8eqYYpg8B8_RTJTxuCCsyWSoXuwbgvzu0npaElKkkzrt-fbDmJgftnV52W865UgtcIunkpiEw446VhKkSxYSJuTN69YuGY7js7ngGH9nT2Ulw/s320/ch2f3.jpg" width="240" /></a></div><div class="MsoNormal" style="line-height: normal; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: IT;">Le cellule più piccole hanno soma sferici od ovoidali e tipicamente due o tre sottili dendriti primari, di solito corti (180 μm), confinati all’interno della sostanza grigia e GABAergici (quindi considerati interneuroni). I neuroni multipolari (o stellati) hanno un soma relativamente ampio, poligonale, e da 3 a 5 dendriti primari, che possono essere anche lunghi (in media 650 μm) tra una suddivisione e l’altra dell’rNST, solitamente dalla regione V alla RC o alla formazione reticolare.<span style="mso-spacerun: yes;"> </span>Essi sono ricchi di spine (quindi riceverebbero afferenze primarie) e principalmente orientati lungo il piano orizzontale, quindi perpendicolari alla fibre afferenti del tratto solitario, in modo tale da poter ricevere impulsi convergenti. I neuroni allungati (o fusiformi) hanno un distintivo corpo cellulare con due sottili dendriti primari che si proiettano dai poli opposti della cellula, tipicamente lunghi (mediamente 800 μm) privi di spine con un orientamento predominante in senso medio-laterale. Essi sono presenti nei siti di risposta sensoriali in RC e RL: similmente ai multipolari, essi possiedono connessioni con il nucleo parabrachiale e la formazione reticolare. La loro abbondanza nell’RL suggerisce un ruolo giocato da questa cellula nel processamento di informazioni non gustative oro sensoriali. <span style="mso-spacerun: yes;"> </span>La popolazione più abbondante è quella dei neuroni ovoidali (quasi il 50%) ma i 3 tipi, pur essendo morfologicamente distinti, non si presentano in gruppi distinti di cellule nel nucleo, non possedendo differenti proprietà biofisiche né diverse risposte ai neurotrasmettitori. Comunque vi è una netta distinzione funzionale: I neuroni ovoidali sono interneuroni, le altre due popolazioni sono neuroni di proiezione. </span></div><div class="MsoNormal" style="line-height: normal;"><br />
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</style> <![endif]--> </div><div class="MsoNormal"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22King%20MS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract"><span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">King MS</span></a><span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">. </span><span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: IT;">PMID: 21204466</span></div><div class="MsoNormal" style="line-height: normal;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt;"> </span></div>GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com0tag:blogger.com,1999:blog-2650750594787397971.post-78561834206192397882011-05-04T12:34:00.000-07:002011-05-04T12:34:03.136-07:00Proprietà morfologiche ed elettrofisiologiche degli interneuroni colinergici dei gangli della base<!--[if gte mso 9]><xml> <o:OfficeDocumentSettings> <o:RelyOnVML/> <o:AllowPNG/> </o:OfficeDocumentSettings> </xml><![endif]--><!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:HyphenationZone>14</w:HyphenationZone> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>IT</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:EnableOpenTypeKerning/> <w:DontFlipMirrorIndents/> <w:OverrideTableStyleHps/> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true"
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<div class="MsoNormal">I gangli della base includono differenti nuclei subcorticali interconnessi coinvolti nella carica motivazionale, nella pianificazione del movimento e nell’apprendimento.<span style="mso-spacerun: yes;"> </span>Lo striato rappresenta il principale nucleo di ingresso per la circuiteria dei gangli della base. Riceve afferenze eccitatorie (glutammatergiche) dalla corteccia e dal talamo ed è densamente innervato da neuroni dopaminergici del mesencefalo. La maggioranza dei neuroni striatali è GABAergica, molti di questi sono appunto neuroni GABAergici di proiezione di medie dimensioni e coperti di spine dendritiche. <span style="mso-spacerun: yes;"> </span>Sono stati poi identificati almeno tre tipi di interneuroni GABAergici in base alle loro proprietà elettrofisiologiche e neurochimiche.<span style="mso-spacerun: yes;"> </span>Questi interneuroni possono presentare proteine leganti calcio come la parvalbumina, la calretinina e il neuropeptide Y, oppure la somatostatina o la NADH diaforasi. Di conseguenza sono stati classificati rispettivamente come neuroni fast-spiking (FS), neuroni con spike persistente e a bassa soglia (PLTS) e neuroni con spike a bassa soglia (LTS). Uno studio relativamente recente ha identificato un nuovo gruppo di neuroni GABAergici<span style="mso-spacerun: yes;"> </span>che esprimono la Tirosina Idrossilasi (TH+). Oltre alla popolazione numericamente superiore di neuroni GABAergici , lo striato contiene anche una piccola percentuale di neuroni che procura per quest’area uno dei più alti livelli di acetilcolina (ACh) del cervello. Sono questi i grandi interneuroni colinergici sprovvisti di spine dendritiche (ChIs) caratterizzati da una densa arborizzazione assonica locale e un’attività di scarica tonificante. E’ ormai risaputa la centralità dei ChIs striatali nella circuiteria dei gangli della base sia per il controllo del movimento volontario che nella patogenesi di malattie quali il morbo di Parkinson (PD) e la distonia, tant’è che i farmaci anticolinergici sono stati a lungo la prima scelta per la terapia di queste malattie. </div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhZscxKjKOPqzxXc_2mOKlASXd4P0KSjV_5pMJfS-8RCmjii26XPjXi-ogWoCFwWlXkyyZrRbjJ0B-QyTnvAFq928suN9Ah_QC290iLYdGsYtzazLwTxqWlHkJd3TGiGWRpqX5S4Y-QFA/s1600/fnana-05-00006-g001.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhZscxKjKOPqzxXc_2mOKlASXd4P0KSjV_5pMJfS-8RCmjii26XPjXi-ogWoCFwWlXkyyZrRbjJ0B-QyTnvAFq928suN9Ah_QC290iLYdGsYtzazLwTxqWlHkJd3TGiGWRpqX5S4Y-QFA/s400/fnana-05-00006-g001.jpg" width="336" /></a></div><div class="MsoNormal">I grandi interneuroni colinergici sprovvisti di spine dendritiche rappresentano meno del 2 % di tutta la popolazione neuronale dello striato. La loro identificazione neurochimica è data dall’espressione di ChAT, l’enzima biosintetico per l’ACh. Morfologicamente sono caratterizzati da un grande soma poligonale (<span class="apple-style-span"><b style="mso-bidi-font-weight: normal;"><span style="color: #212121; font-family: "Times New Roman","serif";">Ø </span></b></span>20-50 micron), arborizzazioni dendritica e assonale diffuse e una peculiare distribuzione nella matrice dello striato (<span class="apple-style-span"><span style="color: black; font-family: "Times New Roman","serif";">PMID: 9706390</span></span>), caratteristiche che suggeriscono il coinvolgimento degli interneuroni colinergici nell’integrazione delle afferenze in aree relativamente ampie, nonché una loro funzione associativa all’interno dello striato. Registrazioni elettrofisiologiche in vitro hanno registrato le peculiarità della membrana dei ChIs che differenziano questi ultimi dagli altri sottogruppi neuronali dello striato: un potenziale di membrana a riposo relativamente basso (depolarizzato, minore in valore assoluto), un potenziale d’azione a lunga durata, alta resistenza d’input, una notevole iperpolarizzazione successiva al potenziale d’azione e una notevole corrente cationica attivata dall’iperpolarizzazione. Queste cellule si attivano autonomamente, presentano modelli di attivazione tonica, da un singolo spike irregolare a schemi ritmici, anche in assenza di input sinaptici, suggerendo la natura intrinseca della loro origine. La prevalenza di un modello di attivazione in ogni singolo neurone è dipendente dalla conduttanza del K+ attivata dal calcio. In particolare, lo spike singolo dipende da un’iperpolarizzazione<span style="color: black; mso-themecolor: text1;"> successiva al potenziale d’azione</span> di media durata generata da rapide correnti SK (Apamin-Sensitive Calcium-Activated Potassium Currents<span style="color: #403838;">) </span><span style="color: black; mso-themecolor: text1;">che sono associate a canali del calcio attivati ad alto voltaggio (HVA), CaV2.2 . D’altro canto, i modelli d’attivazione periodici sono dovuti da una graduale e lenta iperpolarizzazione successiva al potenziale d’azione associata a canali del calcio CaV1. La specifica associazione tra i sottotipi dei canali del calcio HVA e le correnti del K sottostanti alle mAHP e sAHP è generata dalle dinamiche della distribuzione del calcio a livello dei siti con differente cinetica di legame nel citoplasma. Agli interneuroni colinergici giungono le proiezioni glutammatergiche dalla corteccia e dai nuclei centromediano e parafascicolare del talamo nonché un’estesa proiezione dopaminergica dalla substantia nigra pars compatta. </span></div><div class="MsoNormal"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiE6GmgwJrLT1kucfzw4be-RfMsBrscspIEpLqspgqMLqeKopLGBDQPDzh0aZpCBOHNnfGeavQOSJQE13gnttCD_5GE-MBNDWXjapObXvNs_o6vrBLWTtd0JlGlgRIHDwtvKvL-2gNVlQ/s1600/fnana-05-00006-g002.jpg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" height="170" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiE6GmgwJrLT1kucfzw4be-RfMsBrscspIEpLqspgqMLqeKopLGBDQPDzh0aZpCBOHNnfGeavQOSJQE13gnttCD_5GE-MBNDWXjapObXvNs_o6vrBLWTtd0JlGlgRIHDwtvKvL-2gNVlQ/s320/fnana-05-00006-g002.jpg" width="320" /></a><span style="color: black;">L’effetto predominante della dopamina sui ChIs è mediato dai recettori D2 che inibiscono l’efflusso di Ach striatale, riducendo sia l’attivazione autonoma del potenziale d’azione che gli input sinaptici sui ChIs. Il primo si ottiene migliorando la lenta inattivazione dei canali per il Na+ voltaggio-dipendenti e modulando la corrente Ih, il secondo attraverso l’inibizione dei canali del calcio HVA. In più, i ChIs<span style="mso-spacerun: yes;"> </span>esprimono i recettori D1-like e D5 che si collocano soprattutto a livello del soma e dei dendriti e che depolarizzano la cellula promuovendo l’apertura non selettiva dei canali per cationi e la chiusura dei canali per il K+ , quindi, a sua volta, favorisce il rilascio di ACh.<span style="mso-spacerun: yes;"> </span></span>Un ulteriore livello di controllo del rilascio si ACh è rappresentato dagli autorecettori muscarinici M2/M4. L’attivazione degli auto recettori riduce il rilascio di ACh grazie alla chiusura dei canali del calcio Ca<sub>v</sub>2 che mediano l’esocitosi e favorendo l’apertura dei canali del K<sup>+</sup> Kir3 che iperpolarizzano le estremità terminali della membrana e quindi riducono l’apertura dei canali del Ca<sup>2+</sup>. Inoltre gli ChIs ricevono proiezioni estrinseche serotoninergiche<span style="mso-spacerun: yes;"> </span>e noradrenergiche eccitatorie e una innervazione intrinseca GABAergica inibitoria sia dai neuroni di proiezione che dagli interneuroni. Potenziali postsinaptici evocati da stimolazione elettrica delle fibre che innervano gli ChIs sono mediati dai recettori ionotropici NMDA, AMPA e GABA<sub>A</sub> . Su completa inibizione delle componenti sinaptiche glutammatergiche e della proiezione GABAergica , è rivelato un lento potenziale sinaptico inibitorio che è mediato da una conduttanza al K<sup>+</sup> attivata da recettori M2-like. <span class="hps">L'attività</span> <span class="hps"><span title="Fai clic per visualizzare le traduzioni alternative">dei</span></span> <span class="hps"><span title="Fai clic per visualizzare le traduzioni alternative">ChIs</span></span> <span class="hps"><span title="Fai clic per visualizzare le traduzioni alternative">è quindi</span></span> <span class="hps"><span title="Fai clic per visualizzare le traduzioni alternative">altamente</span></span> <span class="hps"><span title="Fai clic per visualizzare le traduzioni alternative">regolata</span> <span title="Fai clic per visualizzare le traduzioni alternative"><span class="hps">tramite</span></span> <span title="Fai clic per visualizzare le traduzioni alternative"><span class="hps">una complessa interazione</span></span> <span title="Fai clic per visualizzare le traduzioni alternative"><span class="hps">tra le</span></span> <span title="Fai clic per visualizzare le traduzioni alternative"><span class="hps">proprietà</span></span> <span title="Fai clic per visualizzare le traduzioni alternative"><span class="hps">intrinseche</span></span> <span title="Fai clic per visualizzare le traduzioni alternative"><span class="hps">e</span></span> <span title="Fai clic per visualizzare le traduzioni alternative"><span class="hps">il controllo</span> neuromodulatorio</span> <span title="Fai clic per visualizzare le traduzioni alternative"><span class="hps">esercitato da</span></span> <span title="Fai clic per visualizzare le traduzioni alternative"><span class="hps">più trasmettitori</span></span><span title="Fai clic per visualizzare le traduzioni alternative">.</span></span></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><span class="hps"><span title="Fai clic per visualizzare le traduzioni alternative">References</span></span></div><ul><li><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="-webkit-border-horizontal-spacing: 3px; -webkit-border-vertical-spacing: 3px; color: #212121; font-family: Arial, sans-serif; font-size: 12px; line-height: 17px;">Bolam J. P., Wainer B. H., Smith A. D. (1984).<span class="Apple-converted-space"> </span><span class="ref-title">Characterization of cholinergic neurons in the rat neostriatum. A combination of choline acetyltransferase immunocytochemistry, Golgi-impregnation and electron microscopy</span>.<span class="Apple-converted-space"> </span><span class="ref-journal" style="font-style: italic;">Neuroscience</span><span class="Apple-converted-space"> </span><span class="ref-vol">12</span>, 711–718. doi: 10.1016/0306-4522(84)90165-9.</span></span><span class="hps"><span title="Fai clic per visualizzare le traduzioni alternative"> </span></span></li>
<li><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="-webkit-border-horizontal-spacing: 3px; -webkit-border-vertical-spacing: 3px; color: #212121; font-family: Arial, sans-serif; font-size: 12px; line-height: 17px;">Smith A. D., Bolam J. P. (1990).<span class="Apple-converted-space"> </span><span class="ref-title">The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones</span>.<span class="Apple-converted-space"> </span><span class="ref-journal" style="font-style: italic;">Trends Neurosci.</span><span class="Apple-converted-space"> </span><span class="ref-vol">13</span>, 259–265. doi: 10.1016/0166-2236(90)90106-K.</span></span></li>
<li><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="-webkit-border-horizontal-spacing: 3px; -webkit-border-vertical-spacing: 3px; color: #212121; font-family: Arial, sans-serif; font-size: 12px; line-height: 17px;">Tepper J. M., Tecuapetla F., Koós T., Ibáñez-Sandoval O. (2010).<span class="Apple-converted-space"> </span><span class="ref-title">Heterogeneity and diversity of striatal GABAergic interneurons</span>.<span class="Apple-converted-space"> </span><span class="ref-journal" style="font-style: italic;">Front. Neuroanat.</span><span class="Apple-converted-space"> </span><span class="ref-vol">4</span>:150. doi: 10.3389/fnana.2010.00150.</span></span></li>
<li><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="-webkit-border-horizontal-spacing: 3px; -webkit-border-vertical-spacing: 3px; color: #212121; font-family: Arial, sans-serif; font-size: 12px; line-height: 17px;">Bennett B. D., Wilson C. J. (1998).<span class="Apple-converted-space"> </span><span class="ref-title">Synaptic regulation of action potential timing in neostriatal cholinergic interneurons</span>.<span class="Apple-converted-space"> </span><span class="ref-journal" style="font-style: italic;">J. Neurosci.</span><span class="Apple-converted-space"> </span><span class="ref-vol">18</span>, 8539–8549.</span></span></li>
<li><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="-webkit-border-horizontal-spacing: 3px; -webkit-border-vertical-spacing: 3px; color: #212121; font-family: Arial, sans-serif; font-size: 12px; line-height: 17px;">Wilson C. J. (2005).<span class="Apple-converted-space"> </span><span class="ref-title">The mechanism of intrinsic amplification of hyperpolarizations and spontaneous bursting in striatal cholinergic interneurons</span>.<span class="Apple-converted-space"> </span><span class="ref-journal" style="font-style: italic;">Neuron</span><span class="Apple-converted-space"> </span><span class="ref-vol">45</span>, 575–585. doi: 10.1016/j.neuron.2004.12.053.<span class="Apple-converted-space"> </span></span></span></li>
<li><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="-webkit-border-horizontal-spacing: 3px; -webkit-border-vertical-spacing: 3px; color: #212121; font-family: Arial, sans-serif; font-size: 12px; line-height: 17px;">Wilson C. J., Chang H. T., Kitai S. T. (1990).<span class="Apple-converted-space"> </span><span class="ref-title">Firing patterns and synaptic potentials of identified giant aspiny interneurons in the rat neostriatum</span>.<span class="Apple-converted-space"> </span><span class="ref-journal" style="font-style: italic;">J. Neurosci.</span><span class="Apple-converted-space"> </span><span class="ref-vol">10</span>, 508–519.<span class="Apple-converted-space"> </span></span></span></li>
<li><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="-webkit-border-horizontal-spacing: 3px; -webkit-border-vertical-spacing: 3px; color: #212121; font-family: Arial, sans-serif; font-size: 12px; line-height: 17px;">Wilson C. J., Goldberg J. A. (2006).<span class="Apple-converted-space"> </span><span class="ref-title">Origin of the slow afterhyperpolarization and slow rhythmic bursting in striatal cholinergic interneurons</span>.<span class="Apple-converted-space"> </span><span class="ref-journal" style="font-style: italic;">J. Neurophysiol.</span><span class="Apple-converted-space"> </span><span class="ref-vol">95</span>, 196–204.<span class="Apple-converted-space"> </span></span></span><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="color: #212121; font-family: Arial,sans-serif; font-size: 12px; line-height: 17px;"><span class="Apple-converted-space"> </span></span></span><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="color: #212121; font-family: Arial,sans-serif; font-size: 12px; line-height: 17px;"><span class="Apple-converted-space"> </span></span></span><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="color: #212121; font-family: Arial,sans-serif; font-size: 12px; line-height: 17px;"> </span></span><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="color: #212121; font-family: Arial,sans-serif; font-size: 12px; line-height: 17px;"> </span></span><span class="Apple-style-span" style="border-collapse: separate; color: black; font-family: 'Times New Roman'; font-size: small; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="Apple-style-span" style="color: #212121; font-family: Arial,sans-serif; font-size: 12px; line-height: 17px;"> </span></span></li>
</ul><div class="MsoNormal"><span class="hps"><span title="Fai clic per visualizzare le traduzioni alternative"> </span><span style="color: black; mso-themecolor: text1;"></span></span></div>GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com1tag:blogger.com,1999:blog-2650750594787397971.post-82507319415031643142011-04-09T06:05:00.000-07:002011-04-09T07:55:31.893-07:00Il nucleo spinale del Trigemino<div style="text-align: left;"><span class="Apple-style-span" style="font-family: 'Times New Roman', serif;"><span class="Apple-style-span" style="line-height: 18px;">Si ringrazia Vobberto per l'articolo.</span></span></div><div style="text-align: left;"><span class="Apple-style-span" style="font-family: 'Times New Roman', serif;"><span class="Apple-style-span" style="line-height: 18px;"><br />
</span></span></div><div style="text-align: left;"><span class="Apple-style-span" style="font-family: 'Times New Roman', serif;"><span class="Apple-style-span" style="line-height: 18px;">"Ogni dolore viene scritto su lastre di una sostanza misteriosa al paragone della quale il granito è burro. E non basta un'eternità a cancellarlo." Dino Buzzati </span></span></div><div style="text-align: left;"><span class="Apple-style-span" style="font-family: 'Times New Roman', serif; font-size: 16px; line-height: 18px;"><br />
</span></div><div style="text-align: left;"><span class="Apple-style-span" style="font-family: 'Times New Roman', serif; font-size: 16px; line-height: 18px;">La radice suprema del nervo trigemino, arrivata a livello del ponte, piega inferiormente formando il fascio spinale del trigemino: esso manda assoni fino al terzo mielomero cervicale ricevendo varie afferenze dai nervi faciale, vago e glossofaringeo, cruciali per riflessi vari (starnuto, riflesso lacrimale, corneale ecc). La maggioranza degli assoni (sensitivi primari) però restano nel tronco encefalico terminando nel nucleo spinale del trigemino, localizzato nel bulbo davanti ai nuclei vestibolari, medialmente al fascio omonimo. Anche in questo caso sono presenti numerosi collaterali provenienti dai nervi faciale glossofaringeo e vago: si tratta di un omologo funzionale del fascicolo dorso laterale del Lissauer presente nel midollo spinale. Esso è tradizionalmente diviso in tre parti: caudalis(dal midollo fino all’obex), interpolaris(fino alla giunzione pontobulbare) e oralis(fino al nucleo pontino del trigemino). La pars caudalis ha una struttura lamellare simile a quella del corno dorsale del midollo: la lamina I riceve afferenze somatiche generali accoppiate a rilascio di sostanza P, la lamina II presenta enkefaline e funzionalmente è assimilabile alla sostanza gelatinosa, le lamine III e IV sono magno cellulari. Si tratta del sottonucleo maggiormente coinvolto nella trasmissione del dolore. E’ presente una somatotopia caudo rostrale che corrisponde ad una rappresentazione somatica sempre più profonda (pertanto la pars oralis è relativa al dolore buccale, mentre la interpolaris a quello cutaneo).</span></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhfriu2NtJdUA_ssxComNVvK_oeoWrOgerIhfybe4k03lVcu8zOFKIlWufg6fxCnqx1Ncp0EXwW8JPP4AG-AAsLO2-hP_Ooa5JJDztrOKYJZCXqniM6ATyVx_VfDMiUJfNy-yDL5Ts1Sg/s1600/a01fig01.gif" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="277" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhfriu2NtJdUA_ssxComNVvK_oeoWrOgerIhfybe4k03lVcu8zOFKIlWufg6fxCnqx1Ncp0EXwW8JPP4AG-AAsLO2-hP_Ooa5JJDztrOKYJZCXqniM6ATyVx_VfDMiUJfNy-yDL5Ts1Sg/s320/a01fig01.gif" width="320" /></a></div><div class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: left;"><br />
</div><div class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: left;"><span style="font-family: 'Times New Roman', serif; font-size: 12pt; line-height: 115%;">I neuroni sensitivi secondari formano il fascicolo tegmentale dorsale (noto anche come fascio trigemino-talamico ventrale) che passa vicino alla formazione reticolare decussando la linea mediana e terminando a livello della divisione mediale del nucleo ventrale posteriore del talamo. Il nucleo spinale proietta inoltre anche direttamente alla formazione reticolare, collaborando alla via spinoreticolotalamica per la regione della testa. Numerosi studi recenti sono stati compiuti per descrivere la presenza di un vasto repertorio di molecole(soprattutto cotrasmettitori) all’interno di questo nucleo. <o:p></o:p></span></div><div class="MsoNormal" style="line-height: normal; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;">In uno di questi sono <span style="font-family: 'Times New Roman', serif; font-size: 12pt;">state valutate le concentrazioni extracellulari di GABA nel nucleo spinale del trigemino durante il formalin test, su campioni di 30 microlitri ognuno, ottenuti da microdialisi e studi farmacologici su due gruppi di 6 ratti, valutando la risposta comportamentale all’iniezione di formalina (gruppo1) o soluzione salina (gruppo 2). Successivamente ad altri 3 gruppi di ratti sono stati iniettati soluzione salina, muscimolo (agonista del recettore del GABA) o bicullina (antagonista dello stesso recettore) sempre a livello del nucleo spinale, prima di iniziare il formalin test. L’iniezione di formaldeide induce una risposta comportamentale bifasica e incrementa i livelli di GABA dopo 15-45 minuti. L’iniezione di bicullina (e non muscimolo o soluzione salina) diminuisce notevolmente la risposta comportamentale al formalin test. Tali risultati suggeriscono che i neuroni gabaergici del nucleo spinale del trigemino siano coinvolti nella trasmissione di informazioni nocicettive. <o:p></o:p></span></div><div class="MsoNormal" style="line-height: normal; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="font-family: 'Times New Roman', serif; font-size: 12pt;">Altri esperimenti sono stati condotti per investigare il possibile coinvolgimento delle specie reattive dell’ossigeno nella nocicezione nel sub nucleo caudalis del nucleo spinale trigeminale. Nel primo il livello extracellulare di perossido di idrogeno è stato valutato tramite microdialisi del sub nucleo di due gruppi di sei ratti prima di iniezione al labbro superiore di soluzione salina (gruppo 2) o formalina (gruppo 1). Nel secondo esperimento il formalin test è stato condotto su 3 gruppi di 6 ratti dopo microiniezione rispettivamente di 2-ME (2metossiestradiolo, un inibitore della superossido-dismutasi) o NAC (Nacetilcisteina, uno scavenger degli intermedi dell’ossigeno) o soluzione salina. Nel terzo esperimento è stato effettuato un saggio istochimico per l’attività della superossido dismutasi su 2 gruppi di 4 ratti dopo 2h dal’iniezione (rispettivamente di formalina o soluzione salina). I risultati mostrano che i livelli di perossido di idrogeno aumentano all’interno del sub nucleo durante il dolore facciale (134% rispetto ai livelli base); l’inibizione della superossido dismutasi o la rimozione di intermedi dell’ossigeno diminuiscono la sensibilità a stimoli di dolore facciale; stimoli persistenti di dolore facciale diminuiscono l’attività del superossido (fino al 90% del nucleo contro laterale). Tali dati suggeriscono che specie reattive dell’ossigeno siano prodotte dal sub nucleo caudalis durante dolore trigeminale persistente e sono necessari per la trasmissione del dolore. </span><span style="font-family: 'Times New Roman', serif; font-size: 12pt;">L’anione superossido è stato rilevato anche dopo un sovraccarico meccanico funzionale dei denti dovuto alla preferenza per la masticazione su un solo lato indotta nei ratti tramite piccola abrasione di un molare, in modo tale che la lateralizzazione della masticazione venisse confermata per elettromiografia. La produzione di superossido è stata valutata tramite microscopia a fluorescenza dopo iniezione di diidroetidio. I risultati mostrano che vi è un aumento della sua produzione a livello del sub nucleo oralis del nucleo spinale del trigemino nello stesso lato in cui la masticazione viene preferita. Questo dimostra che un’aumentata attività di neuroni sensitivi non-nocicettivi può stimolare la produzione di specie reattive dell’ossigeno all’interno dei neuroni di secondo ordine di tale nucleo. </span><span style="font-family: 'Times New Roman', serif; font-size: 12pt;">Tramite ulteriori esperimenti è però stato chiarito che un significativo incremento della produzione di superossido nei nuclei omolaterali avviene dopo 45 minuti e l’attività di SOD (superossido dismutasi) non ha significative differenze tra i nuclei dei due lati. Pertanto lo ione superossido è coinvolto nei processi dolorifici indotti dall’infiammazione, e non dal dolore acuto. <o:p></o:p></span></div><div class="MsoNormal" style="line-height: normal; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="font-family: 'Times New Roman', serif; font-size: 12pt;"><br />
</span></div><div class="MsoNormal" style="line-height: normal; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhZRIrpC0FzgEvsG-ncTOQEnbbLy5CKGRPBv4zy96tKr_gY6MYWIcU7_V7-T2c7Z0JF1dIwBH-tj3wsa_0sManBozu1g7VRL-5o0dJhyy87YP-LDaMrbXD7Bx07SNIUWctpffH05Z-IPw/s1600/F1.small.gif" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhZRIrpC0FzgEvsG-ncTOQEnbbLy5CKGRPBv4zy96tKr_gY6MYWIcU7_V7-T2c7Z0JF1dIwBH-tj3wsa_0sManBozu1g7VRL-5o0dJhyy87YP-LDaMrbXD7Bx07SNIUWctpffH05Z-IPw/s1600/F1.small.gif" /></a><span style="font-family: 'Times New Roman', serif; font-size: 12pt;">Un’altra analisi ha riguardato neuroni enkefalinergici, proposti come aventi ruoli cruciali nella modulazione del dolore nella pars caudalis. Le enkefaline fanno parte del sistema degli oppiati endogeni, tutti accoppiati a G protein di tipo inibitorio, il cui effetto è spesso quello di inibire la sensibilità elettrica dei neuroni adiacenti, giocando quindi un ruolo importante nella modulazione della nocicezione. Per marchiare tale neurotrasmettitore è stata utilizzata proenkephalina-gree fluorescent protein (PPE.GFP) in topi transgenici. E’ stata applicata una FISH combinata a tecniche di immunofluorescenza, quindi è stata esaminata la diversità fenotipica di neuroni PPE-GFP con immunostaining per vari marker che caratterizzano i sottotipi di neuroni ENKergici. Circa il 26% dei neuroni GFP positive erano contemporaneamente immunoreattivi per la GAD(acido glutammico decarbossilasi) e 15% positivi per il GABA. Le proporzioni di cellule positive a calbindina o calretinina tra i neuroni ENKergici sono 8% e 7%. Solamente 1% di tali neuroni è positivo per la parvalbumina, mentre nessuno coesprime l’ossido nitrico sintasi (NOS). E’ stato quindi iniettato un tracciante retrogrado nelle regioni talamiche,, osservando che un piccolo numero di neuroni ENKergici della pars caudalis restano marchiati dal tracciante. Tutti questi dati sperimentali dimostrano che il controllo delle vie dolorifiche è esercitato da molecole molto eterogenee, la cui conoscenza può essere cruciale per lo sviluppo di terapie efficaci contro malattie come la nevralgia del trigemino(in passato nota come “malattia del suicida”).</span><span style="font-family: 'Times New Roman', serif; font-size: 12pt;"><o:p></o:p></span></div><div class="MsoNormal" style="line-height: normal; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="font-family: 'Times New Roman', serif; font-size: 12pt;"><br />
</span></div><div class="MsoNormal" style="line-height: normal; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="font-family: 'Times New Roman', serif;"></span></div><h1 style="font-size: 12pt;"><span lang="EN-US" style="font-size: 12pt;">References:</span></h1><h1 style="font-size: 12pt;"><span class="Apple-style-span" style="font-weight: normal;">Thomas C. Pritchard, Kevin Douglas, Alloway; </span><span class="Apple-style-span" style="font-weight: normal;">M</span><span class="Apple-style-span" style="font-weight: normal;">edical Neuroscience.</span></h1><div class="MsoNormal" style="line-height: normal; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><u><span style="color: #1f497d; font-family: 'Times New Roman', serif; font-size: 12pt;">Viggiano A</span></u><span style="font-family: 'Times New Roman', serif; font-size: 12pt;"> et al. PMID: 15288579<o:p></o:p></span></div><div class="authlist"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Viggiano%20A%22%5BAuthor%5D">Viggiano A</a>, <span class="pmid">PMID: 15979588 <o:p></o:p></span></div><div class="MsoNormal" style="line-height: normal; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Viggiano%20A%22%5BAuthor%5D"><span style="font-family: 'Times New Roman', serif; font-size: 12pt;">Viggiano A</span></a><span style="font-family: 'Times New Roman', serif; font-size: 12pt;">, PMID: 20045451 <o:p></o:p></span></div><div class="rprtid"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Viggiano%20E%22%5BAuthor%5D">Viggiano E</a>, <span class="pmid">PMID: 20058053 <o:p></o:p></span></div><div class="rprtid"><o:p></o:p></div><h1 style="font-size: 12pt;"><span class="Apple-style-span" style="font-weight: normal;"><span class="Apple-style-span" style="font-size: small;"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Huang%20J%22%5BAuthor%5D">Huang J</a></span><span class="Apple-style-span" style="font-size: small;"> </span><span class="Apple-style-span" style="font-size: small;"><span class="pmid">PMID: 20974201</span></span> </span></h1>GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com0tag:blogger.com,1999:blog-2650750594787397971.post-81944820561337885512011-03-29T13:38:00.000-07:002011-03-29T13:38:34.637-07:00Sulla patogenesi dell'Alzheimer<div class="MsoNormal">N.B. Questo articolo è una traduzione a grandi linee di un articolo originale che si può visualizzare con il link seguente: <a href="http://acbjournal.org/Synapse/Data/PDFData/1049ACB/acb-43-332.pdf">http://acbjournal.org/Synapse/Data/PDFData/1049ACB/acb-43-332.pdf</a> e a cui si rimanda per le References.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Il morbo di Alzheimer (Alzheimer’s Desease, AD) è la più comune causa di demenza in età senile. Regioni del cervello adibite all’apprendimento, alla memoria e al comportamento emotivo <span style="mso-spacerun: yes;"> </span>corteccia entorinale, ippocampo, amigdale, telencefalo basale) si riducono di volume nei pazienti affetti da AD come risultato della degenerazione sinaptica e infine per la morte delle cellule neuronali. Le caratteristiche molecolari della patologia consistono in grovigli neurofibrillari intracellulari e in placche amiloidi extracellulari (A<span style="font-family: Symbol;">b</span>). Nonostante l’influenza di vari fattori genetici e ambientali, come l’invecchiamento ,nell’esordio dell’AD, diverse prove derivanti da studi su modelli sperimentali e su tessuto cerebrale affetto da AD hanno dimostrato che la neurodegenerazione che soggiace alla AD è associata a caratteristiche morfologiche e biochimiche dell’apoptosi. <span style="mso-spacerun: yes;"> </span>Studi sull’uomo hanno mostrato una significativa condizione patologica delle sinapsi nell’AD e hanno identificato la perdita delle sinapsi come principale causa della deficienza cognitiva nella malattia. Tra i meccanismi di morte cellulare, l’apoptosi è stata proposta per spiegare la perdita di cellule osservata in molti disordini neurodegenerativi. <span style="mso-spacerun: yes;"> </span>Vi sono due vie principali dell’apoptosi, la via intrinseca e la via estrinseca. Nella via intrinseca l’interazione tra la proteina anti-apoptotica Bcl2 e la proteina pro-apoptotica Bax gioca un ruolo chiave nell’attivazione dei segnali apoptotici che coinvolgono i mitocondri con il rilascio del citocromo C. Successivamente l’iniziatore caspasi-9 è attivato e può condurre l’attivazione della caspasi esecutiva, principalmente caspasi-3. L’attivazione della caspasi-3 porta la cellula a distruzione attraverso proteolisi.</div><div class="MsoNormal"><o:p></o:p></div><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh17EU5w0wHVMeW7o_XfEiVKFApsqdO13j_0hzfsGvvcQQyCcGLIxYlnFbKJsAFovDJaEYN1tl5U9ZcoWFfMdUrFpZlejksSm7-57huWBC8KTIHI4bQcZQCTHpGPdMaudNsNkog0IBvxA/s1600/Apoptosis_Overview.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" height="380" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh17EU5w0wHVMeW7o_XfEiVKFApsqdO13j_0hzfsGvvcQQyCcGLIxYlnFbKJsAFovDJaEYN1tl5U9ZcoWFfMdUrFpZlejksSm7-57huWBC8KTIHI4bQcZQCTHpGPdMaudNsNkog0IBvxA/s400/Apoptosis_Overview.jpg" width="400" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Vie dell'apoptosi</td></tr>
</tbody></table><div class="MsoNormal">Le Neureguline (NGRs) sono altamente espresse nel sistema nervoso, mentre ErbB4 (un recettore di NGR) è molto espresso nei neuroni durante lo sviluppo del cervello. NGR1 e il suo recettore ErbB tirosina chinasi sono espressi non solo nel sistema nervoso in sviluppo, ma anche nel cervello adulto. Inoltre<span style="mso-spacerun: yes;"> </span>la funzione di NGR1 è largamente mediata da una classe di recettori tirosina chinasi che includono ErbB2, ErbB3 e ErbB4. Tra i recettori ErbB, ErbB4 sembra essere il mediatore primario della funzione di NRG1 nel sistema nervoso centrale. Recenti studi biochimici indicano che ErbB4 è presente maggiormente nelle PSD delle sinapsi eccitatorie e nei terminali presinaptici GABAergici della corteccia cerebrale. In più, nell’ippocampo, l’mRNA di NRG1 è espresso nell’area CA3, una regione presinaptica per CA1 che mostra espressione di ErbB4. NRG1, inoltre, può essere neuroprotettiva per i neuroni corticali, i neuroni motori, i neuroni dopaminergici, i neuroni sensoriali della coclea e le cellule PC12. Queste scoperte suggeriscono che il segnale NGR1/ErbB4 potrebbe essere importante nei processi cognitivi, di apprendimento e formazione della memoria attraverso la modulazione della plasticità sinaptica e la sopravvivenza neuronale ed è una molecola critica nelle malattie neurodegenerative. <o:p></o:p></div><div class="MsoNormal"></div><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: right; margin-left: 1em; text-align: right;"><tbody>
<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAKJUZZ_NR0sB_7x8Kk65y68QB3cYAl7y81XQ9Nru7p0bgvyMekxB-lhRUzv1K4PIp0qhuzb6K9MAMA8frht3VQETAdsagSBpuKI1-d77RWLxEloqBR5uF7JwddJ1NTOQ1gjVMozol_w/s1600/acb-43-332-g003-l.jpg" imageanchor="1" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" height="365" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAKJUZZ_NR0sB_7x8Kk65y68QB3cYAl7y81XQ9Nru7p0bgvyMekxB-lhRUzv1K4PIp0qhuzb6K9MAMA8frht3VQETAdsagSBpuKI1-d77RWLxEloqBR5uF7JwddJ1NTOQ1gjVMozol_w/s400/acb-43-332-g003-l.jpg" width="400" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Immunoreattività a ErbB4 e Bax in neuroni apoptotici dell'ippocampo in pazienti affetti da AD e confronto con campione di controllo.</td></tr>
</tbody></table><span class="apple-style-span"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">La regolamentazione della famiglia delle proteine Bcl-2 è fondamentale per il mantenimento dell'integrità e della funzione mitocondriale in tal modo di decidere il destino di una cellula in seguito a stress severo. (Il peptide Aβ1-42 induce la morte delle cellule nel neuroblastoma umano per l'attivazione della caspasi-3, inizialmente tramite un aumento di rapporto Bax/Bcl-2.</span></span><span class="apple-converted-space"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;"> </span></span><span class="apple-style-span"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">Inoltre l’induzione di Bcl2 e Bax ha dimostrato di essere collegata all’iperfosforilazione di tau e alla morte neuronale indotta da acido okadaico nel cervello di ratto).</span></span><span class="apple-style-span"><span style="color: black; font-family: "Arial","sans-serif";"> </span></span><span class="apple-style-span"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">Studi di espressione genica ad ampio spettro hanno dimostrato analoga deplezione dei membri anti-apoptotici del gene della famiglia Bcl-2 nell'ippocampo affetto da AD e nella neocorteccia superiore del lobo temporale e uno spostamento verso l'espressione più pro-apoptotica della famiglia Bcl-2 specie Bax,Bad, Bid e Bik. Nonostante ciò l’immunoreattività a ErbB4 si riscontra insieme a quella per Bax nei neuroni piramidali apoptotici delle zone dell’ippocampo. Recentemente, ErbB4 ha dimostrato di giocare un ruolo chiave nella maturazione, in seguito ad attivazione, e nella plasticità della funzione sinaptica eccitatoria.</span></span><span class="apple-converted-space"><span style="color: black; font-family: "Arial","sans-serif";"> </span></span><span class="apple-style-span"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">Inoltre è stato dimostrato che NRG1 attiva ErbB4 e regola la trasmissione GABAergica nel cervello adulto. </span></span><span class="apple-converted-space"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">E’ stato dimostrato che l’immunoreattività di ErbB4 e NRG1 è associata a placche neuritiche in cervello affetto da AD così come in un modello transgenico di AD. NGR dunque può svolgere un ruolo nella plasticità sinaptica, il mantenimento e la regolazione della struttura sinaptica, o combinazioni di queste funzioni nel cervello dell’adulto.</span></span><span class="apple-converted-space"><span style="color: black; font-family: "Arial","sans-serif";"> </span></span><span class="apple-style-span"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">L'immunoreattività ErbB4 è risultata significativamente aumentata nel cervello umano affetto da AD e colocalizzata con Bax in neuroni piramidali apoptotici delle regioni ippocampali.</span></span><span class="apple-style-span"><span style="color: black; font-family: "Arial","sans-serif";"> </span></span><span class="apple-style-span"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">Tuttavia, se l'aumento di immunoreattività di ErbB4 o la colocalizzazione di ErbB4 con Bax in neuroni piramidali apoptotici siano stati coinvolti in pathway di sopravvivenza o di morte non è stato dimostrato.</span></span><span class="apple-converted-space"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;"> </span></span><span class="apple-style-span"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">Indipendentemente da ciò, risultati in vitro di AD sperimentale hanno mostrato chiaramente che è necessario ErbB4 per la tutela di NRG1 nella morte delle cellule neuronali. Simile a APP, ErbB4 è un substrato per la γ-secretasi e, come tale, presenta una prima scissione per mezzo di TACE e rilascia un peptide solubile extracellulare che contiene il sito di legame per NRG1 (ecto-ErbB4).</span></span><span class="apple-converted-space"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;"> </span></span><span class="apple-style-span"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">Il frammento rimanente di 80 kDa che rimane ancorato alla membrana plasmatica (cioè ErbB4-CTF) è ulteriormente scisso da una γ-secretasi presenilina-dipendente nel suo dominio transmembrana e in un dominio intracellulare (ErbB4-ICD) che viene rilasciato e che trasloca nel</span></span><span class="apple-converted-space"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;"> </span></span><span class="apple-style-span"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">nucleo e regola la trascrizione. </span></span><br />
<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: right; margin-left: 1em; text-align: right;"><tbody>
<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgjCNeEh4CDCDj2yHWmfXN0Ar8byhlXnj52ENgZOkUBs_nf6MOpvSqJOBZE_uh4vN73RerHFeml7SMwIB1fZYD3v00wC0OkHsBwS9Q2W304I7V3El1BSATpJ4B0K6wypNdEvpQg_5pUNQ/s1600/ErbB4+Pathway.jpg" imageanchor="1" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgjCNeEh4CDCDj2yHWmfXN0Ar8byhlXnj52ENgZOkUBs_nf6MOpvSqJOBZE_uh4vN73RerHFeml7SMwIB1fZYD3v00wC0OkHsBwS9Q2W304I7V3El1BSATpJ4B0K6wypNdEvpQg_5pUNQ/s400/ErbB4+Pathway.jpg" width="315" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;"><br />
</td></tr>
</tbody></table><div class="MsoNormal"><span class="apple-style-span"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">L’immunostaining di ErbB4<span style="mso-spacerun: yes;"> </span>è significativamente aumentata nel nucleo, suggerendo che la scissione della presenilina-dipendente di ErbB4 può essere coinvolta nella progressione della patologia AD. Ulteriori analisi del ruolo della NRG1 in AD potrebbe essere utile nella comprensione della patogenesi di AD stessa. Collettivamente, gli studi mostrano chiaramente che l’immunoreattività ErbB4 è significativamente aumentata nel cervello affetto da AD, rispetto ai controlli di pari età e che l’immunoreattività di ErbB4 è colocalizzata con Bax in neuroni piramidali apoptotici dell'ippocampo, suggerendo che la segnalazione NRG1/ErbB4 possa servire come un segnale di sopravvivenza</span></span><span class="apple-converted-space"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;"> </span></span><span class="apple-style-span"><span style="color: black; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">in progressione di AD.</span></span><span style="mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;"><o:p></o:p></span></div>GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com2tag:blogger.com,1999:blog-2650750594787397971.post-1637450004270966462011-03-23T12:18:00.000-07:002011-03-23T12:18:35.276-07:00Regolazione patologica delle spine dendritiche delle cellule di Purkinje<span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;">La concentrazione intracellulare del Ca^2+ </span><!--[if gte msEquation 12]><m:oMath><m:sSup><m:sSupPr><span
style='font-size:10.0pt;mso-ansi-font-size:10.0pt;mso-bidi-font-size:10.0pt;
font-family:"Cambria Math","serif";mso-ascii-font-family:"Cambria Math";
mso-hansi-font-family:"Cambria Math";font-style:italic;mso-bidi-font-style:
normal'><m:ctrlPr></m:ctrlPr></span></m:sSupPr><m:e><i style='mso-bidi-font-style:
normal'><span style='font-size:10.0pt;line-height:115%;font-family:"Cambria Math","serif";
mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;
mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;
mso-ansi-language:IT;mso-fareast-language:EN-US;mso-bidi-language:AR-SA'><m:r>Ca</m:r></span></i></m:e><m:sup><i
style='mso-bidi-font-style:normal'><span style='font-size:10.0pt;line-height:
115%;font-family:"Cambria Math","serif";mso-fareast-font-family:Calibri;
mso-fareast-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";
mso-bidi-theme-font:minor-bidi;mso-ansi-language:IT;mso-fareast-language:
EN-US;mso-bidi-language:AR-SA'><m:r>2+</m:r></span></i></m:sup></m:sSup></m:oMath><![endif]--><!--[if !msEquation]--><span style="font-family: "Calibri","sans-serif"; font-size: 11.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-text-raise: -4.0pt; position: relative; top: 4.0pt;"><v:shapetype coordsize="21600,21600" filled="f" id="_x0000_t75" o:preferrelative="t" o:spt="75" path="m@4@5l@4@11@9@11@9@5xe" stroked="f"> <v:stroke joinstyle="miter"> <v:formulas> <v:f eqn="if lineDrawn pixelLineWidth 0"> <v:f eqn="sum @0 1 0"> <v:f eqn="sum 0 0 @1"> <v:f eqn="prod @2 1 2"> <v:f eqn="prod @3 21600 pixelWidth"> <v:f eqn="prod @3 21600 pixelHeight"> <v:f eqn="sum @0 0 1"> <v:f eqn="prod @6 1 2"> <v:f eqn="prod @7 21600 pixelWidth"> <v:f eqn="sum @8 21600 0"> <v:f eqn="prod @7 21600 pixelHeight"> <v:f eqn="sum @10 21600 0"> </v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:formulas> <v:path gradientshapeok="t" o:connecttype="rect" o:extrusionok="f"> <o:lock aspectratio="t" v:ext="edit"> </o:lock></v:path></v:stroke></v:shapetype><v:shape id="_x0000_i1025" style="height: 13.5pt; width: 21pt;" type="#_x0000_t75"> <v:imagedata chromakey="white" o:title="" src="file:///C:\Users\GIAMMA~1\AppData\Local\Temp\msohtmlclip1\01\clip_image001.png"> </v:imagedata></v:shape></span><!--[endif]--><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"><span style="mso-spacerun: yes;"> </span>è coinvolta nelle principali funzioni neuronali e viene regolata da canali ad esso permeabili o da proteine con la capacità di legarlo alla propria struttura. I canali del Ca^2+</span><!--[if gte msEquation 12]><m:oMath><m:sSup><m:sSupPr><span
style='font-size:10.0pt;mso-ansi-font-size:10.0pt;mso-bidi-font-size:10.0pt;
font-family:"Cambria Math","serif";mso-ascii-font-family:"Cambria Math";
mso-fareast-font-family:"Times New Roman";mso-fareast-theme-font:minor-fareast;
mso-hansi-font-family:"Cambria Math";font-style:italic;mso-bidi-font-style:
normal'><m:ctrlPr></m:ctrlPr></span></m:sSupPr><m:e><i style='mso-bidi-font-style:
normal'><span style='font-size:10.0pt;line-height:115%;font-family:"Cambria Math","serif";
mso-fareast-font-family:"Times New Roman";mso-fareast-theme-font:minor-fareast;
mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;
mso-ansi-language:IT;mso-fareast-language:EN-US;mso-bidi-language:AR-SA'><m:r>Ca</m:r></span></i></m:e><m:sup><i
style='mso-bidi-font-style:normal'><span style='font-size:10.0pt;line-height:
115%;font-family:"Cambria Math","serif";mso-fareast-font-family:"Times New Roman";
mso-fareast-theme-font:minor-fareast;mso-bidi-font-family:"Times New Roman";
mso-bidi-theme-font:minor-bidi;mso-ansi-language:IT;mso-fareast-language:
EN-US;mso-bidi-language:AR-SA'><m:r>2+</m:r></span></i></m:sup></m:sSup></m:oMath><![endif]--><!--[if !msEquation]--><span style="font-family: "Calibri","sans-serif"; font-size: 11.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-text-raise: -4.0pt; position: relative; top: 4.0pt;"><v:shape id="_x0000_i1025" style="height: 13.5pt; width: 21pt;" type="#_x0000_t75"><v:imagedata chromakey="white" o:title="" src="file:///C:\Users\GIAMMA~1\AppData\Local\Temp\msohtmlclip1\01\clip_image001.png"></v:imagedata></v:shape></span><!--[endif]--><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"><span style="mso-spacerun: yes;"> </span>voltaggio dipendenti (VDCC) sono i regolatori principali della concentrazione di questo ione nel neurone.<span style="mso-spacerun: yes;"> </span>Essi sono composti da una subunità </span><span class="Apple-style-span" style="font-family: Symbol; font-size: 13px; line-height: 14px;">a1</span><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"> </span><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"><span style="mso-spacerun: yes;"> </span>che descrive un poro nella membrana ed è voltaggio sensibile e da altre subunità accessorie (</span><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-latin; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;">β,γ,δ,</span><span class="Apple-style-span" style="font-family: Symbol; font-size: 13px; line-height: 14px;">a2</span><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;">); vengono inoltre distinti in base alle caratteristiche farmacologiche ed elettrofisiologiche della loro subunità </span><span style="font-family: "Calibri","sans-serif"; font-size: 11.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-text-raise: -4.0pt; position: relative; top: 4.0pt;"><v:shape id="_x0000_i1025" style="height: 13.5pt; width: 10.5pt;" type="#_x0000_t75"> <v:imagedata chromakey="white" o:title="" src="file:///C:\Users\GIAMMA~1\AppData\Local\Temp\msohtmlclip1\01\clip_image002.png"> </v:imagedata></v:shape></span><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"><span style="mso-spacerun: yes;"> </span>in L, N, P/Q e R. Il tipo P/Q è espresso nel SNC, in particolare nelle cellule del Purkinje e nelle cellule dei granuli della corteccia cerebellare. Delle mutazioni a carico di questo canale sono collegate a diversi disturbi neurologici nell’uomo come l’atassia spino-cerebellare di tipo 6, l’emicrania emiplegica familiare e l’atassia episodica di tipo 2. </span><br />
<!--[if gte msEquation 12]><m:oMathPara><m:oMath><i
style='mso-bidi-font-style:normal'><span style='font-size:10.0pt;line-height:
115%;font-family:"Cambria Math","serif";mso-fareast-font-family:"Times New Roman";
mso-fareast-theme-font:minor-fareast;mso-bidi-font-family:"Times New Roman";
mso-bidi-theme-font:minor-bidi;mso-ansi-language:IT;mso-fareast-language:
EN-US;mso-bidi-language:AR-SA'><m:r>α</m:r></span></i></m:oMath></m:oMathPara><![endif]--><!--[if !msEquation]--><span style="font-family: "Calibri","sans-serif"; font-size: 11.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><v:shapetype coordsize="21600,21600" filled="f" id="_x0000_t75" o:preferrelative="t" o:spt="75" path="m@4@5l@4@11@9@11@9@5xe" stroked="f"> <v:stroke joinstyle="miter"> <v:formulas> <v:f eqn="if lineDrawn pixelLineWidth 0"> <v:f eqn="sum @0 1 0"> <v:f eqn="sum 0 0 @1"> <v:f eqn="prod @2 1 2"> <v:f eqn="prod @3 21600 pixelWidth"> <v:f eqn="prod @3 21600 pixelHeight"> <v:f eqn="sum @0 0 1"> <v:f eqn="prod @6 1 2"> <v:f eqn="prod @7 21600 pixelWidth"> <v:f eqn="sum @8 21600 0"> <v:f eqn="prod @7 21600 pixelHeight"> <v:f eqn="sum @10 21600 0"> </v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:f></v:formulas> <v:path gradientshapeok="t" o:connecttype="rect" o:extrusionok="f"> <o:lock aspectratio="t" v:ext="edit"> </o:lock></v:path></v:stroke></v:shapetype><v:shape id="_x0000_i1025" style="height: 13.5pt; width: 6pt;" type="#_x0000_t75"> <v:imagedata chromakey="white" o:title="" src="file:///C:\Users\GIAMMA~1\AppData\Local\Temp\msohtmlclip1\01\clip_image001.png"> </v:imagedata></v:shape></span><!--[endif]--><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjFiMjzmGXC_gGqOS8xZjaUiD9LaC_FJLQF6rj5_HXu6dYZeDF2fAGdJVoulfCv3zuZcIXoZkSnmxxxrPh-xaMbfOzdBbFWNRm2JJzBTC6uk8IK4KpKiqwrVwNIzOfcJGxmD_AcF6N9hw/s1600/purkinjw.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjFiMjzmGXC_gGqOS8xZjaUiD9LaC_FJLQF6rj5_HXu6dYZeDF2fAGdJVoulfCv3zuZcIXoZkSnmxxxrPh-xaMbfOzdBbFWNRm2JJzBTC6uk8IK4KpKiqwrVwNIzOfcJGxmD_AcF6N9hw/s320/purkinjw.jpg" width="243" /></a></div><span style="font-family: Calibri, sans-serif; font-size: 10pt; line-height: 115%;">Il topo “rolling Nagoya” (Cacna1a^tg.rol) </span><span style="font-family: Calibri, sans-serif; font-size: 10pt; line-height: 115%;">presenta una mutazione puntiforme spontanea al segmento S4 voltaggio sensibile della subunità<span style="mso-spacerun: yes;"> </span></span><span class="Apple-style-span" style="font-family: Symbol; font-size: 13px; line-height: 14px;">a1</span><span class="Apple-style-span" style="font-family: Calibri, sans-serif; font-size: 13px; line-height: 14px;">a</span><span style="font-family: Calibri, sans-serif; font-size: 10pt; line-height: 115%;">. Recenti studi di elettrofisiologia<a href="file:///C:/Users/Giammarco/Documents/Universit%C3%A0/Anatomia/Anatomia%20Microscopica/Regolazione%20spine%20dendritiche%20Purkinje.docx#_ftn1" name="_ftnref1" style="mso-footnote-id: ftn1;" title=""><span class="MsoFootnoteReference"><span style="mso-special-character: footnote;"><span class="MsoFootnoteReference"><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;">[1]</span></span></span></span></a> hanno rivelato che in questi topi avviene una diminuzione dell’ampiezza del PPSE nelle sinapsi che le Purkinje compiono con le fibre parallele e un aumento del PPSE nelle sinapsi tra le stesse Purkinje e le fibre rampicanti. Attraverso l’utilizzo di un HVEM<a href="file:///C:/Users/Giammarco/Documents/Universit%C3%A0/Anatomia/Anatomia%20Microscopica/Regolazione%20spine%20dendritiche%20Purkinje.docx#_ftn2" name="_ftnref2" style="mso-footnote-id: ftn2;" title=""><span class="MsoFootnoteReference"><span style="mso-special-character: footnote;"><span class="MsoFootnoteReference"><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;">[2]</span></span></span></span></a> (high voltage electron microscope) sono state osservate nei topi “rolling Nagoya” numerose spine dendritiche là dove nei topi sani sono per lo più assenti, ovvero sui dendriti prossimali delle cellule di Purkinje; queste inoltre fanno sinapsi con le fibre rampicanti. Sull’arborizzazione dendritica terziaria invece la densità e la dimensione delle spine dendritiche risultano minori rispetto a condizioni normali e persino la loro forma ed orientamento si presentano più irregolari. Prendendo in considerazione uno<span style="mso-spacerun: yes;"> </span>studio di Segal et al.<a href="file:///C:/Users/Giammarco/Documents/Universit%C3%A0/Anatomia/Anatomia%20Microscopica/Regolazione%20spine%20dendritiche%20Purkinje.docx#_ftn3" name="_ftnref3" style="mso-footnote-id: ftn3;" title=""><span class="MsoFootnoteReference"><span style="mso-special-character: footnote;"><span class="MsoFootnoteReference"><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;">[3]</span></span></span></span></a>, uno dei principali fattori che modulano la morfologia delle spine dendritiche è la concentrazione del Ca^2+</span><span style="font-family: Calibri, sans-serif; font-size: 11pt; line-height: 115%; position: relative; top: 4pt;"><v:shape id="_x0000_i1025" style="height: 13.5pt; width: 21pt;" type="#_x0000_t75"><v:imagedata chromakey="white" o:title="" src="file:///C:\Users\GIAMMA~1\AppData\Local\Temp\msohtmlclip1\01\clip_image003.png"></v:imagedata></v:shape></span><span style="font-family: Calibri, sans-serif; font-size: 10pt; line-height: 115%;"><span style="mso-spacerun: yes;"> </span>intracellulare: un moderato aumento della sua concentrazione</span><span style="font-family: Calibri, sans-serif; font-size: 10pt; line-height: 115%;"><span style="mso-spacerun: yes;"> </span>aumenterebbe il numero e la dimensione delle spine dendritiche, al contrario basse o alte concentrazioni porterebbero alla soppressione delle stesse. La concentrazione di Ca^2+</span><span style="font-family: Calibri, sans-serif; font-size: 11pt; line-height: 115%; position: relative; top: 4pt;"><v:shape id="_x0000_i1025" style="height: 13.5pt; width: 21pt;" type="#_x0000_t75"><v:imagedata chromakey="white" o:title="" src="file:///C:\Users\GIAMMA~1\AppData\Local\Temp\msohtmlclip1\01\clip_image003.png"></v:imagedata></v:shape></span><span style="font-family: Calibri, sans-serif; font-size: 10pt; line-height: 115%;"><span style="mso-spacerun: yes;"> </span>nei dendriti terziari delle cellule di Purkinje dei topi “rolling Nagoya” risulta diminuita in conseguenza all’inefficienza del canale del </span><span style="font-family: Calibri, sans-serif; font-size: 11pt; line-height: 115%; position: relative; top: 4pt;"><v:shape id="_x0000_i1025" style="height: 13.5pt; width: 21pt;" type="#_x0000_t75"> <v:imagedata chromakey="white" o:title="" src="file:///C:\Users\GIAMMA~1\AppData\Local\Temp\msohtmlclip1\01\clip_image003.png"> </v:imagedata></v:shape></span><span style="font-family: Calibri, sans-serif; font-size: 10pt; line-height: 115%;"><span style="mso-spacerun: yes;"> </span>P/Q <span style="mso-spacerun: yes;"> </span>e ciò concorda con la scomparsa delle spine dendritiche a questo livello e il conseguente calo del PPSE.<span style="mso-spacerun: yes;"> </span>Le spine ectopiche sui dendriti prossimali delle cellule di Purkinje possono spiegare su basi morfologiche l’aumento del PPSE nelle sinapsi delle cellule di Purkinje con le fibre rampicanti, in quanto offrono una maggiore superficie in qualità di elemento post-sinaptico. La presenza di spine ectopiche può essere a sua volta spiegata dall’alterata omeostasi del Ca^2+</span><span style="font-family: Calibri, sans-serif; font-size: 10pt; line-height: 115%;">, la mutazione del canale P/Q viene compensata in vari modi: con una maggiore attività dei canali del Ca^2+</span><span style="font-family: Calibri, sans-serif; font-size: 11pt; line-height: 115%; position: relative; top: 4pt;"><v:shape id="_x0000_i1025" style="height: 13.5pt; width: 21pt;" type="#_x0000_t75"><v:imagedata chromakey="white" o:title="" src="file:///C:\Users\GIAMMA~1\AppData\Local\Temp\msohtmlclip1\01\clip_image003.png"></v:imagedata></v:shape></span><span style="font-family: Calibri, sans-serif; font-size: 10pt; line-height: 115%;">, del tipo N e L, con la modulazione di proteina leganti Ca^2+</span><span style="font-family: Calibri, sans-serif; font-size: 11pt; line-height: 115%; position: relative; top: 4pt;"><v:shape id="_x0000_i1025" style="height: 13.5pt; width: 21pt;" type="#_x0000_t75"><v:imagedata chromakey="white" o:title="" src="file:///C:\Users\GIAMMA~1\AppData\Local\Temp\msohtmlclip1\01\clip_image003.png"></v:imagedata></v:shape></span><span style="font-family: Calibri, sans-serif; font-size: 10pt; line-height: 115%;"><span style="mso-spacerun: yes;"> </span>e la down-regulation di canali del Ca^2+</span><span style="font-family: Calibri, sans-serif; font-size: 11pt; line-height: 115%; position: relative; top: 4pt;"><v:shape id="_x0000_i1025" style="height: 13.5pt; width: 21pt;" type="#_x0000_t75"><v:imagedata chromakey="white" o:title="" src="file:///C:\Users\GIAMMA~1\AppData\Local\Temp\msohtmlclip1\01\clip_image003.png"></v:imagedata></v:shape></span><span style="font-family: Calibri, sans-serif; font-size: 10pt; line-height: 115%;"><span style="mso-spacerun: yes;"> </span>intracellulari come RyR1. Le indagini morfologiche nei topi “rolling Nagoya” hanno rivelato inoltre alterazioni caratteristiche delle sinapsi tra le varicosità delle fibre parallele e le spine dendritiche delle cellule di Purkinje, queste sinapsi vengono contratte infatti tra una sola varicosità della fibra parallela con più di 3 spine dendritiche. La diminuzione del PPSE nelle sinapsi tra cellule del Purkinje e fibre parallele, causata dalla diminuzione delle spine dendritiche delle Purkinje stesse, indurrebbe la formazione di queste sinapsi multiple attraverso una ipertrofia delle varicosità.</span><br />
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<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj5E-dKVpRSvmkB_rOLuE57sErqZ9800roFhGb0PS2UEm9Inp2S87b-pMO_7nIAPlt3r2zjt6bnDEvxEL-U-BBjlzOY9MO0v1fLrJR0V3HG7EJkp1djFFR5ZOJmWk-oCeA7rYGtXjAexw/s1600/spine.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="220" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj5E-dKVpRSvmkB_rOLuE57sErqZ9800roFhGb0PS2UEm9Inp2S87b-pMO_7nIAPlt3r2zjt6bnDEvxEL-U-BBjlzOY9MO0v1fLrJR0V3HG7EJkp1djFFR5ZOJmWk-oCeA7rYGtXjAexw/s320/spine.jpg" width="320" /></a></div><div class="separator" style="clear: both; text-align: left;"><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;">La morfologia delle spine dendritiche delle cellule di Purkinje e di conseguenza la microcircuiteria principale del cervelletto è il risultato di un’orchestrazione che avviene tra l’omeostasi del calcio e le due maggiori afferenze eccitatorie: le fibre rampicanti e le fibre parallele</span></div><div style="line-height: 14px;"><span class="Apple-style-span" style="font-family: Calibri, sans-serif; font-size: x-small;"><br clear="all" /></span> <hr align="left" size="1" style="font-family: Symbol; font-size: small;" width="33%" /> <!--[endif]--> <div id="ftn1" style="font-size: small;"> <div class="MsoFootnoteText"><a href="file:///C:/Users/Giammarco/Documents/Universit%C3%A0/Anatomia/Anatomia%20Microscopica/Regolazione%20spine%20dendritiche%20Purkinje.docx#_ftnref1" name="_ftn1" style="font-family: Symbol;" title=""><span class="MsoFootnoteReference"><span style="mso-special-character: footnote;"><!--[if !supportFootnotes]--><span class="MsoFootnoteReference"><span style="font-family: "Calibri","sans-serif"; font-size: 10.0pt; line-height: 115%; mso-ansi-language: IT; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;">[1]</span></span><!--[endif]--></span></span></a><span lang="EN-US"><span class="Apple-style-span" style="font-family: inherit;"> Matsushita et al. (2002) Purkinje cell spines of rolling mouse Nagoya. J Neurosci 22: 4388-4398<o:p></o:p></span></span></div></div><div id="ftn2" style="font-size: small;"> <div class="MsoFootnoteText"><span class="Apple-style-span" style="font-family: inherit;"><a href="file:///C:/Users/Giammarco/Documents/Universit%C3%A0/Anatomia/Anatomia%20Microscopica/Regolazione%20spine%20dendritiche%20Purkinje.docx#_ftnref2" name="_ftn2" title=""><span class="MsoFootnoteReference"><!--[if !supportFootnotes]--><span class="MsoFootnoteReference"><span style="font-size: 10pt; line-height: 115%;">[2]</span></span><!--[endif]--></span></a><span lang="EN-US"> Sen-Ich Oda et al. (2010) Differential regulation of Purkinje cell dendritic spines in rolling mouse Nagoya. Abc.2010.43.3.211<o:p></o:p></span></span></div></div><div id="ftn3" style="font-size: small;"> <div class="MsoFootnoteText"><a href="file:///C:/Users/Giammarco/Documents/Universit%C3%A0/Anatomia/Anatomia%20Microscopica/Regolazione%20spine%20dendritiche%20Purkinje.docx#_ftnref3" name="_ftn3" title=""><span class="MsoFootnoteReference"><span class="Apple-style-span" style="font-family: inherit;"><!--[if !supportFootnotes]--><span class="MsoFootnoteReference"><span style="font-size: 10pt; line-height: 115%;">[3]</span></span><!--[endif]--></span></span></a><span lang="EN-US"><span class="Apple-style-span" style="font-family: inherit;"> Segal et al. (2000) Dendritic spines formation and pruning: common cellular mechanisms? Trends Neurosci 23: </span><span class="Apple-style-span" style="font-family: Symbol;">53-53<o:p></o:p></span></span></div></div></div>GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com0tag:blogger.com,1999:blog-2650750594787397971.post-67698761579843377742011-03-21T13:22:00.000-07:002011-03-22T07:57:21.831-07:00Corea di Huntington<div class="separator" style="clear: both; text-align: center;"><iframe allowfullscreen='allowfullscreen' webkitallowfullscreen='webkitallowfullscreen' mozallowfullscreen='mozallowfullscreen' width='320' height='266' src='https://www.youtube.com/embed/EqYBVTLT03s?feature=player_embedded' frameborder='0'></iframe></div>"bisogna avere il caos dentro di sé per partorire una stella danzante" F.W.Nietzsche<br />
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhNb36SRymv8AUwlVUAs5NPlxigPYhKGHQzIOGBjYlI7uq5qQ98Ulk80Qiqlr2UzxiFqeX3Y6ERZZzTcdsskM9PmVCmwfrGMRxko5p6LAIwzPGN5wXnosLqUmpF-uer-a-dtRudSGzaQQ/s1600/George_Huntigton.jpg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" height="200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhNb36SRymv8AUwlVUAs5NPlxigPYhKGHQzIOGBjYlI7uq5qQ98Ulk80Qiqlr2UzxiFqeX3Y6ERZZzTcdsskM9PmVCmwfrGMRxko5p6LAIwzPGN5wXnosLqUmpF-uer-a-dtRudSGzaQQ/s200/George_Huntigton.jpg" width="158" /></a>Questo particolare tipo di corea a carattere ereditario prende il nome da un giovane medico di Long Island, George Huntington, il quale nel 1871, osservando un padre e un figlio che camminavano davanti a lui tenendosi per mano e agitati da movimenti bizzarri e involontari, intuì il carattere ereditario della malattia distinguendola dalle forme non ereditarie di corea.<br />
La corea di Huntington è una malattia neurodegenerativa ereditaria a trasmissione autosomica dominante. Nonostante la malattia sia congenita, l'insorgenza è spesso tradiva, i primi sintomi infatti compaiono tra i 30 e i 45 anni e porta alla morte entro 10-15 anni dall'esordio.<br />
Il quadro clinico è caratterizzato da movimenti involontari che interessano qualsiasi porzione del corpo con l'aspetto di danza, donde il nome corea; sopraggiunge negli stadi più avanzati disartria e quindi incomprensione del linguaggio e impossibilità della deglutizione.<br />
La malattia è caratterizzata inoltre dalla morte cellulare dei neuroni di medie dimensioni del caudato e del putamen e quindi dalla compromissione della proiezione GABAergica striato-pallidale e del sistema colinergico intrastriatale. La distruzione della proiezione GABAergica diretta al segmento esterno del globo pallido libera quest'ultimo dall'inibizione permettendo dunque lo sviluppo dell'ipercinesia.<br />
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi4xpthJNjjwzYsvnkR9joF-elQ1gEnpIadbEKZHuPaZTty-P5i1Z5jJITBS0VYslruqwbhB99HkLLOsWQuQWeDC-lt8bmvqGj2tEXceQ0qCiq_cOrsD6W-6chZE_RjDOvvBpwcNnczzQ/s1600/PDB_3io4_EBI.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="150" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi4xpthJNjjwzYsvnkR9joF-elQ1gEnpIadbEKZHuPaZTty-P5i1Z5jJITBS0VYslruqwbhB99HkLLOsWQuQWeDC-lt8bmvqGj2tEXceQ0qCiq_cOrsD6W-6chZE_RjDOvvBpwcNnczzQ/s200/PDB_3io4_EBI.png" width="200" /></a>L'apoptosi dei neuroni dello striato sarebbe causata da agglomerati di una particolare proteina, l'huntingtina (348 kD). Il gene codificante per questa proteina si colloca sul braccio corto del cromosoma 4 e nella corea di Huntington presenta la ripetizione anomala, da 36 a 120 contro le 10-30 ripetizioni dei soggetti normali, di triplette CAG codificanti per la glutammina. L'huntingtina in condizioni normali stimola la produzione di BDNF (Brain Derived Neurotrophic Factor) avendo come bersaglio una sequenza di 55 paia di basi che ha funzione di interruttore nei confronti del gene di BDNF e altri 20 geni fondamentali per la sopravvivenza dei neuroni. Nella malattia la mutazione dell'huntingtina fa perdere alla proteina questo importante controllo sull'interruttore bersaglio e il BDNF non viene più prodotto. Inoltre l'huntingtina mutata forma degli agglomerati citotossici che vengono accumulati nel nucleo finché non si giunge a morte cellulare programmata.<br />
Non vi è una terapia efficace. Nei modelli animali, trapianti di tessuto striatale fetale nello striato affetto migliora le prestazioni cognitive. Inoltre è stato osservato che l'attività dell'enzima caspasi-1 è aumentata nei pazienti e negli animali affetti dalla malattia e che in topi mutanti privi di questo enzima la progressione della malattia è rallentata.<br />
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References:<br />
Pontieri et Al., "Patologia Generale" ed. Piccin, 2010<br />
Ganong, "Fisiologia Medica" ed Piccin, 2008<br />
Stranding et al., "Anatomia del Gray" ed. Elsevier Masson, 2009<br />
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Si consiglia la visualizzazione di:<br />
<a href="http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2003/McDonald/Huntingtin.htm#Locating">http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2003/McDonald/Huntingtin.htm#Locating</a><br />
<a href="http://www.aichroma.com/">http://www.aichroma.com/</a><br />
<a href="http://www.nature.com/nrn/journal/v6/n12/full/nrn1806.html">http://www.nature.com/nrn/journal/v6/n12/full/nrn1806.html</a>GiammoNeuroNerdhttp://www.blogger.com/profile/12036776277116707319noreply@blogger.com2